Type models genetic. Medical search. Frequent questions

We aimed to increase our understanding of the aetiology of type 2 diabetes by investigating potential interactions between genes and macronutrient intake and their association with the incidence of type 2 diabetes. (nih.gov)
2018). Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types. (harvard.edu)
Researchers at the Johns Hopkins Kimmel Cancer Center , three other cancer centers and the Johns Hopkins Bloomberg School of Public Health compiled a comprehensive genetic architecture atlas for mutant RAS genes in human cancers. (hopkinsmedicine.org)
Their four-year study of the RAS family - including the KRAS , NRAS and HRAS genes that are mutated in approximately one-third of all human cancers - found that the frequency of mutant RAS genes differs among various tumor types, age, sex and racial groups, and co-mutation patterns among RAS genes and other genes potentially can result in different clinical outcomes or identify new areas for therapeutic intervention. (hopkinsmedicine.org)
Similarly, this type of data could help identify genes linked to adaptation in certain mammals. (embl.org)
In stem cells, open chromatin participating in the most significant regression models demonstrated an enrichment for developmental genes and the TAD-forming CTCF binding complex, providing an opportunity for statistical inference of shifting TAD boundaries operating during early development. (elifesciences.org)
This important work substantially advances our understanding of the interplay between genetic variation, chromatin, and genes within topologically associated domains and how this interplay regulates gene expression. (elifesciences.org)
Chromosomes (sequences of genes) are modeled as vectors of 1's and 0's with a 1 indicating the presence of a feature and a 0 its absence. (r-bloggers.com)
Reduced expression of OXPHOS and DNA damage genes is linked to protection from microvascular complications in long-term type 1 diabetes: the PROLONG study. (uib.no)
Our knowledge of the genes influencing sleep and the mechanisms regulating the process can be advanced with the utilization of genetic and genomic approaches which, in turn, may inform us about the functions of sleep as well. (uky.edu)
Recent genetic association studies have found an association for two genes, FXYD6 and MAP2K7, as risk factors in the susceptibility to schizophrenia. (gla.ac.uk)
These results suggest that genetic variations in TNF, TGFB1, PTGS1 and PTGS2 genes contribute to DA susceptibility. (cdc.gov)

Since 1996, seven genetic mouse models have been reported to show increased lifespan: Ames and Snell dwarf mice, the 'little mouse' (Ghrhr(lit/lit)), mice null for either growth hormone receptor/binding protein (GHR/BP(-/-)) or p66(shc) (p66(shc-/-)), mice heterozygous for the IGF-I receptor (Igf1r(+/-)), and fat-specific insulin receptor knockout mice. (nih.gov)
Because data on the age-related pathology and physiological functions are lacking for all of the models, except the dwarf mice, it is too early to conclude that aging is retarded in these mouse models. (nih.gov)
In contrast, comparing wild-type and Cnp −/− mice without/with NMDAR1-AB regarding hippocampal learning/memory and motor balance/coordination revealed distinct stair patterns of behavioral pathology. (nature.com)
We recorded extracellular field potentials from the primary visual cortex (V1) of head-fixed awake FHM1 knock-in ( n = 12) and wild type ( n = 12) mice in response to square-wave gratings with different visual contrasts. (biomedcentral.com)
FHM1 has a differential effect on short-term depression (STD) at TC synapses: compared to wild type (WT) mice, STD is greater at synapses contacting layer IV (L4) excitatory neurons while it is unaltered at synapses contacting L4 inhibitory neurons. (biomedcentral.com)
Researchers at the European Bioinformatics Institute (EMBL-EBI) and Queen Mary University London (QMUL) alongside other colleagues from the International Mouse Phenotyping Consortium (IMPC) compared genetic data from mice with data from gorillas. (embl.org)
To understand how the two conditions interact, we studied a combined mouse model of AD and diabetes (db/AD) which was generated by crossing of db/db (diabetic obese mice) and APP-PS1 (knock-in AD mouse model). (uky.edu)
apply prime editing to precisely correct the disease-causing mutations in mouse models of hereditary tyrosinemia type 1 (HT-1 mice) and Leber congenital amaurosis (LCA mice), using hydrodynamic or subretinal delivery, respectively. (nature.com)

