• some studies have reported that in adult humans about 700 new neurons are added in the hippocampus every day, while more recent studies show that adult hippocampal neurogenesis does not exist in humans, or, if it does, it is at undetectable levels. (wikipedia.org)
  • 2019 ) KCNH2-3.1 mediates aberrant complement activation and impaired hippocampal-medial prefrontal circuitry associated with working memory deficits. (neurotree.org)
  • Ghrelin mediated hippocampal neurogenesis. (illumina.com)
  • Oral exposure to lead acetate for 28 days reduces the number of neural progenitor cells but increases the number and synaptic plasticity of newborn granule cells in adult hippocampal neurogenesis of young-adult rats. (tuat-global.jp)
  • Continuous exposure to alpha-glycosyl isoquercitrin from gestation ameliorates disrupted hippocampal neurogenesis in rats induced by gestational injection of valproic acid. (tuat-global.jp)
  • Oral exposure to high-dose ethanol for 28 days in rats reduces neural stem cells and immediate nascent neural progenitor cells as well as FOS-expressing newborn granule cells in adult hippocampal neurogenesis. (tuat-global.jp)
  • Parent, J.M. & Murphy, G.G. (2008) Mechanisms and Functional Significance of Aberrant Seizure-induced Hippocampal Neurogenesis. (umich.edu)
  • Adult hippocampal neurogenesis, the process of formation of new neurons, occurs throughout life in the hippocampus. (biomedcentral.com)
  • However, the majority of the computational studies have predominantly focused on the late stages of neurogenesis, when newborn neurons integrate into hippocampal circuitry. (biomedcentral.com)
  • Here, based on the branching process theory and biological evidence, we developed a computational model that represents the early stage hippocampal neurogenic cascade and allows prediction of the overall efficiency of neurogenesis in both normal and diseased conditions. (biomedcentral.com)
  • At a practical level, the stochastic model and simulation framework we developed will enable us to predict overall efficiency of hippocampal neurogenesis in both normal and diseased conditions. (biomedcentral.com)
  • However, the functional and structural deficits elicited by binge alcohol consumption were successfully reversed to some extent as a voluntary exercise in the rat models resulted in neurogenesis at the hippocampal region. (specializedtherapy.com)
  • In this chapter, we review the current knowledge about how stressful conditions alter the hippocampal neurogenesis and how astrocyte-derived sEVs are involved, making special focus on their miRNA cargo. (uandes.cl)
  • Axolotls have contributed as a bridge organism between invertebrates and mammals, as the species has the regenerative capacity to undergo complete neurogenesis forming a wide range of neuronal populations not limited to a small niche, yet the complexity and architecture is complex and analogous in many ways to human neural development. (wikipedia.org)
  • The zebrafish displays a strong neurogenerative capacity capable of regenerating a variety of tissues and complete neuronal diversity (with the exception of astrocytes, as they have yet to be identified within the zebrafish brain) with continued neurogenesis through the life span. (wikipedia.org)
  • Though avians have been used primarily to study early embryonic development, in recent decades the developing chick has played a critical role in the examination of neurogenesis and regeneration as the young chick is capable of neuronal-turnover at a young age, but loses the neurogenerative capacity into adulthood. (wikipedia.org)
  • Neuronal hyperexcitability in Alzheimer's disease: what are the drivers behind this aberrant phenotype? (nature.com)
  • Specifically, we discuss contributors to aberrant neuronal excitability, including abnormal levels of intracellular Ca 2+ and glutamate, pathological amyloid β (Aβ) and tau, genetic risk factors, including APOE , and impaired inhibitory interneuron and glial function. (nature.com)
  • This is nowhere more true than in the dentate gyrus, where competing forces such as neurodegeneration and neurogenesis dynamically modify neuronal connectivity, and can occur simultaneously. (frontiersin.org)
  • Thus, ABGCs provide two temporally overlapping but functionally distinct neuronal cell populations, adding a novel level of complexity to our understanding of how life-long neurogenesis contributes to adult brain function. (elifesciences.org)
  • Here, we show that conditional knockout of Mef2c in nestin-expressing neural stem/progenitor cells (NSCs) impaired neuronal differentiation in vivo, resulting in aberrant compaction and smaller somal size. (ca.gov)
  • Gene expression programmes drive many of the changes underlying network reorganisation in epileptogenesis, including neurodegeneration, astrogliosis, microgliosis, aberrant neurogenesis and restructured local and distant neuronal contacts, among other changes [ 3-5 ]. (researchsquare.com)
