Tumors antibodies monoclonal. Medical search. Frequent questions

A highly specific and powerful magnetic resonance imaging contrast agent has been prepared by coating magnetite (Fe3O4) particles with monoclonal antibodies directed against a tumor antigen. (unibas.ch)
A bispecific monoclonal antibody (BsMAb, BsAb) is an artificial protein that can simultaneously bind to two different types of antigen or two different epitopes on the same antigen. (wikipedia.org)
Naturally occurring antibodies typically only target one antigen. (wikipedia.org)
The furthest developed of these newer formats are the bi-specific T-cell engagers (BiTEs), which uses the G4S linker to connect two ScFvs-one CD3 antibody ScFv and one tumor-associated antigen (TAA) or tumor-specific ScFv-to redirect T cells to cancer cells for target killing. (wikipedia.org)
In this approach a nonradiolabeled bispecific monoclonal antibody (bs-mAb) with antitumor-associated antigen (TAA) and antihapten specificity is injected in the first phase. (snmjournals.org)
With the exception of prostate-specific antigen (PSA), tumor markers do not have sufficient sensitivity or specificity for use in screening. (aafp.org)
Cancer antigen (CA) 27.29 is a monoclonal antibody to a glycoprotein (MUC1) that is present on the apical surface of normal epithelial cells. (aafp.org)
Mib-1 monoclonal antibody recognizes the proliferation-related antigen Ki-67. (lu.se)
Murine monoclonal antibodies are produced by injecting a mouse with an antigen, harvesting its spleen to obtain B cells that are producing antibody specific to that antigen, fusing those cells with immortal mouse myeloma cells, growing these hybridoma cells (eg, in cell culture), and harvesting the antibody. (msdmanuals.com)
In both cases, the process usually begins as above with production of mouse hybridoma cells that make antibody to the desired antigen. (msdmanuals.com)
Chimeric monoclonal antibodies activate antigen-presenting cells (APCs) and T cells more effectively than murine monoclonal antibodies but can still induce production of human anti-chimeric antibodies. (msdmanuals.com)
Research on detection methods included voided urine flow cytometry, evaluation of DNA flow cytometry, use of the epithelial surface marker epithelial membrane antigen, use of monoclonal antibodies for the detection of exfoliated bladder cancer cells, and acetylation phenotypes. (cdc.gov)

Infliximab (chimeric anti-tumour necrosis factor alpha monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: a randomised phase III trial. (nih.gov)
Anti-tumor necrosis factor-alpha monoclonal antibody therapy in severe alcoholic hepatitis. (qxmd.com)
Therapeutic efficacy of multiple intravenous infusions of anti-tumor necrosis factor alpha monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis. (ox.ac.uk)

Monoclonal Antibody and Synthetic Peptide Inhibitors of Human Tumor Ce" by Kenneth M. Yamada, Dorothy W. Kennedy et al. (howard.edu)
Other categories of targeted drugs in clinical use are humanized monoclonal antibodies and small-molecule TKI inhibitors. (sciencedaily.com)
We believe peptide inhibitors offer non-toxic, less-expensive alternatives to humanized monoclonal antibodies and small-molecule inhibitors for the treatment of solid tumors, with the potential for improved efficacy and better clinical outcomes," he says. (sciencedaily.com)
What are monoclonal antibodies and immune checkpoint inhibitors? (cancer.net)
There are also 2 checkpoint inhibitors that are used to treat tumors anywhere in the body if they have specific genetic changes. (cancer.net)
function of several poorly characterized proteins expressed in tumor cells and which are structurally related to known complement inhibitors but also suggested to act as tumor suppressors. (lu.se)
There are several different types of EGFRIs, including small molecule tyrosine kinase inhibitors, monoclonal antibodies, and multikinase inhibitors. (medscape.com)

