Types glucose transporter type 5. Medical search. Frequent questions

Understanding of mechanisms underlying lung glucose homeostasis could identify new therapeutic targets for control of ASL glucose and prevention and treatment of lung infection. (ersjournals.com)
Importantly, we observed that enteroids from post-BS non-obese patients exhibited low dietary glucose absorption, indicating that altered glucose absorption is a potential mechanism for the immediate and clinically significant improvement in glucose homeostasis after BS, represented clinically by resolution of Type 2 Diabetes (T2D) within weeks to months of surgery. (mayo.edu)
Recent studies have highlighted zinc's dynamic role as a "cellular second messenger" in the control of insulin signaling and glucose homeostasis. (hindawi.com)
The kidneys play an important role in glucose homeostasis. (medscape.com)
It helps to maintain glucose homeostasis by at least two mechanisms. (medscape.com)
which, when activated, stimulate expression of genes involved in energy homeostasis, specifically the metabolism of glucose and fatty acids (Blaschke et al. (bodybuilding.com)
Glycogen storage disease (GSD) type I, also known as von Gierke disease, is a group of inherited autosomal recessive metabolic disorders of the glucose-6- phosphatase system which helps maintain glucose homeostasis. (medscape.com)

A newly described form, GSD type Ic, does not appear to be related to mutations within the transporter protein. (medscape.com)
Von Gierke disease may be explained by mutations of the phosphohydrolase catalytic unit gene of the G-6-P complex, unlike GSD type Ib and GSD type Ic. (medscape.com)
Seydewitz HH, Matern D. Molecular genetic analysis of 40 patients with glycogen storage disease type Ia: 100% mutation detection rate and 5 novel mutations. (medscape.com)
FRG is a rare disorder due mainly to mutations in the sodium-glucose cotransporter 2 gene ( SGLT2 ) that are responsible for the majority of cases. (medscape.com)
Although the pattern of inheritance that best fits FRG is one of co-dominance, increased glucose excretion was not observed in all individuals with similar or identical mutations. (medscape.com)
Heterozygosity for mutations suggest a role of nongenetic factors or other genes involved in renal glucose transport. (medscape.com)
For practical purposes, depending on the enzyme activity and the presence of mutations in the G6Pase and T genes, respectively, GSD type I may be subdivided into 2 major forms. (medscape.com)
Type 1 results from mutations in the integrin beta-2 gene ( ITGB2 ), encoding CD18 beta-2 integrins. (msdmanuals.com)
Type 2 results from mutations in the glucose diphosphate (GDP)-fucose transporter gene. (msdmanuals.com)
Type 3 is caused by mutations in the FERMT3 gene (11q13.1), which encodes kindlin-3 in hematopoietic cells. (msdmanuals.com)

Since the mid-1960s, it has been known that there are energy-dependent, sodium-coupled glucose transporter (SGLT) and energy-independent, facilitative glucose transporter (GLUT) pathways for glucose uptake in the lung [ 1 ], and that glucose can permeate the alveolar epithelial barrier [ 2 ]. (ersjournals.com)
Glucose removal is determined by cellular glucose uptake and metabolism ( fig. 1 ) [ 4 , 12 - 14 ]. (ersjournals.com)
In males, in physiological conditions, testosterone acts via androgen receptors (AR) to increase insulin receptor (IR) expression and glycogen synthesis, and to decrease glucose uptake controlled by liver-specific glucose transporter 2 (GLUT-2). (nih.gov)
The actions of the proteins that control the uptake, storage, and distribution of zinc, the zinc transporters, are under intense investigation due to their emerging role in type 2 diabetes. (hindawi.com)

