OrganismsChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentHealth Care
ChloroformTrihalomethanesPlant ExtractsSolventsMethanolHydrocarbons, HalogenatedBathsTrichloroethyleneMethylene ChlorideEtherChromatography, Thin LayerSwimming PoolsSolanum nigrumTrichloroethanesOrthosiphonCajanusHazardous SubstancesDisinfectantsChlorineWater PurificationChlorine Compounds
CHClOccupational Exposure to ChloroformBromodichloromethaneSolventChlorineEthanolMethyl trichlorideCHCl3TrichlorideInhalationATSDRExposuresOdor thresholdDisinfection By-ProductsCarbonConcentrationsHazardousHydrogen chlorideToxicPhosgeneGuidelineVolatileNIOSHEvaporatesAnesthesiaEtherStabilizerDrinking waterSolventsGradeExposure limitTTHMLiverMilkChemicalChemicalsDosesHumansHighPriceIncreaseEventually breaks
CHCl3
  • Chloroform (CHCl 3 ) is a colorless liquid that quickly evaporates into gas. (cdc.gov)
  • The four most common trihalomethanes are dibromochloromethane (CHClBr 2 ), dichlorobromomethane (CHCl 2 Br), trichloromethane (CHCl 3 )-better known as chloroform-and tribromomethane (CHBr 3 ). (acs.org)
  • Chloroform, or Trichloro Methane, is an Organic Compound With Formulation Chcl? (ebaytelezoon.com)
Occupational Exposure to Chloroform3
  • The following resources provide information about occupational exposure to chloroform. (cdc.gov)
  • NIOSH Criteria for a Recommended Standard: Occupational Exposure to Chloroform -DHHS (NIOSH) Publication No. 75-114. (cdc.gov)
  • Occupational exposure to chloroform (trichloromethane) may occur during its production and use as a solvent and chemical intermediate. (who.int)
Bromodichloromethane2
  • In the United States, the EPA limits the total concentration of the four chief constituents ( chloroform , bromoform , bromodichloromethane , and dibromochloromethane ), referred to as total trihalomethanes (TTHM), to 80 parts per billion in treated water. (gochemless.com)
  • H 2 O 2 has a major advantage over chlorine in the treatment of water in that it does not produce THM (trihalomethane) disinfection byproducts like trichloromethane (chloroform) & bromodichloromethane. (indigoinstruments.com)
Solvent6
  • However, the Most Use of Chloroform Within the Usa(United States American) Industry is as a Solvent. (ebaytelezoon.com)
  • Chloroform is a Drab, Volatile Chlorinated Organic Solvent Whose Vapors Have a Narcotic Impact. (ebaytelezoon.com)
  • Chloroform ≥99% Lab Grade is stabilized with Ethanol and appears as a clear, colorless, volatile solvent at room temperature. (laballey.com)
  • Chloroform ≥99% Lab Grade is suitable for use in pesticide analysis, and gas chromatography, and it can be widely used as a common, general laboratory solvent. (laballey.com)
  • Formerly used during surgery as an inhaled anaesthetic, the main application of chloroform today is in agriculture, where it is used as a solvent, and also particularly in the manufacture of the refrigerant freon. (byjus.com)
  • Chloroform is used as a reactant and as a solvent. (ducgiangchem.vn)
Chlorine5
  • Small amounts of chloroform are formed as an unwanted product during the process of adding chlorine to water. (cdc.gov)
  • Chloroform is a by-product formed when chlorine disinfects water but also has many industrial uses (Delaware) . (sentryair.com)
  • When heated or exposed to fire, chloroform generates toxic gases such as phosgene and chlorine. (unc.edu)
  • Chloroform is also formed in swimming pools which are disinfected with chlorine or hypochlorite in the haloform reaction with organic substances (e.g. urine, sweat, hair and skin particles). (gochemless.com)
  • The involvement of excess chlorine/chlorine containing detergent in the cleaning procedure of the milking system or bulk tank can result in a TCM (chloroform) residue in milk. (drinagh.com)
Ethanol2
  • Metabolism of chloroform occurs primarily by cytochrome p-450-dependent pathways, with CYP2E1 (ethanol-inducible) being the primary isozyme responsible (Wang et al. (cdc.gov)
  • Our reagent grade Chloroform (trichloromethane) contains a trace of ethanol as a stabilizer. (sciencecompany.com)
Methyl trichloride1
  • Chloroform, also known as trichloromethane and methyl trichloride, and a chemical compound belonging to the trihalomethane group has the formula CHCl₃. (ducgiangchem.vn)
CHCl31
Trichloride1
  • Useful search terms for chloroform include "methane trichloride" and "trichloromethane. (cdc.gov)
Inhalation7
  • Following inhalation exposure, absorption of chloroform appears to be rapid and extensive. (cdc.gov)
  • Following oral exposure in animal studies, distribution of chloroform appears to be similar to following inhalation exposure, with the primary concentrations in lipophilic tissues (Brown et al. (cdc.gov)
