Tumor t lymphocyte subsets. Medical search. Frequent questions

Immune cells can be recruited to the tumor site and form what is known as the tumor microenvironment. (sciencedaily.com)
Notch signaling cascades crosstalk with fibroblast growth factor and WNT signaling cascades in the tumor microenvironment to maintain cancer stem cells and remodel the tumor microenvironment. (spandidos-publications.com)
While GB tumors are frequently infiltrated by natural killer (NK) cells, these are actively suppressed by the GB cells and the GB tumor microenvironment. (frontiersin.org)
Here, we discuss effects of the GB tumor microenvironment on NK-cell functionality, summarize early treatment attempts with ex vivo activated NK cells, and describe relevant CAR target antigens validated with CAR-T cells. (frontiersin.org)
Nevertheless, the composition of the immunologic tumor microenvironment undergoes changes upon radiotherapy, chemotherapy, or even after anti-angiogenic therapy ( 6 ). (frontiersin.org)
TIL exhibit tumor-specificity but are obviously impaired in their capacity to eradicate tumor targets in situ within the tumor microenvironment. (biomedcentral.com)
Mechanistic investigation defined that Axl inhibition reprograms the immunological microenvironment leading to the increased proliferation, activation and effector function of tumor-infiltrating CD4 + and CD8 + T cells possibly through preferential accumulation and activation of CD103 + cross-presenting dendritic cells. (oncotarget.com)
Implication of tumor microenvironment in the resistance to chemotherapy in breast cancer patients. (tilsinbreastcancer.org)
This lack of success may result in part from the fact that most studies focus on tumor cells as potential therapeutic targets and neglect the complex microenvironment that undergoes profound changes during tumor development. (biomedcentral.com)
Furthermore, an unfortunate association of factors such as tumor genetic complexity, overestimation of biomarker and drug potentials, as well as a poor understanding of tumor microenvironment in diagnosis and prognosis leads to the current levels of treatment failure regarding a vast majority of cancer types. (biomedcentral.com)
In this sense, the lack of technologies that would allow for molecular screening of individual stromal cell types poses a major challenge for the development of therapies targeting the tumor microenvironment. (biomedcentral.com)
Unresponsiveness may result, at least in part, because these therapies only target cancer cells and neglect the complex microenvironment around tumors that undergo drastic changes during disease development [ 7 ]. (biomedcentral.com)
In this way, tumor microenvironment cells could represent an extremely attractive therapeutic target either along the course of the disease or during the first steps of malignant transformation. (biomedcentral.com)
Tumor-associated macrophages (TAMs) are key regulators of the complex interplay between cancer and the immune microenvironment. (biomedcentral.com)
However, the mechanism by which SPON2 regulates the accumulation of TAMs in the tumor microenvironment (TME) of CRC is unknown. (biomedcentral.com)
The tumor microenvironment (TME) has been shown to play an essential role in CRC progression and metastasis [ 3 ]. (biomedcentral.com)
However, increasing data has indicated that the clinical potential of most immunotherapies is usually hampered by immunosuppressive status of the tumor microenvironment (TME) [ 7 ]. (thno.org)
γδ T cells recruited into the tumor microenvironment can act as effector cells to mediate cancer immune surveillance. (explorationpub.com)
Therefore, an in-depth understanding of γδ T cells that play conflicting roles in the tumor microenvironment is necessary. (explorationpub.com)
The microenvironment of ovarian carcinomas is mainly represented by macrophages, dendritic cells, neutrophils and lymphocytes. (4science.ge)
Inhibiting DNA methylation and RNA editing upregulates immunogenic RNA to transform the tumor microenvironment and prolong survival in ovarian cancer," J Immunother Cancer, vol. 10, no. 11, p. e004974, Nov. 2022, doi: 10.1136/jitc-2022-004974. (4science.ge)
Oncolytic adenovirus shapes the ovarian tumor microenvironment for potent tumor-infiltrating lymphocyte tumor reactivity," J Immunother Cancer, vol. 8, no. 1, Jan. 2020, doi: 10.1136/jitc-2019-000188. (4science.ge)

