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  • These studies highlight the importance of validating in vitro synergism and the challenge of matching drug exposures to obtain a synergistic outcome in vivo. (uzh.ch)
  • Drug synergistic effects were observed when cells were stimulated to proliferate through both the IL3 and TpoR pathways. (eurekaselect.com)
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  • Such drug interactions are crucial for treatment efficacy, but their underlying mechanisms remain largely unknown. (embopress.org)
  • To uncover the causes of drug interactions, we developed a systematic approach based on precise quantification of the individual and joint effects of antibiotics on growth of genome-wide Escherichia coli gene deletion strains. (embopress.org)
  • We found that drug interactions between antibiotics representing the main modes of action are highly robust to genetic perturbation. (embopress.org)
  • Rare violations of this principle exposed recurring cellular functions controlling drug interactions. (embopress.org)
  • In particular, we found that polysaccharide and ATP synthesis control multiple drug interactions with previously unexplained mechanisms, and small molecule adjuvants targeting these functions synthetically reshape drug interactions in predictable ways. (embopress.org)
  • These results provide a new conceptual framework for the design of multidrug combinations and suggest that there are universal mechanisms at the heart of most drug interactions. (embopress.org)
  • Rare violations of this principle expose cellular functions that control drug interactions and can be targeted by small molecules to alter drug interactions in predictable ways. (embopress.org)
  • Drug interactions between antibiotics are highly robust to genetic perturbations. (embopress.org)
  • Rare violations of this principle expose cellular functions that control drug interactions. (embopress.org)
  • Diverse drug interactions are controlled by recurring cellular functions, including LPS synthesis and ATP synthesis. (embopress.org)
  • A synergism between labetalol HCl and halothane anesthesia has been shown (see PRECAUTIONS: Drug Interactions ). (druglib.com)
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  • nonetheless, mutations of Fd gene ( fd ) may modulate ART resistance and Fd would be an important target for antimalarial drugs. (biorxiv.org)
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  • We investigated the inhibitory effects of dihydroartemisinin (DHA), methoxyamino chalcone (C3), and iron chelators including deferiprone (DFP), 1-( N -acety1-6-aminohexyl)-3-hydroxy-2-methylpyridin-4-one (CM1) and deferiprone-resveratrol hybrid (DFP-RVT) against the growth of wild-type (WT) P. falciparum parasites and those with k13 and fd mutations. (biorxiv.org)
  • The combined effects of drugs and noise or of different types of noise on cochlear pathologies and hearing loss in animals and man were reviewed. (cdc.gov)
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  • Since clinical trials involving ibudilast have shown no adverse side effects and the drug readily penetrates the blood brain barrier, treatment of GBM with this combination is clinically achievable. (nature.com)
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  • In the developed nations, and in some developing ones, the prescription of these drugs will trigger "ototoxicity monitoring" of patients to allow early detection of auditory effects and, when necessary, audiologic interventions to address the hearing impairment (AAA 2009). (cdc.gov)
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  • instead, their effects are attributed to synergism of their herbal ingredients. (rsc.org)
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  • The drugs within each category pose a risk because of sedating properties, stimulant effects, euphoric effects, hallucinatory/dissociative effects, augmentation of another drug's effects, synergism with another drug, self-medication, or the principle that "if a little is good, more is better. (medpagetoday.com)
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  • Genomic, metabolomic approaches and human trials with valid models on Ayurvedic drugs are so far limited, and these efforts need to be further augmented. (rsc.org)
  • We calculated risk ratios and 95% CIs stratified by ARTI tier and region using log-binomial models controlling for patient age, comorbidities, care setting, prescriber type, and diagnosis. (cdc.gov)
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  • Schacht and Hawkins (2006) reviewed initial reports that associated the intake of certain drugs such as quinine and acetylsalicylic acid with temporary hearing loss as well as dizziness and tinnitus. (cdc.gov)
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