whereas in patients who developed a type 2 relapse (subset of clonal mutations lost at relapse), the preservation of the leukemia's composition was more variable. (uzh.ch)
Genetic interaction can be defined as a deviation of the phenotypic quantitative effect of a double gene mutation from the effect predicted from single mutations using a simple (e.g., multiplicative or linear additive) statistical model. (researchgate.net)
We describe a computational methodology allowing to systematically and quantitatively characterize a Boolean mathematical model of a biological network in terms of genetic interactions between all loss of function and gain of function mutations with respect to all model phenotypes or outputs. (researchgate.net)
In genetic interactions, synergy occurs when the contribution of two mutations to the phenotype of a double mutant exceeds the expectations from the additive effects of the individual mutations [74]. (researchgate.net)
In addition, it can be used to predict genetic interactions [3] by comparing the sensitivity value of a double gene mutation from the value predicted from single mutations, and reveal the network intervention [4] by applying the state-flip mutation subject to a single gene. (researchgate.net)
There have been many in silico studies based on a Boolean network model to investigate network sensitivity against gene or interaction mutations. (researchgate.net)
However, there are no proper tools to examine the network sensitivity against many different types of mutations, including user-defined ones. (researchgate.net)
The work, published Sept. 8 in Cancer Research , focused on analyses of targeted next-generation sequence data of more than 600,000 mutations from more than 66,000 tumors in 51 cancer types from the AACR (American Association for Cancer Research) Project GENIE (Genomics Evidence Neoplasia Information Exchange) registry, which pools next-generation sequence data from multiple academic institutions. (hopkinsmedicine.org)
Our study shows that you need to consider who the host is and what the genetic makeup is of the tumor, because RAS-mutant tumors with different co-mutations have completely different profiles and clinical behavior. (hopkinsmedicine.org)
They first looked at the distribution and heterogeneity, or variations, of mutant RAS across cancer types and co-occurring mutations. (hopkinsmedicine.org)
Prevalence of the RAS mutations varied among cancer types - 74% in pancreatic cancers, 43.5% in colorectal cancers, 29.7% in non-small cell lung cancers, 25.3% in melanoma, 20.9% in cancer of unknown primary origin, 5.9% in precancerous blood and bone marrow diseases (myelodysplastic/myeloproliferative syndrome), and 1.5% in central nervous system tumors. (hopkinsmedicine.org)

To cope with the inherent nonlinearity of this optimization problem, the gradient-based Gauss-Newton algorithm commonly used to optimize the likelihood function in terms of output error is complemented with a genetic algorithm. (tudelft.nl)
A fuzzy programming model and a genetic algorithm are developed to solve the proposed model with different sizes. (hindawi.com)
Optimal values of parameters, used during the simulations for controlling the cars, have been determined through the use of a genetic algorithm (GA). This paper reports as well a preliminary experiment on different simulations realised with parameters values derived from the GA. (sciweavers.org)
The judicious selection of which predictor variables to include in a model often has a more beneficial effect on overall classifier performance than the choice of the classification algorithm itself. (r-bloggers.com)
The simulated genetic algorithm then does the following: it selects two individuals, randomly chooses a split point for their chromosomes, maps the front of one chromosome to the back of the other (and vice versa) and then randomly mutates the resulting chromosomes according to some predetermined probability. (r-bloggers.com)
If 10 fold cross validation is selected in the GA control procedure, then the entire genetic algorithm (steps 2 through 13) is run 10 times. (r-bloggers.com)
Genetic algorithm classification models indicated spectral classification accuracies of 85% for control, 80% for MWCNT deposition, and 80% for treatment with no deposition. (cdc.gov)

Lange and his colleagues analyzed genetic sequences from nine commercial cannabis strains and found distinct gene networks orchestrating each strain's production of cannabinoid resins and terpenes, volatile compounds behind the plant's powerful aroma. (phys.org)
Modeling high-stress conditions in the cultured cells, the researchers were able to identify 328 sequences that showed increased activity under ER stress, while decreased activity was found in 656 sequences. (jax.org)
Genetic sequences of the bases are read in groups of three (called a triplet), with a possibility of 64 configurations or "words" in which to code information. (cdc.gov)

