Zika chikv morbidity diseases arbovirus infections. Medical search. Frequent questions

BACKGROUND: Chikungunya virus (CHIKV) is an Aedes mosquito-borne virus that has caused large epidemics linked to acute, chronic, and severe clinical outcomes. (bvsalud.org)
They are transmitted through blood-feeding insects such as mosquitoes and ticks, and include viruses such as chikungunya virus (CHIKV), dengue virus (DENV), West Nile virus (WNV), Zika virus (ZIKV), yellow fever virus (YFV), and eastern equine encephalitis virus (EEEV). (encyclopedia.pub)
Since its introduction in the Caribbean region at the end of 2013, chikungunya virus (CHIKV) rapidly expanded within a year to most countries of South, Central, and North America ( 1 , 2 ). (cdc.gov)
Chikungunya is an infection caused by the Chikungunya virus (CHIKV). (wikipedia.org)
Chikungunya virus infection has a clinical presentation that overlaps with that of Ross River virus infection (fever, rash, polyarthritis) and dengue fever transmitted by the same mosquitoes. (medscape.com)
Both natural and Chikungunya virus infection-induced specific antibodies were essential for controlling Chikungunya virus infections. (medscape.com)
Chikungunya virus infection elicited strong innate immunity with an abundant production of proinflammatory markers and cytokines, including high levels of alpha interferon, interleukin (IL)-4, IL10, and gamma interferon. (medscape.com)
Several murine models with Chikungunya virus-related joint and neurological diseases are being investigated. (medscape.com)
We found that atovaquone was able to inhibit ZIKV and chikungunya virus virion production in human cells and that this antiviral effect occurred early during infection at the initial steps of viral RNA replication. (nyu.edu)

With the reemergence of other arboviruses, new large-scale outbreaks in the near future seem likely ( 18 ). (cdc.gov)
PROBLEM/CONDITION: Dengue is one of the most common vectorborne flaviviral infections globally, with frequent outbreaks in tropical regions. (cdc.gov)
Although dengue, chikungunya and Zika are not the only arboviral threats posed by global warming and globalization in Southern Europe , ArboCat currently focuses on modelling the risk of outbreaks in Catalunya of these three diseases transmitted by the Aedes albopictus mosquito species because they represent the most serious and dramatic emergency we may have to deal with. (arbocat.cat)
While the disease typically occurs in Africa and Asia, outbreaks have been reported in Europe and the Americas since the 2000s. (wikipedia.org)
BACKGROUND: Late relapsing hepatitis after yellow fever (LHep-YF) during the convalescent phase of the disease has been described during recent yellow fever (YF) outbreaks in Brazil. (stanford.edu)
The ongoing global pandemic caused by coronavirus disease 2019 (COVID-19) has once again demonstrated the significance of the Coronaviridae family in causing human disease outbreaks. (preprints.org)

Given the neurological symptoms, this disease is concerning in age extremes, for patients with comorbidities and for patients with more than one viral infection by arboviruses, in whom the most severe neurological manifestations are more common. (intechopen.com)
However, the role of these cells during viral infection is not yet fully understood [ 16 ] . (encyclopedia.pub)
Chikungunya, a reemerging mosquitoborne viral infection, is responsible for one of the most explosive epidemics in the Western Hemisphere in recent years. (cdc.gov)

The real number of cases is most likely higher because of misdiagnosis with dengue virus (DENV) infection and underreporting. (cdc.gov)
I was also involved in other projects regarding SARS-CoV-2 variants and disease severity in infants (DOI 10.3389/fmed.2022.896352), Rift Valley fever virus epidemiology in humans and animals in Kenya (DOI 10.1371/journal.pgph.0000505), and dengue virus evolution in Africa (ongoing Ph.D. candidate mentorship). (stanford.edu)

The coronavirus disease 2019 (COVID-19) pandemic caused an unprecedented global emergency. (news-medical.net)
In March 2020, the World Health Organization declared coronavirus disease 2019 (COVID-19), caused by the novel severe acute respiratory syndrome coronavirus 2, to be a pandemic. (preprints.org)

