Wagner vesicular stomatitis indiana virus. Medical search. Frequent questions

The journal launched in 1966, and Wagner continued in his role for 15 years, overseeing a large expansion in the size of the journal before stepping down in 1982 and being succeeded by Edward M. Scolnick. (wikipedia.org)
1982. H-2Kk and vesicular stomatitis virus G proteins are not extensively associated in reconstituted membranes recognized by T cells . (wisc.edu)

Recently new lysine modifications were detected in histones and other proteins. (cipsm.de)
Vaccination may be with attenuated or inactivated virus, or with viral proteins produced by genetic engineering techniques. (justia.com)
Type I interferon antagonistic properties of influenza B virus polymerase proteins. (uni-muenster.de)

Monoclonal antibodies to murine hepatitis virus-4 (strain JHM) define the viral glycoprotein responsible for attachment and cell-cell fusion. (microbiologyresearch.org)

Also, gle IM injection of VSVG MBGV GP (2 × 107 PFU), new postexposure treatment approaches, based on small and the animal in control group 2 received an equal dose interfering RNA ( 4 ) and antisense oligomers ( 5 , 6 ), have of VSVG/LassaGPC. (cdc.gov)
We analyzed here, the transduction efficiency of a pDC cell line, GEN2.2, and of pDC derived from CD34+ progenitors, using lentiviral vectors (LV) pseudotyped with different envelope glycoproteins such as the vesicular stomatitis virus envelope (VSVG), the gibbon ape leukaemia virus envelope (GaLV) or the feline endogenous virus envelope (RD114). (biomedcentral.com)
We found that efficient gene transfer into pDC can be achieved with VSVG-pseudotyped lentiviral vectors (LV) under the control of phoshoglycerate kinase (PGK) and elongation factor-1 (EF1α) promoters (28% to 90% of E-GFP + cells, respectively) in the absence of phenotypic and functional maturation. (biomedcentral.com)
Surprisingly, promoters (desmin or synthetic C5-12) described as muscle-specific and which drive gene expression in single strand AAV vectors in gene therapy protocols were very highly active in pDC using VSVG-LV. (biomedcentral.com)

Infection GP completely protected rhesus monkeys from a lethal chal- lenge with this virus when administered shortly after expo- sure ( 10 ). (cdc.gov)
recombinant vesicular stomatitis virus-based vaccine is ad- ministered 20-30 min after infection with Marburg virus. (cdc.gov)
Approximately 48 h after MBGV achieved by using strategies that mitigate the coagulation challenge, animals in experimental group 2 received a sin- abnormalities characterizing fi loviral infection ( 2 , 3 ). (cdc.gov)
Virus-induced immune complex disease: identification of specific viral antigens and antibodies deposited in complexes during chronic lymphocytic choriomeningitis virus infection. (microbiologyresearch.org)
In particular, in elderly and frail individuals the infection can lead to severe disease and even fatal outcomes. (bvsalud.org)
HHV-3, also known as varicella-zoster virus (VZV), causes the primary infection chickenpox and the secondary reactivation disease herpes zoster. (medscape.com)
HHV-4, also known as Epstein-Barr virus (EBV), causes the primary infection infectious mononucleosis , and it is implicated in various diseases, such as African Burkitt lymphoma , other immunoproliferative disorders, and nasopharyngeal carcinoma. (medscape.com)
HHV-6, which can produce acute infection in CD4 + T lymphocytes, causes roseola infantum , a febrile illness that affects young children. (medscape.com)
[ 5 , 6 ] In a localized primary infection, the virus penetrates the mucosal epithelium and invades the cells of the basal layer, where the viral DNA inserts into the host DNA. (medscape.com)
Del Sarto J, Gerlt V, Friedrich ME, Anhlan D, Wixler V, Teixeira MM, Boergeling Y, Stephan Ludwig (2021) Phosphorylation of JIP4 at S730 presents anti-viral properties against influenza A virus infection. (uni-muenster.de)
Schloer S, Goretzko J, Pleschka S, Ludwig S, and Rescher U. (2020) Combinatory Treatment with Oseltamivir and Itraconazole Targeting Both Virus and Host Factors in Influenza A Virus Infection. (uni-muenster.de)