Using serum samples of diabetic patients whose glucose concentrations were above the threshold (10.0 mmol/l), spectroscopic methods were used to determine the concentration of glucose and zinc. (scirp.org)
Here, we consider a newly identified role for pulmonary glucose transport in maintaining low airway surface liquid (ASL) glucose concentrations and propose that this contributes to lung defence against infection. (ersjournals.com)
These processes vary between species but universally maintain ASL glucose at 3-20-fold lower concentrations than plasma. (ersjournals.com)
ASL glucose concentrations are increased in respiratory disease and by hyperglycaemia. (ersjournals.com)
This is in contrast to conditions in the gut and kidney, where luminal glucose concentrations regularly exceed plasma glucose concentrations [ 6 , 7 ]. (ersjournals.com)
1 mM in nasal ASL [ 8 ] and mean± sd 0.4±0.2 mM in the lower respiratory tract, 12.5 times lower than plasma concentrations, which are normally maintained at ∼5 mM [ 9 ]. (ersjournals.com)
ASL glucose concentrations are the net result of diffusion of glucose from blood and interstitial fluid across the respiratory epithelium into the ASL, and removal of glucose from ASL by epithelial glucose transport processes. (ersjournals.com)
Current model of the mechanisms controlling glucose concentrations in the surface liquid lining the airway and distal lung epithelium. (ersjournals.com)
Renal glucosuria is the excretion of glucose in the urine in detectable amounts at normal blood glucose concentrations in the absence of any signs of generalized proximal renal tubular dysfunction due to a reduction in the renal tubular reabsorption of glucose. (medscape.com)
Physicians now recognize that zinc supplementation can reduce the incidence and severity of diarrheal disease, and an ORS of reduced osmolarity (i.e., proportionally reduced concentrations of sodium and glucose) has been developed for global use. (cdc.gov)

This gene provides instructions for producing a protein called the glucose transporter protein type 1 (GLUT1). (medlineplus.gov)
In the brain, the GLUT1 protein is involved in moving glucose, which is the brain's main energy source, across the blood-brain barrier. (medlineplus.gov)
The GLUT1 protein also moves glucose between cells in the brain called glia, which protect and maintain nerve cells (neurons). (medlineplus.gov)
Having less functional GLUT1 protein reduces the amount of glucose available to brain cells, which affects brain development and function. (medlineplus.gov)
Further works by [8] have established the fact that Zn transporter (ZnT8) is a key protein for the regulation of insulin secretion from pancreatic Beta-cells. (scirp.org)
GSD type Ib is a similar condition with the defect in the G-6-P transporter protein. (medscape.com)
Zinc has "mimetic" activity where it is involved in a range of functions including insulin receptor signal transduction, insulin storage, secretion and tissues/organelle distribution, and inhibition of protein tyrosine phosphatases [ 5 - 8 ]. (hindawi.com)

RhoA activation triggers a glycolytic burst through the translocation of the glucose transporter SLC2A3/GLUT3 to fuel the cellular contractile machinery, as demonstrated across multiple endothelial cell types. (nature.com)

Forxiga (dapagliflozin) is a first-in-class, oral once-daily selective inhibitor of human sodium-glucose co-transporter 2 (SGLT2) indicated as both monotherapy and as part of combination therapy to improve glycaemic control, with the additional benefits of weight loss and blood pressure reduction, as an adjunct to diet and exercise in adults with T2D. (worldpharmanews.com)

In insulin-dependent peripheral tissues such as skeletal muscle, adipose, and liver, zinc ions play a role in insulin-induced glucose transport and glycemic control [ 9 - 16 ]. (hindawi.com)
Because skeletal muscle is the major site of insulin-mediated glucose utilization (up to 80% in the postprandial state), losses in skeletal muscle mass may lead to metabolic impairments [ 12 ]. (biomedcentral.com)