Gene-macronutrient interactions may contribute to the development of type 2 diabetes but research evidence to date is inconclusive. (nih.gov)
Besides age and smoking, genetic variants from several gene loci have reproducibly been associated with this condition and likely explain a large proportion of disease. (uni-wuerzburg.de)
Here, we developed a genetic risk score (GRS) for AMD based on 13 risk variants from eight gene loci. (uni-wuerzburg.de)
Here, we characterize gene expression patterns in distinct neural cell types of the Drosophila visual system using genetic lines to access individual cell types, the TAPIN-seq method to measure their transcriptomes, and a probabilistic method to interpret these measurements. (biorxiv.org)
They studied the cancer type-specific prevalence of KRAS , NRAS and HRAS mutant alleles (alternative forms of a gene) at codons (units of genetic code) 12, 13 and 61 in the overall population and stratified their results by patient age, race and gender. (hopkinsmedicine.org)
By adding a functional genetic dimension to the selective process, conservation geneticists can identify the crosses that would, for example, avoid a gene variant linked to disease in the offspring. (embl.org)
Although this type of research is still in its very early stages, gene functional knowledge is a powerful tool. (embl.org)
The team used massively parallel reporter assays (MPRA) to assess the effects of variants on gene expression in cultured MIN6 mouse β cells, which have been found to accurately model the regulation networks found in human islet cells. (jax.org)
Altered islet cell CRE activity has been implicated in T2D genetic risk, but previous investigations have found altered gene expression levels or transcription accessibility at only about a quarter of the T2D-associated locations under steady-state conditions. (jax.org)
Gene expression is known to be affected by interactions between local genetic variation and DNA accessibility, with the latter organized into three-dimensional chromatin structures. (elifesciences.org)
With 176 samples profiled for genotype, gene expression, and open chromatin, we used regression modeling to infer genetic-epigenetic interactions on a genome-wide scale. (elifesciences.org)
Yet the interacting effects that genetic and epigenetic factors produce on gene transcription are rarely studied at a genome-wide scale, leaving us without global information on a key step between the genetic code and the phenotype. (elifesciences.org)
Understanding the scope and landscape of these interactions on a genome-wide scale is a vital step towards deciphering the genetic regulation of gene expression and, in turn, the mechanisms of non-coding variation on phenotypic outcomes. (elifesciences.org)
Increased Plasma Soluble Interleukin-2 Receptor Alpha Levels in Patients With Long-Term Type 1 Diabetes With Vascular Complications Associated With IL2RA and PTPN2 Gene Polymorphisms. (uib.no)
Family, twin and adoption studies show schizophrenia is unequivocally a genetic disorder, however the genetics behind schizophrenia are indisputably complex as it is not characterised by a single causative gene. (gla.ac.uk)
Genome-wide association studies and genomic predictions for 1,600 common bean lines belonging to five breeding panels representing Andean and Mesoamerican gene pools and all growth types were used in this sudy. (usda.gov)
Gene-lifestyle interactions have been suggested to contribute to the development of type 2 diabetes. (lu.se)
In this large study of gene-lifestyle interaction, we observed no interactions between genetic and lifestyle factors, both of which were associated with 2-h glucose. (lu.se)

Global nOPV2 genomic surveillance circulating vaccine-derived polioviruses (cVDPVs) across mul- during March-October 2021 confirmed genetic stability of tiple countries in Africa and Asia in recent years pose a major the primary attenuating site. (cdc.gov)
In sum, this study underlines the remarkable genomic stability, and for the first time documents the preservation of the epigenomic landscape in T-ALL-derived PDX models. (uzh.ch)
Factor analysis and genotype by environment interaction (GxE) models performed best for genomic predictions for different traits. (usda.gov)

Capacity control includes several models, algorithms, and policies that allocate seats to maximize expected profits [ 3 ]. (hindawi.com)
The course will cover (1) theory and concepts of computational creativity, (2) some specific application domains (language, images, music), and (3) generic computational techniques for implementing components of creative systems (Markov chains, genetic algorithms). (helsinki.fi)
Caret offers both filter methods and wrapper methods that include recursive feature estimation , genetic algorithms (GAs) and simulated annealing . (r-bloggers.com)

