Vitro hl 60 cells. Medical search. Frequent questions

Flow cytometric analysis revealed partial cell arrest in the G(1) phase at less than 5 micro L/mL and induction of apoptosis at 10 micro L/mL or more of ethanol and water extracts, with the latter exhibiting more pronounced inhibition than the former. (nih.gov)
I'm-Yunity acts selectively in HL-60 leukemic cells, resulting in cell cycle restriction through the G(1)/S checkpoint and the induction of apoptosis. (nih.gov)
These findings indicate that TET and BER, but not CVP, inhibited the proliferation of HL-60 cells via induction of apoptosis. (mushroomstudies.co)
The aim of this study was to test for the molecular and functional expression of the non-gastric H + /K + ATPase ATP12A/ATP1AL1 in unstimulated and butyrate-stimulated (1 and 10 mM) human myelomonocytic HL-60 cells, to unravel its potential role as putative apoptosis-counteracting ion transporter as well as to test for the effect of the H + /K + ATPase inhibitor SCH28080 in apoptosis. (karger.com)
8-10 It inhibits nitric oxide production 11 and cyclooxygenases 1 and 2, 9 and induces apoptosis in HL-60 leukemia cells via caspase 3 activation. (ascopost.com)
polyphenolics in their glycoside and aglycone forms induce apoptosis of HL-60 leukemia cells. (ascopost.com)
Extracts prepared from Trametes versicolor under the trade name of I'm-Yunity exhibit anti-tumorigenic activities, as supported by inhibition of the proliferation and induction of apoptosis in malignant cells. (spandidos-publications.com)
AVM induced the release of cleaved PARP and cleaved caspase‑3 caused apoptosis and inhibited the viability of these cells. (spandidos-publications.com)
On the other hand, hydroquinone induced extensive apoptosis of the cells. (cdc.gov)
They also reported that ELPA-treated cells showed signs of apoptosis (programmed cell death) and necrosis (death due to lack of blood supply), with cell cycle arrest in the G2/M phase. (naturalnews.com)
Based on these results, the researchers concluded that the cytotoxic activity of ELPA against cancer cells may be due to the synergistic action of flavonoids in it, which induces cell death by apoptosis and necrosis. (naturalnews.com)
of the kimchi induced apoptosis in HL-60 human leukemia cells by the DNA fragmentation assay. (jcpjournal.org)
also induced apoptosis in the leukemia cells. (jcpjournal.org)

By assaying their anti-proliferative and anti-apoptotic effects using human promyelocytic HL-60 cells, we found that the ethanolic extract of I'm-Yunity-Too was more active in inducing cell death compared to I'm-Yunity, based on measured changes in the expression of caspase 3 and Bax. (spandidos-publications.com)

proliferation and cell cycle phase distribution, (2). (nih.gov)
In vitro inhibition of proliferation of HL-60 cells by tetrandrine and coriolus versicolor peptide derived from Chinese medicinal herbs. (mushroomstudies.co)
Coriolus versicolor polysaccharide peptide (CVP) and the bis-benzylisoquinoline alkaloids, tetrandrine (TET) and berbamine (BER), the active ingredients isolated from Chinese medicinal herbs known to possess antitumor activities, concentration-dependently inhibited the proliferation of human leukemic HL-60 cells. (mushroomstudies.co)
Duan P, Huang Y, Chen K, Cheng C, Wu Z, Wu Y. 15,16-dihydrotanshinone I inhibits EOMA cells proliferation by interfering in posttranscriptional processing of hypoxia-inducible factor 1. (banglajol.info)
In previous research, the authors demonstrated that the methanol extract of Artemisia vulgaris (AVM) has the ability to inhibit chronic myeloid leukemia (CML) cell proliferation. (spandidos-publications.com)
In conclusion, three sesquiterpene lactone compounds inhibited the proliferation of HepG-2 cells via suppressing the JAK2/STAT3 signaling pathway. (researchsquare.com)
For culturing of adherent cells, a range is limited within a scaffold in which the cells grow during the course of their division and proliferation, and therefore with continued proliferation it is unavoidable that they eventually reach the limit of proliferation in the scaffold. (justia.com)

