• A genetic case-control study confirms the implication of SMAD7 and TNF locus in the development of proliferative vitreoretinopathy. (ox.ac.uk)
  • The development of proliferative vitreoretinopathy with retinal detachment in 4 patients was the main complication observed after pars plana vitrectomy. (thieme-connect.de)
  • Fundus color montage of a case with bilateral Familial Exudative Vitreoretinopathy: retinal vessel dragging from optic disc toward temporal retina, peripheral avascular zone, inferior proliferative vitreoretinal traction. (zeiss.com)
  • Complicated retinal detachments with severe posterior and anterior proliferative vitreoretinopathy (PVR) were included in this study. (springer.com)
  • Seventy-six consecutive patients with total rhegmatogenous retinal detachments and severe proliferative vitreoretinopathy underwent combined pars plana vitrectomy, lensectomy, panretinal photocoagulation, perfluoropropane gas (C3F8)/fluid exchange, and scleral buckling. (nih.gov)
  • Abrams GW, Azen SP, McCuen BW II, Flynn HW Jr, Lai MY, Ryan SJ (1997) Vitrectomy with silicone oil or long-acting gas in eyes with severe proliferative vitreoretinopathy: results of additional and long-term follow-up. (springer.com)
  • If several operations are required to repair proliferative vitreoretinopathy, poor vision may result even with a successfully attached retina. (medscape.com)
  • Figure 10-9 Preretinal membrane (area between arrows) on the surface of the retina, secondary to proliferative vitreoretinopathy. (aao.org)
  • Localized scatter photocoagulation is effective in treating early proliferative changes, especially neovascular lesions that lie flat against the retina. (medscape.com)
  • Retinotomy and silicone oil for detachments complicated by anterior inferior proliferative vitreoretinopathy. (medscape.com)
  • 2. Charteris DG, Downie J, Aylward GW, Sethi C, Luthert P. Intraretinal and periretinal pathology in anterior proliferative vitreoretinopathy. (medline.ru)
  • Anterior proliferative vitreoretinopathy in the silicone study. (medline.ru)
  • 11. Hocaoglu M, Karacorlu M, Giray Ersoz M, Sayman Muslubas I, Arf S. Retinotomy and retinectomy for anterior inferior proliferative vitreoretinopathy: Can visual outcome be improved? (medline.ru)
  • This can occur in such cases as hypotony due to anterior proliferative vitreoretinopathy (PVR), persistent cystoid macular edema (CME) after complicated cataract surgery with retained lens fragments, and endophthalmitis. (ophthalmologytimes.com)
  • Our pre-commercial product candidates are reproxalap, a potential treatment for dry eye disease and allergic conjunctivitis, and ADX-2191, a potential treatment for primary vitreoretinal lymphoma, proliferative vitreoretinopathy, and retinitis pigmentosa. (businesswire.com)
  • The Company is currently developing ADX-2191, a dihydrofolate reductase inhibitor for the treatment of primary vitreoretinal lymphoma cancer, proliferative vitreoretinopathy, and retinitis pigmentosa, as well as rare retinal diseases characterized by inflammation and vision loss. (woodtv.com)
  • Proliferative vitreoretinopathy (PVR) is a disease that develops as a complication of rhegmatogenous retinal detachment. (wikipedia.org)
  • Rhegmatogenous retinal detachment (RRD) is the most common form of retinal detachment (RD). Proliferative vitreoretinopathy (PVR) is primarily a result of failure to correct RRD after initial retinal reattachment surgery, occurs in 5%-10% of patients, and may lead to recurrent RD. 1 Further surgery is the only proven therapy for recurrent RD with PVR. (dovepress.com)
  • Outcomes of vitrectomy with inferior retinectomy in patients with recurrent rhegmatogenous retinal detachments and proliferative vitreoretinopathy. (medline.ru)
  • Comparison of Peroperative Methotrexate Infusion With Postoperative Intra Silicon Oil Methotrexate Injections for Prevention of Proliferative Vitreoretinopathy Development After Vitrectomy for Rhegmatogenous Retinal Detachment Repair. (who.int)
  • Since vitreous hemorrhage and retinal detachment account for most visual loss in hemoglobinopathies, the primary goal in treating proliferative sickle retinopathy is to minimize or eliminate neovascularization. (medscape.com)
  • Different techniques have been advocated in treating proliferative sickle retinopathy, including scatter photocoagulation and feeder vessel photocoagulation. (medscape.com)
  • This technique has been shown to manage proliferative sickle retinopathy effectively, especially in cases where neovascularization has persisted after extensive scatter photocoagulation treatment. (medscape.com)