We investigated the influence of interactions between genetic risk scores (GRSs) for type 2 diabetes, insulin resistance and BMI and macronutrient intake on the development of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct, a prospective case-cohort study across eight European countries (N = 21,900 with 9742 incident type 2 diabetes cases). (nih.gov)
OBJECTIVES- Genome-wide association studies have dramatically increased the number of common genetic variants that are robustly associated with type 2 diabetes. (diabetesjournals.org)
Here, we assess the ability of 18 confirmed type 2 diabetes variants to differentiate between type 2 diabetic case and control subjects. (diabetesjournals.org)
The discriminatory ability of the combined SNP information was assessed by grouping individuals based on number of risk alleles carried and determining relative odds of type 2 diabetes and by calculating the area under the receiver-operator characteristic curve (AUC). (diabetesjournals.org)
RESULTS- Individuals carrying more risk alleles had a higher risk of type 2 diabetes. (diabetesjournals.org)
Type 2 diabetes is a major health problem throughout much of the world, and now JAX researchers are targeting it on a genetic level. (jax.org)
Type 2 diabetes (T2D) is a major and growing health problem throughout much of the world. (jax.org)
Identification of biomarkers for glycaemic deterioration in type 2 diabetes. (uib.no)
Neuronal Dysfunction Is Linked to the Famine-Associated Risk of Proliferative Retinopathy in Patients With Type 2 Diabetes. (uib.no)
Replication and cross-validation of type 2 diabetes subtypes based on clinical variables: an IMI-RHAPSODY study. (uib.no)
Perinatal famine is associated with excess risk of proliferative retinopathy in patients with type 2 diabetes. (uib.no)
Distinct Molecular Signatures of Clinical Clusters in People With Type 2 Diabetes: An IMI-RHAPSODY Study. (uib.no)
Liver nucleotide biosynthesis is linked to protection from vascular complications in individuals with long-term type 1 diabetes. (uib.no)
Multiethnic genome-wide association study of diabetic retinopathy using liability threshold modeling of duration of diabetes and glycemic control. (uib.no)
A genome-wide association study of diabetic kidney disease in subjects with type 2 diabetes. (uib.no)
Sense of Coherence is associated with LDL-cholesterol in patients with type 1 diabetes - The PROLONG-Steno study. (uib.no)
FTO, type 2 diabetes, and weight gain throughout adult life A meta-analysis of 41,504 subjects from the Scandinavian HUNT, MDC, and MPP studies. (uib.no)
Genetic analysis of recently identified type 2 diabetes loci in 1,638 unselected patients with type 2 diabetes and 1,858 control participants from a Norwegian population-based cohort (the HUNT study). (uib.no)
Underlying Genetic Models of Inheritance in Established Type 2 Diabetes Associations. (uib.no)
For the first part of my research (Chapter 3), I examined mouse models of Alzheimer's disease, and a combined model of Alzheimer's disease (AD) and Diabetes. (uky.edu)
There is also growing evidence that type 2 diabetes mellitus (T2DM) poses an increased risk of AD. (uky.edu)
Glucose levels 2 h after a standard 75-g glucose challenge are used to diagnose diabetes and are associated with both genetic and lifestyle factors. (lu.se)
We meta-analyzed single nucleotide polymorphism (SNP) X BMI and SNP x physical activity (PA) interaction regression models for five SNPs previously associated with 2-h glucose levels from up to 22 studies comprising 54,884 individuals without diabetes. (lu.se)
Rapid development of insulin deficiency, usually precipitated by infection or other forms of stress, could result in diabetic ketoacidosis (DKA) as the initial presentation of type 1 diabetes mellitus. (medscape.com)

Jihye Kim received an American Association for Cancer Research Scholar-in-Training Award for the work she will be presenting at the AACR Annual Meeting in Chicago, Absolute risk prediction models for pancreatic cancer. (harvard.edu)
The main expectation is to support psychiatric models on prediction over emergency. (bvsalud.org)

