• For immunohistochemistry, all meningioma tumors at Elhassan Medical Laboratory for histopathology and cytology during the above mentioned period were processed for ki 67 antigen. (journalcra.com)
  • A single pathologist evaluated the protein expression of hormone receptors (estrogen (ER) and progesterone receptor (PR)), HER2, Ki67, and GRB7 by immunohistochemistry (IHC). (bvsalud.org)
  • Finally Immunohistochemistry using Ki-67 was performed and its expression was recorded. (ijcrr.com)
  • The anti-HCC effect of swimming was assessed in vivo by tumor weight monitoring, hematoxylin and eosin (HE) staining, and immunohistochemistry (IHC) detection of proliferating cell nuclear antigen (PCNA) and Ki67. (bvsalud.org)
  • The expression of TLR2 was detected by immunohistochemistry, and tumor proliferation was detected by Ki67 labeling. (biomedcentral.com)
  • Several such molecular markers have been extensively studied through immunohistochemistry (IHC), among them the somatostatin receptors type 2 (SSTR-2) and type 5 (SSTR-5), which are known to correlate with response to somatostatin analogues treatment, the SSTR-2 negative tumors usually being resistant to first-generation analogues, while SSTR-5 potentially being a predictive marker for the novel agent, Pasireotide. (rjme.ro)
  • Methods: Using immunohistochemistry, expression levels of p63 and Ki-67 were determined in 16 myoepithelial carcinoma samples and correlated with clinicopathological characteristics and patient prognosis. (cyberleninka.org)
  • ExperimentalDesign: We investigated ERh by immunohistochemistry in 353 stage II primary breast tumors from patients treated with 2 years adjuvant tamoxifen, and generated gene expres- sion profiles for a representative subset of 88 tumors. (lu.se)
  • The majority of phyllodes tumors have been described as benign (35% to 64%), with the remainder divided between the borderline and malignant subtypes. (hindawi.com)
  • Assessment of activity of nuclear antigen Ki 67 in benign, borderline and malignant tumors. (czytelniamedyczna.pl)
  • Objective: Aim of the study was to evaluate different parameters that are used to categorise phylloides tumor into benign, borderline and malignant type and also to know frequency of Ki-67 expression in different category. (ijcrr.com)
  • 2 In 2003, WHO divided breast phyllodes tumor in three groups as benign, borderline and malignant, based up on the following criteria 3 1. (ijcrr.com)
  • All grades of phyllodes tumor have the potential of local recurrence, but the metastasis is mostly identified in borderline and malignant grades. (ijcrr.com)
  • In addition to the routine histomorphology, the study of Ki-67 antigen expression may be useful to differentiate benign, borderline and malignant phyllodes tumor and are also helpful in predicting the clinical behaviour. (ijcrr.com)
  • Mib-1 monoclonal antibody recognizes the proliferation-related antigen Ki-67. (lu.se)
  • It has been suggested that, in a proportion of fibroadenomas, a somatic mutation can result in a monoclonal proliferation, histologically indistinguishable from the polyclonal element, but with a propensity to local recurrence and progression to a phyllodes tumor which has also been supported by clonal analysis. (hindawi.com)
  • Monoclonal antibodies directed toward nuclear antigens are increasingly used as tools to obtain valuable information concerning the proliferative changes of the tumors. (thejcdp.com)
  • Antigen KI-67 also known as Ki-67 or MKI67 is a protein that in humans is encoded by the MKI67 gene (antigen identified by monoclonal antibody Ki-67). (journalcra.com)
  • 1. Gerdes J., Schwab U., Lemke H., and Stein H. (1983) Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation. (nordicmubio.com)
  • The staining may be performed with the MIB-1 monoclonal antibody, so the test may be referred to as either Ki-67 or MIB-1. (cancer.gov)
  • Note 2:** Code the LI fraction percentage using Ki-67 or MIB-1 (monoclonal antibody) when it is available on the pathology report of the primary tumor. (cancer.gov)
  • The following product was used in this experiment: Ki67 Monoclonal Antibody (OTI5D7), TrueMAB™ from Thermo Fisher Scientific, catalog # TA801577. (thermofisher.com)
  • In retrospective studies the intensity of staining and the frequency of Ki-67 expression in cell nuclei was interpreted as a prognostic factor for the malignancy of tumours (Gerdes et al. (nordicmubio.com)