The goal of this in vitro study was to test the cytostatic and cytotoxic activities of extracts derived from the polysaccharopeptide (PSP), I'm-Yunity (Integrated Chinese Medicine Holdings Ltd., Kowloon, Hong Kong) prepared from strain Cov-1 of the mushroom Coriolus versicolor. (nih.gov)
This bioconjugate exerted in vitro cytostatic/cytotoxic effect on human breast, prostate and colon cancer cells, as well as significant in vivo tumor growth inhibitory effect on colon carcinoma bearing mice. (uni-konstanz.de)

exerted the survival or growth inhibitory effect on HL-60 human leukemia cells as well as antimutagenic activity, and the dichloromethane fr. (jcpjournal.org)

Apoferritin-encapsulation of cysteine protease inhibitors for cathepsin L inhibition in cancer cells. (nottingham.ac.uk)
The kimchi fractions inhibited the survival or growth of HL-60 human leukemia cells in the sulforhodamine B(SRB) assay, 3-(4,5-dimethylthiazol)-2, 5-diphenyltetrazolium bromide(MTT) assay and growth inhibition test. (jcpjournal.org)
The inhibition effect on cancer stemness in vitro was detected using suspension sphere experiments and the expression of stemness transcription factors. (bvsalud.org)
Therefore, when an excessive amount of medium has been used, it is often the case that oxygen may be insufficiently supplied to the cells and the low oxygen condition may lead to inhibition or even cell death. (justia.com)

This study aimed to evaluate the effects of 15,16-dihydrotanshinone I on FLT3-ITD acute myeloid leukemia cells. (banglajol.info)
Mechanistic analysis revealed that phenol, a major metabolite of benzene , significantly induced the expression of CYP4F3A at both mRNA and protein levels in cultured promyelocytic leukemia cells (HL-60) similarly to all-trans retinoic acid (ATRA). (cdc.gov)
Here, we have used two-color multiparameter flow cytometry to study simultaneously its effects on cell membrane permeability, intracellular pH, and cell size/structure of EMT6 mouse mammary tumor cells and HL-60 human promyelocytic leukemia cells in vitro . (aacrjournals.org)
Salmonella typhimurium TA100 and HL-60 human leukemia cells, respectively. (jcpjournal.org)
All the kimchi fractions inhibited survival of HL-60 leukemia cells more than 50% in the addition concentration of 0.2 mg/assay, in particular dichloromethane fr. (jcpjournal.org)

The differentiated HL-60 cell is capable of generating reactive oxygen species (ROS) when challenged with pyrogenic substances. (ku.dk)

In fact, several studies have shown that T2D induces senescence in multiple types of cells, including fibroblasts and endothelial cells ( 11 , 12 ). (frontiersin.org)

HL-60 cells were more sensitive to SRI 62-834 than were EMT6 cells in terms of both cytotoxicity and membrane permeability. (aacrjournals.org)
However, PAF was more potent than SRI 62-834 in causing membrane permeabilization with both cell lines, whereas PAF was less active than SRI 62-834 in cytotoxicity assays. (aacrjournals.org)
Carpesium abrotanoides L. is rich in sesquiterpene lactones, the experiments of anti-tumor activity in vitro showed that total sesquiterpene lactone extracts exhibited the most cytotoxicity activities against HepG-2 cells (IC 50 = 4.2 μg/mL). (researchsquare.com)
Carpesium abrotanoides L., is rich in sesquiterpene lactones with significant cytotoxicity effects on the HepG-2 cell line. (researchsquare.com)
In a study published in the Journal of Medicinal Plants Research , Brazilian researchers investigated the cytotoxicity of various Passiflora species using colon cancer, ovarian cancer and leukemia cell lines. (naturalnews.com)
They then evaluated the in vitro cytotoxicity of these extracts against cancer cell lines using MTT assay. (naturalnews.com)
Among the Passiflora leaf extracts evaluated, ELPA exhibited the highest cytotoxicity against HL-60 cells (IC50 19.37 u g/mL) but was not cytotoxic against PBMC, suggesting selectivity for cancer cells. (naturalnews.com)