Zika virus (ZIKV) is an arbovirus (mosquito-borne), first detected in Uganda in the 1940s. (news-medical.net)
Studies have linked maternal ZIKV infection during the first two trimesters to microcephaly. (news-medical.net)
In particular, the development of novel antivirals for high-risk populations such as pregnant women is essential to prevent devastating disease such as that which was experienced with the recent outbreak of Zika virus (ZIKV) in the Americas. (nyu.edu)
Finally, using an ex vivo human placental tissue model, we found that atovaquone could limit ZIKV infection in a dose-dependent manner providing evidence that atovaquone may function as an antiviral in humans. (nyu.edu)
In this study, we show that the common antiparasitic drug, atovaquone, inhibits arbovirus replication through intracellular nucleotide depletion and can impair ZIKV infection in an ex vivo human placental explant model. (nyu.edu)

Both diseases, together with Zika and yellow fever, are transmitted by mosquitoes of the Aedes genus, whose two most widespread species are Aedes aegypti and Aedes albopictus . (arbocat.cat)
In summary, the presence of Aedes albopictus mosquitoes in Catalunya has opened up the possibility of an Aedes -borne disease outbreak triggered by an imported case, that is, the arrival of an infected person travelling from an endemic country. (arbocat.cat)

The genomic data comprised 241 Brazilian CHIKV genome sequences from GenBank (n=180) and the 2022 CHIKV outbreak in Ceará state (n=61). (bvsalud.org)

Yellow fever virus (YFV) is the agent of the most severe mosquito-borne disease in the tropics. (bvsalud.org)

METHODS: In this epidemiological study, we used CHIKV genomic sequencing data, CHIKV vector information, and aggregate clinical data on chikungunya cases from Brazil. (bvsalud.org)
Unlike most other virus classifications, the arbovirus grouping is based on an epidemiological criterion-the most common route of infection-rather than on phenotypical criteria. (arbocat.cat)
Zoonotic transmission cycles, in which wild or domestic animals are involved in the epidemiological cycle, are also common for most arboviruses but are generally less important from an epidemiological standpoint. (arbocat.cat)
Using disease modeling, epidemiological, and phylogenetic analysis, we study the genomic evolution and transmission dynamics of H5N1 avian influenza A after 2020. (stanford.edu)

The World Health Organization (WHO) introduced the Disease X concept in 2018 to develop a preparedness planning framework for unpredictable events. (news-medical.net)

However, in vulnerable populations, such as newborns, infants, the elderly and immune-compromised individuals, these opportunistic pathogens can also affect the lower respiratory tract, causing a more severe disease (e.g., pneumonia). (mdpi.com)
Taken together, these studies suggest that atovaquone could be a broad-spectrum antiviral drug and a potential attractive candidate for the prophylaxis or treatment of arbovirus infection in vulnerable populations, such as pregnant women and children. (nyu.edu)
IMPORTANCE The ability to protect vulnerable populations such as pregnant women and children from Zika virus and other arbovirus infections is essential to preventing the devastating complications induced by these viruses. (nyu.edu)

Although the most common Chikungunya (do not capitalize the disease unless it is named after a proper noun such as Zika, Ebola or Carrion's Disease) manifestations are osteoarticular, those which bring the most morbidity and mortality are neurological, where thorough mapping through studies with a methodological outline have not yet been well structured. (intechopen.com)

Neutrophils during Arboviral Infections" Encyclopedia , https://encyclopedia.pub/entry/11625 (accessed December 10, 2023). (encyclopedia.pub)
In this review, we highlight the major findings from recent years regarding the role of neutrophils during arboviral infections. (encyclopedia.pub)
Better understanding of neutrophil pathways involved in effective protection against arboviral infections can help identify potential targets for therapeutics. (encyclopedia.pub)
In this review, we highlight the recent advancements in understanding the beneficial and detrimental nature of neutrophils during arboviral infections. (encyclopedia.pub)
Clarifying and quantifying the introduction and propagation range in space and time of the initial epidemic wave of chikungunya within the complex urban settings of Latin America will shed light on arboviral transmission dynamics and help in managing future threats of new or emerging arboviruses operating under similar epidemiologic dynamics. (cdc.gov)
DESCRIPTION OF SYSTEM: State and territorial health departments report dengue cases to CDC through ArboNET, the national arboviral surveillance system, which was developed in 2000 to monitor West Nile virus infections. (cdc.gov)