Understanding gene function and regulation requires rigorous testing in live cells and organisms. (cshlpress.com)
ABSTRACT Codon pair bias (CPB), which has been observed in all organisms, is a neglected genomic phenomenon that affects gene expression. (harvard.edu)
Gene modified dendritic cells (DC) are able to modulate DC functions and induce therapeutic immunity or tolerance in an antigen-specific manner. (biomedcentral.com)
Taken together, our results indicate that LV vectors can serve to design pDC-based vaccines in humans, and they are also useful in vitro to evaluate the immunogenicity of the vector preparations, and the specificity and safety of given promoters used in gene therapy protocols. (biomedcentral.com)
Apparently, Kawade had not determined whether the chimeric gene was actually expressed in the mice, but had already been able to express it in cultured cells induced by Cd.sup.2+ or by heat. (justia.com)
He taught that the gene of choice would be the one encoding the Mx protein that is normally found in the species of animal to be protected. (justia.com)

Sphingolipid-targeting drugs have been tested alone or in combination with chemotherapy, exhibiting antitumor activity alone and in synergism with chemotherapy in vitro and in vivo . (frontiersin.org)
Taking DHEA by mouth before in-vitro fertilization (IVF) might improve the chances of pregnancy and having a baby. (medlineplus.gov)
Human B cells express pro- and anti-inflammatory factors and differentiate into plasmablast-like cells when exposed to autologous melanoma secretomes in vitro. (regenerativemedicine.net)
Plasmablast-like cells also increase PD-1+ T cell activation through anti-PD-1 blockade in vitro and their frequency in pretherapy melanomas predicts response and survival to immune checkpoint blockade. (regenerativemedicine.net)

Dendritic cells (DCs) are specialized antigen-presenting cells that have a notable role in the initiation and regulation of innate and adaptive immune responses. (mdpi.com)

Blood samples for viral infectivity titration, re- have been published of evaluations of either strategy in the verse transcription-PCR (RT-PCR), hematologic analysis, more stringent macaque models. (cdc.gov)
Roles of HTLV-1 basic Zip Factor (HBZ) in Viral Chronicity and Leukemic Transformation. (mdpi.com)
Nonetheless, many other viral infections can affect the oral cavity in humans, either as localized or systemic infections. (medscape.com)
In HHV-1 and HHV-2 oral infections, viral replication within the oral epithelium may cause lysis of epithelial cells, with vesicle formation. (medscape.com)
HIV-1 integrase (IN) is a key viral enzymatic molecule required for the integration of the viral cDNA into the genome. (biomedcentral.com)
Additionally, HIV-1 IN has been shown to play important roles in several other steps during the viral life cycle, including reverse transcription, nuclear import and chromatin targeting. (biomedcentral.com)
These results demonstrate that the C-terminal region of the catalytic core domain of HIV-1 IN is important for binding to host chromatin and is crucial for both viral replication and the promotion of the IN-induced lethal phenotype in yeast. (biomedcentral.com)
The HIV-1 integrase (IN) is the key viral enzyme required for this integration step. (biomedcentral.com)
The importance of LEDGF/p75 in the activity of IN throughout the viral life cycle has been extensively studied. (biomedcentral.com)
Viral infections in agricultural animals represent a major economic loss for farmers and ranchers. (justia.com)
Significant viral diseases in cattle are infectious bovine rhinotracheitis, parainfluenza, bovine viral diarrhea, rabies, and foot and mouth disease. (justia.com)
In 1981, over $500,000,000 was spent to treat agricultural animals against viral infections and the economic loss to agriculture resulting from viral disease is substantially greater that this cost. (justia.com)
Patil A, Anhlan D, Ferrando V, Mecate-Zambrano A, Mellmann A, Wixler V, Boergeling Y, and Ludwig S (2021) Phosphorylation of influenza A virus NS1 at serine 205 mediates its viral polymerase-enhancing function. (uni-muenster.de)

