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VasopressinsAquaporin 1Aquaporin 5Aquaporin 3Arginine VasopressinReceptors, VasopressinAquaporin 4AquaporinsAquaporin 2Aquaporin 6Deamino Arginine VasopressinRats, BrattleboroWaterOxytocinLypressinRenal AgentsWater-Electrolyte BalanceAntidiuretic AgentsKidney Tubules, CollectingNeurophysinsDiabetes InsipidusOsmosisPituitary Gland, PosteriorKidney Concentrating AbilityDiabetes Insipidus, NephrogenicVasotocinSupraoptic NucleusOsmolar ConcentrationPolyuriaMercuric ChloridePituitary Hormones, PosteriorAquaglyceroporinsDiuresisBlood Group AntigensKidney MedullaWater DeprivationPermeabilityReceptors, OxytocinGlycerolDehydrationKidneyCell Membrane PermeabilitySaline Solution, HypertonicHyponatremiaInappropriate ADH SyndromeRats, Sprague-DawleyBiological TransportOsmotic PressureIon ChannelsPlant TranspirationBody WaterRats, Inbred StrainsMolecular Sequence DataAmino Acid SequenceCell MembraneParaventricular Hypothalamic NucleusThirstVasoconstrictor AgentsUrineSodiumPlant ProteinsBlood PressureNeuromyelitis OpticaReceptors, AngiotensinHypothalamusRNA, MessengerDrinkingXenopus laevisCyclic AMPOocytesCorticotropin-Releasing HormoneCalciumBenzazepinesRats, WistarImmunohistochemistryAngiotensin IIInjections, IntraventricularOrnipressinHypothalamo-Hypophyseal SystemSolute Carrier Family 12, Member 1Brain EdemaAdrenocorticotropic HormoneHormone AntagonistsDose-Response Relationship, DrugEpinephrineTulipaVapor PressureHypothalamus, AnteriorTime FactorsUreaCistaceaeMembrane ProteinsPlant RootsSodium ChlorideDogsHypertonic SolutionsMercury CompoundsSodium-Potassium-Chloride SymportersNorepinephrineLiver
ArginineAQP2PhosphorylationAntidiureticReceptorRegulationRenalPermeabilityLocalizationProteinsAQPsIsoformsSubfamilyGeneOxytocin2022TestisPolyuriaGlycerolInteractsCellsProteinEffectsJournalNephrogenic diabetesReceptorsRegulatesReabsorptionRegulationExpression of aquaporinRenal waterCharacterizationHuman aquaporinAqp4KidneyAntidiuretic hormoneHormonePlasma membranePhosphorylationMembraneAntibodyAQP32019Facilitates waterWater channelAldosteroneInteraction
Arginine6
  • The syndrome of inappropriate antidiuretic hormone secretion (SIADH) involves the continued secretion or action of arginine vasopressin (AVP) despite normal or increased plasma volume. (medscape.com)
  • Receptor for arginine vasopressin. (hmdb.ca)
  • The pathophysiological significance of changes in CSF volume is assessed from the respective viewpoints of hemodynamics (choroid plexus blood flow and pulsatility), hydrodynamics (choroidal hypo- and hypersecretion) and neuroendocrine factors (i.e., coordinated regulation by atrial natriuretic peptide, arginine vasopressin and basic fibroblast growth factor). (scienceopen.com)
  • Central DI is characterized by decreased secretion of antidiuretic hormone (ADH)-also known as arginine vasopressin (AVP)-which gives rise to polyuria and polydipsia by diminishing the person's ability to concentrate urine. (medscape.com)
  • Arginine vasopressin (AVP) (also called antidiuretic hormone [ADH]) is released by the posterior pituitary gland in response to increased osmolality, decreased extracellular volume, positive pressure ventilation, and surgical stimuli, including pain. (unboundmedicine.com)
  • The most common inherited NDI is an X-linked trait with variable penetrance in heterozygous females that affects the arginine vasopressin (AVP) receptor 2 gene. (msdmanuals.com)
AQP25
  • Background: Vasopressin induced trafficking of aquaporin-2 (AQP2) containing vesicles has been studied in kidney cell lines using conventional fluorescent proteins as tags. (johnshopkins.edu)
  • The very best studied exemplory case of this is actually the legislation of AQP2 translocation in individual kidney cells, which would depend on vasopressin-mediated activation of proteins kinase A with the G protein-coupled receptor, vasopressin V2 receptor (15). (healthanddietblog.info)