  • p53, mdm-2, p21, and mib-1 expression were assessed by immunohistochemical methods in primary tumors derived from 134 patients who took part in a randomized multicenter trial comparing docetaxel to sequential methotrexate and 5-fluorouracil (MF) in advanced breast cancer. (lu.se)
  • and cell differentiation ( SOX2 and TGFB3 ) as well as immunohistochemical assay for VEGFA, TP53, Bcl2, TGFB1, and Ki67 protein expression have been performed in 85 FFPE RCC tumor specimens. (hindawi.com)
  • [ 7 ] Tumors with pure sarcomatoid morphology due to overgrowth of the RCC components are classified as SRCC if evidence of epithelial differentiation can be demonstrated through immunohistochemical or ultrastructural analysis. (medscape.com)
  • The immunohistochemical detection of proliferation related proteins such as Ki-67 and proliferating cell nuclear antigen is a commonly used method to determine the proliferation index. (wikipedia.org)
  • 3. Gerdes J., Becker M.H.G., Key G., and Cattoretti G. (1992) Immunohistochemical detection of tumour growth fraction (Ki-67 antigen) in formalin-fixed and routinely processed tissues. (nordicmubio.com)
  • The value is expressed as the percentage of carcinoma cells in the tissue sample with positive immunohistochemical staining for the Ki-67 protein. (cancer.gov)
  • We analyzed the immunohistochemical expression of PRAME and Ki-67 in 165 melanocytic lesions, including 92 primary melanomas, 19 metastatic melanomas, and 54 melanocytic nevi using tissue microarrays. (ingentium.com)
  • Consequently, the evaluation of a tumor proliferative index (or growth fraction) has clinical significance in characterizing many solid tumors and hematologic malignancies. (wikipedia.org)
  • Among solid tumors, the clinical significance of the proliferation index on breast cancer has been extensively studied. (wikipedia.org)
  • Oncogenic osteomalacia is a well-known paraneoplastic syndrome associated with solid tumors, including phosphaturic mesenchymal tumors (PMTs). (jbjs.org)
  • Accurate preoperative pathological diagnosis allows correct surgical planning and avoidance of reoperation, either to achieve wider excision or for subsequent tumor recurrence [ 8 - 10 ]. (hindawi.com)
  • The slides of original ovarian tumors in patients with recurrence were reviewed by pathologists in our hospital. (biomedcentral.com)
  • They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. (lookformedical.com)
  • Foot radiographs at that time demonstrated persistent osteoporosis but no evidence of local tumor recurrence. (jbjs.org)
  • In addition, p63 and Ki-67 expression levels were associated with myoepithelial carcinoma recurrence and metastasis. (cyberleninka.org)
  • Conclusions: Recurrence and metastasis in myoepithelial carcinomas are more frequent in p63-positive and Ki-67-positive EMCs, and poor prognosis is associated with overexpression of p63. (cyberleninka.org)
  • Background/Aim: To demonstrate the value of Ki-67 in distinguishing between partial and complete hydatidiform moles. (iiarjournals.org)
  • The independent prognostic value of Ki-67 has been studied with variable results. (ingentium.com)
  • It is believed that the most useful prognostic information can be obtained from the invasive front of a tumor, where the deepest and presumably the most aggressive cells reside. (thejcdp.com)
  • The Ki-67 antigen is one such reliable biomarker of cancers, which is now being widely studied to reveal the prognostic indication of the disease. (thejcdp.com)
  • The Ki-67 score closely correlates with other proliferation markers, and has been shown to have prognostic and predictive value for many different tumor types. (wikipedia.org)
  • The various methods of characterizing the proliferation index have found roles in both the diagnostic and prognostic evaluation of tumors. (wikipedia.org)
  • The Ki-67 labelling index has also been found to have prognostic significance where in many clinical practice guidelines, evaluation of Ki-67 in newly diagnosed invasive breast carcinomas is recommended. (wikipedia.org)
  • Although many factors have been evaluated as potential prognostic indicators, including clinical stage, site and size of the tumour, high proliferative activity, extensive invasion into the surrounding tissue, perineural permeation, the abnormal presence of nuclear DNA content, and marked cellular pleomorphism, there are no definite histological features that clearly correlate with their behaviour. (cyberleninka.org)
