Uptake blood brain barrier. Medical search. Frequent questions

Blood-brain barrier permeability is not routinely evaluated in the clinical setting. (ajnr.org)
Our purpose was to apply blood-brain barrier permeability imaging in patients with global cerebral edema by using extended CT perfusion. (ajnr.org)
Extended CTP was used to evaluate blood-brain barrier permeability in patients with SAH with and without global cerebral edema. (ajnr.org)
K ep is an important indicator of altered blood-brain barrier permeability in patients with decreased blood flow, as K ep is flow-independent. (ajnr.org)
Further study of blood-brain barrier permeability is needed to improve diagnosis and monitoring of global cerebral edema. (ajnr.org)
We investigated the effect of chronic social defeat stress, a mouse model of depression, on blood-brain barrier (BBB) permeability and infiltration of peripheral immune signals. (nih.gov)
Influence of blood-brain barrier permeability on O-(2-[F-18]fluoroethyl)-L-tyrosine uptake in rat gliomas. (snmjournals.org)
The cavitation of MBs can induce temporary and reversible enhancement in the permeability of both individual cells as well as the endothelium including the blood brain barrier. (benthamscience.com)
in this situation, factors influencing permeability of the blood-brain barrier (eg, acidosis, infection) and the amount of unbound (versus albumin-bound) bilirubin may play a role. (medscape.com)

EAAT2 accounts for 80-90% of this activity of extracellular excitatory amino acid uptake ( 7 ). (spandidos-publications.com)
L-Theanine has been studied extensively for its ability to reduce the uptake of the excitatory amino acid glutamate and regulate how much serotonin, dopamine, and norepinephrine are excreted. (integrativepsychiatry.net)

The BBB separates the blood from the extracellular cerebrospinal fluid and protects the brain from bloodborne pathogens and toxins while allowing the diffusion of oxygen, carbon dioxide, and small lipophilic molecules/ethanol [ 4 ]. (hindawi.com)
The term congenital lactic acidosis (CLA) refers to a group of inborn errors of mitochondrial metabolism variably characterised by progressive neuromuscular deterioration and accumulation of lactate and hydrogen ions in blood, urine and/or cerebrospinal fluid, frequently resulting in early death. (bmj.com)
However, the utility of this route of administration is limited by poor brain and spinal cord parenchymal drug uptake from the cerebrospinal fluid. (stanford.edu)
We demonstrate that a simple noninvasive transcranial ultrasound protocol can significantly increase influx of cerebrospinal fluid into the perivascular spaces of the brain, to enhance the uptake of intrathecally administered drugs. (stanford.edu)
Using real-time magnetic resonance imaging and ex vivo histologic analyses, we observed significantly increased uptake of small molecule agents into the brain parenchyma, and of both small and large molecule agents into the perivascular space from the cerebrospinal fluid. (stanford.edu)
We found a time-dependent uptake of IGF-1 in cerebrospinal fluid, decreasing with postnatal age, and a translocation of IGF-1 through the choroid plexus. (lu.se)
The impact of systemic rhIGF-1/rhIGFBP-3 on IGF-1 receptor activation in the choroid plexus decreased with postnatal age, correlating with IGF-1 uptake in cerebrospinal fluid. (lu.se)

We hypothesized that BGL interacts with the effect of tissue water uptake on the occurrence of ICH. (frontiersin.org)
Early tissue water homeostasis has been assessed using quantitative lesion net water uptake (NWU) on admission CT. (frontiersin.org)
A higher degree of early tissue water uptake and high admission BGL were both independent predictors of ICH. (frontiersin.org)

Clonidine is able to affect the heart rate by stimulating α2 receptors instead of β receptors because it has the ability to cross the blood-brain barrier. (proprofs.com)
The end result is a PrimeMyBody CBD compound that was demonstrated to have the ability to cross the blood-brain barrier, deposit their cargo intracellularly and enhance lymphatic circulation of nutrients. (optimumchoices.com)
Chronic diseases of the central nervous system are poorly treated due to the inability of most therapeutics to cross the blood-brain barrier. (caltech.edu)
The experimental treatment method allows small therapeutic agents to safely cross the blood-brain barrier in laboratory rats by turning off P-glycoprotein, one of the main gatekeepers preventing medicinal drugs from reaching their intended targets in the brain. (nih.gov)
Many promising drugs fail because they cannot cross the blood-brain barrier sufficiently to provide a therapeutic dose to the brain," said David Miller, Ph.D., head of the Laboratory of Toxicology and Pharmacology at NIEHS, and leader of the team that performed the study. (nih.gov)