These findings provide evidence that genetic and epigenetic factors operate within the context of three-dimensional chromatin structure. (elifesciences.org)
Conversely, phenotypic variation in genetically diverse populations is a result of both genetic and epigenetic factors operating in tandem. (elifesciences.org)

Based on five equally sized GRS intervals, we present a risk classification with a relative AMD risk of 64.0 (95% CI: 14.11-1131.96) for individuals in the highest category (GRS 3.44-5.18, 0.5% of the general population) compared to subjects with the most common genetic background (GRS -0.05-1.70, 40.2% of general population). (uni-wuerzburg.de)
Except for DF, the results suggest a common genetic basis for traits across all panels and growth types. (usda.gov)

Individual cartridges can be designated for different experimental designs or different researchers, enabling multiple users to share a single SeqStudio Genetic Analyzer. (thermofisher.com)
The approach would allow researchers to identify the matches most likely to produce healthy offspring or preserve genetic variation. (embl.org)
Summary: Researchers report functional alterations in L-type calcium channels were detected in models of Fragile X syndrome. (neurosciencenews.com)

Genetic susceptibility, then, also plays a large role, but efforts to identify the causative factors have encountered daunting challenges. (jax.org)
Title : A Statistical Model for Assessing Genetic Susceptibility as a Risk Factor in Multifactorial Diseases: Lessons from Occupational Asthma Personal Author(s) : Demchuk, Eugene;Yucesoy, Berran;Johnson, Victor J.;Andrew, Michael;Weston, Ainsley;Germolec, Dori R.;De Rosa, Christopher T.;Luster, Michael I. (cdc.gov)
The differences in susceptibility to noise induced hearing loss (NIHL) which may be attributed to genetic factors were discussed. (cdc.gov)

Wonil Chung, Omer Weissbrod and Margaux Hujoel were awarded as semifinalists for the Charles J. Epstein Trainee Award for Excellence in Human Genetic Research for the 2018 American Society of Human Genetics Conference in San Diego, California this October. (harvard.edu)

The following is a list of genetic disorders and if known, type of mutation and for the chromosome involved. (wikipedia.org)
There are over 6,000 known genetic disorders in humans. (wikipedia.org)
Disorders of the autistic spectrum have been associated with hundreds of genetic variations, which have helped in identifying disturbed intracellular signalling pathways and molecular mechanisms typical to autism. (neurosciencenews.com)
The National Institute of Mental Health (NIMH) and The National Institute of Neurological Disorders and Stroke (NINDS) solicit research grant applications to supp ort studies focused on viral and host genetic factors involved in HIV-1 Associated Neurocognitive Disorders (HAND) in the setting of highly active anti-retroviral therapy (HAART). (nih.gov)
We argue in favor of using digital pheno- typing for mental health, particularly to the personality disorders (PD).We undertake a literature review to ground three main issues, applications, implications, and chal- lenges in harnessing digital phenotyping for PD. (bvsalud.org)

Our findings suggest that db genotype and not cerebrovascular pathologies affect sleep in our mouse model. (uky.edu)
There was no significant difference in allele and genotype frequencies of +276G>T between type T2DM patients and controls. (who.int)

2018). Mixed-model association for biobank-scale datasets. (harvard.edu)
2018). Leveraging molecular quantitative trait loci to understand the genetic architecture of diseases and complex traits. (harvard.edu)
Retrieved December 3, 2018 from https://neurosciencenews.com/asd-stem-cell-120196/[/cbtab][cbtab title="Chicago"]University of Helsinki"Genetic Background of Autism Connected to Stem Cell Dysfunction. (neurosciencenews.com)

The use of state-of-the-art genetic approaches (including transcriptomics, phenomics, epigenomics, whole genome association studies, next generation sequ encing, exome sequencing, & systems biology) to identify and validate (including in vitro models, animal models, & human samples) viral and host genetic factors which influence the pathophysiology of HAND are encouraged. (nih.gov)

Current breeding approaches could be improved when supplemented with mouse genetic functional data. (embl.org)
They lead to new approaches in mathematical modeling genetic phenomena and innate biological structures. (preprints.org)

It also uncovered the probable cell-of origin of one of the FLC tumor types. (medicalxpress.com)