Tumor-promoting functions of macrophages include angiogenesis, metastasis formation, and suppression of Th1-type immune responses. (aacrjournals.org)
Strikingly, complete regressions of large established tumors depended on the tumor-infiltrating macrophages that were induced by this immunotherapy, because a small-molecule drug inhibitor targeting CSF-1R diminished the number of intratumoral macrophages and abrogated the complete remissions. (aacrjournals.org)
Myeloid immune cells, specifically tumor-associated macrophages (TAMs), may represent potential novel therapeutic targets in HCC, complementing current ablative or immune therapies. (cancerindex.org)
In advanced disease samples, macrophages produce molecules that support CD8+ T cell exhaustion, at the same time those CD8+ T cells make molecules that supported the life of pro-tumor macrophages. (news-medical.net)
In a vast majority of organs, distinct epithelial tissues form the parenchyma, whereas the stroma constitutes a complex compartment composed of different cell types including fibroblasts and myofibroblasts, vessel cells, pericytes, endothelial and smooth muscle cells, as well as immune cells such as macrophages, lymphocytes and mast cells. (biomedcentral.com)
Tumor cell-derived spondin 2 (SPON2) is an extracellular matrix glycoprotein that has complicated roles in recruitment of macrophages and neutrophils during inflammation. (biomedcentral.com)
Most macrophages have the tendency to polarize into an M2-like state in tumors with advanced stages [ 18 , 19 ]. (biomedcentral.com)
Wei X, Wang J, Liang M, Song M. Development of functional nanomedicines for tumor associated macrophages-focused cancer immunotherapy. (thno.org)
Clinical cancer immunotherapies are usually impeded by tumor immunosuppression driven by tumor associated macrophages (TAMs). (thno.org)
Of note, the TME is rich in immunosuppressive cells (e.g., tumor-associated macrophages (TAMs), regulatory T cells (Tregs), immature dendritic cells (iDCs) and myeloid-derived suppressor cells (MDSCs)), that can suppress antitumor immunity as a result of secretion of various cytokines and chemokines, which enables tumor escape from immune surveillance [ 8 ]. (thno.org)
Compared with controls, the detectable proportion of HIV-1 particles derived from CD14 macrophages and CD26 lymphocytes was increased in persons with acute malaria coinfection and correlated with markedly increased plasma concentrations of both proinflammatory cytokines and soluble markers of macrophage and lymphocyte activation. (lww.com)
The infiltration of multiple types of tumor-promoting immune cells, including myeloid-derived suppressor cells (MDSCs), tumor-associated macrophages (TAMs), regulatory T cells (Tregs) and other immune cells, mediates immune evasion and tumor progression [ 9 ]. (biomedcentral.com)
Activated macrophages kill intracellular organisms and secrete cytokines (eg, tumor necrosis factor-alpha [TNF-alpha], IL-10). (msdmanuals.com)

Therefore the application of immunotherapy has driven the treatment of brain tumors to the study of the response of intratumoral and systemic immune cells and cytokines to these malignancies 10 - 12 . (researchsquare.com)
In two new studies published today in Cancer Cell , researchers from Dana-Farber Cancer Institute and the Broad Institute of MIT and Harvard used the emerging technology of single-cell RNA sequencing to draw a clearer picture of how kidney tumors' microenvironments change in response to immunotherapy. (news-medical.net)
Her research and clinical interests include clinical assay development for tumor immunophenotyping, lymphocyte subset monitoring, and immunotherapy target antigen assessment in a variety of hematologic and immunologic disorders. (stanford.edu)
Tumor infiltrating lymphocytes (TIL) are a universal feature of human cancers and may hold an important key to unlocking effective cancer immunotherapy [ 1 - 3 ]. (biomedcentral.com)
Thus, Axl-directed therapy in Axl expressing tumors could hold a great potential to subvert the innate and/or adaptive resistance to and broaden the coverage of population benefited from ICB-based immunotherapy. (oncotarget.com)
Among the most exciting immunotherapy work being facilitated by the center involves removing a patient's own T cells (a type of lymphocyte), manipulating them in the lab to make them more effective against tumors, then injecting them back into the patient. (duke.edu)
Immunotherapy is currently considered as a promising next-generation therapeutic strategy for various cancers thanks to its ability to modulate cell-specific immune responses toward tumors [ 1 ], which has gradually remodeled the landscape of clinical anticancer modality [ 2 ]. (thno.org)
Among most immunosuppressive cells, TAMs, as crucial drivers of immunosuppressive TME, account for the largest proportion of immune cells in the TME (approximately 50% of tumor mass) [ 9 , 10 ], which possess highly heterogeneity and play a complex regulatory role in tumor immunity and immunotherapy due to helping tumor evade immune surveillance [ 11 ]. (thno.org)
Moreover, TAMs usually display M2-like phenotypes that exert tumor-promoting role in TME, and promote production of related immunosuppressive factors that trigger immunotherapy resistance, including cytokines, chemokines, growth factors and soluble signaling mediators [ 12 ]. (thno.org)
As shown by multiplex tissue immunofluorescence and intravital microscopy, combined immunotherapy treatments enhance T cell infiltration and the intratumoral performance of T lymphocytes. (unav.edu)
What makes the response of PDAC to immunotherapy different from the responses of other solid tumors is the specific host tissue. (biomedcentral.com)