  • We evaluated PRAME as a prognostic marker in cutaneous melanoma, compared to Ki-67. (ingentium.com)
  • Ki-67 is a nuclear antigen expressed in proliferating cells that is coded by the MKI67 gene on chromosome 10, and is expressed during the GI, S, G2, and M phases of the cell cycle. (wikipedia.org)
  • Further, such probes can also reveal the cellular kinetics at the deepest and most invading front of the tumor, which is considered to be a significant histological site disclosing tumor aggression. (thejcdp.com)
  • suggested the use of Ki-67 index and mitotic count in combination with histological characteristics developing a new grading system (G1-G3) [ 6 ]. (springeropen.com)
  • However, knocking out the TLR2 gene reduced the shortening of colorectal length, the number of tumors, and the total tumor volume and inhibited the growth of CAC. (biomedcentral.com)
  • The Ki-67, a large nonhistone protein with molecular weight of approximately 395 kDa, has been extensively used as a marker to read the proliferative activity during the G1, S, G2, and M phases of the cell cycle. (thejcdp.com)
  • Ki-67 is an excellent marker to determine the growth fraction of a given cell population, the fraction of Ki-67-positive tumor cells (the Ki-67 labeling index) is often correlated with the clinical course of cancer. (journalcra.com)
  • Ki-67 is commonly used as a proliferation marker because it is not detected in G0 cells, but increases steadily from G1 through mitosis. (thermofisher.com)
  • Ki-67 is routinely used as a neuronal marker of cell cycling and proliferation. (thermofisher.com)
  • Predictive Role of p53 Protein as a Single Marker or Associated to Ki67 Antigen in Oral Carcinogenesis. (bvsalud.org)
  • Positive immunoreactivity indicated the presence of brown precipitate in the nucleus at the site of the target antigen. (thejcdp.com)
  • Presence of brown colored end product at the site of target antigen was indicative of positive reactivity. (ijcrr.com)
  • Conclusion: Patient age and tumor size increases as the lesions progress from benign to malignant phyllodes tumor so is the ki-67 expression. (ijcrr.com)
  • On the other hand malignant phyllodes tumor were diagnosed when they showed extensive stromal overgrowth, marked stromal cellularity, more than 10 mitotic figures per 10 high power field, infiltrating border and marked nuclear pleomorphism. (ijcrr.com)
  • Only some of these characteristics are seen in atypical Spitz tumors and spitzoid melanomas. (atlasgeneticsoncology.org)
  • Objective: To access p16/Ki-67 double staining (DS) in cervical cells performance for detecting precursor lesions of cervical cancer, in comparison to immediate repetition of the liquid-based cervical cytology (LBCC) in women with screening cytology results of atypical squamous cells of undetermined significance (ASC-US) or low-grade squamous intraepithelial lesion (LSIL). (edu.br)
  • Borderline phyllodes tumors were more atypical than benign but did not fulfil all the criteria of malignancy. (ijcrr.com)
  • The sections were stained with an antibody directed against the Ki-67 antigen. (thejcdp.com)
  • Cells are then stained with a Ki-67 antibody, and the number of stained nuclei is then expressed as a percentage of total tumor cells. (wikipedia.org)
  • Positive tissue control (Lymphoma for Ki-67) and negative control (Omission of primary antibody) were taken. (ijcrr.com)
  • The antigen KI-67 is a nuclear protein that is associated with and may be necessary for cellular proliferation. (journalcra.com)
  • 1987). Ki-67 Protein is a nuclear protein, which is ubiquitous present during cell division, that means in all phases of mitosis (S1, G1, G2 and M phase). (nordicmubio.com)
  • Ki-67 nuclear protein. (nordicmubio.com)
  • Note 1:** Ki-67 antigen is a nuclear protein, expressed by cells in all phases of the active cell cycle (G1,S, G2, and M phase) and absent in resting cells (G0 phase). (cancer.gov)
  • Ki-67 is a nuclear protein that is expressed during various stages in the cell cycle, particularly during late G1, S, G2, and M phases. (thermofisher.com)
  • In their various recent seminal studies, Bryne 3 suggested that the invasive front of the tumor is the region which enunciates the cell character and thus, could contribute toward prognosis. (thejcdp.com)
  • Slides where invasive tumor front (ITF) could not be identified were excluded. (thejcdp.com)
  • For recurrent, invasive tumors, more aggressive attempts at excision or electroporation may be required. (merckvetmanual.com)
