Therefore, our research activities are based on understanding the basic organization and differentiation of the epithelium of the urinary bladder (urothelium) in benign and malignant conditions. (ukaachen.de)
Urinary8
Transitional epithelium lines the organs of the urinary system and is known here as urothelium (PL: urothelia). (wikipedia.org)
Purpose: The repertoire of mucin (MUC) gene expression in the normal human urothelium is poorly defined and the alterations in MUC gene expression following transposition of intestinal segments into the urinary tract has not previously been studied. (ncl.ac.uk)
It is speculated that these urinary proteins and their inhibitors play a crucial role in regulating desquamation of urothelium, which constitutes a vital defence mechanism against bacterial attachment. (biomedcentral.com)
Histologically confirmed, unresectable, locally advanced or metastatic transitional cell carcinoma of the urothelium (UC) (including the renal pelvis, ureter, urinary bladder, or urethra). (nih.gov)
We hypothesize that one or more of these gene products derived from renal urothelium will serve as biomarkers that correlate with the severity of urinary tract obstruction in these children. (sciencedaily.com)
At the level of the lumbosacral spinal cord, lower urinary tract reflex mechanisms are modulated by supraspinal controls with mechanosensory input from the urothelium, resulting in regulation of bladder contractile activity. (duke.edu)
The sensory, transduction, and signalling properties of the urothelium can influence adjacent urinary bladder tissues including the suburothelial nerve plexus, interstitial cells of Cajal, and detrusor smooth muscle cells. (duke.edu)
Changes to the urothelium are associated with a number of bladder pathologies that underlie urinary bladder dysfunction. (duke.edu)
Urothelial6
loss of the umbrella cell layer (superficial urothelium) was evident while intermediate and basal urothelial cells were preserved. (medscape.com)
6 ]. As normal urothelium is characterised by cytoplasmic cytokeratin 20 expression in terminally differentiated superficial cells, cytokeratin 20 was taken as a marker of complete terminal differentiation of urothelial cells in bladder biopsies. (biomedcentral.com)
10. Autologous transplantation of urothelium into demucosalized gastrointestinal segments: evidence for epithelialization and differentiation of in vitro expanded and transplanted urothelial cells. (nih.gov)
Stage III (T1/T2/T3, N0/N1, M0): Tumor invades urethral subepithelial connective tissue right under the urothelium (T1), OR tumor invades the prostatic stroma surrounding ducts either by direct extension from the urothelial surface or by invasion from prostatic ducts (T2), OR tumor invades the periprostatic fat (T3). (oncolink.org)
Diverse stimuli, including those that activate TRP channels expressed by the urothelium, can influence urothelial release of chemical mediators (such as ATP). (duke.edu)
primary_diagnosis A C191672 C177537 GDC Value Terminology C191672 Papillary Urothelial Neoplasm of Low Malignant Potential A papillary neoplasm of the urothelium. (nih.gov)
Differentiation4
In contrast, cultured human stratified urothelium, which does not undergo complete terminal differentiation of its superficial cells, does not express cytokeratin 20. (biomedcentral.com)
their synthesis requires differentiation of the vesical urothelium. (biomedcentral.com)
2 ] In contrast to normal urothelium, cultured human stratified urothelium does not undergo complete terminal differentiation of its superficial cells. (biomedcentral.com)
It is possible that injury to the spinal cord, and consequent lack of trophic effect upon the urothelium, may lead to incomplete maturation and differentiation. (biomedcentral.com)
Autologous1
8. Transplantation of autologous differentiated urothelium in an experimental model of composite cystoplasty. (nih.gov)
Umbrella cells1
Urothelium is characterised by terminally differentiated superficial cells ("umbrella cells"), that express uroplakins in their luminal plasma membrane and cytokeratin 20 in their cytoplasm. (biomedcentral.com)
Papillary1
Papillary tumors stand out against a background of smooth urothelium. (webpathology.com)
Hyperplastic1
other: no hyperplastic changes in the urothelium or carcinomas were found when treated with sodium nitrate alone. (europa.eu)