Wagner, RR (May 1999). (wikipedia.org)
The West Nile virus (WNC) first appeared in North America in 1999. (mdpi.com)
The 2012 WNV season in the United States saw a massive spike in the number of neuroinvasive cases and deaths similar to what was seen in the 2002-2003 season, according to the West Nile virus disease cases and deaths reported to the CDC by year and clinical presentation, 1999-2012, by ArboNET (Arboviral Diseases Branch, Centers for Disease Control and Prevention). (mdpi.com)

With student Alice S. Huang, Wagner characterized what are now known as defective interfering particles. (wikipedia.org)

Mesyl phosphoramidate backbone modified antisense oligonucleotides targeting miR-21 with enhanced in vivo therapeutic potency. (yale.edu)

February 12, 1987) observed inhibition of influenza virus in NIH 3T3 mouse cells genetically modified to express the mouse protein Mx. (justia.com)
Ludwig S, Hrincius ER, and Boergeling Y (2021) The Two Sides of the Same Coin-Influenza Virus and Intracellular Signal Transduction. (uni-muenster.de)
2021) Nonsense-mediated mRNA decay does not restrict influenza A virus propagation. (uni-muenster.de)
Masemann D, Meissner R, Schied T, Lichty BD, Rapp UR, Wixler V, and Ludwig S. (2021) Synergistic anti-tumor efficacy of oncolytic influenza viruses and B7-H3 immune- checkpoint inhibitors against IC-resistant lung cancers. (uni-muenster.de)
Sitnik S, Masemann D, Leite Dantas R, Wixler V, and Ludwig S. (2020) PD-1 IC Inhibition Synergistically Improves Influenza A Virus-Mediated Oncolysis of Metastatic Pulmonary Melanoma. (uni-muenster.de)
Schreiber A, Boff L, Anhlan D, Krischuns T, Brunotte L, Schuberth C, Wedlich-Söldner R, Drexler H, and Ludwig S. (2020) Dissecting the mechanism of signaling-triggered nuclear export of newly synthesized influenza virus ribonucleoprotein complexes. (uni-muenster.de)
In 2003, surveillance for influenza in hospitalized persons was added to the Centers for Disease Control and Prevention Emerging Infections Program network. (cdc.gov)
FluSurv-NET has helped to determine the risk for influenza-associated illness in various segments of the US population, define the severity of influenza seasons and the 2009 pandemic, and guide recommendations for treatment and vaccination programs. (cdc.gov)
OBJECTIVE: To describe rates of influenza-associated hospitalization, intensive care unit (ICU) admission, and in-hospital death by race and ethnicity over 10 influenza seasons. (cdc.gov)
DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional study used data from the Influenza-Associated Hospitalization Surveillance Network (FluSurv-NET), which conducts population-based surveillance for laboratory-confirmed influenza-associated hospitalizations in selected counties, representing approximately 9% of the US population. (cdc.gov)
MAIN OUTCOMES AND MEASURES: The main outcomes were age-adjusted and age-stratified rates of influenza-associated hospitalization, ICU admission, and in-hospital death by race and ethnicity overall and by influenza season. (cdc.gov)

Among the different DC subsets, plasmacytoid DC (pDC) are well known for their ability to recognize and respond to a variety of viruses by secreting high levels of type I interferon. (biomedcentral.com)
The antiviral activities of exogenous interferons in animals are reviewed by Stewart II, THE INTERFERON SYSTEM, 282-283, Table 16 (2d ed. 1979). (justia.com)

The acceleration in vaccine development required to combat the current pandemic is not at the expense of the necessary regulatory requirements, including robust and comprehensive data collection along with clinical product safety and efficacy evaluation. (bvsalud.org)
Due to the previous development of vaccine candidates against the related highly pathogenic coronaviruses SARS-CoV and MERS-CoV, the antigen that elicits immune protection is known: the surface spike protein of SARS-CoV-2 or specific domains encoded in that protein, e.g., the receptor binding domain. (bvsalud.org)
From a scientific point of view and in accordance with legal frameworks and regulatory practices, for the approval of a clinic trial, the Paul-Ehrlich-Institut requires preclinical testing of vaccine candidates, including general pharmacology and toxicology as well as immunogenicity. (bvsalud.org)
For COVID-19 vaccine candidates, based on existing platform technologies with a sufficiently broad data base, pharmacological-toxicological testing in the case of repeated administration, quantifying systemic distribution, and proof of vaccination protection in animal models can be carried out in parallel to phase 1 or 1/2 clinical trials. (bvsalud.org)
In general, phase 1 (vaccine safety) and 2 (dose finding, vaccination schedule) clinical trials can be combined, and combined phase 2/3 trials are recommended to determine safety and efficacy. (bvsalud.org)
Vaccine hesitancy in prenatal women and mothers of newborns: Results of an interventional study. (yale.edu)
Key scientific articles in featured topic areas (this week featuring CDC authored editorials and scientific publications focused on inequities in flu vaccine uptake. (cdc.gov)