The tight junctions between endothelial cells and energy dependent transporters in the BBB influence rate and extent of drug distribution to the brain. (dissertations.se)
Other proposed mechanisms include passage of cell-free virus into the brain and release of the virus from the infected endothelial cells. (medscape.com)
There are insulin receptors on the capillary endothelial cells making up the blood-brain barrier (BBB) and it is proposed that these may play a role, along with exogenously administered insulin, in enhancing the transport of drug molecules across the BBB. (weeksmd.com)
gamma-GT is enriched in blood-brain barrier endothelial cells and is the only enzyme known to cleave the gamma-glutamyl bond of GSH. (mdma.net)
Therapeutics designed to enter the brain through transcytosis by binding the transferrin receptor, however, are restricted within endothelial cells. (caltech.edu)

An in vitro study was performed to find differentially expressed genes in brain capillary-rich fractions of the brain in rats of different ages. (dissertations.se)
We now show that pretreatment of rats with acivicin (18 mg/kg, ip) inhibits brain microvessel endothelial gamma-GT activity by 60%, and potentiates MDA- and MDMA-mediated depletions in serotonin (5-HT) and 5-hydroxylindole acidic acid (5-HIAA) concentrations in brain regions enriched in 5-HT nerve terminal axons (striatum, cortex, hippocampus, and hypothalamus). (mdma.net)
Specifically, we administered small (~1 kDa) and large (~155 kDa) molecule agents into the cisterna magna of rats and then applied low, diagnostic-intensity focused ultrasound in a scanning protocol throughout the brain. (stanford.edu)
Team members then pretreated rats with fingolimod, and administered three other drugs that P-glycoprotein usually transports away from the brain. (nih.gov)

The purpose of this study was to demonstrate experimentally that alterations of in vivo transporter function at the blood-brain barrier (BBB) in disease and during pharmacotherapy can be reconstructed from in vitro data based on our established pharmacoproteomic concept of reconstructing in vivo function by integrating intrinsic transport activity per transporter molecule and absolute protein expression level at the BBB. (aspetjournals.org)
Nanoparticles containing a cleavable link between transferrin and gold nanoparticle cores were found to both cross an in vitro model of the blood-brain barrier and accumulate within the brain in significantly higher numbers than similar nanoparticles lacking the cleavable bond. (caltech.edu)

The blood-brain barrier (BBB) represents a complex interface between the brain parenchyma and systemic blood circulation, strictly controlling exchange of substances between the two sites. (dissertations.se)
Reduced BBB integrity in NAc of stress-susceptible or mice injected with adeno-associated virus expressing shRNA against Cldn5 caused infiltration of the peripheral cytokine interleukin-6 (IL-6) into brain parenchyma and subsequent expression of depression-like behaviors. (nih.gov)
Using a preterm rabbit pup model, we investigated the uptake of systemic recombinant human (rh) IGF-1 in complex with its main binding protein IGF-binding protein 3 (BP-3) to the brain parenchyma via the choroid plexus. (lu.se)

Because it crosses the blood-brain barrier so that the the alpha receptors it binds are ones in the CNS instead of on the effector organ. (proprofs.com)
Phenyl-GABA (β-Phenyl-γ-aminobutyric acid) crosses the blood brain barrier to reduce excitatory activity. (integrativepsychiatry.net)

Competition with L-DOPA for the blood-brain barrier transporter system. (wikipedia.org)
This transporter, known as the MFSD2A can be best described as a multifunctional gatekeeper in the brain. (akerbiomarine.com)
The MFSD2A is the major transporter for DHA/EPA uptake into the brain and only recognizes esterified DHA and EPA in the form of lysophosphatidylcholine (LPC). (akerbiomarine.com)
The brain uptake of 5-GSyl-alpha-MeDA is decreased by glutathione (GSH), but sharply increases in animals pretreated with acivicin, an inhibitor of gamma-glutamyl transpeptidase (gamma-GT) suggesting competition between intact 5-GSyl-alpha-MeDA and GSH for the putative GSH transporter. (mdma.net)
Inhibition of endothelial cell gamma-GT at the blood-brain barrier likely enhances the uptake into brain of thioether metabolites of MDA and MDMA, such as 5-(glutathion-S-yl)-alpha-MeDA and 2,5-bis-(glutathion-S-yl)-alpha-MeDA, by increasing the pool of thioether conjugates available for uptake via the intact GSH transporter. (mdma.net)
Inhibition of glucose uptake correlates with a reduction in glucose transporter protein expression (GLUT1 in astrocytes and GLUT3 in neurons). (njit.edu)

In amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases, these barriers become hyperpermeable, allowing a wider variety of molecules to pass through leading to more severe and more rapidly progressing disease. (hindawi.com)

They are being developed for the treatment of traumatic brain injuries (TBI) and other neurological diseases. (genengnews.com)
These barriers are fundamental to all neurological processes as they provide the extreme nutritional demands of neural tissue, remove wastes, and maintain immune privileged status. (hindawi.com)
Inhibition of HSP90β expression improved neurological deficits and alleviated brain injury by increasing EAAT2 expression. (spandidos-publications.com)
New research offers a possible strategy for treating central nervous system diseases, such as brain and spinal cord injury, brain cancer, epilepsy, and neurological complications of HIV. (nih.gov)
2011) for multiple sclerosis integrate data from neurological history, physical examination, and MRI appearances of the brain and cord. (medscape.com)

These excitotoxic effects play important roles in neuronal and blood-brain barrier damage after cerebral ischemia ( 5 , 6 ). (spandidos-publications.com)
In this study, we hypothesized that ethanol (EtOH)-mediated disruption in glucose uptake would deprive energy for human astrocytes and neurons inducing neurotoxicity and neuronal degeneration. (njit.edu)
Acetyl-L-carnitine (ALC), a neuroprotective agent, suppresses the effects of alcohol on glucose uptake and GLUT levels, thus reducing neurotoxicity and neuronal degeneration. (njit.edu)
CONCLUSIONS: We conclude that the olfactory neuronal pathway is efficient for translocating in the brain. (cdc.gov)
Bilirubin staining of the brain without accompanying neuronal necrosis can be observed in babies who did not demonstrate clinical signs of bilirubin encephalopathy but who succumbed from other causes. (medscape.com)

Pretreatment with the rho kinase inhibitor, fasudil, was able to prevent brain fluorescein uptake and neuroinflammation. (cdc.gov)

The blood-brain barrier (BBB) controls the movement of substances into and out of the brain. (dissertations.se)

Assessment of brain metabolite correlates of adeno-associated virus-mediated over-expression of human alpha-synuclein in cortical neurons by in vivo (1) H-MR spectroscopy at 9.4 T. (lu.se)

Brain temperature is a physiological parameter, reflecting the balance between metabolism-related intra-brain heat production and heat loss by cerebral circulation to the rest of the body and then to the external environment. (nih.gov)
It allows non-invasive quantification of cerebral blood flow, metabolism, and receptor binding. (bmj.com)
A variety of imaging modalities, including structural and functional magnetic resonance imaging (MRI) and positron emission tomography (PET) studies of cerebral metabolism, have shown characteristic changes in the brain of patients with Alzheimer disease in prodromal and even presymptomatic states. (medscape.com)
Impaired brain metabolism and neurocognitive function in childhood leukemia survivors despite complete hormone supplementation in adulthood. (lu.se)

The brain capillary glucose uptake by red-cells leads to the endogenous generation of 2,3-DPG, and promotes the oxyHb-deoxygenation to discharge Mg2+ at the noradrenergic synapses. (novapublishers.com)