Samarium-153 and technetium-99m-labeled monoclonal antibodies in angiogenesis for tumor visualization and inhibition. (ox.ac.uk)
We describe areas where major inroads were initially achieved by targeting angiogenesis and by unraveling pathways in the heterogeneous tumors of mesenchymal origin-spurred by the identification of c-Kit-activating mutations in GIST and the regressions that ensued when tumors harboring these mutations were exposed to the tyrosine kinase inhibitor imatinib (Gleevec). (cancernetwork.com)
Here, in Part I, we describe areas where major inroads were initially achieved by targeting angiogenesis (central to the biology of renal cell carcinoma and hepatocellular cancer) and by unraveling pathways in the heterogeneous tumors of mesenchymal origin-spurred by the identification of c-Kit-activating mutations in gastrointestinal stromal tumors (GIST) and the regressions that ensued when tumors harboring these mutations were exposed to the tyrosine kinase inhibitor imatinib (Gleevec). (cancernetwork.com)
Folkman, J. Tumor angiogenesis: therapeutic implications. (nature.com)
When we combined our peptide HER-2 inhibitor with the VEGF peptide that inhibits angiogenesis, we observed significant additive benefits in reducing tumor burdens in preclinical studies," says principal investigator Pravin Kaumaya, professor of obstetrics and gynecology, of molecular and cellular biochemistry, and of microbiology, and director of the division of vaccine development at the OSUCCC -- James. (sciencedaily.com)
Myeloid cells promote tumor growth by stimulating tumor angiogenesis, suppressing tumor immunity, and promoting metastasis to distinct sites. (hindawi.com)
In this review, we discuss the role of myeloid cells in promoting tumor angiogenesis. (hindawi.com)
Angiogenesis, the growth of new blood vessels, occurs at different stages during embryonic development, physiological processes such as wound healing and reproduction, and numerous diseases, including inflammation, tumor progression, and metastasis [ 1 ]. (hindawi.com)
Importantly, during tumor progression, myeloid cells are implicated in promoting tumor angiogenesis, causing resistance against antiangiogenic therapies in cancer, and suppressing the immune response during cancer [ 3 - 5 ]. (hindawi.com)
These observations stimulated an intensive search for the mechanisms regulating tumor angiogenesis. (hindawi.com)
Although tumor cells were first thought to drive the cellular events underpinning tumor angiogenesis and growth, considerable evidence has now emerged for the central role of tumor infiltrating myeloid cells such as monocytes, macrophages, and neutrophils in this phenomenon [ 8 - 12 ]. (hindawi.com)
This suggested that EPCs are able to differentiate into endothelial cells and that such cells are incorporated into sites of active angiogenesis including ischemia, tumor angiogenesis, and metastasis in adult organisms [ 16 , 17 ]. (hindawi.com)

Monoclonal antibodies developed against immunogenic proteins (Tumor Specific Antigens/TSA's) that are expressed in human cancers, display a unique behavioral pattern. (jcancer.org)
This includes the early recognition of these immunogenic membrane proteins that can serve as diagnostic markers, and the targeting of such markers for the destruction of the tumor, primarily thru ADCC. (jcancer.org)
The monoclonals (mAbs) that we have developed against specific immunogenic tumor membrane proteins have been studied in detail. (jcancer.org)
These tumor proteins, when first defined, were referred to as tumor associated antigens. (jcancer.org)
Monoclonals that we were able to develop from tumor specific proteins derived from colon and pancreas cancer were found capable of targeting those tumors to induce apoptosis. (jcancer.org)
There are also fusion proteins mimicking the variable domains of two antibodies. (wikipedia.org)
Adipocyte-derived factors involved in tumor progression include proteins such as adiponectin, leptin, TNF-α, monocyte chemotactic protein-1 (MCP-1), IL-6, and ECM components that control tumor cell behavior within the tumor microenvironment. (jci.org)
Antibodies are proteins that fight infection by attaching to antigens. (cancer.net)
This is also considered a type of targeted therapy , which is a cancer treatment using medication that targets a cancer's specific genes, proteins, or the tissue environment that helps the tumor grow and survive. (cancer.net)
Monoclonal antibodies attach to specific proteins or antigens. (who.int)
We study how these proteins are related to tumor development in breast, prostate and melanoma cancer models. (lu.se)

How Do Anti-CD20 Monoclonal Antibodies Work? (rxlist.com)
Anti-CD20 monoclonal antibodies are administered as a solution (liquid) to be added to fluid and injected intravenously (into a vein). (rxlist.com)