  • On the basis of pharmacokinetic results obtained in rats and mice exposed to chloroform by inhalation, and of enzymatic studies in human tissues in vitro , in vivo metabolic rate constants (VmaxC = 15.7 mg/hour/kg, Km = 0.448 mg/L) were defined for humans (Corley et al. (cdc.gov)
  • Chloroform exposure mainly occurs through inhalation. (sentryair.com)
  • Equipped with a carbon pre-filter and activated granule carbon main filter, these systems help protect the operator from the inhalation hazards of chloroform. (sentryair.com)
  • Aside from a high odor threshold, Chloroform also fatigues the olfactory system through continued exposure by inhalation. (unc.edu)
  • Local symptoms following chloroform inhalation include shortness of breath, and nose and throat irritation. (byjus.com)
ATSDR3
  • This appendix was written based primarily on the Toxicological Profile for Chloroform (ATSDR 1997). (cdc.gov)
  • Animal toxicity studies of inhaled chloroform have provided evidence for absorption, but quantitative estimates have not been reported (see ATSDR 1997). (cdc.gov)
  • The Agency for Toxic Substances and Disease Registry (ATSDR) developed a ToxFAQs sheet on chloroform, where it states that most of the chloroform in air eventually breaks down, but it is a slow process. (sentryair.com)
Exposures2
  • Personal monitoring can be requested to determine potential exposures for individual employees who work with chloroform. (unc.edu)
  • The hazards at this facility included possible chemical burns, damage to the nervous system or liver from methanol exposure, and a suspected cancer risk from chloroform (67663) and carbon-tetrachloride exposures. (cdc.gov)
Odor threshold1
  • The odor threshold for chloroform is 85ppm(415.02 mg/m3)1 (above OSHA's ceiling limit), so it does not have good warning properties. (unc.edu)
Disinfection By-Products1
  • A survey of levels of chloroform, as well as of other disinfection by-products (DBPs), in U.S. drinking water (Weinberg et al. (who.int)
Carbon7
  • The conversion of chloroform to carbon dioxide was highest in mice (80%) and lowest in squirrel monkeys (18%) (Brown et al. (cdc.gov)
  • Regardless of the route of exposure, chloroform is excreted from the body primarily as expired carbon dioxide, although at higher concentrations, where metabolism is saturated, appreciable levels of parent compound may be exhaled as well (Brown et al. (cdc.gov)
  • The process also produces the other three C 1 chlorohydrocarbons-chloromethane, trichloromethane (chloroform), and tetrachloromethane (carbon tetrachloride). (acs.org)
  • A source capture chemical fume extractor equipped with activated granule carbon filtration, is an excellent solution for chloroform vapor control. (sentryair.com)
  • Granule carbon has an intricate porous structure that adsorbs hazardous chloroform molecules before they become airborne and potentially inhaled. (sentryair.com)
  • To ensure chloroform vapors have plenty of time to breakdown and adsorb, a larger carbon filter is recommended. (sentryair.com)
  • A walk through survey was conducted at the Diamond Shamrock Chemical Company, Belle, West Virginia, where chloroform (67663), methylene - chloride (75092), carbon-tetrachloride (56235) and muriatic-acid (7647010) were produced. (cdc.gov)
Concentrations2
  • Immediately Dangerous to Life or Health Concentrations (IDLH) Value Profile: Chloroform -NIOSH reviews relevant scientific data and researches methods for developing IDLH values. (cdc.gov)
  • Concentrations of chloroform in breath appear highly associated with levels in water, and blood and breath levels are also associated with each other (Gordon et al. (who.int)
Hazardous1
Hydrogen chloride1
  • The breakdown products in air include phosgene, which is more toxic than chloroform, and hydrogen chloride, which is also toxic. (cdc.gov)
Toxic1
  • Chloroform can be toxic if inhaled or swallowed. (cdc.gov)
Phosgene1
  • Chloroform on oxidation forms phosgene and hydrochloric acid. (byjus.com)
Guideline2
  • Occupational Health Guideline for Chloroform -This guideline is intended as a source of information for employees, employers, and those in the health professions who need more information on exposure to chloroform. (cdc.gov)
  • This means that if you are able to smell chloroform in the room air, you have surpassed the exposure limit guideline. (sentryair.com)
Volatile1
  • Chloroform is a volatile and colourless liquid which is a trichloromethane derivative with a smell similar to ether. (byjus.com)
NIOSH1
  • NIOSHTIC-2 search results on chloroform -NIOSHTIC-2 is a searchable database of worker safety and health publications, documents, grant reports, and journal articles supported in whole or in part by NIOSH. (cdc.gov)