After US Food and Drug Administration approval in 2019, some US clinicians rapidly implemented BPaL using an initial 600-mg linezolid dose adjusted by serum drug concentrations and clinical monitoring. (cdc.gov)
In this cohort, effective treatment required less than half the duration recommended in 2019 US guidelines for drug-resistant tuberculosis. (cdc.gov)

1981. Measurement of rotational motion in membranes using fluorescence recovery after photobleaching . (wisc.edu)

Wagner has been recognized as a major contributor to the development of molecular virology. (wikipedia.org)
Much of his research focused on the molecular biology of the vesicular stomatitis virus. (wikipedia.org)
Molecular studies of LCM virus-induced immunopathology: development and characterization of monoclonal antibodies to LCM virus. (microbiologyresearch.org)
In this study, we performed mutagenic analyses of the C-terminal region of the catalytic core domain of HIV-1 IN in order to delineate the critical amino acid(s) and/or motif(s) required for the induction of the lethal phenotype in the yeast strain HP16, and to further elucidate the molecular mechanism which causes this phenotype. (biomedcentral.com)

The antiviral activity of various mammalian interferons is reviewed in Colowick, S. P. and Kaplan, N. O. Interferons, S. Pestka (Ed.), Methods in Enzymology. (justia.com)
Orlando: Academic Press, Inc., 1986, Vol. 119(C). The interferons do not act directly against the virus, rather, they stimulate the antiviral response of the immune system. (justia.com)

In the context of cancer, appropriately activated DCs can induce anti-tumor immunity by activating innate immune cells and tumor-specific lymphocytes that target cancer cells. (mdpi.com)
Tumor associated inflammation predicts response to immune checkpoint blockade in human melanoma. (regenerativemedicine.net)

Sphingolipids are remarkably diverse and have crucial roles in maintaining barrier function and fluidity, as well as regulating the cell cycle, cell motility, differentiation, adhesion, and apoptosis ( 1 ). (frontiersin.org)
CTCs are recognized as playing important roles in the metastasis of carcinomas ( 11 , 12 ) and their analysis enables the prediction of metastatic relapse and progression ( 11 ). (iiarjournals.org)

The North American lineages of WNV were characterized by the presence of neuroinvasive and neurovirulent strains causing disease and death in humans, birds and horses. (mdpi.com)
In addition, the establishment and recent spread of lineage II WNV virus strains into Western Europe and the presence of neurovirulent and neuroinvasive strains among them is a cause of major concern. (mdpi.com)
HPV infections have received particular attention in recent years, as high-risk strains have been linked to some cases of oral squamous cell carcinoma. (medscape.com)
Interestingly, previous studies have demonstrated that the expression of HIV-1 IN induces the lethal phenotype in some strains of Saccharomyces cerevisiae . (biomedcentral.com)

Fifteen healthy, fi lovirus-serone- of hemorrhagic fever (HF) in Central Africa that produce gative rhesus macaques (each weighing 4 kg-7 kg) were severe disease and high mortality rates among infected pa- randomized into 2 experimental groups of 6 monkeys per tients ( 1 ). (cdc.gov)
Histoplasmosis is a major cause of mortality in people living with HIV (PLHIV). (cdc.gov)
Rapid methods to diagnose Histoplasma capsulatum disease could dramatically decrease the time to initiate treatment, resulting in reduced mortality. (cdc.gov)
Breast cancer is the most common type of cancer and the primary cause of cancer mortality in women ( 1 ). (iiarjournals.org)