In 2009, the American Association of Blood Banks (AABB) published a detailed description of 68 infectious agents capable of being transmitted by blood transfusion and prioritizing emerging infectious diseases for which there was not yet an implemented intervention. (medscape.com)
Open forum infectious diseases. (nyu.edu)
in Immunology and Infectious diseases, Ph.D. in Microbiology. (stanford.edu)
I have a Ph.D. in Microbiology, with an emphasis in Virology, and a Master's in Infectious Diseases. (stanford.edu)
2 Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore. (jci.org)
5 Department of Infectious Diseases, Singapore General Hospital, Singapore. (jci.org)

COVID-19 appears to have a low mortality rate in pediatric populations relative to adults but a high multifactorial morbidity. (news-medical.net)
This group of viruses have been known to cause significant morbidity and mortality around the world, with the potential to spread quickly and expand their geographical range due to their distinct mode of transmission using arthropods. (encyclopedia.pub)

Diagnoses and treatments for these infections are still limited and prophylaxis through vaccines is still far from being achieved. (ufg.br)

Arboviruses ( ar thropod- bo rne viruses ) are viruses transmitted primarily by arthropod vectors, such as mosquitoes, flies, ticks and fleas. (arbocat.cat)

Vaccination or infection offers lifetime immunity. (news-medical.net)

As such, the present study reviewed emerging and re-emerging viral diseases, focusing on pediatric populations. (news-medical.net)

This information will help in managing future threats of new or reemerging arboviruses. (cdc.gov)

Arboviruses are known to cause large-scale epidemics in many parts of the world. (encyclopedia.pub)

Neutrophils are generally the first leukocytes to be recruited to a site of infection, playing a major role in regulating inflammation and, as a result, viral replication and dissemination. (encyclopedia.pub)
However, the underlying mechanisms through which neutrophils control the progression of inflammation and disease remain to be fully understood. (encyclopedia.pub)
the other half have severe disease with inflammation of the brain and seizures. (wikipedia.org)

Moderna's mRNA-1273 and Pfizer's BNT162b2 vaccines have been safe and effective in children under 18 to prevent infection, hospitalization, severe illness, MIS-C, and death. (news-medical.net)
The recommendation for the dengue vaccine offers public health professionals and health care providers a new intervention for preventing illness and hospitalization in the age group with the highest burden of disease in the four territories (Paz Bailey G, Adams L, Wong JM, et al. (cdc.gov)
Persons aged 9-16 years in those jurisdictions with laboratory evidence of previous dengue infection can receive the dengue vaccine and benefit from a reduced risk for symptomatic disease, hospitalization, or severe dengue. (cdc.gov)

This method was applied to 56 YFV sequences from human infections and 27 from non-human primate (NHPs) infections to investigate the presence of genetic signatures possibly related to disease severity (in human related sequences) and differences in PCR cycle threshold (Ct) values (in NHP related sequences). (bvsalud.org)
Improvements in HRQoL after hospital discharge are independent of imaging improvement, and there seems to be no association between HRQoL after hospital discharge and disease severity on hospital admission. (scielo.br)

Three different single-nucleotide polymorphisms (SNPs) in human TLR-7 (rs179010, rs5741880, rs3853839) and 1 SNP in TLR-8 (rs3764879) were associated with increased susceptibility to infection and related clinical manifestations. (medscape.com)
The symptoms of disease may vary from case to case, with a clinical spectrum ranging from infection with no symptoms, mild respiratory illness to severe respiratory disease and death. (cepi.net)
We review the endemic and emerging alpha- and betacoronavirus infections of wildlife, livestock, and companion animals, and provide information on the receptor usage, known hosts, and clinical signs associated with each host for 15 coronaviruses discovered in people and animals. (preprints.org)