The heterogeneity of tumor infiltrating lymphocytes (TILs) is not well characterized in brain metastasis. (akoyabio.com)
Classifying tumors as either high (>30%) or low (<30%) TILs, we found that increased TILs density correlated with survival. (akoyabio.com)
Contrastingly, the tumors with high TILs displayed higher levels of microglia, as measured by IBA-1 expression. (akoyabio.com)
Researchers determined that the number of tumor-infiltrating lymphocytes (TILs) present in esophageal cancer tumors correlated with patient long-term survival rates. (sciencedaily.com)
A high number of TILs could also help predict a patient's response to treatment aiming to pre-operatively shrink the tumor. (sciencedaily.com)
A subset of these are called tumor-infiltrating lymphocytes (TILs). (sciencedaily.com)
In an article published in Annals of Surgery , a team led by physician researchers at Osaka University determined that the number of TILs present in tumors from esophageal cancer (EC) patients could indicate their likelihood of survival. (sciencedaily.com)
Recently, a scoring system, known as the Immunoscore (IS), has been used to quantify the number of TILs present in and around a tumor. (sciencedaily.com)
To evaluate this, the team used a technique called immunohistochemistry that could help them visualize the TILs within the mixture of other cell types in the tumor. (sciencedaily.com)
In contrast to other cancers such as adenocarcinomas of the lung or melanoma, primary brain tumors like GB and low grade gliomas (LGG) are known as rather immunologically "cold" tumors, typically with low numbers of tumor-infiltrating lymphocytes (TILs) ( 4 ), and the mere amount of TILs is not associated with patient survival ( 5 ). (frontiersin.org)
Adoptive cell therapy using tumor-infiltrating lymphocytes (TILs) has shown activity in melanoma, but has not been previously evaluated in metastatic non-small cell lung cancer. (nature.com)
Autologous TILs were expanded ex vivo from minced tumors cultured with interleukin-2. (nature.com)
The evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer: recommendations by an International TILs Working Group 2014. (tilsinbreastcancer.org)
Tumour infiltrating lymphocytes (TILs) in breast cancer during pregnancy. (tilsinbreastcancer.org)
Ovarian cancer is a heterogeneous disease concerning tumour-infiltrating lymphocytes and TILs. (4science.ge)

Incubation of tumor cells with T cell-derived IFNγ and TNFα recapitulated the chemokine profile observed in vivo , confirming the capacity of antitumor CD8 T cells to mediate macrophage infiltration of tumors. (aacrjournals.org)
Expression of programmed death-ligand 1, IRF1 and CD8 T lymphocyte infiltration in a primary subset of breast cancer patients in Sudan. (bvsalud.org)
This study aimed to investigate the protein expression of programmed death ligand 1 (PD-L1) in breast cancer (BC) tissues and link this data with estrogen status, the expression of interferon regulatory factor1 (IRF-1), and CD8+ T lymphocyte infiltration by immunohistochemistry (IHC). (bvsalud.org)
Lymphocyte infiltration in breast cancer: a key prognostic factor that should not be ignored. (tilsinbreastcancer.org)
Subcutaneous tumor formation and orthotopic implantation assays were performed in C57 BL/6 mice to confirm the effects of SPON2 on TAM infiltration in tumors. (biomedcentral.com)
SPON2 expression is positively correlated with M2-TAM infiltration in clinical CRC tumors and poor prognosis of CRC patients. (biomedcentral.com)
Our findings demonstrate that SPON2-driven M2-TAM infiltration plays an important role during CRC tumor growth and metastasis. (biomedcentral.com)

We tested an essential-oil derivative, camphor white oil (CWO), for anti-tumor activity in a mouse model of keratinocyte-derived skin cancer. (biorxiv.org)
While conventional animal models have identified an array of potential anti-tumor therapies, mouse models often fail to translate into effective human treatments. (biomedcentral.com)
HemoHIM may be a beneficial supplement during cisplatin chemotherapy for enhancing the anti-tumor efficacy and reducing the toxicity of cisplatin. (biomedcentral.com)
Purpose Tumor infiltrating Compact disc4+CD25+FoxP3+ regulatory immune cells (Treg) have been associated with impaired anti- tumor immune response and unfavorable prognosis for individuals affected by ovarian carcinoma whereas CD8+ T-cells have been found out to positively influence survival rates in a large panel of stable tumors. (acancerjourney.info)
Studies possess since aimed at GSK256066 identifying methods to further depict the different cells that are involved in the anti-tumor immune response. (acancerjourney.info)
Treg cells are able to modulate the anti- tumor response of CD8+ effector T-cells and are associated with poor prognosis in ovarian carcinoma [20]-[24]. (acancerjourney.info)