ChemotherapyAdvisor) - A first-in-human phase 1 monotherapy study of RG7212, a novel monoclonal antibody that targets TWEAK signaling-frequently active in advanced solid tumors-has "demonstrated excellent tolerability," a study presented at the 24th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics in Dublin, Ireland, November 7, has found. (cancertherapyadvisor.com)
The phase I data show that RG7212 is safe for multi-cycle administration in patients with advanced cancer, and results from tests of blood and tumor samples suggest that it would be feasible to administer over a prolonged period of time. (cancertherapyadvisor.com)
Pantomics Array Description: Stomach cancer tissue array containing 48 cases of paired primary and metastatic tumors (in. (delos.info)
Is Tumor a Cancer? (medicinenet.com)
The most widely used application of this approach is in cancer immunotherapy, where BsAbs are engineered to simultaneously bind a cytotoxic cell and a target (a tumour cell) to be destroyed. (wikipedia.org)
A neuroendocrine cancer, also known as a neuroendocrine tumor (NET) or neuroendocrine neoplasm, starts in the body's neuroendocrine system's specialized cells. (medgadget.com)
Collagen VI (COL6) is highly expressed in adipose tissue, upregulated in the obese state, and enriched in breast cancer lesions and is a stimulator of mammary tumor growth. (jci.org)
There have been studies on whether monoclonal antibodies or other drugs might help macrophages kill cancer cells. (webmd.com)
For each cancer discussed in the first part of our overview, as well as in Part II, which will deal with more common cancers, we briefly cover the tumor biology, how targeting was achieved, the introduction of immune modulation or immune-conjugates, and the impact these therapies are having in the disease. (cancernetwork.com)
IRVINE, Calif. , April 10, 2012 /PRNewswire/ -- GeneTex, a leading manufacturer of antibodies , is pleased to announce that they will be launching a new antibody against CAIX, a marker of hypoxia that shows great promise for cancer research. (prnewswire.com)
Assessment of Tumour Hypoxia for Prediction of Response to Therapy and Cancer Prognosis. (prnewswire.com)
A major impediment to treating the deadly brain cancer glioblastoma has been that the most potent chemotherapy can't permeate the blood-brain barrier to reach the aggressive brain tumor. (medicalxpress.com)
The cancer diagnostics market is on the verge of explosion, as the researchers approach major technological breakthroughs in tumor diagnosis and therapy, discover new specific antigens, and unlock the mystery of the genetic basis of the disease. (aarkstore.com)
Anticipated technological breakthroughs will create numerous opportunities for determining genetic predisposition, detecting specific tumors, and monitoring biological response to cancer therapy. (aarkstore.com)
Besides CAR-T cell therapy, other adoptive cell therapies that use your body's own T-cells to destroy the cancer are being developed including tumor-infiltrating lymphocyte (TIL) therapy. (webmd.com)
Radiotherapy exacerbates tumor-promoting innervation and nerve signaling in rectal cancer. (rochester.edu)
Toll-like receptor 7/8 agonist R848 alters the immune tumor microenvironment and enhances SBRT-induced antitumor efficacy in murine models of pancreatic cancer. (rochester.edu)
Because family physicians are assuming a greater role in caring for patients with cancer, an understanding of tumor markers is becoming increasingly important. (aafp.org)
Each tumor marker has a variable profile of usefulness for screening, determining diagnosis and prognosis, assessing response to therapy, and monitoring for cancer recurrence. (aafp.org)
This early test of the two agents in a breast cancer model suggests that the double hit can stifle tumor progression, avoid drug resistance and cause few side effects, say researchers at the Ohio State University Comprehensive Cancer Center -- Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC -- James) who developed the agents and evaluated their effectiveness in laboratory and animal tests. (sciencedaily.com)
Finally, we will comment on the mechanisms regulating myeloid cell recruitment to the tumor microenvironment and on the potential of myeloid cells as new targets for cancer therapy. (hindawi.com)
Monoclonal antibodies can help fight cancer in different ways. (cancer.net)
p53, mdm-2, p21, and mib-1 expression were assessed by immunohistochemical methods in primary tumors derived from 134 patients who took part in a randomized multicenter trial comparing docetaxel to sequential methotrexate and 5-fluorouracil (MF) in advanced breast cancer. (lu.se)
cancer in the organs and ducts that make and store bile, the liquid made by the liver), renal cell carcinoma (RCC, a type of cancer that begins in the kidneys), breast cancer, and certain other solid tumors. (medlineplus.gov)
Requests for reprints: Sofia K. Gruvberger-Saal, Institute for Cancer Genetics, tumors in the adjuvant or metastatic setting. (lu.se)
Generally, the higher the CA 27-29 level, the more advanced the breast cancer or larger the tumor burden. (medscape.com)
Other tumor markers to follow breast cancer include CEA, CA 15-3, HER2 extracellular domain, and CA 125. (medscape.com)
You have metastatic breast cancer (breast cancer that has spread beyond the original tumour) with high levels of HER2. (who.int)
Complement-dependent cytotoxicity is one of the mechanisms by which therapeutic monoclonal antibodies are toxic to cancer cells. (lu.se)
[ 3 , 4 ] These antibodies are approved for the treatment of advanced EGFR-expressing colorectal cancer, and cetuximab is also approved for treatment of squamous cell carcinoma of the head and neck. (medscape.com)

Adipocytes represent a major cell type in the mammary tumor microenvironment and are important for tumor growth. (jci.org)
CD4 + T cells contribute to the remodeling of the microenvironment required for sustained tumor regression upon oncogene inactivation. (nature.com)
Stereotactic Body Radiation and Interleukin-12 Combination Therapy Eradicates Pancreatic Tumors by Repolarizing the Immune Microenvironment. (rochester.edu)
Tumors exhibit significant myeloid cell infiltrates, which are actively recruited to the tumor microenvironment. (hindawi.com)

CONCLUSION: Monoclonal antibodies raised against epithelial growth factors or their receptors, when labeled with appropriate radionuclides, may be a useful tool for early tumor detection and eventually for therapy. (ox.ac.uk)
These effects were partially mediated through enhanced TGF-β signaling, which contributes to tissue fibrosis and epithelial-mesenchymal transition (EMT) of tumor cells. (jci.org)

With the ability of the mAbs to demonstrate therapeutic antitumor activity in those patients with relatively advanced malignancies, the term tumor specific was introduced. (jcancer.org)
Mabs capable of targeting the malignancies noted above were produced following immunization of BALBc mice with the Tumor Specific Antigens. (jcancer.org)
As such we plan to eventually employ the therapeutic mAbs in combination with chemotherapy as a means of enhancing the immunogenicity of the tumor system being treated and to possibly weaken the malignant growth for easier destruction by the mAb. (jcancer.org)
The therapeutic landscape has witnessed a transformative shift with the dominating presence of monoclonal antibodies (mAbs). (reportlinker.com)
The biopharmaceutical industry is entering an era dominated by sophisticated therapeutics, and Bi-Specific Monoclonal Antibodies (MAbS) represent a cutting edge development in this sphere. (reportlinker.com)
Monoclonal antibodies (mAbs) directed against tumor-associated antigens have excellent characteristics to target tumor cells selectively ( 1 - 3 ). (snmjournals.org)

