• In particular, tamoxifen-N-glucuronide and uridine 5'-diphosphate can be biosynthesized from tamoxifen and uridine diphosphate glucuronic acid through the action of the enzyme UDP-glucuronosyltransferase 1-4. (foodcomex.org)
  • Uridine Diphosphate Glucuronosyltransferase, Severe Def. (valleyfamilymedicineurgentcarecenter.com)
  • Major advances in the characterization of uridine diphosphate (UDP)-glucuronosyltransferase (UGT) enzyme substrate and inhibitor selectivities and the development of experimental paradigms to investigate xenobiotic glucuronidation in vitro now permit the prediction of a range of drug-glucuronidation parameters in humans. (nih.gov)
  • No association between cyclooxygenase-2 and uridine diphosphate glucuronosyltransferase 1A6 genetic polymorphisms and colon cancer risk. (snpedia.com)
  • Uridine 5'-diphosphate is an important extracellular pyrimidine signaling molecule that mediates diverse biological effects via P1 and P2 purinergic receptors, such as the uptake of thymidine and proliferation of gliomas. (foodcomex.org)
  • Before glucose can be stored as glycogen in the liver and muscles, the enzyme UDP-glucose pyrophosphorylase forms a UDP-glucose unit by combining glucose 1-phosphate with uridine triphosphate, cleaving a pyrophosphate ion in the process. (wikipedia.org)
  • Cell‐free multi‐enzyme synthesis and purification of uridine diphosphate galactose. (mpg.de)
  • Nucleoside diphosphate kinase (Ndk) is an important enzyme that generates nucleoside triphosphates (NTPs) or their deoxy derivatives by terminal phosphotransfer from an NTP such as ATP or GTP to any nucleoside diphosphate or its deoxy derivative. (embl.de)
  • 14. Subject taking uridine diphosphate glucuronosyl transferase enzyme modulators medication. (who.int)
  • UDPG=uridine diphosphate-glucose. (medscape.com)
  • Bacterial RNA polymerase (RNA Pol) can initiate transcription in vitro by accepting nucleotide metabolites capped with flavin adenine dinucleotide (FAD), uridine diphosphate glucose (UDP-Glc), and uridine diphosphate N-acetylglucosamine (UDP-GlcNAc). (biosyn.com)
  • It is an ester of pyrophosphoric acid with the nucleoside uridine. (wikipedia.org)
  • Nucleoside diphosphate kinases (NDK) are characterized by high catalytic turnover rates and diverse substrate specificity. (rcsb.org)
  • Catalytic mechanism of nucleoside diphosphate kinase investigated using nucleotide analogues, viscosity effects, and X-ray crystallography. (expasy.org)
  • These are enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. (embl.de)
  • Nucleoside diphosphate kinases ( EC 2.7.4.6 ) (NDK) are enzymes required for the synthesis of nucleoside triphosphates (NTP) other than ATP. (embl.de)
  • Nucleoside diphosphate kinase: role in bacterial growth, virulence, cell signalling and polysaccharide synthesis. (embl.de)
  • These oligomeric proteins exhibit nucleoside diphosphate kinase (NDPK) activity that catalyzes nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. (embl.de)
  • IC1 has a unique primary structure, the N-terminal part is homologous to the sequence of thioredoxin, the middle part consists of three repetitive sequences homologous to the sequence of nucleoside diphosphate kinase, and the C-terminal part contains a high proportion of negatively charged glutamic acid residues. (embl.de)
  • Uridine 5′-diphosphoglucuronic acid ammonium salt has been used in the initiation of UDP-glucuronosyl transferase (UDGPT) assay towards 14 C-testosterone in the liver S9 protein. (sigmaaldrich.com)
  • Uridine diphosphate glucuronosyl transferase 1A1 promoter polymorphism predicts the risk of gastrointestinal toxicity and fatigue induced by irinotecan-based chemotherapy. (cdc.gov)
  • In humans, uridine 5'-diphosphate is involved in tamoxifen metabolism pathway. (foodcomex.org)
  • Uridine 5'-diphosphate, also known as 5'-UDP or uridine diphosphoric acid, belongs to the class of organic compounds known as pyrimidine ribonucleoside diphosphates. (foodcomex.org)
  • Abbreviation for uridine diphosphoglucuronic acid. (theodora.com)
  • Uridine 5′-diphosphoglucuronic acid (UDPGA) is a cofactor, synthesized from UDPglucose and nicotinamide adenine dinucleotide (NAD + ) intracellularly by the catalytic activity of UDPglucose dehydrogenase. (sigmaaldrich.com)