  • and NF-?B signaling play a critical role in cigarette smoke-induced epithelial-mesenchymal transition of retinal pigment epithelial cells in proliferative vitreoretinopathy. (rochester.edu)
  • Mysore Y, Del Amo EM, Loukovaara S, Hagström M, Urtti A, Kauppinen A. Statins for the prevention of proliferative vitreoretinopathy: cellular responses in cultured cells and clinical statin concentrations in the vitreous . (helsinki.fi)
  • The name Proliferative vitreo retinopathy was provided in 1989 by the Silicone Oil Study group. (wikipedia.org)
  • Cox MS, Trese MT, Murphy PL (1986) Silicone oil for advanced proliferative vitreoretinopathy. (springer.com)
  • Epimacular membranes occurring after retinal detachment surgery can be thought of as limited proliferative vitreoretinopathy. (medscape.com)
  • Proliferative vitreoretinopathy (PVR) is a disease that causes severe blindness and is characterized by the formation of contractile fibrotic subretinal or epiretinal membranes. (stanford.edu)
  • Specific platelet-derived growth element (PDGF) isoforms are connected with proliferative vitreoretinopathy (PVR), a sight-threatening complication that develops inside a subset of individuals dealing with retinal reattachment surgery. (woofahs.com)
  • Proliferative vitreoretinopathy (PVR) is the most common cause of failure in retinal detachment surgery. (medscape.com)
  • Of all retinal detachment surgery cases, 5-10% develop proliferative vitreoretinopathy. (medscape.com)
  • PURPOSE: Proliferative vitreoretinopathy (PVR) is still the major cause of failure of retinal detachment (RD) surgery and although the risk for developing this complication is associated with some clinical characteristics, the correlation is far from absolute, raising the possibility of genetic susceptibility. (ox.ac.uk)
  • Presence of proliferative vitreoretinopathy grade C, previous retinal detachment surgery in the same eye, penetrating ocular trauma, Presence of intraocular foreign bodies, previous glaucoma filtration surgery, allergy to methotrexate, and pregnant and lactating women. (who.int)
  • However, in cases where scatter photocoagulation alone does not achieve the desired result (ie, regression of proliferative changes), feeder vessel photocoagulation may be used as an adjunct to induce infarction to the remaining sea fans. (medscape.com)
  • To determine differences of K + channel activity between Müller glial cells obtained from retinas of healthy human donors and of patients with retinal detachment and proliferative vitreoretinopathy. (arvojournals.org)
  • RRD patients with or without proliferative vitreoretinopathy (PVR) were included. (dovepress.com)
  • Although proliferative vitreoretinopathy can occur at all ages, some observers believe that proliferative tissue may develop more rapidly in children. (medscape.com)
  • Interaction between surgical procedure for repairing retinal detachment and clinical risk factors for proliferative vitreoretinopathy. (medscape.com)
  • Translational and clinical advancements in management of proliferative vitreoretinopathy. (rochester.edu)
  • however, recurrence rates for retinal detachment could be as high as 10% to 20%, 1 and even higher in the presence of proliferative vitreoretinopathy (PVR). (bmj.com)
  • To evaluate the effect of extrascleral cryocoagulation for the treatment of proliferative vitreoretinopathy (PVR) during retinal detachment repair. (kssg.ch)
  • 4. Pastor JC, de la Rúa ER, Martín F. Proliferative vitreoretinopathy: risk factors and pathobiology. (medline.ru)
  • The increased activity of BK channels may support the proliferative activity of gliotic cells via feedback regulation of Ca 2+ entry and membrane potential. (arvojournals.org)
  • Penetrating or blunt trauma may also result in proliferative vitreoretinopathy. (medscape.com)
  • Intro Proliferative vitreoretinopathy (PVR) can be a blinding disease occurring in up to 10% of individuals dealing with retinal reattachment medical procedures (16, 23, 52). (woofahs.com)
  • Proliferative vitreoretinopathy (PVR) is a blind-causing disease initiated by the activation of retinal pigmented epithelium (RPE) primarily induced by TGF-β families. (stanford.edu)
  • Proton magnetic resonance imaging (MRI) was employed to obtain information on early vitreal changes preceding ophthalmoscopically visible proliferative vitreoretinopathy. (unimib.it)
  • Proliferative vitreoretinopathy is a reparative process, similar to a keloid, initiated by full- or partial-thickness retinal breaks, retinopexy, and other types of retinal damage. (medscape.com)
  • en-INT_31_173_0139I This is a code assigned to all external communications materials, to assist in tracking and monitoring during the internal approval process. (zeiss.com)