To evaluate the safety and efficacy of a chimeric monoclonal antibody to tumor necrosis factor alpha (TNF alpha) in the treatment of patients with rheumatoid arthritis (RA). (nih.gov)

Immunotherapy, with an emphasis on the use of Tumor Infiltrating Lymphocytes (TILs), is carving out a significant niche within the field of oncology. (reportlinker.com)
One clinical trial has studied a type of engineered macrophage called CAR-M and found that it may be an effective form of immunotherapy for solid tumors. (webmd.com)
Because tumour dormancy provides a unique therapeutic window to prevent metastatic disease, we discuss on-going clinical trials and weigh the potential for immunotherapy to eradicate dormant disease. (nature.com)
Microspheres Encapsulating Immunotherapy Agents Target the Tumor-Draining Lymph Node in Pancreatic Ductal Adenocarcinoma. (rochester.edu)
For example, the side effects of monoclonal antibodies used for targeted therapy are not like those used for immunotherapy. (cancer.net)

We therefore investigated whether infliximab, a chimeric human-mouse anti-TNFalpha monoclonal antibody would provide additional clinical benefit to patients who had active rheumatoid arthritis despite receiving methotrexate. (nih.gov)
32 were treated with a single infusion of the anti-TNF monoclonal antibody Infliximab at a dose of 5mg/kg body weight. (qxmd.com)

The PR81 is a new murine anti-MUC1 monoclonal antibody that was found to react with the membrane extracts of several human breast cancerous tissues and the cell surface of some MUC1 positive cell lines. (ac.ir)
They are man-made antibody that was developed using cloning and recombinant DNA technology from human and murine (mice or rat) genes and work by inhibiting early-stage B lymphocyte activation. (rxlist.com)
Intertumoral Genetic Heterogeneity Generates Distinct Tumor Microenvironments in a Novel Murine Synchronous Melanoma Model. (rochester.edu)
Co-administration of a clinically relevant dexamethasone dosage with ablative radiotherapy reduces peripheral lymphocytes but does not alter in vivo intratumoral lymphocyte phenotype or inhibit efficacy of radiotherapy in a murine colorectal tumor model. (rochester.edu)

Characterization of binding and biological effects of monoclonal antibodies against a human tumor necrosis factor receptor. (docksci.com)
A monoclonal antibody that suppresses growth of human tumor in nude mice. (jax.org)

Our results identify a non-placental site of PSG expression in the gut and associated tumors, with implications for determining whether PSGs have a role in tumor progression, and utility as tumor biomarkers. (ucc.ie)
The findings suggest that the double hit can stifle tumor progression, avoid drug resistance and cause few side effects, say the researchers who developed the agents and evaluated their effectiveness in laboratory and animal tests. (sciencedaily.com)

It's packed with antibodies, growth factors, and cytokines. (webmd.com)

These tumor markers are most useful for monitoring response to therapy and detecting early relapse. (aafp.org)
This article describes the use of common tumor markers in primary care practice. (aafp.org)
Nevertheless, tumor markers can play a crucial role in detecting disease and assessing response to therapy in selected groups of patients. (aafp.org)
Consideration may be given to ordering multiple tumor markers because of the heterogeneity in cell composition of each tumor. (medscape.com)

one patient with refractory, BRAF wild type melanoma had tumor regression on CT (−14.4% reduction in 3D volume), along with 18 F FDG-PET PMR and ≥70% reduction in tumor Ki-67 and pERK. (cancertherapyadvisor.com)
A decrease in CA 27-29 levels can indicate tumor response or regression of disease. (medscape.com)
This in turn attracts inflammatory cells that may be associated with malignant transformation but also with tumor regression. (lu.se)