Furthermore, a linear relationship between increasing serum glucose and ischemic brain edema has been elucidated ( 11 ) and the latter is an independent risk factor for ICH after successful MT. The current state of literature provides no sufficient data for the mutual impact of serum glucose and early ischemic brain edema on the risk of ICH in patients with AIS ( 12 - 14 ). (frontiersin.org)
The hormone is made in the beta cells of the pancreas, and the stimulus for its secretion into the blood stream is a rise in the blood glucose concentration. (weeksmd.com)
We previously reported that alcohol inhibits glucose transport across the blood-brain barrier (BBB), leading to BBB dysfunction and neurodegeneration. (njit.edu)
EtOH may also have a direct effect on glucose uptake in neurons and astrocytes, which has not been previously described. (njit.edu)
Our results indicate that ethanol exposure decreases the uptake of D-(2- 3 H)-glucose by human astrocytes and neurons. (njit.edu)
These findings suggest that deprivation of glucose in brain cells contributes to neurotoxicity in alcohol abusers, and highlights ALC as a potential therapeutic agent to prevent the deleterious health conditions caused by alcohol abuse. (njit.edu)
Our results indicate that ethanol exposure decreases the uptake of D-(2-3H)-glucose by human astrocytes and neurons. (njit.edu)

Also, this increased accumulation was not seen when using this same strategy with an antibody to transferrin receptor, indicating that behavior of nanoparticles at the blood-brain barrier varies depending on what type of targeting ligand is used. (caltech.edu)

The hypothalamus contains the highest diversity of neurons in the brain. (nature.com)
I. Demonstration of monoamines in cell bodies of brain stem neurons. (nature.com)

Quantitative targeted absolute proteomic analysis of 31 membrane proteins showed that P-glycoprotein (P-gp/mdr1a) protein expression levels were significantly increased in brain capillaries of PTZ (129%), EL (143%), and PHT mice (192%) compared with controls. (aspetjournals.org)
We found reduced expression of the endothelial cell tight junction protein claudin-5 (Cldn5) and abnormal blood vessel morphology in nucleus accumbens (NAc) of stress-susceptible but not resilient mice. (nih.gov)
Huntingtin (Htt) is a multi-function protein of the brain. (benthamscience.com)
Protein misfolding cyclic amplification (PMCA) can detect prions in blood from vCJD patients with 100% sensitivity and specificity. (cdc.gov)

Today, the most promising therapy for lysosomal storage disorders including alpha-Mannosidosis is Enzyme Replacement Therapy (ERT) where the respective enzyme lacking in the patient is produced by recombinant approaches and then introduced into the blood stream, from where it is internalized by the cells and reaches the lysosomes replacing the missing endogenous enzyme. (europa.eu)

Here, we characterize the uptake of systemic rhIGF-1/rhIGFBP-3 to the preterm brain, and show that the interaction between systemic rhIGF-1/rhIGFBP-3 and choroid plexus varies over time. (lu.se)

Neurovascular dysfunction, including blood-brain barrier (BBB) breakdown and cerebral blood flow (CBF) dysregulation and reduction, is increasingly recognized as contributing to Alzheimer disease. (medscape.com)
Typical symptoms of relapses may be referable to demyelinating pathology involving the optic nerves (e.g. optic neuritis), brainstem (e.g. internuclear ophthalmoplegia) or spinal cord (e.g. partial myelitis), although non-specific symptoms referable to the cerebral hemispheres or other brain regions can also occur (Katz Sand and Lublin, 2013). (medscape.com)

A quantitative understanding of how the molecular transport systems at the human BBB are altered in diseases is essential not only to elucidate the pathophysiological roles of the BBB in human brain, but also to aid development of effective drugs and appropriate pharmacotherapies for CNS diseases. (aspetjournals.org)

In all mice, reconstructed K p brain values agreed well with the observed values within a 1.21-fold range. (aspetjournals.org)
The results of this study in human brain samples and in transgenic mice are consistent with the hypothesis that Shank3 deficiency makes a key contribution to cognitive impairment in AD. (jneurosci.org)
Putative receptors that are responsible for rhLAMAN uptake into the brain across the Blood Brain Barrier were investigated and we were able to study the outcome of long-term ERT on the neuropathology and associated behavioural deficits observed in immune-tolerant alpha-Mannosidosis mice. (europa.eu)
These nanoparticles were capable of increasing dopamine quantities in the brains of healthy mice, highlighting the therapeutic potential of this design. (caltech.edu)
A study performed in transgenic mice models to compare the risk for primary and secondary transmission of vCJD showed that, although transmission of BSE to humans is probably restricted by the presence of a major species barrier, secondary transmission between humans has a substantially reduced barrier ( 14 ). (cdc.gov)
Detection of prions in blood has been hampered because of the unconventional nature of prions (absence of nucleic acids) and the minute amount of them circulating in blood, making them difficult to detect even by bioassay in transgenic mice ( 15 ). (cdc.gov)