During the early 1960s, while at Johns Hopkins, he became involved in research on interferons, which eventually entered clinical use. (wikipedia.org)
Aslthough all these drugs have produced good results in preclinical studies of multiple cancers, the outcomes of clinical trials have not been similar. (frontiersin.org)
In contrast, minor adverse effects restricted to a few subjects and hepatic toxicity have been observed in clinical trials of ABC294640 and safingol, respectively. (frontiersin.org)
In the case of CNLs, SKI-II, fingolimod and sonepcizumab there are some limitations and absence of enough clinical studies to demonstrate a benefit. (frontiersin.org)
By applying these fundamental requirements not only for the approval and analysis of clinical trials but also for the regulatory evaluation during the assessment of marketing authorization applications, several efficacious and safe COVID-19 vaccines have been licensed in the EU by unprecedentedly fast and flexible procedures. (bvsalud.org)
Herpesviruses establish latent permanent infections in their hosts, although clinical signs of disease may not be detected. (medscape.com)
Using an initial 600-mg linezolid dose daily adjusted by therapeutic drug monitoring and careful clinical and laboratory monitoring for adverse effects, supportive care, and expert consultation throughout BPaL treatment, 3 patients (4.4%) with hematologic toxicity and 4 (5.9%) with neurotoxicity required a change in linezolid dose or frequency. (cdc.gov)
According to the American Society of Clinical Oncology (ANCO) guidelines on breast cancer follow-up and management, symptoms of breast cancer recurrence include presence of new breast lumps, pain in the bone, chest or abdomen, dyspnea and constant headaches ( 5 ). (iiarjournals.org)

Protein structure of lymphocytic choriomeningitis virus: identification of the virus structural and cell associated polypeptides. (microbiologyresearch.org)
IN is a 32 kDa protein with three distinct structural domains, the N-terminal zinc-binding domain, the central catalytic core domain and the C-terminal domain. (biomedcentral.com)
1979. Lateral diffusion of M-13 coat protein in model membranes . (wisc.edu)
1980. Lateral diffusion of M-13 coat protein in mixtures of phosphatidylcholine and cholesterol . (wisc.edu)

Comparison of Acute and Chronic Toxicity Laboratory Bioassay Endpoints with Benthic Community Responses in Field-Exposed Contaminated Sediments. (yale.edu)

Protection of guinea pigs inoculated with Tacaribe virus against lethal doses of Junin virus. (microbiologyresearch.org)
Our study identified three HIV-1 IN mutants, V165A, A179P and KR186,7AA, located in the C-terminal region of the catalytic core domain of IN that do not induce the lethal phenotype in yeast. (biomedcentral.com)
Overall, this study demonstrates that three mutations located in the C-terminal region of the catalytic core domain of HIV-1 IN inhibit the IN-induced lethal phenotype in yeast by inhibiting the binding of IN to the host chromatin. (biomedcentral.com)

Methods in Enzymology. (wisc.edu)
In this review, the current and novel methods for detection of breast cancer metastasis, as well as the mechanisms involved in metastasis and the treatment of breast cancer metastasis, are discussed. (iiarjournals.org)
An emerging method to detect metastasis is the analysis of circulating tumor cells (CTCs), which has shown promise in filling the gaps left by other diagnostic methods. (iiarjournals.org)

Following his internship, he joined the U.S. Navy Medical Corps, where he was first exposed to virology research while assigned to the U.S. Navy Medical Research Institute in Bethesda, Maryland. (wikipedia.org)
Wagner joined the faculty at Yale University in 1951 and then moved to Johns Hopkins in 1957, where he became the director of the Infectious Disease Division and later the head of the Division of Virology. (wikipedia.org)
Following a brief stint as the virology section editor for the Journal of Bacteriology, run by the American Society for Microbiology, Wagner served as the founding editor-in-chief of the Journal of Virology, working with fellow editors Lloyd Kozloff and Norman Salzman. (wikipedia.org)
With Heinz Fraenkel-Conrat, Wagner collaborated in editing a vast 19-volume treatise called Comprehensive Virology. (wikipedia.org)
In the early 1980s, Wagner was among the group of American virologists who helped organize and became the founding members of the American Society for Virology. (wikipedia.org)