Giant cell tumors (GCTs) arise from cells called osteoclast precursors. (medicinenet.com)
Catumaxomab, one of the first trifunctional antibodies approved for therapeutic use, binds both CD3 on cytotoxic T cells and EpCAM on human adenocarcinomas. (wikipedia.org)
Three different antibodies against a human TNF receptor (htr-1, htr-5, and htr-9) have been examined for their binding pattern to U937 cells and abili. (docksci.com)
Our results highlight the crucial role of ETP as an obesity-associated factor that promotes tumor growth in the context of adipocyte interactions with tumor and stromal cells. (jci.org)
Background ICT01 is an anti-BTN3A mAb that selectively activates γ9δ2 T cells to orchestrate a robust antitumor immune response of the innate and adaptive immune systems that leads to solid tumor infiltration of activated γ9δ2 T cells, CD8 T cells, and NK cells. (bmj.com)
The 131 I radiolabel generally clears rapidly from the tumor after internalization and subsequent degradation of the bivalent l -amino acid peptide ( l -a.a. peptide) in the tumor cells. (snmjournals.org)
Unfortunately, after internalization and degradation of the 131 I-labeled peptide in the lysosomes, the metabolite 131 I-Tyr is rapidly cleared from tumor cells ( 12 - 15 ). (snmjournals.org)
As has often been the case, hematologic malignancies have led the way in the introduction of this new generation of therapeutics-perhaps because of easy access to tumor samples for pharmacodynamics, and the narrow spectrum of cells of origin. (cancernetwork.com)
elicits antiproliferative and proapoptotic activities in vitro in solid and hematologic tumor cells. (medscape.com)
Defects in the genome derived from the incorrect separation of chromosomes (and the DNA packed within) in each division of cells drive tumor growth and resistance to therapy. (medicalxpress.com)
A virus, called wild-type reovirus, which has been changed in a certain way, may be able to kill tumor cells without damaging normal cells. (mayo.edu)
Sargramostim may increase the production of blood cells and may promote the tumor cell killing effects of wild-type reovirus. (mayo.edu)
Giving wild-type reovirus together with sargramostim may kill more tumor cells. (mayo.edu)
Elotuzumab ( Empliciti ) is a monoclonal antibody that attaches to the SLAMF7 protein to kill multiple myeloma cells. (webmd.com)
Tumor cells (like most normal cells) have receptors on their surfaces. (rxlist.com)
Molecules that attach to CD20 (a receptor present in more than 90% of B-cell non-Hodgkin's lymphomas) can affect the growth and development of the tumor cells and, sometimes, the production of new tumor cells. (rxlist.com)
Anti-CD20 antibodies attach to the CD20 receptor and cause the tumor cells to disintegrate (lyse). (rxlist.com)
In addition, they prevent the production of additional tumor cells. (rxlist.com)
Agonist anti-ChemR23 mAb reduces tissue neutrophil accumulation and triggers chronic inflammation resolution " (1) reports on the discovery and preclinical data for OSE-230, an innovative agonist antibody against ChemR23, also known as chemerin chemokine-like receptor 1 (CMKLR1), a G-protein coupled receptor (GPCR) expressed on myeloid immune cells known to modulate inflammation. (pharmiweb.com)
A new study suggests that combining two experimental anticancer peptide agents might simultaneously block formation of new tumor blood vessels while also inhibiting the growth of tumor cells. (sciencedaily.com)
Myeloid cells are a heterogeneous population of bone marrow-derived cells that play a critical role during growth and metastasis of malignant tumors. (hindawi.com)
In 1971, Dr. Judah Folkman observed that neovascularization occurs around tumors and proposed that new blood vessel growth is necessary to supply nutrients and oxygen to tumor cells during exponential tumor growth [ 6 ]. (hindawi.com)
Specific growth factors, such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), stimulate the proliferation and migration of naturally quiescent endothelial cells, resulting in the formation of new vessel structures during embryonic development and tumor growth [ 7 ]. (hindawi.com)
Fully human monoclonal antibodies are produced using transgenic mice that contain human immunoglobulin genes or using phage display (ie, a bacteriophage-based cloning method) of immunoglobulin genes isolated from human B cells. (msdmanuals.com)
Another is SUSD4, which we recently showed to be bind and inhibit C1 and which we found on T cells infiltrating various solid tumors. (lu.se)

Tumor Necrosis Factor (TNF)-like weak inducer of apoptosis (TWEAK) and fibroblast inducible factor 14 (Fn14) are a ligand-receptor pair of the TNF superfamily that are frequently overexpressed in solid tumors," noted presenter Ulrik Lassen, MD, PhD, head of the oncology phase I unit at the Rigshospitalet, Copenhagen, Denmark. (cancertherapyadvisor.com)

People with GCTs need regular follow-up care to monitor for any recurrence or transformation of the tumor. (medicinenet.com)
In monitoring patients for disease recurrence, tumor marker levels should be determined only when there is a potential for meaningful treatment. (aafp.org)
Some cases progress, however, and most patients experience recurrence at least once in the follow-up period, creating the need for accurate tumor surveillance. (medscape.com)
Stable or increasing CA 27-29 levels, despite adequate treatment, can indicate tumor nonresponsiveness or tumor recurrence. (medscape.com)

Pantomics Array Description: Soft tissue tumor tissue array, 102 cases of benign and malignant tumors of various soft tissues. (delos.info)

Introduction: The radioimmunoscintigraphy (RIS) has found widespread clinical applications in tumor diagnosis. (ac.ir)
Albany, USA) DelveInsight's ' Neuroendocrine Tumors Pipeline Insight 2023 ' report provides comprehensive global coverage of pipeline Neuroendocrine Tumors therapies in various stages of clinical development, major pharmaceutical companies are working to advance the pipeline space and future growth potential of the Neuroendocrine Tumors pipeline domain. (medgadget.com)
The grant will support the initiation and execution of Phase 1 clinical trial with TraceNETTM, a novel copper-based radio diagnostic for detecting neuroendocrine tumors (NET). (medgadget.com)
Our research is focussed on understanding these complex processes using a variety of complementary models and systems to better inform antibody selection, design and clinical application. (southampton.ac.uk)
Mersana Therapeutics (NASDAQ: MRSN) is a clinical-stage biopharmaceutical company focused on developing antibody-drug conjugates. (cbinsights.com)
However, a consistent increase in tumor marker levels, coupled with lack of clinical improvement, may indicate treatment failure. (aafp.org)