  • On the other hand, a hypotonic stimulus acquired little influence on AQP2 localization (-)-Epicatechin IC50 in the lack of the vasopressin V2 receptor necessary for AQP2 translocation (19). (healthanddietblog.info)
  • The best-characterised example of this type of rules is definitely that of human being AQP2 in the kidney: AQP2 large quantity in the apical membrane is dependent on vasopressin-activated phosphorylation of a carboxy-terminal serine residue (Ser 256) by cAMP-dependent protein kinase A (PKA) [7]. (idplink.net)
  • ADM significantly decreased aquaporin-2 (AQP2) phosphorylation at Serine 256 (pS256) and increased it at Serine 261 (pS261). (emory.edu)
Phosphorylation2
  • Phosphorylation events and the modulation of aquaporin 2 cell surface expression. (massgeneral.org)
  • Constructions of gated AQPs have exposed the molecular details of AQP gating by phosphorylation, pH and Ca2+ for the spinach aquaporin SoPIP2;1 [4] and mechanosensitivity for the candida aquaporin AQY1 [5]. (idplink.net)
Antidiuretic3
  • ADH, antidiuretic hormone is also called vasopressin. (khanacademy.org)
  • Vasopressin causes greatly enhanced water absorption by the kidney and is sometimes known as the 'antidiuretic hormone'(ADH). (urhelpmate.com)
  • Дефіцит аргінін- вазопресину (центральний нецукровий діабет) Diabetes insipidus results from a deficiency of vasopressin (antidiuretic hormone [ADH]) due to a hypothalamic-pituitary disorder (central diabetes insipidus) or from resistance of the kidneys. (msdmanuals.com)
Receptor2
  • North WG, Fay MJ, Longo KA, Du J: Expression of all known vasopressin receptor subtypes by small cell tumors implies a multifaceted role for this neuropeptide. (hmdb.ca)
  • Fay MJ, Du J, Yu X, North WG: Evidence for expression of vasopressin V2 receptor mRNA in human lung. (hmdb.ca)
Regulation1
  • Novel ways to modulate CSF formation emanate from recent analyses of choroid plexus transcription factors (E2F5), ion transporters (NaHCO3 cotransport), transport enzymes (isoforms of carbonic anhydrase), aquaporin 1 regulation, and plasticity of receptors for fluid-regulating neuropeptides. (scienceopen.com)
Renal3
  • También se discuten las perspectivas futuras con respecto a la evaluación y el diagnóstico temprano de lesión renal en estos pacientes. (revistanefrologia.com)
  • The renal medulla receives only 6% of total renal blood flow but extracts approximately 80% of the oxygen that it receives, making it very susceptible to ischemia, particularly the medullary thick ascending loop of Henle. (unboundmedicine.com)
  • Nephrogenic diabetes insipidus (NDI) is an inability to concentrate urine due to impaired renal tubule response to vasopressin (ADH), which leads to excretion of large amounts of dilute urine. (msdmanuals.com)
Permeability2
Localization1
  • Protein kinase A type II activation is sufficient to control the cellular localization of the water channel aquaporin-2 in the kidney 72 3.3.1. (fu-berlin.de)
Proteins5
  • Aquaporins/major intrinsic proteins (MIP) are a family of water-selective membrane channels. (wikipedia.org)
  • This review focuses on emerging topics encompassing the functional involvement of aquaporin channel proteins (AQPs) and membrane transport systems, also allowing permeation of NO and hydrogen peroxide, a major ROS, in oxidative stress physiology and pathophysiology. (hindawi.com)
  • This notion has been challenged by the discovery of new membrane transport functions, especially those exerted by aquaporins (AQPs), a family of membrane channel proteins widespread in nature [ 10 , 11 ]. (hindawi.com)
  • The control of cellular water flow is mediated with the aquaporin (AQP) category of membrane proteins. (healthanddietblog.info)
  • These water channels consist of a family of proteins called aquaporin. (urhelpmate.com)
