• isolates
  • After excluding patients with multidrug-resistant TB, we analyzed 4,289 nonduplicate isolates, of which 3,842 (89.6%) were susceptible to isoniazid and the other 447 (10.4%) were resistant to isoniazid. (cdc.gov)
  • Our results are in agreement with those reported in a previous study in the United States, which found that the rate of isoniazid resistance was lower for isolates from elderly patients ( 1 , 4 ). (cdc.gov)
  • Continuous monitoring of antimicrobial drug resistance among M. tuberculosis isolates isolated from various body sites needs to be incorporated into any TB surveillance program. (cdc.gov)
  • Importantly, the most frequently encountered isoniazid-resistant clinical isolates remain fully susceptible to pyridomycin, thus opening new avenues for drug development. (epfl.ch)
  • rifampin
  • Patients with multidrug-resistant TB were excluded on the basis of evidence for differences in the epidemiology of isoniazid-resistant (rifampin-susceptible) TB and multidrug-resistant TB ( 4 ). (cdc.gov)
  • Daily rifampin (RIF) for 4 months for adults and 6 months for children is recommended when the M. tuberculosis is presumed to be INH-resistant and RIF-susceptible or when INH is contraindicated or is not tolerated by the patient ( 2 ). (cdc.gov)
  • All continuation phases consisted of isoniazid (600 to 1000 mg) and rifampin (600 mg) 3 times/wk for 6 months. (acpjc.org)
  • After an extensive modification program Rifampin was eventually produced, that is orally available and has become a mainstay of Tuberculosis therapy Lepetit filed for patent protection of Rifamycin B in the UK in August 1958, and in the US in March 1959. (wikipedia.org)
  • tuberculin skin
  • Participants who were tuberculin skin test positive (ie, ≥5 mm induration) at enrolment received a substantial benefit from continued isoniazid treatment (0·26, 0·09-0·80, p=0·02), whereas participants who were tuberculin skin test-negative received no significant benefit (0·75, 0·38-1·46, p=0·40). (www.gov.uk)
  • Intervention
  • A total minimum sample size of 1204 is required for the study to detect a 35% reduction in the hazard rates for tuberculosis in the intervention group (h1= 0.052) compared to the control group (h0=0.085) at a power of 80% and a Type II error of 0.05. (clinicaltrials.gov)
  • susceptible
  • After excluding 2 patients with multidrug-resistant TB, we found that 31 patients (mean age 56.6 years) had isoniazid-susceptible TB meningitis and a 50-year-old man had meningitis caused by isoniazid-resistant TB. (cdc.gov)
  • RPT is microbicidal for susceptible M. tuberculosis . (cdc.gov)
  • incidence
  • First, in defining tuberculosis incidence Taylor and associates use, in part, data generated in several surveys of Southeastern U.S. populations (3). (annals.org)
  • The incidence of Tuberculosis (TB) in poor settlements around Cape Town continues to rise despite highly-active-anti-retroviral therapy (HAART) roll-out and DOTS. (clinicaltrials.gov)
  • Drug
  • Tuberculosis, a global threat to public health, is becoming untreatable due to widespread drug resistance to frontline drugs such as the InhA-inhibitor isoniazid. (epfl.ch)
  • These 2 studies are part of an ongoing research program of the Medical Research Council Cardiothoracic Epidemiology Group (British) evaluating effectiveness of short-course, multiple-drug combination chemotherapy in active pulmonary tuberculosis. (acpjc.org)
  • Her early work was studying the tuberculosis drug, isoniazid, and how it worked. (wikipedia.org)
  • These both diseases become dreadful in combination as HIV declines the human immunity while tuberculosis becomes progressive due to defective immune system.This condition becomes more severe in case of multi-drug (MDRTB) and extensively drug resistant TB (XDRTB), which are difficult to treat and contribute to increased mortality. (wikipedia.org)
  • See Multi-drug-resistant tuberculosis. (wikipedia.org)
  • The drug is widely regarded as having helped conquer the issue of drug-resistant tuberculosis in the 1960s. (wikipedia.org)
  • Vitamin B6
  • Among the early achievements of Cadila Laboratories were the production of Isopar, a formulation of the anti-tuberculosis drugs Isoniazid & Para-amino salicylic acid in 1957, and Neuroxin-12, a single-vial mixture of vitamin B1, vitamin B6, and vitamin B12, in 1959. (wikipedia.org)
  • adults
  • In the present study, the resistant rate was lower for M. tuberculosis strains isolated from elderly persons than from younger adults. (cdc.gov)
  • patients
  • 1 ) reported that the risk factors associated with initial isoniazid resistance among patients with tuberculous meningitis in the United States during 1993-2005 included young age (25-34 years) and foreign birth ( 1 ). (cdc.gov)
  • In addition, patients with extrapulmonary TB were less likely than patients with pulmonary TB to be infected with isoniazid-resistant TB. (cdc.gov)
  • Tuberculosis and tuberculosis-related deaths are likely to represent a considerable proportion of morbidity and mortality among HIV-infected patients with high CD4 counts in sub-Saharan Africa. (clinicaltrials.gov)
  • Isoniazid prevents active TB in diverse at- risk patients, and six- and 12-month regimens have a similar effect. (cochrane.org)
  • In fact, death from tuberculosis was greater in diabetic patients. (wikipedia.org)
  • strains
  • Differentiation between individual members of the M tuberculosis complex is possible using a variety of molecular techniques, and individual strains within a species may be further distinguished using a variety of molecular typing methods. (wikipedia.org)
  • Daily
  • Up to 20% of people taking isoniazid experience peripheral neuropathy when taking doses of 6 mg/kg of weight daily or higher. (wikipedia.org)