Willebrand wnt1 protein. Medical search. Frequent questions

WNT1-inducible-signaling pathway protein 1 (WISP-1), also known as CCN4, is a matricellular protein that in humans is encoded by the WISP1 gene. (wikipedia.org)

This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. (utsouthwestern.edu)
This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. (utsouthwestern.edu)

Connective Tissue Growth Factor belongs to the CCN family of proteins. (neuromics.com)
The CCN family presently consists of six members in human also known as: Cyr61 (Cystein rich 61), CTGF (Connective Tissue Growth Factor), Nov (Nephroblastoma Overexpressed gene), WISP-1, 2 and 3 (Wnt-1 Induced Secreted Proteins). (neuromics.com)

CCN proteins are matricellular proteins which are involved in the regulation of various cellular functions including: proliferation, differentiation, survival, adhesion and migration. (neuromics.com)

WISP-1 is highly homologous to CYR61 (CCN1) and CTGF (CCN2), and is a member of the CCN family of secreted, extracellular matrix (ECM)-associated signaling proteins (CCN intercellular signaling protein). (wikipedia.org)
The CCN genes encode secreted proteins associated with the Extracellular Matrix (ECM) and cell membrane. (neuromics.com)

The CCN family of proteins shares a common molecular protein structure, characterized by an N-terminal secretory signal peptide followed by four distinct domains with homologies to insulin-like growth factor binding protein (IGFBP), von Willebrand type C repeats (vWC), thrombospondin type 1 repeat (TSR), and a cysteine knot motif within the C-terminal (CT) domain. (wikipedia.org)

The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. (utsouthwestern.edu)

Proteolysis of the secreted full-length CCN proteins that has been reported in the case of CCN2 and CCN3 might result in the production of CCN-derived peptides with high affinity for ligands that full-length CNN proteins bind only poorly. (neuromics.com)

It is 72% identical to the mouse protein at the amino acid level. (utsouthwestern.edu)
Our results showed that multifaceted protein engineering, far beyond a few amino acid substitutions, could significantly improve rFVIII pharmacokinetic properties while maintaining hemostatic function. (bvsalud.org)

Full length secreted CCN proteins can show an antiproliferative activity, whereas truncated isoforms are likely to stimulate proliferation and behave as oncogenes. (neuromics.com)

Module II includes a stretch of 70amino acid residues - which shares sequence identity with the Von Willebrand Factor Type C repeat (VWC). (neuromics.com)

The full length protein consists of four modulesModule I shares partial identity with the N-terminal part of the Insulin-like Growth Factor Binding Proteins (IGFBPs). (neuromics.com)
Module IV resembles the CT domain of several extracellular protein including, Von Willebrand's factor and mucins. (neuromics.com)
Extended half-life recombinant FIX (rFIX) molecules have been generated to reduce the dosing burden and increase the protection of patients with hemophilia B. Clinical pharmacology studies with recombinant factor IX Fc fusion protein (rFIXFc) report a similar initial peak plasma recovery to that of rFIX, but with a larger volume of distribution. (bvsalud.org)
Endogenous von Willebrand factor (VWF) stabilizes and protects FVIII from degradation and clearance, but it also subjects FVIII to a half-life ceiling of â ¼15 to 19 hours. (bvsalud.org)

The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. (utsouthwestern.edu)
BIVV001 was bioengineered as a unique fusion protein consisting of a VWF-D'D3 domain fused to rFVIII via immunoglobulin-G1 Fc domains and 2 XTEN polypeptides (Amunix Pharmaceuticals, Inc, Mountain View, CA). Plasma FVIII half-life after BIVV001 administration in mice and monkeys was 25 to 31 hours and 33 to 34 hours, respectively, representing a three- to fourfold increase in FVIII half-life. (bvsalud.org)

It is the leasts conserved one of the four domains at the level of nucleotide sequence, but it appears to be critical for several of the biological functions attributed to the CCN proteins. (neuromics.com)

WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. (utsouthwestern.edu)

WNT1-inducible-signaling pathway protein 1 (WISP-1), also known as CCN4, is a matricellular protein that in humans is encoded by the WISP1 gene. (wikipedia.org)
O teste molecular identificou uma deleção em homozigose do éxon 4 do gene WNT1. (bvsalud.org)
The molecular test identified a homozygous deletion of exon 4 of the WNT1 gene. (bvsalud.org)

FluoBolt™-Technology provides a high sensitivity Klotho protein assay for basic and clinical research, which increases detection and may improve data consistency in literature. (diapharma.com)
Measurement of human klotho protein is ideal for use as a kidney disease biomarker in basic and clinical research. (diapharma.com)

Tested for human KLOTHO protein, human shares high sequence identity with mice, rats, and non-human primates (see chart below). (diapharma.com)
Human α-KLOTHO protein shares between 84-100% aa sequence identity with primates, mice, rats, hamster, and pig protein (shown in the chart below). (diapharma.com)