In type 1 diabetes, there is a lack of insulin production, in type 2 diabetes, resistance of the effect of insulin is predominant. (scirp.org)
The synthesis, secretion, and action of insulin are dependent on zinc and the transporters that make this ion available to cellular processes. (hindawi.com)
The Japanese Ministry of Health, Labour and Welfare (MHLW) has approved Forxiga (dapagliflozin) as an oral adjunct treatment to insulin for adults with type-1 diabetes (T1D). (worldpharmanews.com)
Results showed that Forxiga, when given as an oral treatment in addition to adjustable insulin in patients with inadequately-controlled T1D, demonstrated significant and clinically-meaningful reductions from baseline in average blood glucose levels HbA1c (primary endpoint), weight and total daily insulin dose (secondary endpoints) at 24 weeks(1,2,3), at both 5mg and 10mg doses. (worldpharmanews.com)
Elisabeth Björk, Senior Vice President, Head of late Cardiovascular, Renal and Metabolism, R&D BioPharmaceuticals, said: "This approval of Forxiga in Japan means that people with type-1 diabetes whose glucose levels are not adequately controlled with insulin alone now have a new oral treatment option available to them. (worldpharmanews.com)
The DEPICT (Dapagliflozin Evaluation in Patients with Inadequately Controlled Type 1 Diabetes) clinical trial programme consists of two trials: DEPICT-1 and DEPICT-2 which are 24-week, randomised, double-blinded, parallel-controlled trials designed to assess the effects of Forxiga 5mg or 10mg on glycaemic control in patients with T1D inadequately controlled by insulin. (worldpharmanews.com)

Results obtained showed a negative correlation between level of glucose and zinc. (scirp.org)
The animals from F1:Fin group have statistically elevated level of glucose. (nih.gov)

Correction of glycogen storage disease type 1a in a mouse model by gene therapy. (medscape.com)
Elucidating the function of the mutated gene, ALMS1 , is critical for the development of specific treatments and may uncover pathways relevant to a range of other disorders including common forms of obesity and type 2 diabetes. (springer.com)

Glucose is removed from ASL in proximal airways via facilitative glucose transporters, down a concentration gradient generated by intracellular glucose metabolism. (ersjournals.com)
Two means of glucose transport are noted: facilitative and secondary active transport. (medscape.com)

0.01 mM and plasma glucose 0.19 mM [ 3 ]. (ersjournals.com)
As plasma glucose concentration increases, there is concordant increase in the filtered load of glucose. (medscape.com)

The role of zinc deficiency which could at least potentially exacerbate the cytokinine-induced damage in autoimmune attack which destroys the islet cell in type 1 diabetes is still not clear. (scirp.org)
Although at least 14 unique GSDs are discussed in the literature, the 4 that cause clinically significant muscle weakness are Pompe disease (GSD type II, acid maltase deficiency), Cori disease (GSD type III, debranching enzyme deficiency), McArdle disease (GSD type V, myophosphorylase deficiency), and Tarui disease (GSD type VII, phosphofructokinase deficiency). (medscape.com)
One form, von Gierke disease (GSD type Ia, glucose-6-phosphatase [G-6-P] deficiency), causes clinically significant end-organ disease with significant morbidity. (medscape.com)
[ 1 ] In 1952, Cori and Cori demonstrated that glucose-6-phosphatase (G6Pase) deficiency was a cause of GSD type I. (medscape.com)
[ 3 ] Thus, GSD type I is divided into GSD type Ia caused by G6Pase deficiency and GSD type Ib resulting from deficiency of a specific translocase T1. (medscape.com)
GSD type Ic is deficiency of translocase T2 that carries inorganic phosphates from microsomes into the cytosol and pyrophosphates from the cytosol into microsomes. (medscape.com)
GSD type Id is deficiency in a transporter that translocates free glucose molecules from microsomes into the cytosol. (medscape.com)
GSD type II, also known as alpha glucosidase deficiency (GAA, acid maltase deficiency) or Pompe disease, is a prototypic lysosomal disease. (medscape.com)
GSD type IV, also known as amylopectinosis, Glycogen Branching enzyme deficiency (GBE) or Andersen disease, is a rare disease that leads to early death. (medscape.com)

Von Gierke described the first patient with GSD type I in 1929 under the name hepatonephromegalia glycogenica. (medscape.com)

