• Historically, zygotic induction provided insight into the nature of bacterial conjugation. (wikipedia.org)
  • This study led to a definition of the mechanism of bacterial conjugation, and also enabled an analysis of the genetic apparatus of the bacterial cell. (nobelprize.org)
  • In 1947, Joshua Lederberg and Edward Tatum discovered that nutritional mutants of the bacterium E. coli, when incubated in mixed cultures, exchanged genetic markers to generate new recombinants, although the mating efficiency was inefficient. (wikipedia.org)
  • In 1954 he began a long and fruitful collaboration with Elie Wollman, in an attempt to establish the nature of the relationships between the prophage and genetic material of the bacterium. (nobelprize.org)
  • In analogy with fertilization and meiosis of higher organisms, he proposed that all of the genetic material was transferred but that breakage of the donor chromosome occurred at specific locations so that segments of the donor chromosome could be deleted. (wikipedia.org)
  • In 1958 the remarkable analogy revealed by genetic analysis of lysogeny and that of the induced biosynthesis of ß-galactosidase led François Jacob, with Jacques Monod , to study the mechanisms responsible for the transfer of genetic information as well as the regulatory pathways which, in the bacterial cell, adjust the activity and synthesis of macromolecules. (nobelprize.org)
  • Since then, he has devoted his attention to the genetic analysis of the mechanisms of cell division. (nobelprize.org)
  • When DNA is transferred to the recipient cell by conjugation, the viral genes in the transferred DNA are immediately turned on because the recipient cell lacks the repressor. (wikipedia.org)
  • Élie Wollman and François Jacob showed that genes were transferred in a certain order from the Hfr donor cell to the F− recipient cell during mating. (wikipedia.org)
  • These observations provided evidence that genetic markers was transferred in one direction during conjugation, from the Hfr to F− cell. (wikipedia.org)