Positron emission tomography (PET) is a powerful imaging technique which enables in vivo examination of brain functions. (bmj.com)
These nanoparticles showed decreased avidity for the transferrin receptor after exposure to reducing agents and increased ability to enter the brain in vivo compared to those lacking the disulfide link. (caltech.edu)

There is a tremendous unmet medical need in treating patients with acute neurodegeneration such as stroke, cardiac arrest-induced brain damage, and spinal cord injuries, where one can expect the blood-brain barrier (BBB) to significantly prevent drug penetration to the central nervous system (CNS). (genengnews.com)
The blood-brain barrier (BBB) and the blood-spinal cord barrier (BSCB) are responsible for controlling the microenvironment within neural tissues in humans. (hindawi.com)
Further separation of the central nervous system (CNS) from the cardiovascular system occurs via the blood-spinal cord barrier (BSCB). (hindawi.com)

Inhibition of striatal uptake of tyrosine. (wikipedia.org)

Glutathione, a natural antioxidant, is found at high levels in the brain, and its receptor is abundantly expressed at the blood-brain barrier. (genengnews.com)

As we know, it is necessary to produce the passage of L-DOPA administered to the blood brain barrier (BBB) to supplement the lack of dopamine suffered by patients with Parkinson's. (wikipedia.org)
It is our most potent calming brain chemical and is critical for counter-balancing excitatory neurotransmitters, such as dopamine, norepinephrine, adrenalin, and glutamate. (integrativepsychiatry.net)

MWCNT exposure impaired blood brain barrier integrity, as noted by fluorescein uptake, which was associated with increased gene expression of IL-6 and CCL5 in the cortex and hippocampus. (cdc.gov)
2004) did not find doi:10.1289/ehp.9030 available via http://dx.doi.org/ [Online 20 April 2006] any evidence of changes in GFAP levels in the brain after exposure to Mn sulfate or phos- phate. (cdc.gov)

A considerable uptake of the compounds was seen in the lungs, kidney, liver, bone marrow, urinary bladder, gastrointestinal tract and in various glands e.g. adrenal, Harderian and salivary glands. (erowid.org)

Consequently, it plays an important role in maintaining brain homeostasis and in restricting the delivery of many therapeutic and diagnostic drugs to the brain. (aspetjournals.org)

Pericytes are mural cells located on the abluminal membrane of the brain endothelium, involved in BBB formation and maintenance. (dissertations.se)

These drugs bind to α1 receptors and activate them, leading to vasoconstriction and increased blood pressure. (proprofs.com)

One promising method to overcome this obstacle is to use endogenous solute influx systems at the blood-brain barrier to transport drugs. (caltech.edu)

Since high temperature could irreversibly damage neural cells and worsen various pathological processes, we consider the situations associated with pathological brain hyperthermia and evaluate its role in acute perturbations of brain functions, neurotoxicity, and neurodegeneration. (nih.gov)
An ischemic stroke consists of two related pathological injury processes: Primary ischemia-induced brain injury and secondary ischemia reperfusion injury ( 3 ). (spandidos-publications.com)
The focus of this work was to develop a method to increase uptake of transferrin-containing nanoparticles into the brain by overcoming these restrictive processes. (caltech.edu)
Insulin-like growth factor-1 (IGF-1) is essential for normal brain development and regulates essential processes of vascular maturation and stabilization. (lu.se)

Wyss-Coray, T. Ageing, neurodegeneration and brain rejuvenation. (benthamscience.com)

Moreover, this study showed that all humans, irrespective of PrP codon-129 genotype, could be susceptible to secondary transmission of vCJD through routes such as blood transfusion. (cdc.gov)

Practice parameters for diagnosis and evaluation of dementia, as published by the American Academy of Neurology (AAN), consider structural brain imaging to be optimal. (medscape.com)

We also discuss the limitations in consideration of brain temperature within the frameworks of physiological regulation and homeostasis. (nih.gov)

yet at the same time it can induce ischemia-reperfusion injury, which leads to brain damage both in the ischemic core and penumbra area. (spandidos-publications.com)
Notably, there was no evidence of brain parenchymal damage following this intervention. (stanford.edu)