Hepatic anaplerotic outflow fluxes are redirected from gluconeogenesis to lactate synthesis in patients with Type 1a glycogen storage disease. (medscape.com)
It produces glucose by gluconeogenesis. (medscape.com)
The key enzymes of gluconeogenesis are phosphoenolpyruvate carboxykinase (PEPCK) and glucose 6-phosphatase (G6Pase). (medscape.com)
Gluconeogenesis in the kidneys exceeds renal glucose consumption. (medscape.com)

The glucose transporters expressed in the renal proximal tubule ensure that less than 0.5 g/day (range 0.03-0.3 g/d) is excreted in the urine of healthy adults. (medscape.com)
As the rate of glucose entering the nephron rises above 260-350mg/1.73m 2 /min (14.5-19.5mmol/1.73m 2 /min), the excess glucose exceeds the reabsorptive capacity of proximal tubule and is excreted in the urine (i.e. glucosuria). (medscape.com)

Our understanding of the role of glucose transport in the lung and the mechanisms that regulate glucose movement across the human lung epithelium lags far behind that of the gut and kidney. (ersjournals.com)
This review summarized the associations between various types of diabetes and cancers and updated available evidence of underlying mechanisms between diabetes and cancers. (frontiersin.org)
However, the underlying mechanisms between various types of diabetes and cancers have not yet been summarized. (frontiersin.org)
Moreover, absence seizures result principally from disruptions in thalamocortical pathways involving T-type calcium channels and antiepileptic drugs effective against absence seizures among other mechanisms, exert their effect principally at these channels [ 13 ] . (encyclopedia.pub)

Glucose diffuses into ASL via paracellular pathways at a rate determined by paracellular permeability and the transepithelial glucose gradient. (ersjournals.com)

Further, previous studies have suggested that diabetes is associated with increased risk of cancer mortality ( 5 , 6 ). (frontiersin.org)

Significant upregulation of major intestinal sugar transporters, including SGLT1, GLU2 and GLUT5 was responsible for hyper-absorptive phenotype and their pharmacologic inhibition significantly decreased glucose absorption. (mayo.edu)

Renal glucosuria has also been reported in patients with acute pyelonephritis in the presence of a normal blood glucose level. (medscape.com)

Here, discover the type of medical professionals that can help, tools for finding them, and tips for getting the most out of your care as you navigate to a diagnosis. (nih.gov)
Early diagnosis and treatment may prevent the development of complications in an adult patient with glycogen storage disease type Ia. (medscape.com)
Type 1 diabetes (clinical diagnosis and/or positive GAD antibodies). (mayo.edu)

Additionally, sugar transporters responsible for hyper-absorptive phenotype represent potential targets for future drugs that could provide an alternative approach to BS. (mayo.edu)

GSD type III is also known as Forbes-Cori disease or limit dextrinosis. (medscape.com)

GSD type Ia demonstrates deficient G6Pase activity in the fresh and frozen liver tissue. (medscape.com)
GSD type Ib demonstrates normal G6Pase activity in the frozen tissue samples and lowered activity in the fresh specimens. (medscape.com)

it protects the brain's delicate nerve tissue by preventing many other types of molecules from entering the brain. (medlineplus.gov)

Glucose production increases with age, making hypoglycemia less of an issue. (medscape.com)
Consequently the affinity of the transporters for glucose along the tubule increases to allow for complete reabsorption of glucose from the urine. (medscape.com)

Geberhiwot T, Alger S, McKiernan P, Packard C, Caslake M, Elias E. Serum lipid and lipoprotein profile of patients with glycogen storage disease types I, III and IX. (medscape.com)
The percentage of PAS-positive glycogen areas were correlated with the immunoexpression of GLUT-2, serum levels of T and DHT were correlated with GLUT-2, IR, and AR transcript levels, and serum glucose concentration was correlated with the age of animals and with the GLUT-2 mRNA by Spearman's rank correlation coefficients. (nih.gov)