In this paper we describe a new pyrogen assay using the human leukemia cell line HL-60. (ku.dk)

Induction of CYP4F3 by benzene metabolites in human white blood cells in vivo, in human promyelocytic leukemic cell lines, and ex vivo in human blood neutrophils. (cdc.gov)
Induction of CYP4F3 by phenol was also observed in differentiated HL-60 cells, in pro-erythroid cell line K562, and ex vivo in human neutrophiles. (cdc.gov)
In the present study, we examined the molecular mechanism by which multi-walled CNTs (MWCNTs) induce M1 polarization in vitro, with focus on induction of arachidonate 5-lipoxygenase (ALOX5), which is required to produce proinflammatory LMs, such as leukotriene B4 (LTB4). (cdc.gov)
MWCNTs preferentially induced the expression of CD68, a cell surface marker of M1, by 2.5-fold and induction was persistently high to 3-day post-exposure. (cdc.gov)
Taken together, these results support that persistent exposure to MWCNTs polarizes macrophages to M1 cells with induction of ALOX5 and elevated production of proinflammatory LMs to boost the acute inflammatory response to fibrogenic nanoparticles. (cdc.gov)

The cell line is differentiated using all-trans retinoic acid (ATRA) to generate a cell population that resembles mature granulocytes. (ku.dk)

Calcium antagonistic actions of tetrandrine depend on cell types. (mcmaster.ca)
Capacitative Ca2+ entry in HL-60 cells: tetrandrine and SK & F 96365 as probes. (mcmaster.ca)
Inhibitory effects of tetrandrine and hernandezine on Ca2+ mobilization in rat glioma C6 cells. (mcmaster.ca)

The findings demonstrated, for the first time, that benzene and metabolites induce CYP4F3 in human blood cells both in vivo and in vitro. (cdc.gov)
Similarly, GATA-1 has been shown to induce lineage switching expression values even if, for simplicity, we assume only ``on'' of committed cells in hematopoiesis, first in cell lines (Kulessa and ``off'' states for each gene. (lu.se)

3 A few in vitro and in vivo studies show that acai has anti-inflammatory, apoptotic 4-7 and antioxidant effects. (ascopost.com)

In a luminol enhanced chemilumimetric assay the responsiveness of differentiated HL-60 cells is tested towards Salmonella typhimurium, Bacillus subtilis, Saccharomyces cerevisiae, Candida albicans, lipopolysaccharide (LPS) and lipoteichoic acid (LTA). (ku.dk)

The two monoclonal antibodies MAX.1 and MAX.11 recognize cell surface antigens that are almost undetectable on monocytes but highly expressed on differentiated macrophages. (uni-regensburg.de)
Moreover, in vitro differentiated macrophages show the highest specific activity yet described in any tissue. (uni-regensburg.de)
The cell-free media from MWCNT-polarized macrophages induced the migration of neutrophilic cells (differentiated from HL-60), which was blocked by Acebilustat, a specific leukotriene A4 hydrolase inhibitor, or LY239111, an LTB4 receptor antagonist, but not NS-398, a cyclooxygenase 2 inhibitor, revealing LTB4 as a major mediator of neutrophil chemotaxis from MWCNT-polarized macrophages. (cdc.gov)

Morphological observation and DNA analysis revealed that CVP elicited no effect on the morphological features of HL-60 cells and did not cause DNA fragmentation, but TET and BER caused cell shrinkage with the formation of apoptotic bodies, and showed clear evidence of DNA fragmentation. (mushroomstudies.co)
They then conducted morphological analyses using light and fluorescence microscopy, and cell cycle and DNA fragmentation analyses using flow cytometry to study the mechanism of cell death induced by ELPA in HL-60 cells. (naturalnews.com)