NK cells contribute to cancer immune surveillance not only by their direct natural cytotoxicity which is triggered rapidly upon stimulation through germline-encoded cell surface receptors, but also by modulating T-cell mediated antitumor immune responses through maintaining the quality of dendritic cells and enhancing the presentation of tumor antigens. (frontiersin.org)
Fig. 3: Examples of complete responses mediated by TIL-recognizing tumor antigens. (nature.com)
Fig. 4: Summary of tumor-specific antigens tested for all patients. (nature.com)
Taking advantage of the diverse γδ TCR repertoire or other ligand-receptor interactions, γδ T cells can recognize a broad spectrum of tumor-associated antigens (TAAs) in a major histocompatibility complex (MHC)-independent manner, thereby activating downstream pleiotropic effects. (explorationpub.com)
Efficacy was dependent on the number of CD8+ T cells able to recognize tumor antigens that infiltrated the malignant tissue. (unav.edu)
MHC class I molecules consist of the main mechanism by which cells display viral or tumor antigens to cytotoxic T-cells. (wikidoc.org)

In most solid tumors, the presence of a specific type of immune cell, the CD8+ T cell is a good thing. (news-medical.net)

Comparison of tumor biopsies before and after treatment reveals an increase of activated, conventional CD4+ tumor-infiltrating lymphocytes (TIL) in most patients and higher clonality by TCRβ sequencing. (bepress.com)
The complex interactions that occur between human tumors, tumor infiltrating lymphocytes (TIL) and the systemic immune system are likely to define critical factors in the host response to cancer. (biomedcentral.com)
Diagnostic and therapeutic implications of tumor-infiltrating lymphocytes in breast cancer. (tilsinbreastcancer.org)
Tumor-infiltrating lymphocytes in breast cancer: A new predictor for responses to therapy. (tilsinbreastcancer.org)
Oncogene addiction and immunity: clinical implications of tumour infiltrating lymphocytes in breast cancers overexpressing the HER2/neu oncogene. (tilsinbreastcancer.org)
Tumor Infiltrating Lymphocytes - The Next Step in Assessing Outcome and Response to Treatment in Patients with Breast Cancer. (tilsinbreastcancer.org)
PD-L1 protein expression in breast cancer is rare, enriched in basal-like tumours and associated with infiltrating lymphocytes. (tilsinbreastcancer.org)
Relevance of tumor-infiltrating lymphocytes in breast cancer. (tilsinbreastcancer.org)
Current Issues and Clinical Evidence in Tumor-Infiltrating Lymphocytes in Breast Cancer. (tilsinbreastcancer.org)
Adoptive T-cell therapies using tumor-infiltrating lymphocytes have demonstrated an ability to induce deep and durable responses in a subset of patients with cervical cancer. (medpagetoday.com)
The correlation between tumor-infiltrating lymphocytes and prognosis of malignancy patients has been investigated by several papers throughout the past thirty years [11]-[13]. (acancerjourney.info)
Epithelial ovarian carcinoma-infiltrating lymphocytes (TIL) have attracted much interest in the last five years. (4science.ge)
Treatment regimen, surgical outcome, and t-cell differentiation influence prognostic benefit of tumor-infiltrating lymphocytes in high-grade serous ovarian cancer," Clinical Cancer Research, vol. 22, no. 3, pp. 714-724, Feb. 2016, doi: 10.1158/1078-0432.CCR-15-1617. (4science.ge)

Serum from145 iGCTs patients were collected and lymphocyte subsets were analyzed by flow cytometry. (researchsquare.com)
In addition, leukocyte and lymphocyte subsets were analyzed via flow cytometry, and the production of lipopolysaccharide-induced interleukin 6 and tumor necrosis factor alpha was measured before and then 5 and 45 min after the orgasm. (karger.com)
Methods: Identification of tumour-associated endothelial markers (TEM) by comparing antigen expression on normal vs t-CEC and assess the presence of t-CEC in peripheral blood of cancer patients by incorporating TEM in our novel flow cytometry-based CEC detection assay. (researchgate.net)
Tumor growth was evaluated over time and the phenotype of recovered splenocytes and TIL characterized by flow cytometry and immunohistochemistry (IHC). (biomedcentral.com)
GEP analyses were performed on highly purified, flow-cytometry sorted tumor-cells from eight subgroups of BCLs. (lu.se)

The immune system in NOD/SCID/IL-2Rγnull (NSG) mice was reconstituted by the co-administration of human peripheral blood lymphocytes (PBL) or subsets (CD4+ or CD8+) and autologous human dendritic cells (DC), and animals simultaneously challenged by implanting human prostate cancer cells (PC3 line). (biomedcentral.com)
As a proof of concept, peripheral blood lymphocytes (PBL) and dendritic cells (DC) were obtained from healthy donors and used to reconstitute NSG animals, followed by implantation with cells from the human prostate cancer cell line, PC3. (biomedcentral.com)

