Stearoyl-CoA desaturase 1 ( SCD1 ) is a critical rate-limiting enzyme of de novo synthesis of monounsaturated fatty acids (MUFAs) [ 4 ]. (biomedcentral.com)
Furthermore, stearoyl-CoA desaturase-1 (SCD1), a transcriptional target of SREBP1, mediates the ferroptosis-suppressing activity of SREBP1 by producing monounsaturated fatty acids. (biomed.news)
Insulin and a hormone called leptin, released by fat cells, control long term fat storage levels by manipulating the level of saturation of body fat via their effects on an enzyme called stearoyl-CoA desaturase (SCD1). (fireinabottle.net)
Fatty acid syn2
Fatty acid synthase ( FAS ) organizes the structural skeleton of fatty acid with malonyl-CoA. (biomedcentral.com)
We also find that the SREBP target genes fatty acid synthase (FASN) and stearoyl-CoA desaturase (SCD) are conditionally required to support YAP-dependent proliferation and tissue growth. (biomed.news)
Acetyl-CoA carboxy2
For example, acetyl-CoA carboxylase ( ACC ) converts the acetyl-CoA to malonyl-CoA, which is the direct carbon donor for de novo synthesis of fatty acid. (biomedcentral.com)
Consequently, LW1564 promoted the phosphorylation of acetyl-CoA carboxylase, which inhibited lipid synthesis. (biomed.news)
Monounsaturated fatty1
Stearoyl-CoA desaturase (Δ-9-desaturase) is an endoplasmic reticulum enzyme that catalyzes the rate-limiting step in the formation of monounsaturated fatty acids (MUFAs), specifically oleate and palmitoleate from stearoyl-CoA and palmitoyl-CoA. (wikipedia.org)
Adipose tissue3
Due to the potential economic impact, it is important that the poultry industry identify the genes and polymorphisms that cause population variation in chicken adipose tissue development. (tnstate.edu)
Genome-Wide Association Studies of Estimated Fatty Acid Desaturase Activity in Serum and Adipose Tissue in Elderly Individuals: Associations with Insulin Sensitivity. (ox.ac.uk)
Genome-wide association studies of δ-5-desaturase (D5D), δ-6-desaturase (D6D) and stearoyl-CoA desaturase-1 (SCD) activities (estimated by product-to-precursor ratios of fatty acids analyzed by gas chromatography) in serum cholesterol esters (n = 1453) and adipose tissue (n = 783, all men) were performed in two Swedish population-based cohorts. (ox.ac.uk)
Enzyme5
Stearoyl-CoA desaturase-1 is a key enzyme in fatty acid metabolism. (wikipedia.org)
The systematic name of this enzyme class is stearoyl-CoA,ferrocytochrome-b5:oxygen oxidoreductase (9,10-dehydrogenating). (wikipedia.org)
It catalyzes the chemical reaction stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ ⇌ {\displaystyle \rightleftharpoons } oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O The 4 substrates of this enzyme are stearoyl-CoA, ferrocytochrome b5, O2, and H+, whereas its 3 products are oleoyl-CoA, ferricytochrome b5, and H2O. (wikipedia.org)
cDNA cloning and in situ hybridization of Δ11-desaturase, a key enzyme of pheromone biosynthesis in Ostrinia scapulalis (Lepidoptera:Crambidae)[J]. Journal of Insect Physiology, 2006, 52(5):430-435. (zgswfz.com.cn)
The FADS1 gene codes for the fatty acid delta-5 desaturase, a key enzyme in the metabolism of long-chain polyunsaturated omega-3 and omega-6 fatty acids. (metabolomix.com)
Gene1
The OLE1 gene of Saccharomyces cerevisiae encodes the delta 9 fatty acid desaturase and can be ceremonyally redigsd nigh the rat stearoyl-CoA desaturase gene. (upb.ro)
Synthesis1
Acyl-CoA Δ11 desaturase is one of the fatty acid desaturases that are key enzymes in the synthesis pathway of unsaturated fatty acids. (zgswfz.com.cn)
Genes1
Functional annotation resulted in the identification of almost all genes involved in diverse lipid-metabolic pathways, including the novel fatty acid desaturase/epoxygenase, diacylglycerol acyltransferase 1 and 2, and phospholipid:diacylglycerol acyltransferases. (researchsquare.com)
Delta1
In summary, we can conclude that the direction of all those associations can be explained by a modification in the efficiency of the fatty acid delta-5 desaturase reaction. (metabolomix.com)
Genetic3
Nutritionists typically ignore genetic variation, and many genetic association studies do not measure environmental influences. (sciencewatch.com)
This paper was actually one of many reviews of the early 2000s which began summarizing the need to study nutrient intakes and genetic variation. (sciencewatch.com)
Different feeding practices and genetic variation within and between breeds influences the amount of IMF and fatty acid (FA) composition in meat. (biomedcentral.com)
Activity1
Because MUFAs are heavily utilized in cellular processes, variation in SCD activity in mammals is expected to influence physiological variables, including cellular differentiation, insulin sensitivity, metabolic syndrome, atherosclerosis, cancer, and obesity. (wikipedia.org)
Domains1
Amino acid sequence analysis showed that CsFadΔ11 contains three histidine boxes and six transmembrane domains, which are composite characteristics of a fatty acid desaturase. (zgswfz.com.cn)
Study1
13] Pereira S L, Leonard A E, Mukerji P. Recent advances in the study of fatty acid desaturases from animals and lower eukaryotes[J]. Prostaglandins, Leukotrienes and Essential fatty Acids, 2003, 68(2):97-106. (zgswfz.com.cn)
Studies1
Previous studies in our laboratory have implicated Tenascin C (TNC), Collagen type III alpha 1 (COL3A1), Ephrin type-B receptor 2 (EPHB2), Fibroblast growth factor receptor 3 (FGFR3), Insulin-like growth factor binding protein 2 (IGFBP2), Stearoyl-CoA desaturase (SCD), Acyl-CoA binding domain containing 7 (ACBD7 ), and Gremlin 1(GREM1) as regulators of fat tissue in broiler chickens. (tnstate.edu)
Environmental1
Variation in the strength of clines was explained by environmental changes in drought stress and vegetation cover that varied among cities. (arizona.edu)
Fatty acid composition1
Seasonal variation in fatty acid composition of cow milk in relation to the feeding system. (org.in)
Milk1
Seasonal variation in milk conjugated linoleic acid and Δ9-desaturase activity in dairy cows. (org.in)
Molecular2
A series of redox reactions, during which two electrons flow from NADH to flavoprotein cytochrome b5, then to the electron acceptor cytochrome b5 as well as molecular oxygen introduces a single double bond within a row of methylene fatty acyl-CoA substrates. (wikipedia.org)
Please check COA/MSDS for correct molecular weight. (adooq.com)
Double bond2
It is responsible for forming a double bond in stearoyl-CoA. (wikipedia.org)
FADs can also be functionally categorized as front-end and methyl-end desaturase, which introduces a double bond towards the carboxyl terminus and methyl-end of the fatty acyl chain, respectively [ 3 ]. (biomedcentral.com)
Association1
Clinical data identified an association between the use of HMG-CoA reductase inhibitors (statins) and incident diabetes in patients with underlying diabetes risk factors such as obesity, hypertension and dyslipidemia. (biomedcentral.com)
Present1
Given this strong positional and biological candidacy, the present study sought to establish whether sequence variation in SCD influences susceptibility to type 2 diabetes and related traits. (nih.gov)