Wagner also became the director of the newly created University of Virginia Cancer Center and was appointed the Marion McNulty and Marvin C. Weaver Professor of Oncology in 1984. (wikipedia.org)

Chromatin binding assays in yeast and mammalian cells demonstrated that these IN mutants were impaired for the ability to bind chromatin. (biomedcentral.com)

HHVs replicate in the host cell nucleus. (medscape.com)
Furthermore, we observed that VSV-G-pseudotyped HIV-1 containing these IN mutants was unable to replicate in the C8166 T cell line and this defect was partially rescued by complementation with the catalytically inactive D64E IN mutant. (biomedcentral.com)

This plasmablast-like phenotype can be reconciled in human melanomas where plasmablast-like cells also express T cell-recruiting chemokines CCL3, CCL4, CCL5. (regenerativemedicine.net)

Evaluation of plaque size reduction as a method for the detection of Pichinde virus antibody. (microbiologyresearch.org)
The aim of this study was to validate a MiraVista(®) Diagnostics (MVD) Histoplasma urine antigen lateral flow assay (MVD LFA) for the detection of H. capsulatum antigen (Ag) in urine and compare this LFA against the MVista(®) Histoplasma Ag quantitative enzyme immunoassays (MVD EIA). (cdc.gov)
1986. Fluorescence detection in automated DNA sequence analysis . (wisc.edu)
In addition, ASCO also recommends mammography for the early detection of relapse in breast cancer ( 5 ). (iiarjournals.org)

An Outbreak Investigation of Salmonella Typhimurium Illnesses in the United States Linked to Packaged Leafy Greens Produced at a Controlled Environment Agriculture Indoor Hydroponic Operation - 2021. (yale.edu)

Sphingolipids are modified in multiple cancers and are responsible for tumor proliferation, progression, and metastasis. (frontiersin.org)
Emerging techniques using the analysis of circulating tumor cells show promising results in predicting and identifying the early stages of breast cancer metastasis in patients. (iiarjournals.org)
The majority of deaths from breast cancer are not due to the primary tumor itself, but are the result of metastasis to other organs in the body ( 2 ). (iiarjournals.org)
6 ) emphasized that the inclusion of serum tumor markers is an important factor in the postoperative monitoring of breast cancer patients ( 7 , 8 ). (iiarjournals.org)
CTCs are tumor cells originating from primary sites or metastases that circulate in the patients' bloodstream and are very rarely found in healthy individuals ( 9 , 10 ) ( Figure 1 ). (iiarjournals.org)
This method uses either epithelial cell-specific markers which are generally expressed in all tumor cells, or tumor markers expressed by specific types of cancer ( 13 ). (iiarjournals.org)
Circulating tumor cells in the blood stream. (iiarjournals.org)
Depletion of B cells in melanoma patients by anti-CD20 immunotherapy decreases tumor associated inflammation and CD8+ T cell numbers. (regenerativemedicine.net)

Additionally, a deeper understanding of the metastatic cascade in breast cancer will be critical for developing therapeutic interventions to combat breast cancer metastasis. (iiarjournals.org)

Monoclonal antibodies prepared against Tacaribe and Junin viruses have been used to define further the serological relationships between arenaviruses of the Tacaribe complex. (microbiologyresearch.org)
The kinetics of reaction between antibody and virus were examined for all five neutralizing antibodies. (microbiologyresearch.org)
Variants of Tacaribe virus resistant to neutralization by antibody 2.25.4 were obtained by growth in the presence of this antibody and neutralization kinetics were reexamined using the heterologous monoclonal neutralizing antibodies. (microbiologyresearch.org)
Several different neutralization profiles were obtained, suggesting that point mutations resulted in conformational changes at topographically selected distinct epitopes recognized by the remaining antibodies. (microbiologyresearch.org)
Monoclonal antibodies to lymphocytic choriomeningitis virus react with pathogenic arenaviruses. (microbiologyresearch.org)
Monoclonal antibodies to lymphocytic choriomeningitis virus and Pichinde viruses: generation, characterization and cross-reactivity with other arenaviruses. (microbiologyresearch.org)
1979. Antibodies bound to lipid haptens in model membranes diffuse as rapidly as the lipids themselves . (wisc.edu)