Renal cell carcinoma primary tumors and lung metastases are infiltrated by activated natural killer (NK) cells. (nih.gov)
To that effect, we investigated the ability of pre-SABR immune cells in peripheral blood to predict early tumor response to SABR in patients with lung metastases from NSCLC. (biomedcentral.com)
A pre-SABR CD8+CD28+ T-cell count could predict early tumor response to SABR in patients with lung metastases from NSCLC. (biomedcentral.com)
17 ] reported the mean and maximum values of pre-SABR standard uptake value to be both significantly correlated with a complete response within 6 months after SABR treatment of lung metastases from various primary tumors. (biomedcentral.com)

d T cell subset in humans, recognize phosphoantigens, certain tumor cells, and cells treated with aminobisphosphonates. (biolegend.com)
Vγ9Vδ2 T lymphocytes, a major γ/δ T cell subset in humans, recognize phosphoantigens, certain tumor cells, and cells treated with aminobisphosphonates. (biolegend.com)
T Lymphocytes = These cells can either directly kill certain tumor or virally infected cells (CD8+ or "cytotoxic" version) or they can secrete factors that activate other white blood cells (CD4+ or "helper" version). (hiddenrhythmacupuncture.com)

OX40, GITR, and 4-1BB), can enhance T cell immunity in tumor-bearing hosts. (bepress.com)
This humanized platform provides an opportunity to study the two-way interaction that occurs between human immunity and tumor growth, over time, and to manipulate individual components to test hypotheses and potential clinical impact. (biomedcentral.com)
showed that human being tumor Treg cells suppress tumor-specific T-cell immunity and contribute to tumor growth in vivo. (acancerjourney.info)
Some tumor cell-inherent resistance mechanisms, such as the tumor mutational burden and aberrant expression of oncogenic pathways, restrain antitumor immunity [ 10 ]. (biomedcentral.com)

Our work suggests that increases in the tumor-reactive CD103+ CD39+ CD8+ TIL could serve as a potential biomarker of anti-OX40 clinical activity. (bepress.com)
These fascinating clinical data offer strong evidence that evaluating TIL levels in EC tumors could provide valuable information for a personalized medicine approach that could significantly extend patients' lives. (sciencedaily.com)
Phase III clinical trials of Rova‑T for patients with small‑cell lung cancer and a phase III clinical trial of nirogacestat for patients with desmoid tumors are ongoing. (spandidos-publications.com)
Our goal is to establish a humanized tumor model as a more effective pre-clinical platform for understanding and manipulating TIL. (biomedcentral.com)
Here, we found that Axl inhibition by tyrosine kinase inhibitors induces antitumor efficacy critically depending on immune effector mechanisms in two highly clinical relevant murine tumor models. (oncotarget.com)
The clinical significance of tumor infiltrating lymphoctyes in breast cancer: does subtype matter? (tilsinbreastcancer.org)
However, the clinical application of tumor-infiltrating γδ T cells has certain limitations. (explorationpub.com)

Central build up of CD8+ effector cells within the tumor bed shows a positive effect on survival (P? (acancerjourney.info)
Large numbers of and intratumoral penetration by CD8+ effector T-cells were found to slow down tumor growth and have been identified as self-employed prognostic factors for serous ovarian carcinoma [22]. (acancerjourney.info)
On a similar note a high CD8+ effector T-cell-to-Treg cell percentage rather than the complete number of each has been suggested as an independent predictor of survival for patients affected by ovarian carcinoma [14] as well as breast tumor GSK256066 [28]. (acancerjourney.info)

However, it is ambiguous for simple tumor makers to evaluate patients' changing conditions and to predict outcomes, not to mention the evaluation and prognostic significance of patients with negative tumor indicators. (researchsquare.com)
Lymphocytes prognostic in breast cancer. (tilsinbreastcancer.org)
Generally approved prognostic factors are optimal medical debulking histological subtype tumor grading and staging [2] [6]. (acancerjourney.info)

Dynamic monitoring of serum lymphocyte subsets can be used as an auxiliary indicator for prognosis judgment. (researchsquare.com)
0 1 Summary The distribution design of immune cells inside the tumor environment strongly affects prognosis and overall success time of sufferers with ovarian carcinoma. (acancerjourney.info)

These changes of the intratumoral myeloid composition coincided with macrophage recruitment by chemokines, including CCL2 and CCL5, and were completely dependent on a vaccine-induced influx of tumor-specific CD8 T cells. (aacrjournals.org)
Upon mRNA intratumoral injections in the transplantable mouse cancer models CT26, MC38, and B16OVA, potent therapeutic effects were observed following repeated injections into the tumors. (unav.edu)
The results of our study show that the quantitative evaluation of T lymphocytes and their subpopulations does not show a statistically reliable correlation between different histological types of tumours, which may be due to the intratumoral heterogeneity and individual specificity of tumours. (4science.ge)