Relationship between hematogenous tumor cell dissemination and cellular immunity in DCIS patients. (nature.com)

In March 2023 , RayzeBio, Inc., a targeted radiopharmaceutical company developing an innovative pipeline against validated solid tumor targets, announced the completion of enrollment in the Phase 1b portion of the ACTION-1 Phase 1b/3 trial of RYZ101 in patients with SSTR+ gastroenteropancreatic neuroendocrine tumors (GEP-NETs) who have progressed on Lutetium-177 labeled somatostatin analog therapy. (medgadget.com)
In March 2023 , NUCLIDIUM announced that the Neuroendocrine Tumors Research Foundation ("NETRF") has selected the company and its collaboration partner the University Hospital Basel (Universitätsspital Basel, "USB") as recipients of its Investigator Award. (medgadget.com)
More than 14,490 people in the U.S. will be diagnosed with glioblastoma in 2023, according to the National Brain Tumor Society, and 10,000 people in the U.S. will die of the disease. (medicalxpress.com)

Scholars@Duke publication: Monoclonal antibodies to growth factors and growth factor receptors: their diagnostic and therapeutic potential in brain tumors. (duke.edu)
This phase I trial studies the side effects and the best dose of wild-type reovirus (viral therapy) when given with sargramostim in treating younger patients with high grade brain tumors that have come back or that have not responded to standard therapy. (mayo.edu)

ExperimentalDesign: We investigated ERh by immunohistochemistry in 353 stage II primary breast tumors from patients treated with 2 years adjuvant tamoxifen, and generated gene expres- sion profiles for a representative subset of 88 tumors. (lu.se)

Giant cell tumors typically affect young and middle-aged adults and are more common in women than in men. (medicinenet.com)

DelveInsight's Neuroendocrine Tumors Pipeline analysis depicts a robust space with 55+ active players working to develop 60+ pipeline therapies for Neuroendocrine Tumors treatment. (medgadget.com)
The situation with solid tumors is considerably more complex, and the evolution of targeted therapies for these cancers is still in its infancy. (cancernetwork.com)
CAIX is involved in both the extracellular acidification of hypoxic tumors, as well as the regulation of intracellular pH, making it an attractive target for therapies based on the manipulation of pH (Parks, et al. (prnewswire.com)

Tumors were pretargeted with the bispecific monoclonal antibody (bs-mAb) G250xDTIn-1 and, 72 h later, mice were injected intravenously with one of both radiolabeled peptides. (snmjournals.org)

This is the first peer-reviewed publication to describe an agonist monoclonal antibody, which triggers pro-resolutive mechanisms in macrophages and neutrophils in chronic inflammatory condition. (pharmiweb.com)

In some cases, GCTs may recur after treatment, and there is a small risk of GCTs transforming into cancerous tumors. (medicinenet.com)
Treatment for GCTs usually involves surgically removing the tumor. (medicinenet.com)
In some cases, additional treatment with medications or radiation could be necessary to prevent the tumor from returning. (medicinenet.com)
In general, treatment was well tolerated and stable blood levels of cA2 were achieved in all groups, except for the group receiving 1 mg/kg of cA2 alone, at which dosage antibodies to cA2 were observed in approximately 50% of the patients. (ox.ac.uk)
Matsuoka, K & Kanai, T 2013, ' Mechanism and therapeutic strategy of secondary failure to anti-tumor necrosis factor-α monoclonal antibody treatment for crohn's disease ', Digestion , vol. 88, no. 1, pp. 17-19. (elsevierpure.com)
Antibody Effector Functions Monoclonal antibodies (mAb) have become established in the treatment of a variety of malignancies - transforming patient outcomes. (southampton.ac.uk)
At present, and for some years to come, the treatment of most solid tumors will continue to rely on a patchwork of empirically derived and newly introduced molecularly targeted agents. (cancernetwork.com)
Hypoxia in tumors is closely associated with tumor aggressiveness and resistance to radio- and chemotherapeutic treatment. (prnewswire.com)
Combined AFP and β-hCG testing is an essential adjunct in the evaluation and treatment of nonseminomatous germ cell tumors, and in monitoring the response to therapy. (aafp.org)
Conversely, tumor marker levels may rise after effective treatment (possibly related to cell lysis), but the increase may not portend treatment failure. (aafp.org)
This kind of approach is called a "tumor-agnostic treatment. (cancer.net)
The side effects of monoclonal antibody treatment depend on the drug's purpose. (cancer.net)

Their primary antibodies and secondary antibodies are created through a process involving extensive research, development and validation. (prnewswire.com)
GeneTex has over 55,000 primary antibodies in its catalog that are all backed by a 100% Satisfaction Guarantee. (prnewswire.com)

Arlen M, Arlen P, Tsang A, Wang X, Gupta R. The Therapeutic Value of Monoclonal Antibodies Directed Against Immunogenic Tumor Glycoproteins. (jcancer.org)
These soluble molecules in the blood are usually glycoproteins detected by monoclonal antibodies. (aafp.org)

Upregulating mutations of EGFR have been found in many solid tumors. (medscape.com)
In contrast, monoclonal antibodies that target EGFR, such as cetuximab and panitumumab, bind to its extracellular domain and competitively inhibit endogenous ligand binding to the receptor. (medscape.com)