One antibody (2.25.4) effectively neutralized all infectious virus. (microbiologyresearch.org)

1985. The synthesis of oligonucleotides containing an aliphatic amino group at the 5' terminus: synthesis of fluorescent DNA primers for use in DNA sequence analysis . (wisc.edu)
1987. The synthesis and use of fluorescent oligonucleotides in DNA sequence analysis . (wisc.edu)

In humans, at least two subsets of DC are known in the blood, myeloid DC (also known as interstitial or dermal DC), and plasmacytoid DC (pDC) and Langerhans cells (LC) in the tissues [ 3 ]. (biomedcentral.com)

The effectiveness or lack of a major therapeutic effect of sphingolipid modulation by some drugs as a cancer therapy and other aspects related to their mechanism of action are discussed in this review. (frontiersin.org)

1980. Lateral distribution and diffusion of the C3b receptor of complement, HLA antigens, and lipid probes in peripheral blood leukocytes . (wisc.edu)

HHV-7 has been isolated from the saliva of healthy adults and has been implicated as one cause of roseola infantum and febrile seizures in children. (medscape.com)
Infected saliva or droplets spread the viruses in the oral cavity. (medscape.com)

Antigens of Pichinde virus. (microbiologyresearch.org)

DHEA has been used safely for up to 2 years, usually in doses of 50 mg daily. (medlineplus.gov)
DHEA is possibly unsafe when used in high doses or long-term. (medlineplus.gov)
Do not use DHEA in doses higher than 50-100 mg daily or for a long period of time. (medlineplus.gov)

In 1967 Wagner moved to the University of Virginia School of Medicine to serve as the chair of the Department of Microbiology. (wikipedia.org)
His department - now the Department of Microbiology, Immunology, and Cancer Biology - awards the Robert R. Wagner Prize to excellent graduate students. (wikipedia.org)

Recognition and Treatment of Sleep-Disordered Breathing in Obese Hospitalized Patients May Improve Survival. (harvard.edu)

Wagner died of cancer in 2001. (wikipedia.org)

Moreover, the immunity diminishes with time and must be restored by follow-up immunizations, a practice which is inconvenient in the case of livestock allowed to roam on free range. (justia.com)

Procedural and regulatory-scientific aspects of the COVID-19 licensing processes are described in this review. (bvsalud.org)

Sphingolipids are an extensive class of lipids with different functions in the cell, ranging from proliferation to cell death. (frontiersin.org)

Plasmacytoid DC are well known for their ability to recognize and respond to a variety of viruses [ 6 ]. (biomedcentral.com)

Editors select a small number of articles recently published in the journal that they believe will be particularly interesting to readers, or important in the respective research area. (mdpi.com)
The aim is to provide a snapshot of some of the most exciting work published in the various research areas of the journal. (mdpi.com)

Taking DHEA by mouth daily for up to 2 years doesn't seem to improve body shape, bone strength, muscle strength, or quality of life in people older than 60 who have low DHEA levels. (medlineplus.gov)

HHV infections are common in the oral cavity. (medscape.com)

HHV-4 causes oral hairy leukoplakia in patients who are immunosuppressed. (medscape.com)

Anatomy12

Organisms29

Diseases13

Chemicals and Drugs28

Analytical, Diagnostic and Therapeutic Techniques and Equipment5

Phenomena and Processes15

Information Science3

Health Care1

Geographicals3

19822

Proteins3

Glycoprotein1

VSVG4

Infection11

Gene6

Vitro4

Dendritic Cells1

Viral13

19993

Huang1

Vivo1

Influenza11

Interferon2

Vaccine7

20192

19811

Molecular4

Antiviral2

Immune2

Roles2

Strains4

Mortality4

Clinical8

Protein4

Toxicity1

Lethal3

Methods3

Virology5

Oncology1

Chromatin1

Replicate2

Phenotype1

Detection4

20211

Tumor8

Metastasis1

Antibodies7

Infectious1

Oligonucleotides2

Humans1

Therapeutic1

Receptor1

Saliva2

Antigens1

Doses3

Microbiology2

Survival1

Died of cancer1

Immunity1

Processes1

Lipids1

Plasmacytoid1

Journal2

Bone1

Infections1

Patients1