  • A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane. (lookformedical.com)
  • Objective: To analyze differences in the presentation of clinicopathological variables according to GRB7 protein expression in HER2-positive tumors in Colombian patients with invasive ductal breast carcinomas diagnosed between 2013 and 2015 at the Instituto Nacional de CancerologĂ­a (Bogotá, Colombia).Methods: A total of 158 breast cancer patients were included with a confirmed diagnosis of invasive ductal carcinoma. (bvsalud.org)
  • Introduction: Meningiomas are predominantly benign tumors, which arise from the arachnoids' cap cells. (journalcra.com)
  • Depending upon the above criteria benign tumors were classified when there was moderate stromal cellularity, mitotic figures were few if any per 10 high power field, well circumscribed border and absence of or mild nuclear pleomorphism. (ijcrr.com)
  • They make up 0.3 to 0.5% of female breast tumors [ 1 ] and have an incidence of about 2.1 per million, the peak of which occurs in women aged 45 to 49 years [ 2 , 3 ]. (hindawi.com)
  • The factors responsible for response to tamoxifen in 5% to 10% of patients with ERa-negative tumors are not clear. (lu.se)
  • negative tumors do seem to be sensitive to tamoxifen (5 - 7). (lu.se)
  • Phyllodes tumors are rare fibroepithelial lesions. (hindawi.com)
  • At one extreme, malignant phyllodes tumors, if inadequately treated, have a propensity for rapid growth and metastatic spread. (hindawi.com)
  • In contrast, benign phyllodes tumors on clinical, radiological, and cytological examination are often indistinguishable from fibroadenomas and can be cured by local surgery. (hindawi.com)
  • With the nonoperative management of fibroadenomas widely adopted, the importance of phyllodes tumors today lies in the need to differentiate them from other benign breast lesions. (hindawi.com)
  • It has also been postulated that stromal induction of phyllodes tumors can occur as a result of growth factors produced by the breast epithelium. (hindawi.com)
  • KI-67 antigen is expressed in the nucleus and Ki-67 labelling index is defined as the percentage of cells that showed a positive nuclear stain. (ijcrr.com)
  • The Ki-67 or MIB-1 LI may also be called the growth fraction or proliferative fraction. (cancer.gov)
  • In 1981 [ 6 ] the World Health Organization adopted the term phyllodes tumor and as described by Rosen [ 7 ] subclassified them histologically as benign, borderline, or malignant according to the features such as tumor margins, stromal overgrowth, tumor necrosis, cellular atypia, and number of mitosis per high power field. (hindawi.com)
  • Cell kinetic data may also be a useful adjunct to histologically based tumor classifications, and are among the most important indicators of treatment response and relapse in many types of cancers. (thejcdp.com)
  • The correlation between low Ki-67 index and histologically low-grade tumors is strong. (thermofisher.com)
  • Recurrent tumors were mostly ipsilateral to the primary tumor and located in retroperitoneum. (biomedcentral.com)
  • Although highly preliminary, the findings suggest that different tumor biological factors may predict response to different chemotherapy regimens with distinct mechanisms of action. (lu.se)
  • The results of our phenotype analysis also indicate that it is more likely that a panel of tumor biological factors instead of only one single factor may be needed for better prediction of chemotherapy response. (lu.se)
  • It was believed to be benign until 1943, when Cooper and Ackerman reported on the malignant biological potential of this tumor. (hindawi.com)
  • With this view in mind, the present study is designed to elucidate the biological behavior of the cancer cells in OSCC respective to their location, using Ki-67 immunological probe for cellular proliferation. (thejcdp.com)
  • Proliferation, as one of the hallmarks and most fundamental biological processes in tumors, is associated with tumor progression, response to therapy, and cancer patient survival. (wikipedia.org)
  • Anticipated technological breakthroughs will create numerous opportunities for determining genetic predisposition, detecting specific tumors, and monitoring biological response to cancer therapy. (aarkstore.com)
  • DS-p16/Ki-67 identified a greater number of women with CIN2-3, addressing 50% of the women to colposcopy, but failing to detect these lesions in 50% of cases. (edu.br)