EC is frequently treated with neoadjuvant chemotherapy (NAC), where attempts are made to shrink the tumor before the primary treatment method, like surgery. (sciencedaily.com)
Physicians still treat a vast majority of tumors using relatively old protocols involving surgery, hormonal therapy, radio and chemotherapy [ 4 ]. (biomedcentral.com)
However, in many cases, chemotherapy or radiotherapy alone cannot achieve a satisfactory therapeutic outcome, namely the complete remission of tumors, and induces severe side effects at therapeutically effective doses. (biomedcentral.com)

More importantly, we show that Axl inhibition induces an adaptive immune resistance evidenced by unregulated PD-L1 expression on tumor cells and combined Axl inhibition with PD-1 blockade mounts a potent synergistic antitumor efficacy leading to tumor eradication. (oncotarget.com)
According to current challenges, there is a need to explore innovative immunotherapies, maximize the tumor-killing efficacy of γδ T cells, and attenuate or eliminate tumor immunosuppression. (explorationpub.com)
Combining tumor-specific adoptive T cell therapy to the aCTLA-4/aPD1/rIL2 or aCTLA-4/aPD1/aCD137 reg-imens enhances efficacy in a synergistic manner. (unav.edu)

To investigate association of apoptosis in the pathogenesis of EBV-associated HLH, the serum EBV loads, and serum concentrations of soluble tumor necrosis factor receptor 1 (sTNF-R1), soluble Fas ligand, and cytochrome c were examined in 15 patien. (researchgate.net)

Alterations in either the innate or adaptive arm of the immune system and cross-talk between them make the immune system tolerant to tumors, leading to disease progression. (wjgnet.com)
shown as early as 2003 that CD3+ lymphocytes influence the progression-free and overall survival rates of individuals [9]. (acancerjourney.info)

Neoadjuvant anti-OX40 (MEDI6469) therapy in patients with head and neck squamous cell carcinoma activates and expands antigen-specific tumor-infiltrating T cells. (bepress.com)
Analyses of CD8+ TIL show increases in tumor-antigen reactive, proliferating CD103+ CD39+ cells in 25% of patients with evaluable tumor tissue (N = 4/16), all of whom remain disease-free. (bepress.com)
The vast majority of Tregs are characterized by expressing CD3 GSK256066 CD4 CD25 the glucocorticoid- induced tumor necrosis element receptor family related gene (GITR) the cytotoxic T-lymphocyte antigen-4 (CTLA-4) and most importantly the transcription element forkhead package P3 (FoxP3) [16]-[19]. (acancerjourney.info)
NK-cells are defined as large granular lymphocytes that do not express T-cell antigen receptors (TCR) or Pan T marker CD3 or surface immunoglobulins (Ig) B cell receptor but that usually express the surface markers CD16 (FcγRIII) and CD56 in humans, and NK1.1/NK1.2 in certain strains of mice. (wikidoc.org)
They can be distinguished by antigen-specific surface receptors and other cell surface molecules called clusters of differentiation (CDs), whose presence or absence define some subsets. (msdmanuals.com)

B-cell lymphomas (BCLs) constitute a diverse set of tially identify new functional, diagnostic, and therapeutic tumors, both morphologically and clinically, that are mainly targets. (lu.se)

Intracranial Germ Cell Tumors (iGCTs) are rare brain tumors that originate from embryonic germ cells. (researchsquare.com)

Cisplatin (cis-diaminedichloroplatinum (II) or CDDP), a platinum-containing anticancer drug, is one of the most commonly used cytotoxic agents for the treatment of a variety of solid malignant tumors. (biomedcentral.com)

This study retrospectively analyzed serum lymphocyte subsets and survival outcomes in intracranial germ cell tumors (iGCTs) patients. (researchsquare.com)
We show that treatment of the mice with a combination of anti-CTLA-4 + anti-PD1 mAbs results in partial clearance of the tumor with an improvement in survival. (unav.edu)
Results We found that FoxP3+ cells located within lymphoid aggregates surrounding the tumor were strongly associated with reduced survival time (P? (acancerjourney.info)

While a basic understanding of the composition and phenotype of TIL has come from the study of human tumors, these studies are limited by patient heterogeneity, a lack of access to corresponding lymphoid tissue, and an inability to directly investigate mechanisms and interactions. (biomedcentral.com)

Tumour tissue determination for transitional mucosa malignancies. (wikipedia.org)
Cancerous tumors are made up of many more components than just malignant cells from the tissue of origin. (sciencedaily.com)
In one study, researchers performed single-cell RNA and T cell receptor sequencing on 164,722 individual cells from tumor and adjacent non-tumor tissue. (news-medical.net)
Immune cells engage in extensive and dynamic crosstalk with stromal components in the tumor tissue in addition to tumor cells, which subsequently impacts tumor suppression or promotion to a large extent. (biomedcentral.com)
In this review, we discuss how infiltrating immune cells influence PDAC development and explore the contributions of complex components to the immune landscape of tumor tissue. (biomedcentral.com)
However, most GEP studies have typically been performed on whole tissue samples, containing varying degrees of tumor cell content, which results in uncertainties in data analysis. (lu.se)