The symptoms can be mistaken for those of dengue fever and Zika fever. (wikipedia.org)
MERS-CoV infection typically causes respiratory symptoms including cough, shortness of breath and pneumonia. (cepi.net)

Mpox, previously known as monkeypox, is a zoonotic disease caused by the mpox virus. (news-medical.net)
The term "Chikungunya" often refers to both the virus (CHIKV) and the illness or fever (CHIKF) caused by this virus. (medscape.com)
The organization has also invested in the development of rapid response platforms to develop vaccines against Disease X (the threat of an unknown virus). (cepi.net)
Dromedary camels have been shown to also carry the virus, and are thought to be the main source of infections in humans. (cepi.net)
The virus appears to cause more severe disease in older people, people with weakened immune systems, and those with chronic diseases such as renal disease, cancer, chronic lung disease, and diabetes. (cepi.net)

MERS is a zoonotic disease, meaning it passes from animals to humans. (cepi.net)

Most (72%-93%) infected persons develop symptomatic disease characterized by fever, rash, and incapacitating arthralgia, progressing in 42%-60% of patients to chronic, long-lasting relapsing or lingering rheumatic disease ( 8 , 9 ). (cdc.gov)

A 2017 study reported that Chikungunya infection activates toll-like receptors (TLR), triggering the innate immune system. (medscape.com)

Therefore, the objective was to review the literature to identify neurological manifestations of CHIKV. (intechopen.com)

This information can be used to guide implementation of a One Health approach that involves human health, animal health, environmental, and other relevant partners in developing strategies for preparedness, response, and control to current and future coronavirus disease threats. (preprints.org)

CHIKV is a public health problem for many reasons including its chronic potential complications. (intechopen.com)
These terms refer to the "stooped-over posture" exhibited by individuals with the disease as a consequence of severe chronic incapacitating arthralgias. (medscape.com)
Hence, severe or chronic infections could be attributed to an absence or deregulation of 1 of these pathways. (medscape.com)

Understanding the trends of these diseases and the state of global prevention and control efforts is necessary to address the ongoing public health challenge. (news-medical.net)
Centers for Disease Control and Prevention. (cdc.gov)
The best means of prevention is overall mosquito control and the avoidance of bites in areas where the disease is common. (wikipedia.org)
In this study, we addressed the antiviral role of atovaquone, a FDA Pregnancy Category C drug and pyrimidine biosynthesis inhibitor used for the prevention and treatment of parasitic infections. (nyu.edu)
Adherence to strict infection prevention protocols in health care settings is essential. (cepi.net)

CHIKV belongs to the genus Alphavirus (Togaviridae), first isolated in Tanzania during 1952 ( 3 ). (cdc.gov)

Arthropod-borne viruses or arboviruses have a unique effect on neutrophil function since viral factors as well as vector factors can affect the activity of these cells. (encyclopedia.pub)
Most arthropods require warm and humid conditions to survive and arboviruses are, therefore, encountered mainly in the tropics, where the weather conditions ensure the year-round-or at least seasonal-presence of the vector. (arbocat.cat)
As mentioned above, the main diseases transmitted by this vector are yellow fever, dengue, chikungunya and Zika. (arbocat.cat)

Respiratory viruses infect the human upper respiratory tract, mostly causing mild diseases. (mdpi.com)

PUBLIC HEALTH ACTION: The Advisory Committee on Immunization Practices recommends vaccination with Dengvaxia for children aged 9-16 years with evidence of previous dengue infection and living in areas where dengue is endemic. (cdc.gov)
ABSTRACT Visceral leishmaniasis (VL) has shown endemic pattern and epidemic episodes in urban and rural areas, however, there are still gaps in knowledge with regards to disease transmission. (scielo.br)

Signs of infection typically begin with fever, rash, and swelling in the extremities. (wikipedia.org)

The very young, old, and those with other health problems are at risk of more severe disease. (wikipedia.org)

feeds almost exclusively on humans and is therefore the more efficient disease spreader, making it the main culprit for the huge burden posed by these diseases in tropical regions. (arbocat.cat)
For better measures in public health, the dual burden of zoonoses seems a logical way to determine the integral impact of such diseases in society and thus take better measures to prevent and reduce the impact of these diseases. (preprints.org)