AQPs2
  • Intro The flux of water across biological Chlorpheniramine maleate membranes is definitely facilitated by transmembrane protein channels called aquaporins (AQPs). (idplink.net)
  • The Role of Aquaporins in the Kidneys The majority of water reabsorption that occurs in the nephron is facilitated by the AQPs. (urhelpmate.com)
Isoforms1
Subfamily1
  • Aquaporin-7 has greater sequence similarity with AQP3 and AQP9 and they may be a subfamily. (wikipedia.org)
Gene3
  • Aquaporin-7 (AQP-7) is a protein that in humans is encoded by the AQP7 gene. (wikipedia.org)
  • 2002). "Human aquaporin adipose (AQPap) gene. (wikipedia.org)
  • In rare cases, NDI is caused by an autosomal recessive or autosomal dominant mutation that affects the aquaporin-2 gene and can affect both males and females. (msdmanuals.com)
Oxytocin2
  • controlled by the hormone vasopressin which is a peptide very similar in structure to oxytocin (cf. (urhelpmate.com)
  • The intrinsic binding ability of 7 natural peptides (oxytocin, arg8 -vasopressin, bradykinin, angiotensin-I, substance-P, somatostatin, and neurotensin) with copper in 2 different oxidation states (CuI/II ) derived from different Cu+/2+ precursor sources have been investigated for their charge-dependent binding characteristics. (2sars.com)
20222
Testis1
  • Tissue extracts of Mouse Testis (Lane 6) and Mouse Kidney (Lane 7) were electrophoresed using NuPAGE™ 3-8% Tris-Acetate Protein Gel (Product # EA0378BOX). (thermofisher.com)
Polyuria1
  • Primary polydipsia occurs because the amount of liquid ingested by the patient is much higher than the requirement hypersensitivity center thirst, thereby decreasing the osmolality of the internal environment, causing a suppression of secretion of ADH, thus giving the clinical feature is polyuria, occurs in patients with psychiatric, anxious or diseases drugs such as phenothiazines [1,5,6]. (crimsonpublishers.com)
Glycerol2
Interacts1
  • PLB interacts directly with AKAP18δ 79 4.1.6. (fu-berlin.de)
Cells2
  • Although it is now accepted that the CNS undergoes constant immune surveillance that takes place within the meningeal compartment 1 - 3 , the mechanisms governing the entrance and exit of immune cells from the CNS remain poorly understood 4 - 6 . (scienceopen.com)
  • Neutrophil gelatinase-associated lipocalin (NGAL in humans, siderocalin/24p3 in rodents) or lipocalin-2 (Lcn2) is secreted by cells [ 6 ] in an Fe 3+ -free apo form, which binds Fe 3+ through association with bacterial siderophores (forming holo-Lcn2). (biomedcentral.com)
Protein1
  • and aquaporin-1 and with unfavorable staining of aquaporin-2, Tamm-Horsfall protein, and vimentin. (holyexperiment.org)
Effects1
  • In that event, NOS is turned into a peroxynitrite generator, leading to detrimental effects on vascular function, due to lipidic peroxidation [ 6 ]. (hindawi.com)
Journal1
  • Journal of Electrocardiology 40 (6 Suppl): S42-S46. (mdc-berlin.de)
Nephrogenic diabetes7
Receptors4
  • The hormone binds to vasopressin V2 receptors (V2R) on the surface of the cells and stimulates cAMP synthesis. (mdpi.com)
  • Vasopressin binds V2 receptors, which are coupled to G proteins. (medscape.com)
  • AVP binding to vasopressin V2 receptors (V2Rs) located on kidney collecting duct epithelial cells triggers activation of Gs proteins, leading to increased cAMP levels, trafficking of aquaporin-2 water channels, and consequent increased water permeability and antidiuresis. (uaeu.ac.ae)
  • When in the circulation, vasopressin eventually binds to receptors on epithelial cells in the distal convoluted tubule. (smpdb.ca)
Regulates1
  • ciliary chain, a domain insufficient acyltransferase and a reporting 5,6-dimethylbenzamidizole( quality) class, but Once regulates a 1980)The addition and a PDZ-binding role. (familie-vos.de)
Reabsorption2