Flow cytometric analysis of TCR Vα24-Jα18 (iNKT cell) expression on human peripheral blood CD3+ lymphocytes. (bdbiosciences.com)
Flow cytometric results showing development of Jin Li, Bo-An Li, and Yuan-Li Mao1 peripheral blood lymphocyte subsets during the disease course were divided into 3 groups on the basis of time of We analyzed changes in immunologic values over time illness onset until date of blood sample collection: 1-3, for 28 hospitalized patients with pandemic (H1N1) 2009. (cdc.gov)
Flow cytometric analysis of peripheral blood lymphocyte understanding of disease pathogenesis. (cdc.gov)

This work led to the accelerated approval of pembrolizumab for PD-L1+ cervical cancers and cervical cancers exhibiting a tumor mutational burden of 10 or greater. (medpagetoday.com)

In another approach, called tumor-infiltrating lymphocyte (TIL) adoptive cell therapy, the subset of a patient's T cells that have already managed to find their way into the tumor are extracted and then grown to large numbers before being returned to the patient. (duke.edu)

On the basis of the expression of CD11b, CD11c, F4/80, Ly6C, Ly6G, and MHC II, we identified four myeloid subpopulations that increased in numbers from 2.0-fold to 8.7-fold in regressing tumors. (aacrjournals.org)
Strong T cell infiltrated VSCC displayed a coordinated immune response reflected by a positive association between T cells and different lymphocyte and myeloid cell subsets. (bmj.com)
The expression of genes involved in the migration of T cells and myeloid cells, T cell activation and costimulation, interferon (IFN)-γ signaling, cytotoxicity and apoptosis was higher than in low infiltrated tumors. (bmj.com)

Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). (thermofisher.com)
Despite SABR's remarkable control of local NSCLC lesions, patients have shown mixed early tumor responses. (biomedcentral.com)
Activated γδ T cells exhibit strong cytotoxic activity and cytokine secretion functions and are effective antitumor lymphocytes with simple and direct recognition modes and rapid responses. (explorationpub.com)

It is common to evaluate lymphocytes subsets in virus infection, immunodeficiency diseases and cancer. (researchsquare.com)
The Notch signaling network exerts oncogenic and tumor‑suppressive effects in a cancer stage‑ or (sub)type‑dependent manner. (spandidos-publications.com)
Defining lymphocyte-predominant breast cancer by the proportion of lymphocyte-rich stroma and its significance in routine histopathological diagnosis. (tilsinbreastcancer.org)
Overexpression of SPON2 has been shown to promote tumor cell migration in colorectal cancer (CRC). (biomedcentral.com)
The thought is that heating a tumor up to 113 F will kill cancer cells but leave healthy cells relatively intact. (hiddenrhythmacupuncture.com)
Natural Killer Cells (NK) = These cells directly attack and kill infected and cancer / tumor cells. (hiddenrhythmacupuncture.com)

To address this, we performed a targeted analysis of immune-cell subsets in brain metastasis tissues to test immunosuppressive routes involved in brain metastasis. (akoyabio.com)

Monocytes are recruited to tumors by chemokines (e.g. (biomedcentral.com)

Immune reconstitution slowed but could not eliminate tumor growth and this effect required the presence of CD4+ T cell help. (biomedcentral.com)

Understanding the components of the TME and their interplay with tumor cells is helpful for developing new strategies against metastatic CRC. (biomedcentral.com)

In contrast, T cell (CD3+) and B cell (CD3-CD20+) subpopulations as well as the production of interleukin 6 and tumor necrosins factor alpha remained unaffected by sexual activity. (karger.com)
Interleukin (IL)-9-producing subset called Th9 cell, Th22 cells which primarily secrete IL-22, IL-13 and tumor necrosis factor- and Th25 cells via producing IL-25 are believed to be important for initiating allergic reactions and developing airway inflammation. (cdc.gov)

For recent decades, it has been recognized that malignant tumor cells potentially induce local and systemic immunosuppression 9 . (researchsquare.com)
Here, the underlying mechanisms of tumor immunosuppression caused by TAMs are first emphatically elucidated, and then the basic design of TAMs-focused immune-nanomedicines are discussed, mainly including diverse categories of nanomaterials, targeted and stimulus-responsive modifications, and TAM imaging in nanomedicines. (thno.org)

