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  • patients
  • In fact, in recent years, PCR amplification has proven to be invaluable in assisting identification of M. tuberculosis from skin biopsies in patients with negative TB cultures. (asmscience.org)
  • This case highlights the fact that in some patients, analysis of the aqueous may not provide any clue to the confirmation of an active tubercular choroidal granuloma and an association between splenic tuberculosis and choroidal tubercles has never been reported in the past. (springeropen.com)
  • case
  • We report a case of choroidal tuberculoma in a patient with miliary tuberculosis and the features noted on imaging studies performed on this patient which include fundus fluorescein angiography (FFA), indocyanine green angiography (ICG), and optical coherence tomography (OCT). (springeropen.com)
  • Infections
  • Although Tuberculosis therapy remains the most important use of Rifampin, an increasing problem with serious Multiple Drug Resistant bacterial infections has led to some use of antibiotic combinations containing Rifampin to treat them. (wikipedia.org)
  • Intervention
  • A total minimum sample size of 1204 is required for the study to detect a 35% reduction in the hazard rates for tuberculosis in the intervention group (h1= 0.052) compared to the control group (h0=0.085) at a power of 80% and a Type II error of 0.05. (clinicaltrials.gov)
  • isolates
  • After excluding patients with multidrug-resistant TB, we analyzed 4,289 nonduplicate isolates, of which 3,842 (89.6%) were susceptible to isoniazid and the other 447 (10.4%) were resistant to isoniazid. (cdc.gov)
  • Our results are in agreement with those reported in a previous study in the United States, which found that the rate of isoniazid resistance was lower for isolates from elderly patients ( 1 , 4 ). (cdc.gov)
  • Continuous monitoring of antimicrobial drug resistance among M. tuberculosis isolates isolated from various body sites needs to be incorporated into any TB surveillance program. (cdc.gov)
  • Importantly, the most frequently encountered isoniazid-resistant clinical isolates remain fully susceptible to pyridomycin, thus opening new avenues for drug development. (epfl.ch)
  • tuberculin skin
  • Participants who were tuberculin skin test positive (ie, ≥5 mm induration) at enrolment received a substantial benefit from continued isoniazid treatment (0·26, 0·09-0·80, p=0·02), whereas participants who were tuberculin skin test-negative received no significant benefit (0·75, 0·38-1·46, p=0·40). (www.gov.uk)
  • Drug
  • on the mechanism of action of isoniazid, the worldwide known drug against tuberculosis. (epfl.ch)
  • Tuberculosis, a global threat to public health, is becoming untreatable due to widespread drug resistance to frontline drugs such as the InhA-inhibitor isoniazid. (epfl.ch)
  • Previous tuberculosis treatment and abandonment of treatment were risk factors for drug resistance. (scielo.br)
  • Her early work was studying the tuberculosis drug, isoniazid, and how it worked. (wikipedia.org)
  • These both diseases become dreadful in combination as HIV declines the human immunity while tuberculosis becomes progressive due to defective immune system.This condition becomes more severe in case of multi-drug (MDRTB) and extensively drug resistant TB (XDRTB), which are difficult to treat and contribute to increased mortality. (wikipedia.org)
  • See Multi-drug-resistant tuberculosis. (wikipedia.org)
  • The drug is widely regarded as having helped conquer the issue of drug-resistant tuberculosis in the 1960s. (wikipedia.org)
  • incidence
  • First, in defining tuberculosis incidence Taylor and associates use, in part, data generated in several surveys of Southeastern U.S. populations (3). (annals.org)
  • The incidence of Tuberculosis (TB) in poor settlements around Cape Town continues to rise despite highly-active-anti-retroviral therapy (HAART) roll-out and DOTS. (clinicaltrials.gov)
  • adults
  • In the present study, the resistant rate was lower for M. tuberculosis strains isolated from elderly persons than from younger adults. (cdc.gov)
  • strains
  • Differentiation between individual members of the M tuberculosis complex is possible using a variety of molecular techniques, and individual strains within a species may be further distinguished using a variety of molecular typing methods. (wikipedia.org)
  • susceptible
  • Patients with multidrug-resistant TB were excluded on the basis of evidence for differences in the epidemiology of isoniazid-resistant (rifampin-susceptible) TB and multidrug-resistant TB ( 4 ). (cdc.gov)
  • After excluding 2 patients with multidrug-resistant TB, we found that 31 patients (mean age 56.6 years) had isoniazid-susceptible TB meningitis and a 50-year-old man had meningitis caused by isoniazid-resistant TB. (cdc.gov)
  • rifampin
  • After an extensive modification program Rifampin was eventually produced, that is orally available and has become a mainstay of Tuberculosis therapy Lepetit filed for patent protection of Rifamycin B in the UK in August 1958, and in the US in March 1959. (wikipedia.org)
  • resistance
  • 1 ) reported that the risk factors associated with initial isoniazid resistance among patients with tuberculous meningitis in the United States during 1993-2005 included young age (25-34 years) and foreign birth ( 1 ). (cdc.gov)
  • Therefore, to determine the risk factors associated with initial isoniazid resistance among patients with TB in Taiwan, we conducted a retrospective study. (cdc.gov)
  • The World Health Organization (WHO) defines multidrug-resistant tuberculosis (MDR-TB) as TB involving resistance to at least INH and RMP. (scielo.br)
  • pulmonary
  • In addition, patients with extrapulmonary TB were less likely than patients with pulmonary TB to be infected with isoniazid-resistant TB. (cdc.gov)