To test whether extracts also affected normal cells, similar experiments were also performed using isolated peripheral blood lymphocytes from healthy volunteers, with and without stimulation by the mitogen phytohemagglutinin (PHA). (nih.gov)
Chili peppers are rich in the bioactive component capsaicin (CAP), which has been reported to have diverse biological properties such as anti-obesity, anti-oxidant, and anti-inflammatory effects in vitro and vivo experiments ( 4 - 6 ). (frontiersin.org)
In vitro experiments showed that treating cells with the serum from the swimming intervention mice significantly reduced the formation of SMMC-7721 cell suspension sphere, as well as the mRNA expression level of stemness transcription factors. (bvsalud.org)

These beneficial biological properties have been extensively studied in humans and animal models, both in vitro and in vivo . (hindawi.com)

7. Jensen GS, Wu X, Patterson KM, Barnes J, et al: In vitro and in vivo antioxidant and anti-inflammatory capacities of an antioxidant-rich fruit and berry juice blend. (ascopost.com)

Expression of carboxypeptidase M on mRNA level and enzymatic activity markedly increase during in vitro differentiation of monocytes, according to the described increase in MAX.1 and MAX.11 antigen expression. (uni-regensburg.de)
The activities of these compounds against two human cancer cell lines (HL-60 and AZ521), and their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation, were also evaluated. (noniresearch.org)
The anti-HCC effect of swimming was assessed in vivo by tumor weight monitoring, hematoxylin and eosin (HE) staining, and immunohistochemistry (IHC) detection of proliferating cell nuclear antigen (PCNA) and Ki67. (bvsalud.org)

Molecular mechanism of cell cycle blockage of hepatoma SK-Hep-1 cells by Epimedin C through suppression of mitogen-activated protein kinase activation and increased expression of CDK inhibitors p21(Cip1) and p27(Kip1). (jcimjournal.com)

PKC412 inhibits the growth of leukemic cell lines with FLT3 mutations such as the MV4-11. (lu.se)

Chronic lymphoid leukaemia and hairy cell leukaemia due to chronic exposure to benzene: Report of three cases. (cdc.gov)
Exposure to benzene elicits a spectrum of hematotoxicity ranging from reduction of peripheral blood cell counts to aplastic anemia and leukemia. (cdc.gov)
For example, for hollow fiber culturing, a liquid phase/gas phase exposure bioreactor has been proposed (PTL 3), as a system wherein hollow fibers inhabited by cells are rotated for alternate exposure to a gas phase and a liquid phase. (justia.com)

In vitro antitumor activity was seen over the same concentration range, as measured by tetrazolium dye reduction and cell growth curves. (aacrjournals.org)
Tripodal O-N-O Bis-Phenolato Amine Titanium(IV) Complexes Show High in vitro Anti-Cancer Activity EUROPEAN JOURNAL OF INORGANIC CHEMISTRY. (nottingham.ac.uk)
Further, we show that the known phosphatase inhibitor fumonisin inhibits SiaA mediated phosphatase activity in vitro. (uni-konstanz.de)
Dose-dependent increase in glucose uptake activity (GUA) was observed in both cell lines. (wiley.com)
Over the past 30 years, bacterial ASNases have received considerable attention for their anticancer activity in the treatment of acute lymphoblastic leukemia and lymphosarcoma after the first report was published in 1967 by Hill JM et al. (fortunepublish.com)
Using expertise in CRISPR editing and functional imaging, we hope to identify abberant lysosomal flux and calcium activity in neuronal and glial cells that may lead to neurodegeneration. (lu.se)

This study evaluated the in vitro effects of the combination of PKC412 and ara-C or daunorubicin, studying the effect of co-incubation, pre-incubation and sequential incubation of the drugs in patient samples and cell lines. (lu.se)
In cell lines, antagonistic effects were seen frequently in HL-60 (90%) and less so in MV4-11 (60%) regardless of sequence or timing of the drugs. (lu.se)
The combination of daunorubicin and PKC412 resulted in more synergistic and less antagonistic effects compared to combinations with ara-C, in both patient material and cell lines. (lu.se)
The combination of Lonafarnib, a farnesyl-transferase inhibitor (FTI) and PKC412 had additive and synergistic effects in both FLT3/ITD positive and negative cell lines. (lu.se)