  • We show that Ankrd11 is expressed in the embryonic cortex, and that when it was knocked-down in murine cortical precursors this caused decreased proliferation, reduced neurogenesis, and aberrant neuronal positioning in developing cortex. (springeropen.com)
  • With respect to the control, the mutant forebrain contained fewer Tbr2-positive intermediate neuronal progenitors and displayed aberrant neurogenesis. (canada.ca)
  • In addition to the participation of calcium in the processes involved with epileptogeneses, such as neuronal death, aberrant synaptic plasticity, and neurogenesis, changes in intracellular Ca2 + homeostasis play a fundamental role in the generation and spread of epileptiform events. (fapesp.br)
  • Con respecto a los modelos animales en TEA, muchos estudios se centran en la expresión génica, la migración y maduración neuronal cortical y los déficits de la red neuronal, pero muy pocos son los estudios que relacionen directamente la comunicación oral animal y la expresión génica en áreas corticales del lenguaje. (bvsalud.org)
  • Here we begin with studies of the balance between excitation and inhibition, synaptic plasticity, neurogenesis and neuromodulators. (sfari.org)
  • The outcome of LPA signaling is dependent on cellular context and impacts on biological processes such as wound healing, differentiation, neurogenesis, and survival, to name a few [ 4 ]. (hindawi.com)
  • The K27M and G34R mutations induced several of the same pathways suggesting key shared oncogenic mechanisms including activation of neurogenesis and NOTCH pathway genes. (nature.com)
  • We analyze changes in the transcriptome of ependymoglial cells and their progeny after injury to infer the molecular pathways governing restorative neurogenesis. (synergy-munich.de)
  • GSE162556 Abstract Translation-dependent quality control pathways such as no-go decay (NGD), non-stop decay (NSD), and nonsense-mediated decay (NMD) govern protein synthesis and proteostasis by resolving non-translating ribosomes and preventing the production Shh of potentially harmful peptides derived from faulty and aberrant mRNAs. (antiviralbiologic.com)
  • Related effects on signaling pathways, including mTOR activation, the translatome and mouse cerebellar development were observed upon deletion of the NMD element and resulted in strikingly similar effects within the translatome, signaling pathways, and neurogenesis. (antiviralbiologic.com)
  • Our data reveal that problems in translation-dependent quality control pathways, which mitigate errors in translation to prevent the production of defective peptide products from aberrant mRNAs, can result in similar cellular reactions and neurodevelopmental abnormalities. (antiviralbiologic.com)
  • Employing birth date labelling and immunohistological markers, we show that mice harbouring an S140G mutation in Tuba1a present with normal neurogenic potential, but that this neurogenesis is often ectopic. (karger.com)
  • Research in the Naegele Laboratory aims to understand at a mechanistic level, how neurodegenerative changes, axonal sprouting, and aberrant neurogenesis contribute to epileptogenesis and spontaneous seizures in temporal lobe epilepsy. (wesleyan.edu)
  • Taken together, our findings suggest striking overlap between putative mechanisms of K27M and G34R mutations and point to increased NOTCH signaling playing a key role in K27M-related gliomagenesis, resulting from aberrant gene derepression due to impaired H3K27me3 deposition at super-enhancers in H3.3 mutant cells. (nature.com)
  • It is believed that the basal rate of neurogenesis is genetically determined [ 29 ], but the mechanisms that govern it under various physiological and pathological stimuli are poorly understood. (biomedcentral.com)
  • Here we present data indicating that when overexpressed, Sema 3A causes human neural progenitors (NP) axonal retraction and an aberrant dendritic arborization. (biomedcentral.com)
  • Moreover, the transplantation of BMMSCs can decrease aberrant amyloid-beta peptides as well as tau aggregates, inhibit neuroinflammation, and stimulate synaptogenesis. (biomedcentral.com)
  • Jyo studies chromatin organization during cell fate transitions in neural stem cells and determines how its mis-organization drives aberrant expression of immune modulatory genes and tumorigenesis. (mdanderson.org)
  • Alzheimer's disease (AD) is characterized by the accumulation of aberrant Aβ peptide plaques and neurofibrillary tau tangles in pathology [ 1 ]. (biomedcentral.com)
  • Another aberrant protein buildup is Tau protein, deposits of which form misfolded and clumps of neurofibrillary tangles within brain cells. (specializedtherapy.com)
  • Computational models of neurogenesis have attempted to derive biologically relevant knowledge, hard to achieve using experimentation. (biomedcentral.com)