  • The expression of PCNA also correlates well with other proliferation markers such as mitotic count, S-phase fraction and Ki-67 staining. (wikipedia.org)
  • Expression of cell cycle proteins in head and neck cancer correlates with tumour site rather than tobacco use. (bvsalud.org)
  • The fraction of Ki-67-positive tumor cells (the Ki-67 labeling index, or LI) may correlate with the clinical course of cancer. (cancer.gov)
  • Clinical and outcome characteristics of children with adrenocortical tumors: a report from the International Pediatric Adrenocortical Tumor Registry. (oncolink.org)
  • Biology, clinical characteristics, and management of adrenocortical tumors in children. (oncolink.org)
  • Hence, Ki-67 antigen-labeled cells can prove to be an effective tool to grade the tumors and finally contribute to the prognosis of the disease. (thejcdp.com)
  • The present meta analysis demonstrated that high Ki-67 expression is significantly correlated with poor overall survival and disease free survival, indicating that high Ki-67 expression may serve as a valuable predictive method for poor prognosis of colorectal cancer patients. (hs-analysis.com)
  • To describe the histologic features of bronchiolar adenoma/ciliated muconodular papillary tumors (BA/CMPTs) and analyze the pitfalls in diagnosis from frozen sections. (bvsalud.org)
  • Papillary tumor of the pineal region (PTPR) is a neuroectodermal tumor thought to originate from cells of the subcommissural organ. (thieme-connect.de)
  • Interestingly, tumors with both negative mdm-2 and p21 expression, irrespective of p53 status, had a high response rate to docetaxel but no response to MF. (lu.se)
  • Surgery is the primary treatment of malignant tumors of the salivary glands. (medscape.com)
  • MEC is an extremely rare tumour of the minor salivary glands, accounting for less than 1% of tumours of this origin [3]. (cyberleninka.org)
  • The evaluation of the morphologic profile of the tumor cells is considered to be a determinant factor appropriating the aggressiveness of the tumor. (thejcdp.com)
  • In addition to this, morphologic profiles of the neoplastic cells are different and are unisomorphic at different zones in the same field as well as in different fields of the same tumor, thus creating a scope for confusion. (thejcdp.com)
  • RR CC was named for its morphologic resemblance to pediatric malignant rhabdoid tumor (MRT) of the kidney, which is a highly aggressive tumor characterized by cells that resemble rhabdomyoblasts and by genetic alterations involving chromosome 22, particularly the hSNF5/INI1 gene on 22q11.2. (medscape.com)
  • The predominant component of this tumor has intermediate morphologic features between granulosa cell tumors and Sertoli cell tumors and focal differentiation into either of these tumor types may occur [ 2 ]. (biomedcentral.com)
  • This may include oncomir (oncogenic miRNA) inhibition, or tumor suppressor-miRNA replacement therapies [ 6 , 9 ]. (hindawi.com)
  • However, in recent years, there has been increasing evidence that metformin exerts its anticancer effects through the inhibition of oxidative phosphorylation (OXPHOS) of tumor cell mitochondria, and metabolic pathways based on metformin targeting have only recently become the focus of intensive research. (spandidos-publications.com)
  • Inactivation of antigen KI-67 leads to inhibition of ribosomal RNA synthesis. (journalcra.com)
  • Certain metabolic alterations, also referred to as metabolic reprogramming, are commonly observed in tumor cells and are proposed to be hallmarks of cancer ( 8 ). (spandidos-publications.com)
  • Colorectal cancer (CRC) is one of the most commonly diagnosed malignant tumors in the world. (biomedcentral.com)
  • Sarcomatoid renal cell carcinoma (SRCC) is currently defined in the 2004 World Health Organization (WHO) classification of renal tumors as any histologic type of renal cell carcinoma (RCC) containing foci of high-grade malignant spindle cells. (medscape.com)
  • Focal spindling due to noncohesion of tumor cells is not considered to represent sarcomatoid differentiation. (medscape.com)
  • however, occasional tumors composed entirely of rhabdoid cells have been described in which no RCC component is detected despite extensive sampling. (medscape.com)
  • Thymidine-labeling indexing is determined by counting the number of tumor nuclei labeled on autoradiographed sections after incubating the tumor cells with thymidine. (wikipedia.org)