Additionally, we reproduced in silico the obtained experimental results with a novel spiking neurons network model of mouse V1, by implementing in the model both the synaptic alterations characterizing the FHM1 genetic mouse model adopted. (biomedcentral.com)
Our network model can help to shed light on the relationship between cellular and network levels of migraine neural alterations. (biomedcentral.com)
I investigated sleep-wake alterations in 5XFAD, a double transgenic mouse model of AD which displays an early onset of AD pathology and cognitive impairments. (uky.edu)
Direct and indirect ionization of DNA is ultimately responsible for the DNA alterations that adversely affect the structural and genetic integrity of the system. (cdc.gov)

The knockout models are designed to be null alleles. (taconic.com)

Interactions between each personality dimension or coping style and GCOS score were assessed using mixed-effects linear regression models. (nsgc.org)

The model exhibited good discriminative accuracy, area-under-curve (AUC) of the receiver-operating characteristic of 0.820, Late-stage age-related macular degeneration (AMD) is a common sight-threatening disease of the central retina affecting approximately 1 in 30 Caucasians. (uni-wuerzburg.de)
Cavion's portfolio of T-type calcium channel modulators is being developed to restore the brain's natural rhythms in a variety of neurological diseases such as essential tremor, Parkinson's disease tremor, neuropathic pain, and epilepsy with absence seizures. (businesswire.com)
Functional changes in the voltage-dependent L-type calcium channels were detected in fragile X syndrome (FraX), the disease model used in the study. (neurosciencenews.com)
Pompe disease (type II glycogen storage disease) is an inherited enzyme defect that usually manifests in childhood. (medscape.com)
Although at least 14 unique GSDs are discussed in the literature, the 4 that cause clinically significant muscle weakness are Pompe disease (GSD type II, acid maltase deficiency ), Cori disease ( GSD type III , debranching enzyme deficiency), McArdle disease ( GSD type V , myophosphorylase deficiency), and Tarui disease ( GSD type VII , phosphofructokinase deficiency). (medscape.com)
One form, Von Gierke disease ( GSD type Ia , glucose-6-phosphatase deficiency ), causes clinically significant end-organ disease with significant morbidity. (medscape.com)
Genetic topography and cortical cell loss in Huntington's disease link development and neurodegeneration. (medscape.com)

To conclude, genetic brain inflammation may explain an encephalitic component underlying autoimmune conditions. (nature.com)

In addition, we suggest several computational tools for studying the distribution of double mutants in the space of model phenotype probabilities. (researchgate.net)
The computational model showed how these network effects may arise from a combination of changes in thalamocortical and intra-cortical synaptic transmission, with the former inducing a lower cortical activity and the latter inducing the higher frequencies ɣ oscillations. (biomedcentral.com)
An introduction to central concepts and models of computational creativity, to some computational creativity methods in fields such as poetry, music and images. (helsinki.fi)

Many genetic mouse models of monogenic subtypes of migraine have been engineered [ 10 ]. (biomedcentral.com)

Our results demonstrate that statistical interactions between genetic variants and chromatin accessibility are common throughout the genome. (elifesciences.org)

stool specimens collected as part of routine AFP surveillance nOPV2 was demonstrated to be safe and well-tolerated, have from six countries, and 123 nOPV2 isolates corresponding to 39 noninferior immunogenicity, and have superior genetic stabil- distinct environmental surveillance samples were detected from ity compared with Sabin monovalent type 2 (as measured by seven countries. (cdc.gov)
Distinct neuroinflammatory signatures exist across genetic and sporadic amyotrophic lateral sclerosis cohorts. (medscape.com)

Due to compensatory genetic mechanisms, knockout status cannot be guaranteed and will have to be confirmed by the customer. (taconic.com)

These preliminary data suggest that genetic counseling may increase empowerment regardless of personality dimensions and coping styles. (nsgc.org)

This mouse population segregates millions of variants from eight inbred founders, enabling precision genetic mapping with extensive genotypic and phenotypic diversity. (elifesciences.org)

Models themselves can be classified according to their essential attributes (for example: descriptive, grade-tonnage models, genetic, geoenvironmental, geophysical, probability of occurrence, and quantitative process models). (usgs.gov)