However, for most BBB transporters, it is still difficult to synthesize selective probes and inhibitors to enable specific evaluation of the transport activities of the target transporters, because of the effects of other transporters, including functionally unknown transporters, as well as binding to brain tissues. (aspetjournals.org)

Visual assessment of brain perfusion MRI scans in dementia: a pilot study. (lu.se)

In a two-pronged approach, the research team first determined that treating rat brain capillaries with the multiple sclerosis drug marketed as Gilenya (fingolimod) stimulated a specific biochemical signaling pathway in the blood-brain barrier that rapidly and reversibly turned off P-glycoprotein. (nih.gov)

Postsynaptic adenylyl cyclase (AC) of several areas of the brain shows Mg2+-dependent responsiveness to the neurotransmitter in the absence of Ca2+ when the free Mg2+ is present in excess of substrate Mg-ATP. (novapublishers.com)

First, we present data on brain temperature fluctuations occurring under physiological and behavioral conditions and discuss their mechanisms. (nih.gov)
The blood-brain barrier is an anatomical and physiological barrier that severely restricts solute influx, including most drugs, from the blood to the brain. (caltech.edu)

This thesis examines the transport of exogenous molecules across the blood-brain barrier (BBB), focusing on active efflux, using positron emission tomography (PET), computer simulation and modelling. (dissertations.se)

Due to the high peripheral degradation rate of L-DOPA, high doses are required to improve the levels of this enzyme in blood brain barrier. (wikipedia.org)

Brain image reveals hippocampal atrophy, especially on the right side. (medscape.com)

Neuroimaging is widely believed to be generally useful for excluding reversible causes of dementia syndrome such as normal-pressure hydrocephalus, brain tumor, and subdural hematoma, and for excluding other likely causes of dementia such as cerebrovascular disease. (medscape.com)

NeuroVive's drug candidates will be coupled with to-BBB's drug delivery system, G-Technology®, which has been designed to mediate safe targeting and enhance delivery of drugs to the brain. (genengnews.com)
Though the underlying mechanism is yet to be fully understood, there is evidence to suggest that mechanical pore formation of cellular membranes allows for the temporary uptake of drugs. (benthamscience.com)
For this reason the development of an effective strategy for the delivery of antiviral drugs across the blood-brain barrier is of paramount importance in the treatment of HIV infection. (weeksmd.com)
Intrathecal drug delivery is routinely used in the treatment and prophylaxis of varied central nervous system conditions, as doing so allows drugs to directly bypass the blood-brain barrier. (stanford.edu)
They observed a dramatic decline in P-glycoprotein transport activity, which led to a threefold to fivefold increase in brain uptake for each of the three drugs. (nih.gov)

Researchers at Nicklaus Children's Hospital in Miami, Florida have performed the first procedure in a pediatric and young adult brain tumor study. (fusfoundation.org)

Blood-brain barrier uptake of the 40 and 42 amino acid sequences of circulating Alzheimer's amyloid beta in guinea pigs. (alzforum.org)

This state of unrelenting alarm keeps our brains and bodies a brewing, bubbling cauldron of excess stress hormones and neurochemicals. (integrativepsychiatry.net)

The results of this study in human samples show lower levels of SHANK3a in AD brain, correlating with cognitive decline. (jneurosci.org)
The Brain-NA-adrenaline Axis Controls the Fight-or-flight Response in the Hypothalamus Signals for a Multi-hormonal Adaptive Response Shifting Levels of Oxytocin, Serotonin, etc. (novapublishers.com)
Unfortunately, when GABA is taken orally, GABA levels in the brain do not increase, presumably because the substance itself cannot pass the blood-brain barrier and enter the central nervous system. (integrativepsychiatry.net)
The recommendations continued herein are based mainly on the scientific data showing adverse effects of lead in young children at increasingly lower blood lead levels. (cdc.gov)
These range from evaluating the efficacy of chelation therapy at lower blood lead levels in terms of preventing the adverse effects of lead to developing science-based criteria for determining when an abated unit is cleaned up enough for rehabilitation. (cdc.gov)
In addition to laying out the actions needed to eliminate childhood lead poisoning, this plan describes the need for infrastructure and technology development, including for the evaluation of blood and environmental lead levels. (cdc.gov)