  • Vasopressin, acting on the kidney, causes increased reabsorption of water (antidiuresis). (mhmedical.com)
  • [ 8 ] This interferes with the cell's responsiveness to aldosterone and vasopressin, which, in turn, limits insertion of aquaporin-2 and leads to decreased water reabsorption. (medscape.com)
Regulation3
  • Regulation of vasopressin secretion and serum osmolality. (mhmedical.com)
  • Research in the Epithelial Systems Biology Laboratory, led by Dr. Mark A. Knepper, concentrates on the physiology and pathophysiology of the kidney, with particular focus on regulation of water and salt transport by the peptide hormone vasopressin. (nih.gov)
  • Much of the focus is on regulation of molecular water channels ( aquaporins ) by the hormone vasopressin in renal collecting duct epithelial cells. (nih.gov)
Expression of aquaporin1
  • [ 8 ] Increased COX-2 leads to the production of prostaglandin E2 (PGE2), which interferes with the ability of the collecting duct to concentrate urine by modulating the expression of aquaporin-2 (Figures 1 and 2). (medscape.com)
Renal water1
Characterization1
  • 4] "Cloning, characterization, and chromosomal mapping of human aquaporin of collecting duct. (tcdb.org)
Human aquaporin2
  • 2002). "Human aquaporin adipose (AQPap) gene. (wikipedia.org)
  • 2] "Isolation of human aquaporin-CD gene. (tcdb.org)
Aqp41
  • The primary aquaporins expressed in the mammalian brain are AQP1, which is densely packed in choroid plexus cells lining the ventricles, and AQP4, which is abundant in astrocytes and concentrated especially in the end-feet structures that surround capillaries throughout the brain and are present in glia limitans structures, notably in osmosensory areas such the supraoptic nucleus . (brainmaps.org)
Kidney3
  • [ 4 ] It has been demonstrated that hypocortisolism results in overexpression of aquaporin-2 water channels, which results in decreased water excretion by the kidney. (medscape.com)
  • Vasopressin (VP) action in the kidney. (mhmedical.com)
  • Cadherin-6 is a type II cadherin and may play a role in kidney development as well as endometrium and placenta formation. (bicellscientific.com)
Antidiuretic hormone2
  • The placement of these channels is controlled by a hormone called vasopressin or antidiuretic hormone (ADH). (medlineplus.gov)
  • Vasopressin (also termed antidiuretic hormone [ADH]) is a 9-amino acid peptide synthesized in hypothalamic paraventricular and supraoptic magnocellular neurons and stored in the posterior pituitary, or neurohypophysis, from where it is released into the systemic circulation ( Fig. 518-2 ) to regulate plasma osmolality. (mhmedical.com)
Hormone2
  • This hormone triggers chemical reactions that ultimately insert aquaporin 2 water channels into the membrane of collecting duct cells. (medlineplus.gov)
  • 6 Describe Steroid hormones synthesis and outline Steroid Hormone Biosynthesis Reactions. (slideshare.net)
Plasma membrane1
Phosphorylation1
  • 7] "The role of putative phosphorylation sites in the targeting and shuttling of the aquaporin-2 water channel. (tcdb.org)
Membrane3
Antibody1
  • Anti-Cadherin-6 (zebrafish) antibody is recommended for immunofluorescence labeling, IHC, or western blot of materials from zebrafish tissues. (bicellscientific.com)
AQP32
  • Aquaporin-7 has greater sequence similarity with AQP3 and AQP9 and they may be a subfamily. (wikipedia.org)
  • Aquaporin-7 and AQP3 are at the same chromosomal location suggesting that 9p13 may be a site of an aquaporin cluster. (wikipedia.org)
20192
Facilitates water1
Water channel1
Aldosterone1
  • Angiotensin II stimulates the release of aldosterone from the adrenal cortex and release of vasopressin from the posterior pituitary gland. (smpdb.ca)
Interaction1
  • Normal blood tonicity is maintained over a 10-fold variation in water intake by a coordinated interaction among vasopressin, thirst, and the renal system. (mhmedical.com)