AnticoagulantsAntagonistsAnticoagulationPhenprocoumon and acenocoumarolHeparinVitaminAnticoagulant activityIncluding intracranial hemorrhageMyocardial infarctionDabigatranConcomitantPatientsClinicallyDoseAtrial fibrillationComplicationsClinicalPregnancyMedicinesChronicTrialsTherapyDrugsLiverFoundTreatmentResponseStudyEffectiveBackground
Anticoagulants8
- The availability of oral, non-vitamin K based anticoagulants that provide similar protection against thrombosis but have fewer adverse side effects and do not require regular monitoring of INR has decreased the use of warfarin, particularly in the elderly who are most prone to bleeding complications. (nih.gov)
- Warfarin has been the most commonly used oral anticoagulants ever since its approval in 1954 [ 1 ]. (hindawi.com)
- Warfarin (Coumadin) and some anticoagulants used primarily in Europe antagonize the activity of vitamin K and, in turn, prothrombin [ 8 ]. (nih.gov)
- Newer oral anticoagulants have a slightly lower risk of intracranial hemorrhage compared with warfarin (Coumadin), but dose adjustment is required in patients with renal disease. (aafp.org)
- Anticoagulants eg warfarin, and acenocoumarol (periodically monitor platelets, prothrombin time/INR & physical exam). (saifpharma.com)
- Theoretical potential for compd metabolized by CYP3A4/2C9, oral anticoagulants eg warfarin & acenocoumarol. (arogga.com)
- For decades, the main anticoagulants were heparin and warfarin , but a lot of new drugs were developed since their discovery. (hospenterprise.com)
- The antithrombotic drugs include indirect anticoagulants - vitamin K antagonists (VKA) (warfarin, acenocoumarol, phenprocoumarol) and antiplatelet agents (aspirin, dipyridamole and clopidogrel) [6][7]. (scardio.ru)
Antagonists2
- Side bar - in the Netherlands, the vitamin K antagonists acenocoumarol or phenprocoumon are much more commonly used than warfarin . (medscape.com)
- Increased coagulation tests (prothrombin time/INR) and/or bleeding with vit K antagonists (e.g. warfarin, acenocoumarol, fluindione). (shombhob.com)
Anticoagulation6
- S -warfarin is 3-5 times more potent than R -enantiomer in anticoagulation effects. (hindawi.com)
- The potency shown in clinical use boosts the studies on the mechanisms of warfarin anticoagulation. (hindawi.com)
- The anticoagulation effects are currently believed to be due to warfarin interrupting the vitamin K cycle in liver: in coagulation cascade, activated clotting factors are indispensable for the formation of blood clot. (hindawi.com)
- The James Paget University Hospital Anticoagulation Service provides INR testing, monitoring and dosing advice service for patients taking Warfarin/Acenocoumarol. (jpaget.nhs.uk)
- Advice and guidance for patients taking Warfarin, including anticoagulation review at James Paget University Hospital Clinic or Telephone Clinic for patients experiencing difficulty maintaining good anticoagulation control. (jpaget.nhs.uk)
- Acenocoumarol is used for short-term anticoagulation needs but is not approved for use in the USA. (superiortoxicology.com)
Phenprocoumon and acenocoumarol2
- Coumarin derivatives include warfarin, dicumarol, phenprocoumon and acenocoumarol. (nih.gov)
- Liver injury is more common with other coumarin derivatives such as phenprocoumon and acenocoumarol, which are available in other countries but not in the United States. (nih.gov)
Heparin1
- Warfarin is more efficacious than unfractionated heparin (UFH) for thromboembolic prophylaxis of pregnant women with mechanical valves. (medscape.com)
Vitamin4
- Warfarin is a commonly used oral anticoagulant with anti-vitamin K activity. (nih.gov)
- Since vitamin K epoxide reductase (VKOR) is responsible for the synthesis of reduced vitamin K, warfarin, by targeting at and inhibiting VKOR, can block the activation of clotting factors and decrease the blood clot [ 3 ]. (hindawi.com)
- Acenocoumarol is an anticoagulant that functions as a vitamin K antagonist (like warfarin). (wikipedia.org)
- Similar to other coumarin derivatives, the anticoagulant effects of acenocoumarol are mediated via inhibition of vitamin K epoxide reductase, which impairs gamma carboxylation of glutamic acid residues of the precursor proteins of factors II, VII, IX, and X. (superiortoxicology.com)
Anticoagulant activity1
Including intracranial hemorrhage1
- Warfarin crosses the placenta and can cause fetal bleeding (including intracranial hemorrhage) and teratogenicity, with the latter occurring mainly during the first trimester. (medscape.com)
Myocardial infarction1
- Warfarin is highly effective in preventing and treating deep venous thrombosis and can meliorate symptoms in patients suffering from arterial fibrillation, prosthetic heart valves, indwelling central venous catheters, and myocardial infarction [ 2 ]. (hindawi.com)
Dabigatran1
- In patients with prior unprovoked bleeding, warfarin-associated bleeding, or at high risk of bleeding, we suggest using apixaban, edoxaban, or dabigatran 110 mg (where available) as all demonstrate significantly less major bleeding compared with warfarin. (guidelinecentral.com)
Concomitant1
- Concomitant use of warfarin, a highly efficacious oral anticoagulant, and herbs causes major safety concerns due to the narrow therapeutic window of warfarin. (hindawi.com)
Patients11
- Finally, warfarin is very sensitive to drug-drug interactions involving its metabolism or function and great care must be given to starting or stopping concurrent medications in patients on warfarin therapy. (nih.gov)