Synthesis of folic acid functionalized gold nanoclusters for targeting folate receptor-positive cells. (nottingham.ac.uk)
Endothelial cells are the primary site of plasma TFPI synthesis. (medscape.com)

In conclusion, the combination of PKC412 together with chemotherapeutic drugs is more effective in FLT3/ITD positive AML cells. (lu.se)

Overall these results indicate that the HL-60 cell assay possibly could be evolved to a supplementary assay for the known pyrogenic detection assays. (ku.dk)

In the patient cells PKC412 exerted its effect at concentrations between 0.1 and 2.0 muM. (lu.se)

Different volumes of 70% ethanol and water extracts of I'm-Yunity were incubated with cultures of human promyelocytic leukemic HL-60 cells, and compared to nontreated control cells. (nih.gov)
HL-60 cells incubated with various amounts (1, 3, 5, 7.5, and 10 micro l/mL) of the extracts for 1-3 days showed dose-dependent, time-dependent growth suppression and decrease in cell viability. (nih.gov)
The researchers also determined the IC50 of P. alata (ELPA) leaf extracts against both cancer (HCT-116, SF-295, OVACAR-8 and HL-60) cells and non-cancer cells (PBMC). (naturalnews.com)

Over lifetime, due to the action of several stressors such as DNA damage and telomere shortening, senescent cells accumulate in the organism and release a variety of pro-inflammatory cytokines responsible for low-grade inflammation. (frontiersin.org)
In recent years, with increasing interest being directed toward cultured cell-based production of vaccines, and in vivo proteins such as enzymes, hormones, antibodies and cytokines, as well as cell grafts for use in regenerative medicine, greater focus has been placed on efficient and convenient methodologies for mass cell culturing. (justia.com)

In addition, compounds 1 - 3 were evaluated for their cytotoxic activities against HepG-2 cell line with IC 50 value of 9.83, 2.95, and 4.15 μM, respectively. (researchsquare.com)
These compounds proved to be highly cytotoxic to the leukemia cell line HL-60 but not to normal cancer cells, suggesting a selectivity to cancer cells that could prove beneficial in clinical settings. (naturalnews.com)

Increasing evidence suggests that CAP facilitates the growth and migration of esophageal squamous cell carcinoma (ESCC) and human colon cancer cells ( 7 , 8 ). (frontiersin.org)
Most of these compounds inhibited the in vitro growth of B16 melanoma cells. (noniresearch.org)
Drugs used in combination chemotherapy, such as oxaliplatin, leucovorin calcium, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. (stanford.edu)
In cell culturing, regardless of whether or not a cell culture support is used and regardless of whether suspended cells or adherent cells are used, supply of oxygen is an essential issue for achieving healthy growth of the cells, with the exception of anaerobic bacteria. (justia.com)
Subculturing is absolutely indispensable to promote cell growth and is an important process regardless of the purpose and method, but the operations of treating the cells with trypsin or collagenase to remove them from the scaffold, and reseeding them via a cell suspension, not only run the risk of contamination but are also time consuming, while stress exerted on the cells is another factor that cannot be overlooked. (justia.com)
External insults (eg, infections, radiation, drugs) may disrupt stem cell homeostasis in marrow environment, leading to altered growth. (medscape.com)

[ 4 ] Most circulating TFPI is bound to lipoproteins, but on the surface of endothelial cells, a second pool of TFPI is bound to heparan sulfates. (medscape.com)

Low-power view of hematoxylin-eosin-stained bone marrow showing hypocellularity, with increased adipose tissue and decreased hematopoietic cells in the marrow space. (medscape.com)
The clinical presentation of patients with aplastic anemia includes signs and symptoms related to the decrease in bone marrow production of hematopoietic cells. (medscape.com)
The specific medications administered depend on the choice of therapy and whether it is supportive care only, immunosuppressive therapy, or hematopoietic cell transplantation. (medscape.com)
We discuss these properties with examples both from the hematopoietic and embryonic stem cell (ESC) systems. (lu.se)