  • It is recommended to count at least 500 tumor cells in the highest labeled area. (wikipedia.org)
  • For instances, the number of mitotic cells is used to classify tumors. (wikipedia.org)
  • Therapeutic approaches that target the metabolism of tumor cells have been a popular research topic in recent years. (spandidos-publications.com)
  • However, the mitochondrial oxidative phosphorylation (OXPHOS) pathway in tumor cells has also been implicated in lung cancer metabolism. (spandidos-publications.com)
  • Given the vast differences in metabolism between healthy and tumor cells, there is hope that selective targeting of tumor metabolism may be achieved while limiting toxicity to healthy tissue. (spandidos-publications.com)
  • It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. (lookformedical.com)
  • A cell line derived from cultured tumor cells. (lookformedical.com)
  • At least 1000 stromal cells were counted for this analysis, and all Ki-67 indices were determined by one observer. (ijcrr.com)
  • HE staining and IHC results showed a lower necrotic area ratio as well as fewer PCNA or Ki67 positive cells in mice receiving the swimming intervention. (bvsalud.org)
  • A very effective Ki67-CRC module from HS Analysis GmbH can quickly identify both malignant and tumor cells that are on the verge of developing into cancer. (hs-analysis.com)
  • The Ki-67 labeling index, indicating the percentage of Ki-67-positive cells, presents important insight into the tumor's aggressiveness and propensity for growth. (hs-analysis.com)
  • A high Ki-67 labeling index suggests more actively dividing cancer cells since it shows a higher proliferation rate. (hs-analysis.com)
  • The technician by selecting and marking a few amount of tumor cells. (hs-analysis.com)
  • TLR2 was localized in the cell membrane of the colorectal epithelium of the NC group and of the colorectal tumors of the NT group and was highly expressed in the NT group, while antigen Ki67 was localized in the nucleus of the colorectal tumor cells of the NT group and the KT group, and its expression was reduced in the KT group. (biomedcentral.com)
  • Inflammatory infiltrates in areas positive for VSBV-1 RNA and antigen consisted of CD4+ and CD8+ T cells, with perivascular B-cell accumulation. (cdc.gov)
  • Among these cases, 36.5% were associated with PJS and tumors in these patients were usually benign, multifocal, bilateral, calcified, and very small or even microscopic in size. (biomedcentral.com)
  • Microscopic tumor border (circumscribed or infiltrating). (ijcrr.com)
  • The advanced pathological grade was associated with strong TGFB1, VEGFA, and Ki67 protein expression and absent Tp53 staining. (hindawi.com)
  • Germline TP53 mutations are almost always the predisposing factor for adrenocortical tumors. (oncolink.org)
  • Tumor specimens from 259 NSCLC patients were collected and analyzed. (cancerindex.org)
  • For patients with recurrent SCTAT, complete recurrent tumor resection (RTR) was the main treatment of choice. (biomedcentral.com)
  • [ 2 ] Options for second-line therapy in patients with relapsed/refractory disease include chemotherapy-free regimens with biologic targeted agents such as covalent Bruton tyrosine kinase (BTK) inhibitors, lenalidomide,venetoclax, and chimeric antigen receptor (CAR) T-cell therapy. (medscape.com)
  • Results: Positive immmuno-staining for Ki67 was identified in 88% of the patients. (journalcra.com)
  • The long time lapse between transplantation and tumor manifestation, 7 and 11 years, respectively, further supports the concept of multistep carcinogenesis cascade and long-term risk for these patients. (northwestern.edu)
  • Results: Most of patients in the entire category were more than 35 years of age and also severity of all the parameters increased as tumor spectrum shift from benign to malignant side. (ijcrr.com)
  • High levels of TLR2 expression in tumor tissues of colorectal cancer (CRC) patients have been reported. (biomedcentral.com)
  • Other novel markers, such as the E-cadherin cell-adhesion protein, the aryl hydrocarbon receptor-interacting protein (AIP), the cytoskeleton molecule filamin A (FLNA) and the Ki-67 nuclear antigen have also been the highlight of IHC studies on growth hormone (GH)-producing tumors, with promising results regarding their predictive roles for the outcome of acromegalic patients. (rjme.ro)
  • Patients with tumors lacking ERa in general do not charges. (lu.se)