The new analysis of the genetic and chemical characteristics of cannabis is believed to be the first thorough examination of its kind. (phys.org)
Accurate estimates of the pilot model parameters and the remnant characteristics were obtained. (tudelft.nl)
USGS Mineral Deposit Models are "an organized arrangement of information describing the essential characteristics or properties of a class of mineral deposits. (usgs.gov)
This report summarizes the primary characteristics of alkalic-type epithermal gold (Au) deposits and provides an updated descriptive model. (usgs.gov)
Common bean (Phaseolus vulgaris L.) has two major origins for domestication, Andean and Mesoamerican, which contributed to high genetic diversity reflected by different pod and seed characteristics and growth types. (usda.gov)

In vitro results highlighted thalamocortical and intra-cortical glutamatergic synaptic gain-of-function associated with a monogenic form of migraine (familial-hemiplegic-migraine-type-1: FHM1). (biomedcentral.com)
The FHM1 mouse model is consequently characterized by increased neurotransmission at both intra-cortical [ 15 ] and thalamocortical (TC) excitatory synapses [ 16 ]. (biomedcentral.com)

Models of genetic differentiation which incorporate migration matrices generally assume that the recorded rates of migration between subdivisions of an isolate have persisted for a very long time. (wayne.edu)
This technicjue is applied to migration data from Papua New Guinea that have already been used in an analysis of genetic differentiation. (wayne.edu)
The ratio of L-type/T-type Cav channel expression is increased in FXS progenitors and correlates with enhanced progenitor differentiation to glutamate-responsive cells. (neurosciencenews.com)
A key challenge is to understand how state, but must also afford flexibility in cell-fate choice to permit the different cell-fate options confronting stem and progenitor cell-type diversification and differentiation in response to cells are selected and coordinated such that adoption of a given intrinsic cues or extrinsic signals. (lu.se)

The model framework is applicable for other types of spatial flow questions. (r-project.org)
Performing feature selection with GAs requires conceptualizing the process of feature selection as an optimization problem and then mapping it to the genetic framework of random variation and natural selection. (r-bloggers.com)

The use of this methodology for validating mathematical models from experimental data and designing new experiments is discussed. (researchgate.net)
Computer modelling experiments show once you control for other factors, ethnocentric groups will dominate and displace less ethnocentric groups. (vdare.com)

We sought to conduct a comprehensive phenotypic and genetic analysis in common bean to facilitate breeding strategies and improvements of climbing beans. (usda.gov)

Distinguishing genetic correlation from causation across 52 diseases and complex traits. (harvard.edu)

In this article, we describe and evaluate these mouse models with respect to their relevance for aging studies. (nih.gov)
While these seven genetic models all show a significant increase in lifespan, issues of sample size and animal husbandry procedures require further evaluation before firm conclusions can be drawn on the reproducibility of life extension in most of these mouse models. (nih.gov)
However, these mouse models are already providing new information about the mechanism underlying mammalian aging. (nih.gov)
For most lines, the mouse ES cells used in generating the model are of the 129S5 strain. (taconic.com)
Here we adopted a genetic mouse model of pure familial hemiplegic migraine type 1 (FHM1) (van den Maagdenberg et al. (biomedcentral.com)
Open access research for "Increased Calcium Influx through L-type Calcium Channels in Human and Mouse Neural Progenitors Lacking Fragile X Mental Retardation Protein" by Claudia Danesi, Venkat Swaroop Achuta, Padraic Corcoran, Ulla-Kaisa Peteri, Giorgio Turconi, Nobuaki Matsui, Ilyas Albayrak, Veronika Rezov, Anders Isaksson, and Maija L. Castrén in Stem Cell Reports . (neurosciencenews.com)
Human muscle biopsies and mouse models of NF1 deficiency in muscle show intramyocellular lipid accumulation, and preclinical data have indicated that L-carnitine supplementation can ameliorate this phenotype. (bvsalud.org)
Findings seeks to understand how were done using mouse models, environmental exposures which will be used to inform lead to epigenetic changes-- human studies. (medlineplus.gov)