The monoclonals, so produced, were not only more efficient in controlling tumor growth but minimized the development of a HAMA response. (jcancer.org)
Moreover, ETP expression was associated with aggressive mammary tumor growth and high metastatic growth. (jci.org)
Hence, the adipocyte, as a major constituent of the mammary tumor stroma ( 3 ), is a likely contributor to tumor growth. (jci.org)
Parks SK , Chiche J , Pouyssegur J . pH control mechanisms of tumor survival and growth. (prnewswire.com)
The other inhibitor blocks the action of vascular endothelial growth factor (VEGF), which stimulates the growth of new blood vessels that tumors need to grow beyond a certain size. (sciencedaily.com)

To minimize the problems due to use of pure mouse antibody, researchers have used recombinant DNA techniques to create monoclonal antibodies that are part human and part mouse. (msdmanuals.com)

A monoclonal antibody against tumor necrosis factor-alpha improves survival in experimental multiple organ dysfunction syndrome. (ru.nl)
To date, no tumor marker has demonstrated a survival benefit in randomized controlled trials of screening in the general population. (aafp.org)
The strategy of targeting both HER-2 and VEGF pathways should also discourage the development of drug resistance, Kaumaya says, because it simultaneously inhibits two pathways that are essential for tumor survival. (sciencedaily.com)

Biopharmaceuticals, particularly therapeutic antibodies, are revolutionizing modern medical treatments due to their targeted approach and ability to harness the body's own immune responses. (reportlinker.com)
Since the Fc region is still intact, this allows for the BsAb to trigger common immune responses when recognized by an Fc receptor, such as antibody-dependent cell-mediated cytotoxicity or complement-dependent cytotoxicity. (wikipedia.org)
When the immune system detects something harmful, it makes antibodies. (cancer.net)
Other types of monoclonal antibodies boost your immune system by inhibiting or stopping immune checkpoints. (cancer.net)
Also, complement is currently undergoing re-appreciation of its role in the immune surveillance of tumors. (lu.se)

Pantomics Array Description: Soft tissue tumor tissue array, set 1, non-overlapping with SFT962, 96 cores, 48 cases of benign and. (delos.info)
Giant cell tumors (GCTs) are benign or noncancerous. (medicinenet.com)
Giant cell tumors (GCTs) are benign (noncancerous) tumors that most commonly occur in the bones of the arms and legs. (medicinenet.com)
Although giant cell tumors are benign, they can cause problems if they press on nearby structures or grow and weaken the bone to the point of fracture . (medicinenet.com)

AFM11 showed dose-dependent inhibition of Raji tumors in vivo. (wikipedia.org)

Tumor necrosis factor-alpha (TNFalpha) has been demonstrated to play an important role in its pathophysiology. (qxmd.com)
Acyclovir-resistant herpes simplex encephalitis in a patient treated with anti-tumor necrosis factor-α monoclonal antibodies. (bvsalud.org)
We report a case of herpes simplex type 1- encephalitis in a 50-year-old woman receiving anti- tumor necrosis factor -α monoclonal antibodies adalimumab . (bvsalud.org)
Tumor necrosis factor (TNF) is implicated in the pathophysiology of gram-negative sepsis. (jamanetwork.com)
The results of our phenotype analysis also indicate that it is more likely that a panel of tumor biological factors instead of only one single factor may be needed for better prediction of chemotherapy response. (lu.se)
Detection techniques were examined and included intervention trials, urine cytology, quantitative fluorescence image analysis, flow cytometry detection, cystoscopy and bladder mucosal biopsy, hematuria screening, evaluation of urinary autocrine motility factor and tumor cell collagenase stimulating factor, and molecular and cellular biological approaches. (cdc.gov)

Pantomics Array Description: Testis tumor tissue array, set 1, containing 69 cases of testis germ cell tumors, 18 cases of non-tumor. (delos.info)
Even though non-IgG-like BsAbs have low molecular weight and thus high tumor tissue permeability, their half-life is relatively short and they require multiple doses. (wikipedia.org)

It is required by FDA that the potential effects of tumor control and toxicity be defined using the naked antibodies produced under GMP conditions, In those situations where patients with recurrent malignancies are to be studied we have come to realize that a number of factors can influence the response to monoclonal therapy. (jcancer.org)
So far, radioimmunotherapy (RIT) has only induced significant therapeutic effect in patients with hematologic tumors, presumably due to their relatively high radiosensitivity ( 4 , 5 ). (snmjournals.org)
In patients with a history of low-grade Ta disease and a noted sub-centimeter papillary tumor(s), consider in-office fulguration as an alternative to resection under anesthesia. (medscape.com)
For intermediate-risk patients whose first surveillance cystoscopy is negative for tumor, perform subsequent cystoscopy with cytology every 3-6 months for 2 years, then 6-12 months for years 3 and 4, and then annually thereafter. (medscape.com)
Le pourcentage de CD44 dans les lymphocytes T périphériques était significativement plus élevé chez les patients que chez les témoins, comme détecté par la cytométrie en flux. (who.int)
En outre, il y avait une aug- mentation significative de la forme soluble du c-kit dans le sérum des patients atteints de pemphigus vulgaire actif par rapport aux témoins. (who.int)
The factors responsible for response to tamoxifen in 5% to 10% of patients with ERa-negative tumors are not clear. (lu.se)
Patients with tumors lacking ERa in general do not charges. (lu.se)