Evaporates1
  • Chloroform evaporates very quickly when exposed to air. (cdc.gov)
Anesthesia1
  • Chloroform was one of the first inhaled anesthetics to be used during surgery, but it is not used for anesthesia today. (cdc.gov)
Ether2
  • Chloroform is a transparent liquid with a slightly sweet taste and an ether-like odour. (byjus.com)
  • Doctors will use a cloth mask with a constant drip of chloroform (or ether) onto it, placed over the nose and mouth with a wire frame, to knock someone out with chloroform. (byjus.com)
Stabilizer1
  • The Product Incorporates Amylene as a Stabilizer, When You Consider That Chloroform is Liable to Degradation With Time. (ebaytelezoon.com)
Drinking water5
  • You are probably exposed to small amounts of chloroform in your drinking water and in beverages (such as soft drinks) made using water that contains chloroform. (cdc.gov)
  • You are most likely to be exposed to chloroform by drinking water and breathing indoor or outdoor air containing it. (cdc.gov)
  • The general population may be exposed as a result of the presence of chloroform in chlorinated drinking water, ambient air, and some foods. (who.int)
  • Drinking water is the main medium by which people are exposed to chloroform. (who.int)
  • Chloroform may be released into the air as a result of its formation in the chlorination of drinking water, wastewater and swimming pools. (byjus.com)
Solvents1
  • Chloroform is used in some refrigerants, solvents, and chemical manufacturing. (cdc.gov)
Grade7
Exposure limit1
  • The Federal Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (PEL) for chloroform is 50 ppm (244.13 mg/m3) as a ceiling limit (exposure must never exceed this level). (unc.edu)
TTHM1
  • Our study concluded that increased use of products containing the antimicrobial agent TCS contributes to higher levels of total organochlorine contaminant, trichloromethane, leading to an increase in TTHM levels recorded annually on water quality reports. (scirp.org)
Liver3
  • After whole-body autoradiography to study the distribution of inhaled 14C-labeled chloroform in mice, most of the radioactivity was found in fat immediately after exposure, while the concentration of radioactivity in the liver increased during the postanesthetic period, most likely due to covalent binding to lipid and protein in the liver (Cohen and Hood 1969). (cdc.gov)
  • Breathing air with chloroform for a long period damages the brain, liver and kidneys. (sentryair.com)
  • Chloroform is a suspect carcinogen (IARC Group 2B) which can cause adverse health effects to the cardiovascular system, central nervous system, blood, liver, kidney and nerves. (unc.edu)
Milk1
  • The spectrum of pure chloroform is used as the reference or background, and pure cholesterol powder or cholesterol extract from milk products is dissolved in chloroform and used for FTIR analysis. (byjus.com)
Chemical6
  • Chloroform enters the environment from chemical companies and paper mills. (cdc.gov)
  • If you work in an industry that uses chloroform, please read chemical labels and the accompanying Safety Data Sheets for hazard information. (cdc.gov)
  • This reduces the nose's ability to detect chloroform, which would increase the ppm of chloroform in the air needed to detect the chemical. (unc.edu)
  • All operations involving handling chloroform must be conducted in a properly operating chemical fume hood. (unc.edu)
  • Chloroform is an organic chemical compound initially employed as an ideal anaesthetic . (byjus.com)
  • Chloroform is an industrial chemical that can act as a lacrimator. (byjus.com)
Chemicals1
  • Nearly all the chloroform made in the United States today is used to make other chemicals, but some is sold or traded to other countries. (cdc.gov)
Doses1
  • 1972). Experiments in mice, rats, and monkeys indicate that oral doses (up to 60 mg/kg) of 14C-labeled chloroform in olive oil were almost completely absorbed, as indicated by an 80-96% recovery of radioactivity in expired air, urine, and carcass (Brown et al. (cdc.gov)
Humans4
  • 1986). Studies of distribution of chloroform in humans following oral exposure are not available. (cdc.gov)
  • 1974). Similarly, chloroform metabolism was calculated to be slower in humans than in rodents. (cdc.gov)
  • There is inadequate evidence in humans for the carcinogenicity of chloroform. (who.int)
  • Chloroform is possibly carcinogenic to humans (Group 2B) . (who.int)
High1
  • Due to its lipophilic character, chloroform accumulates to a greater extent in tissues of high lipid content. (cdc.gov)
Price1
Increase1
Eventually breaks1
  • Most chloroform in the air eventually breaks down, but this process is slow. (cdc.gov)