  • 1970. Tumors of the urinary bladder: An analysis of the occupations of 1030 patients in Leeds, England. (cdc.gov)
  • Chronic inhalation exposure to AT particulates in B6C3F1/N mice and Wistar Han rats resulted in increased incidences and tumor multiplicities of alveolar/bronchiolar carcinomas (ABCs). (bvsalud.org)
  • Using paclitaxel (Taxol), another antimicrotubule drug, alone has had moderate activity against mucoepidermoid tumors and adenocarcinomas but no effect adenoid cystic carcinoma. (medscape.com)
  • Adrenocortical tumors encompass a spectrum of diseases with often seamless transition from benign (adenoma) to malignant (carcinoma) behavior. (oncolink.org)
  • Background: Myoepithelial carcinoma is a rare tumour. (cyberleninka.org)
  • Myoepithelial carcinoma (MEC) is a rare tumour that was first described by Stromayer et al. (cyberleninka.org)
  • 9. Iamaroon A, Khemaleelakul U, Pongsiriwet S, Pintong J. Co-expression of p53 and Ki67 and lack of EBV expression in oral squamous cell carcinoma. (bvsalud.org)
  • Expression of p53 in leukoplakia and squamous cell carcinoma of the oral mucosa: correlation with expression of Ki67. (bvsalud.org)
  • The patient was diagnosed with a metastatic phosphaturic mesenchymal tumor. (jbjs.org)
  • Oncogenic osteomalacia secondary to a metastatic phosphaturic mesenchymal tumor in the talus: A case report and review of the literature. (jbjs.org)
  • Requests for reprints: Sofia K. Gruvberger-Saal, Institute for Cancer Genetics, tumors in the adjuvant or metastatic setting. (lu.se)
  • There was no statistically significant association between ABCB1 C3435T and ABCG2 C421A polymorphisms and tissue expression of ER, PR, Her2/neu, and Ki67. (ac.ir)
  • Therefore, for assessment of the Ki-67 labelling index (LI) and area percentage (area%) of Ki-67-positive nuclei, we used only QPRODIT with systematic random sampling. (nih.gov)
  • The percentage of Ki-67-positive tumor nuclei was used to calculate the proliferation index. (ingentium.com)
  • Owing to the rarity of sex cord tumor with annular tubules (SCTAT), it is difficult to recognize SCTAT clinically and there is no standard treatment. (biomedcentral.com)
  • No unique cancer-associated mutations were found, but some viral T antigen mutations were potentially associated with increased rate of viral replication and risk for "rare" carcinogenic events. (northwestern.edu)
  • In this study, we demonstrated Kras (43%) and Egfr (46%) hotspot mutations in mouse lung tumors (n = 80) and only Egfr (50%) mutations in rat lung tumors (n = 26). (bvsalud.org)
  • Knocking out the TLR2 gene also reduced the pathological score and tumor severity. (biomedcentral.com)
  • Most of these tumors are locally confined, and complete but conservative surgical excision is the treatment of choice. (merckvetmanual.com)
  • When tumors are multiple or when surgical excision is not feasible, radiation therapy appears to be the best secondary treatment. (merckvetmanual.com)
  • Carefully planned and executed surgical excision is the primary treatment for all primary salivary gland tumors. (medscape.com)
  • For tumors resistant to radiation and for those animals unable to receive radiation therapy, systemic treatment with administration of chemotherapeutic agents, including melphalan, chlorambucil, cyclophosphamide, and glucocorticoids, have been recommended and have yielded long-term survival. (merckvetmanual.com)
  • The median progression-free survival (PFS) was 97.8 months, and the 1-year and 5-year PFS were 92% and 67%, respectively. (biomedcentral.com)
  • The use of radiation in T1 and T2 parotid gland tumors found that 5-year disease-free survival increased from 70% to 92% with postoperative radiation. (medscape.com)
  • however, there was no statistically significant difference between Ki-67 expression and survival (P = 0.24). (cyberleninka.org)
  • The incidence of adrenocortical tumors in children is extremely low (only 0.2% of pediatric cancers). (oncolink.org)
  • In the non-Brazilian cases, relatives of children with adrenocortical tumors often, although not invariably, have a high incidence of nonadrenal cancers (Li-Fraumeni syndrome). (oncolink.org)
  • In cases in which the histologic subtype of the RCC component is not recognizable, the tumor is designated as unclassified RCC with sarcomatoid differentiation. (medscape.com)
  • RESULTS@#Swimming significantly reduced the body weight and tumor weight in nude mice bearing HCC tumor. (bvsalud.org)