These data provide evidence that anti-OX40 prior to surgery is safe and can increase activation and proliferation of CD4+ and CD8+ T cells in blood and tumor. (bepress.com)
Parasite clearance following treatment with antimalarial drugs resulted in decreased detection of HIV-1 particles derived from the CD14 macrophage cell subset and correlated with a marked diminution in systemic immune activation. (lww.com)

Nature communications 2022 - Prdm1 attenuates its effects on tumor growth inhibition through PD-L1-induced tumor immune evasion in immune-competent mice. (thermofisher.com)
These cells may be a key factor ultimately mediating the deviation of the antagonistic response between tumor inhibition and tumor promotion. (explorationpub.com)

However, PDAC is characterized by an abundant tumor stroma that includes a heterogeneous mixture of immune cells, fibroblasts, endothelial cells, neurons and some molecular events. (biomedcentral.com)

The main types of lymphocytes are morphologically indistinguishable but have different immune functions. (msdmanuals.com)

Together, these studies identify T cell-mediated tumor regression as the mechanism through which a plant-derived essential oil diminishes established tumor burden. (biorxiv.org)

a Representative subcutaneous tumors (left)/orthotopic transplantation tumors (right) collected from Hepa1-6-bearing C57BL/6 mice. (thermofisher.com)

76 patients were confirmed germinoma, 29 mixed germ cell tumor, 4 teratoma, 9 malignant teratoma, 6 endodermal sinus tumor, 20 choriocarcinoma and 1 embryonal carcinoma. (researchsquare.com)
They examined tumors from 300 EC patients who did not receive any pre-operative treatment, as well as tumors from 146 EC patients who ultimately received NAC. (sciencedaily.com)
In one report, a subset of patients with limbic encephalitis associated with a systemic neoplasm previously attributed to antibodies against voltage gated potassium channel antibodies actually recognize LGI1 protein complex epitopes and do not represent a channelopathy. (medscape.com)
We evaluated the early tumor response 1 month and 6 months after SABR in these patients following RECIST 1.1 guidelines. (biomedcentral.com)
Twelve patients -- all with tumors expressing PD-L1 -- achieved an objective response. (medpagetoday.com)
55% of Changes during total lymphocyte counts in 4 (14.3%) patients (Table). (cdc.gov)
31% of total lymphocyte counts in 8 (28.6%) patients. (cdc.gov)
In a recent report, a subset of patients with limbic encephalitis associated with a systemic neoplasm previously attributed to antibodies against voltage gated potassium channel antibodies actually recognize LGI1 protein complex epitopes and do not represent a channelopathy. (medscape.com)

In vivo , CWO induced transcriptional changes in immune-related genes, resulting in cytotoxic T cell-dependent tumor regression. (biorxiv.org)

b Tumor proliferation curves of subcutaneous xenografts in Hepa1-6-bearing C57BL/6 mice. (thermofisher.com)

The drugs are designed to stop the immune system from stopping itself, thus allowing it to attack the tumor like any other unwanted pathogen. (news-medical.net)
Simultaneous implantation of human PBL, DC and tumor results in a huPBL-NSG model that recapitulates the development of human TIL and allows an assessment of tumor and immune system interaction that cannot be carried out in humans. (biomedcentral.com)
The work presented in this study carries animal modeling one step further by simultaneously humanizing the immune system of recipient NOD/SCID/IL-2Rγnull (NSG) animals and challenging them with implanted human tumor cells. (biomedcentral.com)
Natural killer cells (or NK cells ) are a type of cytotoxic lymphocyte that constitute a major component of the Innate immune system . (wikidoc.org)
More than 300 CDs have been identified many of which are absent from lymphocytes but present on other cells of the immune system. (msdmanuals.com)

Anatomy44

Organisms12

Diseases37

Chemicals and Drugs80

Analytical, Diagnostic and Therapeutic Techniques and Equipment45

Phenomena and Processes45

Disciplines and Occupations1

Information Science3

Health Care4

Microenvironment22

Macrophages13

Immunotherapy11

TILs15

Infiltration7

Anti-tumor6

Antigens6

Solid tumors1

Infiltrating Lymphocytes13

Flow cytometry5

Dendritic cells2

Metastases4

Certain tumor3

Immunity4

Clinical7

Effector3

Prognostic3

Prognosis2

Intratumoral3

Chemotherapy3

Efficacy3

Necrosis factor receptor1

Progression2

Antigen5

Therapeutic1

Brain tumors1

Malignant tumors1

Survival3

Heterogeneity1

Tissue6

Peripheral blood3

Cancers1

Adoptive1

Myeloid3

Responses3

Cancer6

Metastasis1

Chemokines1

Eliminate tumor1

Metastatic1

Interleukin2

Immunosuppression2

Activation2

Inhibition2

Stroma1

Morphologically1

Burden1

Orthotopic1

Patients8

Vivo1

Proliferation1

Immune system5