The experimental evidence is being accumulated to show opposing roles of complement in tumor control. (lu.se)

For instance, pembrolizumab (Keytruda) is approved to treat any tumors that have spread to distant parts of the body if they have a specific molecular change called microsatellite instability-high (MSI-H) or DNA mismatch repair deficiency (dMMR). (cancer.net)
Pembrolizumab injection is in a class of medications called monoclonal antibodies. (medlineplus.gov)

GeneTex is proud to introduce a superior monoclonal antibody against CAIX that has been fully validated through immunohistochemistry, immunofluorescence, western blotting and FACS. (prnewswire.com)
At a realistic immunohistochemistry antibody utilization efficiency of 70%, biomarker analysis comprises 48.7% (US$ 67.33) of diagnostic costs and takes 33 min. (bvsalud.org)

Accordingly, the radiation dose to the tumor, correlating with the therapeutic efficacy of pretargeted RCC, can be enhanced substantially. (snmjournals.org)
Chemotherapeutic agents, corticosteroids, and monoclonal antibodies are used to reduce the disease burden, and bisphosphonates are used to promote bone healing and to provide secondary prophylaxis against skeletal-related events (eg, hypercalcemia, bone fracture, spinal cord compression, need for radiation, and need for surgery). (medscape.com)

Therapeutic efficacy of these radionuclides depends on the E max , physical half-life, and residence time of the radiolabel in the tumor. (snmjournals.org)

Although highly preliminary, the findings suggest that different tumor biological factors may predict response to different chemotherapy regimens with distinct mechanisms of action. (lu.se)

Despite this undoubted impact, responses remain variable and their mechanisms of action and of tumour resistance are controversial. (southampton.ac.uk)

The majority of human tumors are low immunogenic and complement may be involved in their recognition via direct "danger signal" elicited activation. (lu.se)

Biodistribution of the radiolabeled species was assessed in normal female Swiss mice, while tumor uptake was also evaluated. (ox.ac.uk)
Finally, satisfactory tumor uptake was observed for both radiolabeled derivatives. (ox.ac.uk)
The uptake and retention in the tumor of 111 In-/ 125 I-labeled bivalent peptides ( l -a.a. peptide and d -a.a. peptide) were studied in female BALB/c athymic mice with subcutaneous SK-RC-52 RCC tumors. (snmjournals.org)
The maximum uptake and retention of 125 I-labeled l -a.a. peptide in the tumor were significantly lower compared with that of the 111 In-labeled l -a.a. peptide. (snmjournals.org)
In contrast, the tumor uptake and retention of the 125 I-labeled d -a.a. peptide) were similar to that of the 111 In-labeled l -a.a. peptide but were superior at later time points. (snmjournals.org)
Uptake and retention in the tumor of the iodinated peptide after pretargeting with a bs-mAb can be significantly improved using d -a.a. peptides. (snmjournals.org)

In 1975, the problem of producing pure antibodies was solved by the creation of hybridoma technology, and the new era of monoclonal antibodies (MoAbs) came. (wikipedia.org)

Why and how it is replacing past approaches in the management of solid tumors is the subject of this two-part overview. (cancernetwork.com)
they are used to treat solid and hematopoietic tumors, inflammatory disorders, and infections. (msdmanuals.com)

The original concept of BsAbs was proposed by Nisonoff and his collaborators in the 1960s, including the first idea of antibody architecture and other findings. (wikipedia.org)

The combination of the long circulating half-life of the radiolabeled mAb and the radiosensitivity of the bone marrow limits the radioactive doses of labeled antibodies that can be administered safely ( 6 , 7 ). (snmjournals.org)

Anatomy19

Organisms9

Diseases46

Chemicals and Drugs85

Analytical, Diagnostic and Therapeutic Techniques and Equipment58

Phenomena and Processes46

Disciplines and Occupations3

Information Science3

Health Care6

Antigen12

Necrosis factor alpha monoclonal3

Inhibitors7

Angiogenesis12

Proteins11

Anti-CD20 monoclonal2

Cancer30

Microenvironment4

Epithelial2

MAbs6

Chimeric monoclonal1

Immunotherapy5

Infliximab2

Murine4

Human tumor2

Progression2

Cytokines1

Markers4

Regression3

Cells25

Oncology1

Recurrence4

Malignant tumors1

Clinical6

Immunity1

20233

Brain tumors2

Breast tumors1

Middle Aged1

Therapies3

Bispecific1

Macrophages1

Treatment12

Primary antibodies2

Glycoproteins2

EGFr2

Growth5

Recombinant1

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Immune5

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Factor6

Tissue2

Patients8

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Pembrolizumab2

Immunohistochemistry2

Radiation2

Efficacy1

Biological1

Resistance1

Immunogenic1

Uptake6

Hybridoma1

Solid2

Findings1

Radiosensitivity1