- Methods and Results: All patients (n = 716) for whom warfarin was prescribed from November 1, 2010 to October 30, 2011 were extracted from electronic health records. (scirp.org)
- Among them, 108 patients were taking warfarin for more than 6 weeks before and after PPI. (scirp.org)
- The patients who had warfarin for shorter periods before PPI, or those who had PPI first (n = 141) had similar dose of warfarin and INR. (scirp.org)
- Warfarin/ Acenocoumarol dosing for patients at home, Care Homes etc. (jpaget.nhs.uk)
- In the two trials, 8,281 patients with deep-vein thrombosis or pulmonary embolism were randomly assigned to receive rivaroxaban at 15 mg twice daily for 21 days followed by 20 mg once daily or standard therapy consisting of subcutaneous enoxaparin at 1.0 mg/kg twice daily and warfarin or acenocoumarol (target INR of 2.0 to 3.0). (ascopost.com)
- To assess and compare the efficacy of Acenocoumarol and Warfarin in valve replaced patients with Rheumatic heart disease. (makhillpublications.co)
- The risk of overanticoagulation in patients with cytochrome P450 CYP2C9*2 or CYP2C9*3 alleles on acenocoumarol or phenprocoumon. (ox.ac.uk)
- We investigated CYP2C9 polymorphisms in relation to the international normalized ratio (INR) during the first 6 weeks of treatment and its effect on the maintenance dose in a cohort of 1124 patients from the Rotterdam Study who were treated with acenocoumarol or phenprocoumon. (ox.ac.uk)
- A clear genotype-dose relationship was found for acenocoumarol-treated patients. (ox.ac.uk)
- Individuals with one or more CYP2C9*2 or CYP2C9*3 allele(s) require a significantly lower dose of acenocoumarol compared to wild-type patients. (ox.ac.uk)
Clinically3
- Warfarin therapy is associated with rare instances of idiosyncratic, clinically apparent liver injury that are usually mild and rapidly reversible on stopping. (nih.gov)
- Liver injury due to warfarin therapy is rare, but clinically apparent acute liver injury attributable to it has been reported. (nih.gov)
- Clinically, warfarin is administered as a racemic mixture of the S - and R -enantiomers. (hindawi.com)
Dose2
- Warfarin dose and INR did not change after PPI. (scirp.org)
- However, an effect on acenocoumarol dose requirements appears to be absent for the CYP2C9*2 allele and the consequences for the metabolism of phenprocoumon have not yet been established. (ox.ac.uk)
Atrial fibrillation2
- Warfarin or acenocoumarol is better in the anticoagulant treatment of chronic atrial fibrillation? (wikipedia.org)
- Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. (lookformedical.com)
Complications1
Clinical7
- This paper presents an update overview of clinical findings regarding herb-warfarin interaction, highlighting clinical outcomes, severity of documented interactions, and quality of clinical evidence. (hindawi.com)
- In summary, herb-warfarin interaction, especially the clinical effects of herbs on warfarin therapy should be further investigated through multicenter studies with larger sample sizes. (hindawi.com)
- Use of warfarin is still limited despite the strong evidence for its clinical value. (hindawi.com)
- A literature survey over the herb-drug interactions in clinical cases showed that warfarin accounted for 34 of the total 133 cases of interactions, making itself the most frequently involved drug in herb-drug interactions [ 6 ]. (hindawi.com)
- The incidence of interaction between herbs and warfarin is not yet fully known, and there is no body of reliable information currently available to draw upon when assessing the scale of any possible problem or predicting clinical outcomes. (hindawi.com)
- Herb-warfarin interaction has considerable clinical significance, so it is especially necessary to identify the herbs that interact with warfarin. (hindawi.com)
- Conclusions: Unfavorable interaction between warfarin and PPI was negligible in clinical use. (scirp.org)
Pregnancy1
- Acenocoumarol is contraindicated during pregnancy . (wikidoc.org)
Medicines1
- Herbal medicines and food interaction are now cited as the main cause of adverse events with warfarin. (hindawi.com)
Chronic1
Trials1
- Ruff and colleagues' meta-analysis of the four seminal warfarin vs DOAC trials found that DOACs are better at stroke prevention and associated with numerically less major bleeding. (medscape.com)
Therapy2
- Monitoring of the INR is essential during warfarin therapy, because bleeding is a common side effect and can be life-threatening and fatal. (nih.gov)
- The typical case of acute liver injury arises within 3 to 8 weeks of starting warfarin, although rare instances of liver injury arising after months or years of therapy have been reported (and these long latencies are common with phenprocoumon hepatotoxicity). (nih.gov)
Drugs1
- Drugs.com Drugs.com international listings for acenocoumarol Diseases Database (DDB): 29202 Cesar J, García-Avello A, Navarro J, Herraez M (2004). (wikipedia.org)
Liver1
Found1
- The most commonly used anticoagulant, warfarin, was found after the outbreak of sweet clover disease, which occurred in 1920' (internal bleeding that manifested in cattle after eating the spoiled sweet clover hay). (hospenterprise.com)
Treatment1
- 2011) Proton Pump Inhibitors and the Risk of Overanticoagulation during Acenocoumarol Maintenance Treatment. (scirp.org)
Response1
Study1
- In absence of good evidence, speculation has taken its place, and poor quality of available information in turn restricts future study of herb-warfarin interaction. (hindawi.com)