The genetic maximum likelihood method is successfully applied to data from a recent human-in-the-loop experiment. (tudelft.nl)
Both empirical data and genetic counselors' clinical experience suggest that patients differ in the extent to which they benefit from genetic counseling (GC). (nsgc.org)
The SeqStudio Genetic Analyzer offers data quality, usability, service, and support at an affordable price. (thermofisher.com)
Comparing climate data to the climate models reveals the inadequacy of many models. (creation.com)
Assess the performance of the SVM model using the subset of the test data that contains the selected features. (r-bloggers.com)
Train the SVM model on the entire training data set. (r-bloggers.com)
Assess the performance of this second SVM model using the test data set. (r-bloggers.com)
Reference: Stoeser, D.B., and W.D. Heran, 2000, USGS mineral deposit models: U.S. Geological Survey Data Series 64, 1 disk, https://doi.org/10.3133/ds64 . (usgs.gov)
Using GWAS data, this study aimed to improve our understanding of the genetic relationship between common epilepsies and major psychiatric disorder. (medscape.com)

The degree of psychosis is subject to numerous genetic and environmental factors. (gla.ac.uk)
Other genetic and environmental factors, for example certain bacterial and viral infections, also affect the chances of developing this disorder. (medlineplus.gov)
the causes of diseases and the effects of environment, diet, Some factors, such as healthy diet and access to lifestyle, and genetic factors on human health. (medlineplus.gov)

It can maximise adaptive genetic diversity within a species and reduce genetic variants that negatively affect health and survival. (embl.org)

A widely unexplored field in humans, though clearly documented in rodents, is genetic brain inflammation, particularly that associated with myelin abnormalities, inducing primary white matter encephalitis. (nature.com)

Seven QTL associated with growth type were confirmed from earlier studies, indicating the high detection power of our panel. (usda.gov)
Neurologic complications in herpes simplex encephalitis: clinical, immunological and genetic studies. (medscape.com)

Approximately 111 million doses of nOPV2 were administered vaccine (nOPV2), produced by genetic modification of the type worldwide during the initial use phase (March-October 2021). (cdc.gov)
We changed the genetic background of the organoids using the DNA modification technique CRISPR-Cas9, that works as a 'molecular scissor. (medicalxpress.com)

Here we undertake a genome-scale analysis of these interactions in a genetically diverse population to systematically identify global genetic-epigenetic interaction, and reveal constraints imposed by chromatin structure. (elifesciences.org)

Genetic control of malaria parasite transmission: threshold levels for infection in an avian model system. (ox.ac.uk)
Combination of VE and ALA increased collagen type IV alpha 1 chain expression (P ≤ 0.05) and improved basement membrane structure indicating increased gut basement membrane integrity at 2 and 3 wk of age compared to the control. (bvsalud.org)

The AUC for age, BMI, and sex was 0.78, and adding the genetic risk variants only marginally increased this to 0.80. (diabetesjournals.org)

Cavion, Inc . is a privately held clinical stage biotechnology company creating therapies aimed at modulating the T-type calcium channel for the treatment of chronic and rare neurological diseases. (businesswire.com)

One of the first steps is understanding from which cell type the cancer originates: the cell-of-origin. (medicalxpress.com)
Surprisingly, viruses appear to be good models for understanding this type of cellular decision-making," he further went on to say. (healthjockey.com)

Genes12

Mice8

Mutations11

Algorithm7

Sequences3

Gene18

Genomic3

Algorithms3

Diabetes24

Prediction2

Epigenetic Factors2

Common genetic2

Researchers3

Susceptibility3

Genetics1

Disorders5

Genotype2

20183

Vitro models1

Approaches2

Tumor types1

Alterations4

Alleles1

Regression models1

Disease7

Conclude1

Computational3

Subtypes1

Interactions between genetic1

Distinct2

Mechanisms1

Suggest that genetic1

Variants from eight1

Probability1

Characteristics5

Cortical2

Differentiation4

Framework2

Experiments2

Phenotypic1

Complex traits1

Mouse8

Data9

Factors3

Diversity1

Rodents1

Studies2

Modification2

Systematically1

Control2

Risk1

Clinical1

Understanding2