In a perfused, fluid-filled, adult rat lung model, ASL glucose was estimated to be 0.5 mM when perfusate glucose was 10 mM [ 4 ]. (ersjournals.com)

Forxiga will help address a significant unmet need in this patient population, and this approval in type-1 diabetes builds on the well-established clinical profile of Forxiga. (worldpharmanews.com)

Because glucose cannot leave the hepatocyte phosphorylated, an increase in glycolytic pathway metabolites occurs. (medscape.com)

Increased de novo lipogenesis and delayed conversion of large VLDL into intermediate density lipoprotein particles contribute to hyperlipidemia in glycogen storage disease type 1a. (medscape.com)
Natural history of hepatocellular adenoma formation in glycogen storage disease type I. J Pediatr . (medscape.com)
Schwahn B, Rauch F, Wendel U, Schönau E. Low bone mass in glycogen storage disease type 1 is associated with reduced muscle force and poor metabolic control. (medscape.com)
A monocentric pilot study of an antioxidative defense and hsCRP in pediatric patients with glycogen storage disease type IA and III. (medscape.com)
Nutritional deficiencies in a patient with glycogen storage disease type Ib. (medscape.com)
Contrast-enhanced ultrasonography in patients with glycogen storage disease type Ia and adenomas. (medscape.com)
Bijvoet AG, Van Hirtum H, Vermey M. Pathological features of glycogen storage disease type II highlighted in the knockout mouse model. (medscape.com)

The risk of cancers appears to be increased in both type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) ( 2 ). (frontiersin.org)

Under normal circumstances, the kidney filters and reabsorbs 100% of glucose, approximately 180 g (1 mole) of glucose, each day. (medscape.com)

[ 2 ] In 1978, Narisawa et al proposed that a transport defect of glucose-6-phosphate (G6P) into the microsomal compartment may be present in some patients with GSD type I. (medscape.com)

Mutation in ZnT8 has been associated with type 2 diabetes. (scirp.org)

Our previous study indicated that this mechanism may be impaired by finasteride, a popular drug used in urology and dermatology, inhibiting 5α-reductase 2, which converts testosterone (T) into dihydrotestosterone (DHT). (nih.gov)
Haider KS, Haider A, Saad F, Doros G, Hanefeld M, Dhindsa S, Dandona P, Traish A. Remission of type 2 diabetes following long‐term treatment with injectable testosterone undecanoate in patients with hypogonadism and type 2 diabetes: 11‐year data from a real‐world registry study. (tangello.com.au)

Glucose loss in the urine may vary from a few grams to more than 100g (556 mmol) per day. (medscape.com)

The aim of this study was to investigate the impact of glucose (Glu), fructose (Fru), glucose and fructose (GluFru) and sucralose on blood glucose response in healthy individuals. (mdpi.com)
where it transports a simple sugar called glucose into cells from the blood or from other cells for use as fuel. (medlineplus.gov)
In health individuals this equates to a blood glucose concentration of approximately 200mg/dL (11mmol/L), which is believed to be threshold for the appearance of glucosuria. (medscape.com)

It is only recently that we and others have begun to investigate glucose transport as an important mechanism for maintaining a nutrient-depleted environment in the lung lumen to limit the growth of pathogenic organisms. (ersjournals.com)

Tracks a child's milestones from age 2 months to 5 years with Center for Disease Control and Prevention's (CDC) easy-to-use illustrated checklists. (nih.gov)
For over 50 years, glucose has been recognised to cross the lung epithelial barrier and be transported by lung epithelial cells. (ersjournals.com)
Active malignancy within the last 5 years. (mayo.edu)
The typical age of onset is between 6 to 7 years but it can also be observed between 4 to 10 years of age in patients with a normal psychomotor development and without a particular personal or family history for neurologic diseases [ 5 ] . (encyclopedia.pub)