  • Uridine 5′-diphosphoglucuronic acid (UDGPA) is the glucuronic acid donor for the conjugation of bilirubin in the endoplasmic recticulum. (sigmaaldrich.com)
  • Revisiting the Latency of Uridine Diphosphate-Glucuronosyltransferases (UGTs)-How Does the Endoplasmic Reticulum Membrane Influence Their Function? (mdpi.com)
  • Uridine diphosphate-glucuronosyltransferases (UGTs) are phase 2 conjugation enzymes mainly located in the endoplasmic reticulum (ER) of the liver and many other tissues, and can be recovered in artificial ER membrane preparations (microsomes). (mdpi.com)
  • Uridine diphosphate, abbreviated UDP, is a nucleotide diphosphate. (wikipedia.org)
  • Uracil phosphoribosyltransferase (UPRTase) catalyzes the conversion of 5-phosphate-alpha-1-diphosphate (PRPP) and uracil to uridine 5'-monophosphate (UMP) and diphosphate. (rcsb.org)
  • SYN: UDPgalactose 4-epimerase, uridine diphosphoglucose 4-epimerase. (theodora.com)
  • In the literature this growth arrest was so far described being caused by the depletion of one of the two uridine diphosphate (UDP) precursor sugars needed for HA synthesis. (europa.eu)
  • Scocca, JR & Krag, SS 1990, ' Sequence of a cDNA that specifies the uridine diphosphate N-acetyl-D-glucosamine:dolichol phosphate N-acetylglycosamine-1-phosphate transferase from Chinese hamster ovary cells ', Journal of Biological Chemistry , vol. 265, no. 33, pp. 20621-20626. (johnshopkins.edu)
  • This could make uridine 5'-diphosphate a potential biomarker for the consumption of these foods. (foodcomex.org)
  • This conversion is required to make a sugar called uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc), which is needed to transfer sugars to growing oligosaccharides during glycosylation. (medlineplus.gov)
  • SLC35A3 encodes the major Golgi uridine diphosphate N -acetylglucosamine (UDP-GlcNAc) transporter. (bmj.com)
  • We have isolated a portion of the uridine diphosphate N-acetyl-D-glucosamine:dolichol phosphate N-acetyl-glucosamine-1-phosphate transferase gene (GTR2) from the genome of a tunicamycin-resistant clonal Chinese hamster ovary cell line, 3E11. (johnshopkins.edu)
  • Galactosaemia: a new severe variant due to uridine diphosphate galactose-4-epimerase deficiency. (nih.gov)
  • A case of uridine diphosphate galactose-4-epimerase deficiency detected by neonatal screening for galactosaemia. (nih.gov)
  • Pharmacogenetic Testing for Uridine Diphosphate Glucuronosyltransferase 1A1 Polymorphisms: Are We There Yet? (medscape.com)
  • By performing uridine diphosphate glucuronosyltransferase (UGT) 1A1 genetic testing, some studies have been able to predict which patients receiving irinotecan will experience the toxicity. (medscape.com)
  • Y, Liu J. Association of neonatal hyperbilirubinemia with uridine diphosphate-glucuronosyltransferase 1A1 gene polymorphisms: meta-analysis. (nih.gov)
  • Activity and expression of various isoforms of uridine diphosphate glucuronosyltransferase are differentially regulated during hepatic regeneration in rats. (nih.gov)
  • Current use of a cytochrome P3A4 inhibitor or inducer and strong uridine diphosphate (UDP)-glucuronosyltransferase 1A1 ( UGT1A1 ) inhibitors. (mycancergenome.org)
  • In mammals, detoxification of the hydrophobic bilirubin occurs mainly in the liver via its conjugation with uridine diphosphate glucuronic acid. (aspetjournals.org)
  • It inactivates the enzyme, enolpyruvyl transferase, irreversibly blocking the condensation of uridine diphosphate-N-acetylglucosamine with p-enolpyruvate, one of the first steps in bacterial cell wall synthesis. (pharmacytimes.com)
  • Glucosamine 6-phosphate N-acetyltransferase, encoded by the highly conserved gene GNPNAT1, is one of the enzymes required for synthesis of uridine diphosphate N-acetylglucosamine, which participates in protein glycosylation. (kb.se)
  • Using a new liquid chromatography-UV-mass spectrometry method, we could show a rapid glucuronidation for all OH-TCCs by the uridine-5′-diphosphate-glucuronosyltransferases (UGT) present in liver microsomes of humans (HLM), cynomolgus monkeys (CLM), rats (RLM), and mice (MLM). (aspetjournals.org)