This work deals with a systematic review of the intrinsic mechanisms used by humans to fight fungal infections, focusing on chitinases, discussing the main enzymes and gene polymorphism with them involved. (ufg.br)

The studies show that headaches were characterized as the most common symptom in adult patients affected by CHIKV, followed by meningeal involvement. (intechopen.com)
Fungal infections are increasingly common in the world, being considered one of the main causes of death in immunocompromised and immunosuppressive patients. (ufg.br)

Our study provides a novel function for atovaquone and highlights that the rediscovery of pregnancy-acceptable drugs with potential antiviral effects can be the key to better addressing the immediate need for treating viral infections and preventing potential birth complications and future disease. (nyu.edu)

MERS-CoV can infect people of any age, however middle-aged adults are at highest risk of infection. (cepi.net)

ABSTRACT Chagas disease (CD) is a neglected tropical disease associated with poverty in which patients are surrounded by stigma. (scielo.br)

Although nationally the disease attack rate was estimated at 6.9%-13.8% ( 13 ), the observed attack rate in populated urban areas was ≈40%-50%, comparable to those reported in the Dominican Republic ( 14 ) and Asia and higher than those in La Reunion ( 15 , 16 ). (cdc.gov)

It is believed most people become immune after a single infection. (wikipedia.org)

Dengue and chikungunya, by contrast, have already demonstrated the potential threat they pose for southern Europe, and the same is true of Zika, as illustrated by the 2015 South American pandemic. (arbocat.cat)
Despite the potential for disease transmission through transfused blood, the safety of the blood supply in the United States continues to improve and, in fact, is the greatest that it has ever been. (medscape.com)
One class of antiviral therapies may lie in known pregnancy-acceptable drugs that have the potential to mitigate arbovirus infections and disease yet this has not been explored in detail. (nyu.edu)

A recent study published in the journal Pediatric Research reviewed emerging and re-emerging viral diseases. (news-medical.net)
The recent re-emergence and travel-related spread of Chikungunya infection to Europe and the United States has drawn global attention. (medscape.com)

The directionality and heterogeneity of transmission during the first introduction of chikungunya indicated existence of areas of diffusion and elevated risk for disease and highlight the importance of epidemic preparedness. (cdc.gov)

Newborns are susceptible to particularly severe effects of Chikungunya infection. (wikipedia.org)

The rapid expansion and worldwide spread in the last decade make CHIKV one of the most public health-relevant arboviruses ( 17 ). (cdc.gov)
on the other hand, feeds less often and on a variety of host species and does not, therefore, spread disease so effectively. (arbocat.cat)
In fact, international travel stands out as one of the major risk factors for the rapid global spread of the disease. (medscape.com)

Direct or indirect contact with infected dromedary camels, including animal husbandry, care, and slaughter, increases the risk of infection with MERS-CoV. (cepi.net)

See 11 Travel Diseases to Consider Before and After the Trip , a Critical Images slideshow, to help identify and manage infectious travel diseases. (medscape.com)

While preparations for Disease X led to calls for action and recommendations, public health institutions, which were underfunded for a long time, were slow to react. (news-medical.net)

Organisms6

Diseases6

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Information Science1

Health Care2

Geographicals2

Chikungunya virus9

Outbreaks6

Viral infection3

Dengue virus2

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ZIKV5

Aedes2

Outbreak1

Mosquito-borne1

Epidemiological4

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Vulnerable populations3

Ebola1

Arboviral6

Infectious diseases6

Mortality2

Prophylaxis1

Mosquitoes1

Immunity1

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Future threats1

Epidemics1

Inflammation3

Hospitalization3

Severity2

Clinical3

Symptoms2

Virus5

Zoonotic disease1

Symptomatic disease1

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Neurological1

Threats1

Chronic3

Prevention5

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Respiratory1

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Rash1

Severe disease1

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Humans1

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Adults1

Abstract1

Nationally1

Immune1

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Preparedness1

Newborns1

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Risk1

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Public health1