HydrastisKavaChalconeHerb-Drug InteractionsCimicifugaPyronesRhizomePlant MucilagePlant ExtractsLactonesPacific IslandsHibiscusPyransCarcinogenicity Testsgamma-GlutamyltransferasePlant PreparationsAnti-Anxiety AgentsPlants, MedicinalDrug-Induced Liver InjuryRats, Inbred F344Mutagenicity TestsCytochrome P-450 CYP2D6PyridonesPhytotherapyCapsulesCytochrome P-450 Enzyme SystemDietary SupplementsDigoxinLiverDose-Response Relationship, DrugNeoplasms, ExperimentalOrgan SizeAdministration, OralMice, Inbred StrainsDrug Administration ScheduleCell Line, Tumor