Compounds isolated in freeze-dried açaí extract have been shown to enter human cells and neutralize free radicals at very low doses. (lifeextension.com)
Three sesquiterpene lactone compounds, 2 α ,5 α -dihydroxy-11 α H-eudesma-4(15)-en-12,8 β -olide ( 1 ), telekin ( 2 ), oxoeudesm-11(13)-eno-12,8 α -lactone ( 3 ) were obtained. (researchsquare.com)

METHODS: Our metabolomics framework was applied in a wide range of experimental systems including cancer cell lines, tumors, extracellular media, primary cells, immune cells, organoids, organs (e.g. pancreata), tissues, and sera from human and mice. (bvsalud.org)

Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. (stanford.edu)
Some block the ability of tumor cells to grow and spread. (stanford.edu)
Others find tumor cells and help kill them or carry tumor-killing substances to them. (stanford.edu)
Absence of L- asparagine causes tumor cells to die [2]. (fortunepublish.com)

In addition, carboxypeptidase M expression could be detected in HL-60, U937, and THP-1 myeloid cell lines. (uni-regensburg.de)
Vitamin D3-induced monocytic differentiation resulted in an increased carboxypeptidase M expression in all three cell lines. (uni-regensburg.de)

In this paper, we review the different protocols available to study human Plasmodium species either by using stem cell or alternative animal models. (wjgnet.com)
Thanks to recent progresses, stem cells have been extensively employed to study Plasmodium liver and blood cycle in vitro . (wjgnet.com)
As a result, cells expressing different forms of BCR/ABL were recruited for the present study, including K562 (human wild‑type) or TCCY‑T315I (human imatinib‑resistant) and the Ba/F3‑(T315I/E279K/Y253H) (mouse BCR/ABL point mutation‑transfected cells). (spandidos-publications.com)
Thus, cells expressing different forms of BCR/ABL were recruited for the present study, including K562 [human wild-type (WT)] or TCCY-T315I [human imatinib-resistant (IR)] and the Ba/F3-(T315I/E279K/Y253H) (mouse BCR/ABL point mutation-tranfected cells). (spandidos-publications.com)
Infants suffering of cell death occurring as a series of changes from chronic illnesses, chromosomal abnor- in dying cells under several physiological malities and those on medication prior to conditions [ 6,7 ] and has been implicated enrolment were excluded from the study. (who.int)

And only recently, evidence has emerged of a Passiflora species having cytotoxic potential against different cancer cells. (naturalnews.com)
Abrogation of G2 checkpoint specifically sensitize p53 defective cells to cancer chemotherapeutic agents. (mcmaster.ca)
Evidence the fate of stem cells has broad ramifications for biomedical suggests that during development or differentiation, cells make science from elucidating the causes of cancer to the use of very precise transitions between apparently stable ``network stem cells in regenerative medicine. (lu.se)

Interestingly, AVM appeared to be more sensitive to imatinib‑resistant (T315I, Y253H, and E279K) than wild‑type BCR/ABL cells, indicating its potential to overcome imatinib‑resistant severe issues in CML. (spandidos-publications.com)

Correspondence with low molecular weight chemicals that results in the priming of chemical-specific, Prof. Dr. Stefan F. Martin, Allergy Research skin-homing CD8+ Tc1/Tc17 and CD4+ Th1/Th17 cells. (cdc.gov)

The recent development of stem cell research and the possibility of generating cells that can be stably and permanently modified in their genome open a broad horizon in the world of in vitro modeling. (wjgnet.com)
The theoretical basis for marrow failure includes primary defects in or damage to the stem cell or the marrow microenvironment. (medscape.com)
Understanding cell-fate decisions in stem cell populations is a major goal of modern biology. (lu.se)
Stem and progenitor cell populations are often heterogeneous, which may reflect stem cell subsets that express subtly different properties, including different propensities for lineage selection upon differentiation, yet remain able to interconvert. (lu.se)
The nature of the stem cell substates and their relationship to commitment to differ- entiate and lineage selection can be elucidated in terms of a landscape picture in which stable states can be defined mathematically as attractors. (lu.se)

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Promyelocytic HL-601

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Inhibition4

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Reactive oxygen1

Induces1

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Human leukemia cell-line1

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