In immortalised human airway cells (line H441) with 10 mM glucose in the basolateral medium, apical ASL glucose was 0.24±0.07 mM [ 10 ]. (ersjournals.com)
In primary cultures of human bronchial epithelial cells (HBECs) with 16.6±0.4 mM glucose in the basolateral medium, ASL glucose was 2.2±0.5 mM [ 11 ]. (ersjournals.com)

In another study, [3] has shown that malabsorption of zinc results in various types of disorders including the dermal, gastrointestinal, neurological and immunological abnormalities. (scirp.org)

However, if only a little carbohydrate remains in the diet, the liver converts fat into fatty acids and ketone bodies, the latter passing into the brain and replacing glucose as an energy source. (wikipedia.org)
A growing body of data indicates that the physiology of the liver is sex-hormone dependent, with some types of liver failure occurring more frequently in males, and some in females. (nih.gov)

Elevated ASL glucose in intensive care patients was associated with increased Staphylococcus aureus infection. (ersjournals.com)
We identified that enteroids from obese patients were characterized by glucose hyper-absorption (~ 5 fold) compared to non-obese patients. (mayo.edu)
Thus, our results and other published data led us to the current hypothesis: an intestinal glucose hyper-absorptive phenotype in obese patients may be a predictor for successful outcome of BS. (mayo.edu)
The safety profile of Forxiga in these T1D trials was consistent with its well-established profile in type-2 diabetes (T2D), with the exception of a higher number of diabetic ketoacidosis (DKA) events in Forxiga-treated patients versus placebo. (worldpharmanews.com)
Efficacy and safety of dapagliflozin in patients with inadequately controlled type 1 diabetes (DEPICT-1): 24-week results from a randomised controlled trial. (worldpharmanews.com)
These subtypes are clinically indistinguishable from one another, except for the fact that patients with GSD type Ib have altered neutrophil functions predisposing them to gram-positive bacterial infections. (medscape.com)
Differentiating patients with GSD type III from those with GSD type I solely on the basis of physical findings is not easy. (medscape.com)

The urine should contain glucose as the only source of carbohydrate, and individuals should have normal carbohydrate storage and use. (medscape.com)

In the distal lung, glucose transport via sodium-coupled glucose transporters predominates. (ersjournals.com)
However, much subsequent research in this area was focused on the role of pulmonary SGLT transport as a modifier of lung liquid volume [ 3 , 4 ], and the effects of starvation and diabetes on glucose transport [ 1 , 5 ]. (ersjournals.com)

This study investigated the relationship of zinc and glucose in diabetics. (scirp.org)
It has been shown that there appears to be a complex interrelationship between zinc and type 1 and 2 diabetes. (scirp.org)
However, questions on how zinc transporters are regulated and effectively facilitate zinc flux contributing to cell signaling are largely unknown. (hindawi.com)

4) Different factors, including genetics and some viruses, may contribute to type-1 diabetes. (worldpharmanews.com)

Anatomy14

Organisms5

Diseases3

Chemicals and Drugs73

Analytical, Diagnostic and Therapeutic Techniques and Equipment7

Psychiatry and Psychology1

Phenomena and Processes13

Information Science3

Homeostasis7

Mutations10

Uptake4

Concentrations10

Protein7

GLUT31

SGLT21

Skeletal muscle2

Insulin6

Level of glucose2

Gene2

Facilitative2

Plasma glucose2

Deficiency9

Gierke1

Gluconeogenesis4

Proximal2

Mechanisms4

Pathways1

Mortality1

Inhibition1

Renal1

Diagnosis3

Additionally1

Cori1

G6Pase2

Molecules1

Increases2

Serum2

Adult1

Clinical1

Glycolytic1

Glycogen storage7

Diabetes mellitus1

Kidney1

Defect1

Mutation1

Testosterone2

Mmol1

Blood3

Investigate1

Years4

Human2

Neurological1

Liver2

Patients7

Carbohydrate1

Transport2

Zinc3

Genetics1