Mammalian2
citation needed] The urothelium is the most impermeable membrane in the mammalian body. (wikipedia.org)
Thus the mammalian urothelium, besides acting as a permeability barrier, may serve important functions in prevention of bacterial cystitis. (biomedcentral.com)
Superficial1
Normal urothelium is characterised by terminally differentiated superficial cells, which express cytokeratin 20 in the cytoplasm. (biomedcentral.com)
Basal1
The basal expression patterns of the metallothionein (MT) and heat shock proteins 27, 60, and 70 were determined in these cells, and expression was in agreement with that known to occur for in situ urothelium. (nih.gov)
Kidney2
Figure Legend: Figure 1 Kidney, Urothelium - Hyperplasia in a male F344/N rat from a chronic study. (nih.gov)
Although Dr. Becknell and his research team expected changes in the expression of certain genes depending on the type and amount of kidney damage present, they were surprised to learn that the changes were primarily restricted to a single cell layer, in this case, the renal urothelium. (sciencedaily.com)
Outcome1
9. Prerequisite for successful surgical outcome in urothelium lined seromuscular colocystoplasty. (nih.gov)
Tissue2
All of them provided cancer tissue samples and 50 of them provided non-cancerous urothelium samples. (medsci.org)
Stage I (T1, N0, M0): Tumor invades urethral subepithelial connective tissue right under the urothelium (T1). (oncolink.org)
Genes2
Both MUC1 and MUC4 were up-regulated in transposed ileal segments, genes expressed by the normal human urothelium. (ncl.ac.uk)
Nonmalignant urothelium had uniform expression of LN5 genes and lacked methylation. (nih.gov)
Diffuse1
Altogether the abovementioned findings were suggestive of a diffuse disruption of the urothelium. (medscape.com)
Findings1
The findings suggest that the UROtsa cells grown with a serum-free medium could be a valuable adjunct for studying environmental insult to the human urothelium in general and for the stress response in particular. (nih.gov)
Regulation1
In patients with clam enterocystoplasty there was evidence of increasing up-regulation of MUC2, 3, 4 and 5AC expression in the urothelium toward the anastomotic site. (ncl.ac.uk)
Intermediate1
The overall morphology was most consistent with that found in the intermediate layers of in situ urothelium. (nih.gov)
Normal1
The UROtsa cell line was isolated from a primary culture of normal human urothelium through immortalization with a construct containing the SV40 large T antigen. (nih.gov)
Cells3
On bladder specimens an immunohistochemical study using mouse monoclonal anti-pan cytokeratin antibody AE1/AE3 was performed in order to investigate the urothelium cells. (medscape.com)
Routine ultrastructural examination disclosed these three-dimensional areas to consist of a stratified layer of cells that strongly resembled in situ urothelium. (nih.gov)
In this regard, homografts and allografts have been implemented in bladder augmentation with varying results, but recent studies have shown promising data in terms of proliferation of urothelium and muscle cells by using biological silk grafts. (springermedizin.at)
Human1
The immortalized UROtsa cell line as a potential cell culture model of human urothelium. (nih.gov)
Layer1
Of the remaining 53 cases, in which the umbrella cell layer of the urothelium was intact, immunostaining for cytokeratin 20 was seen only in ten biopsies. (biomedcentral.com)
Cell1
The working hypothesis in the present study was that this cell line could be induced to differentiate and express known features of in situ urothelium if the original serum-containing growth medium was changed to a serum-free formulation. (nih.gov)
Study1
18. Seromuscular colocystoplasty lined with urothelium: experimental study. (nih.gov)
Patients1
In two patients with bladder malignancy, there was histologic evidence of outward pagetoid extension of this process along urothelium and onto the genital mucosa. (nih.gov)
Figure1
Figure 1) may be observed as a chemically induced lesion or as a regenerative lesion associated with inflammation (Figure 2) or secondary to an injury to the urothelium. (nih.gov)
Conditions1
Examination of some of these workers indicated the presence of a damaged urothelium consistent with premalignant conditions. (cdc.gov)