Data are not available regarding percentage of dose as unchanged drug and metabolites, concentration of the drug in body fluids, degree of uptake by a particular organ or in the fetus, or passage across the blood-brain barrier. (nih.gov)

Variant Creutzfeldt-Jakob disease (vCJD) is caused by prion infection with bovine spongiform encephalopathy and can be transmitted by blood transfusion. (cdc.gov)
To determine whether PMCA enables prion detection in blood during the preclinical stage of infection, we performed a blind study using blood samples longitudinally collected from 28 control macaques and 3 macaques peripherally infected with vCJD. (cdc.gov)

The blood-brain barrier (BBB) is one of the major blood-central nervous system (CNS) interfaces. (aspetjournals.org)

The collaboration with to-BBB opens up the possibility of treating brain disorders beyond TBI," says Eskil Elmér, M.D., CSO of NeuroVive. (genengnews.com)
The use of nanocarriers is an intriguing approach in the development of efficacious treatment for brain disorders. (dissertations.se)
We hope our new strategy will have a positive impact on people with brain disorders in the future. (nih.gov)

to-BBB's proprietary G-Technology can safely enhance drug delivery to the brain, and we are excited to address this with NeuroVive's cyclosporin-based pharmaceuticals. (genengnews.com)
The aim of the conducted research was to evaluate and quantify the impact of a liposomal nanocarrier formulation on the brain drug delivery. (dissertations.se)
The developmental aspect of drug transport across the blood-brain barrier (BBB) was investigated. (dissertations.se)
The blood-brain barrier (BBB) is a special conformation of cellular membranes that has at times served to confound effective drug therapy for intra-CNS conditions, most notably tertiary neurosyphilis. (weeksmd.com)
NT008 trade name] is indicated in adults and children for the elimination through mass drug administration programmes of schistosoma infections due to various types of blood fluke worms ( Schistosoma mansoni, Schistosoma haematobium, Schistosoma japonicum, Schistosoma mekongi, Schistosoma intercalatum ) following the recommendations of the WHO Global Programme to Eliminate Schistosomiasis. (who.int)

Gamma-aminobutyric acid (GABA) is a brain chemical (neurotransmitter) that tends to calm down or inhibit your frazzled, over-excited nerves, literally. (integrativepsychiatry.net)

So far Russell has had good results in reducing brain fog, anxiety, depressive thoughts, afternoon brain and body fatigue and increased energy, optimism, creativity and daily stamina. (optimumchoices.com)

has also shown that this key brain chemical improves our performance when we are under stress. (integrativepsychiatry.net)
Several studies show how dietary LPC-DHA efficiently increases brain DHA content and improves brain function in animal studies, thus providing a novel nutraceutical approach for Improving cognitive decline during aging. (akerbiomarine.com)

L-Taurine inhibits and modulates neurotransmitters in the brain and helps to stabilize cell membranes. (integrativepsychiatry.net)

Anatomy20

Organisms4

Diseases11

Chemicals and Drugs11

Analytical, Diagnostic and Therapeutic Techniques and Equipment7

Psychiatry and Psychology1

Phenomena and Processes10

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science1

Permeability9

Excitatory amin2

Cerebrospinal fluid7

Water uptake3

Cross the blood-brain b5

Endothelial cells5

Rats4

Vitro2

Parenchyma3

Crosses the blood-brain b2

Transporter6

Neurodegenerative diseases1

Neurological5

Neuronal5

Neuroinflammation1

Substances1

Correlates1

Metabolism4

Capillary1

Glucose7

Behavior1

Neurons2

Protein4

Recombinant1

Systemic1

Cerebral2

Quantitative1

Mice6

Vivo2

Spinal3

Inhibition1

Glutathione1

Dopamine2

Exposure2

Compounds1

Therapeutic1

Endothelium1

Receptors1

Endogenous1

Processes4

Neurodegeneration1

Humans1

Parameters1

Homeostasis1

Damage2

Tissues1

Perfusion1

Capillaries1

Substrate1

Physiological2

Molecules1

Enzyme1

Reveals1

Dementia1

Drugs5

Tumor1

Amino1

Bodies1

Levels6

Passage1

Infection2

Central nervou1

Disorders3

Drug5

Neurotransmitter1

Anxiety1

Improves2

Inhibits1