RituximabVincristineRadiotherapyDoxorubicinEtoposideChemotherapyChemotherapeutic agentsMelphalanRats1985PotentSystemicEpidemiologyPatientsDiagnosis and treatmentWidelyCancersSurvivalImmunosuppressiveOutcomesPrognosisImmunotherapyClinical trialsDrugsTumorsPathophysiologyCombinationProgressionResultsSurveillanceSurgicalLeukemiaPregnancyCasesDisordersCommonProgressDataTotalMedicationCharacteristicsShownPatientLong-termMolecularDiseaseNoteYearWomenDrugType
Rituximab3
- The efficacy of intensive immunosuppressive therapy with agents such as cyclophosphamide (CYC) or rituximab (RTX) has been established as a remission-inducing therapy in patients with organ/life-threatening AAV 1-5 and is recommended as a conventional therapy. (bmj.com)
- AML - Acute Myeloid Leukaemia The elderly still do badly Targeted therapy anti CD33 (Mylotarg) RIC transplant for the older patient - (50-65) ALL - Acute Lymphoblastic Leukaemia Adults still do badly Kids 90% survival Adults 35% survival Antibody treatment arrives Rituximab may also be useful in ALL More transplant! (slidesfinder.com)
- MYC Pathway Activation Is Frequently Observed in Treatment-Naive CLL and Defines a Subgroup with Particular Benefit from the Addition of Rituximab to Chemotherapy. (uni-koeln.de)
Vincristine1
- Subsequently, a combination of cyclophosphamide (CTX), vincristine (VCR), and methotrexate (MTX) was shown to be active, but a survival advantage compared to CTX alone could not be demonstrated because effective CNS prophylactic therapy, in the form of intrathecal therapy, was not given. (hindawi.com)
Radiotherapy6
- Dose-dependent risks were observed after radiotherapy and treatment with melphalan and cyclophosphamide. (elsevierpure.com)
- Melphalan is a more potent leukemogen than cyclophosphamide or radiotherapy. (elsevierpure.com)
- This staging system was used to select the appropriate treatment regimen: chemotherapy in combination with thoracic radiotherapy in patients with LS-SCLC, and chemotherapy alone in patients with ES-SCLC. (ersjournals.com)
- NPC is mainly treated by RT and is profoundly radiosensitive and radiotherapy treatment is the spine of treatment for all stages of NPC without far off metastases. (intechopen.com)
- At a time when modern radiation treatment like intensity-modulated radiotherapy (IMRT) are accomplishing great good local control, distant metastases are getting to be the transcendent design of treatment failure, particularly in patients with locally progressed illness. (intechopen.com)
- Radiotherapy remains one of the corner stones in the treatment of various malignancies and often leads to an improvement in overall survival. (biomedcentral.com)
Doxorubicin1
- Chemotherapy treated patients usually get a combination of three drugs - fluorouracil, doxorubicin, and cyclophosphamide. (real-agenda.com)
Etoposide1
- The first-line treatment of ES-SCLC currently consists of chemotherapy with a platinum derivative and etoposide, a combination that was first reported to be effective in the treatment of SCLC in 1985 8 , 9 . (ersjournals.com)
Chemotherapy5
- So does it seem reasonable that researchers claim that exposing pregnant women to chemotherapy (a deadly treatment that kills living cells) does not APPEAR to affect the fetus? (real-agenda.com)
- Eighteen patients received adjuvant chemotherapy as a component of primary treatment (9 FIGO stage I, 9 stage II - IV) and seven after recurrence. (thieme-connect.de)
- Treatment involves surgery, radiation therapy, and chemotherapy. (merckmanuals.com)
- There are numerous results from clinical trials looking at combined radiation treatment (RT) and chemotherapy for NPC. (intechopen.com)
- Common risk factors for developing MDS include advanced age, male gender, and antecedent exposure to chemotherapy or radiation as treatment for other cancers, which alone accounts for 10% of MDS cases. (jnccn.org)
Chemotherapeutic agents2
- For tumors resistant to radiation and for those animals unable to receive radiation therapy, systemic treatment with administration of chemotherapeutic agents, including melphalan, chlorambucil, cyclophosphamide, and glucocorticoids, have been recommended and have yielded long-term survival. (merckvetmanual.com)
- To date, many different chemotherapeutic agents have been widely used as common treatments for oral cancers. (oncotarget.com)
Melphalan1
- Melphalan was 10 times more leukemogenic than cyclophosphamide (relative risk, 31.4 vs. 3.1). (elsevierpure.com)
Rats1
- In experiments on male albino rats cyclophosphamide (100-250 mg/kg) was shown to produce a hepatic lesion presented with the increase in the activity of alanine- and aspartate aminotransferase of blood serum, and the inhibition of secretion of bile, bile acids and bilirubin. (bvsalud.org)
19851
- We conducted a case-control study in a cohort of 82,700 women given a diagnosis of breast cancer from 1973 to 1985 in five areas of the United States. (elsevierpure.com)
Potent2
- Cyclophosphamide (CP) is one of the most potent and widely used alkylating anticancer agents. (researchwap.com)
- This type of barbaric cancer treatment and the potent drug regimen during pregnancy carries the possibility of having disastrous effects in many cases. (real-agenda.com)
Systemic2
- The present review addresses the systemic tumour-directed treatment of ES-SCLC. (ersjournals.com)
- If a doctor treats a systemic infection without first doing a culture and sensitivity test to determine which bacteria is involved and which antibiotics the bacteria is sensitive to, then he might prescribe the wrong treatment and thereby strengthen the infection. (dunphynunley.com)
Epidemiology2
- Comparing adult and pediatric rhabdomyosarcoma in the surveillance, epidemiology and end results program, 1973 to 2005: An analysis of 2,600 patients. (merckmanuals.com)
- Radiat epidemiology, and end results experience, 1973-2000. (who.int)
Patients5
- The objective of this research was to synthesize studies that characterize the clinical and epidemiological profile of patients with leukemia, the types of treatments used, duration and outcomes for the cases. (sld.cu)
- Although leukemia occurs in few patients with breast cancer, significantly elevated risks were linked to treatments with regional radiation and alkylating agents. (elsevierpure.com)
- However, the therapeutic efficacy of MMF compared with that of cyclophosphamide (CYC) in patients with AAV has not been established. (bmj.com)
- In the CYCLOPS Study, the rate of adverse events was relatively high (the percentages of leucocytopenia and infections in patients after intravenous CYC treatment were both 26% and those after oral CYC treatment were 45% and 29%, respectively). (bmj.com)
- Chimeric antigen receptor (CAR) T-cell therapy is an example of how immunotherapy is revolutionizing the treatment of hematologic malignancies with unprecedented response rates in patients with relapsed/refractory lymphoma, multiple myeloma, and acute lymphoblastic leukemia. (ajmc.com)
Diagnosis and treatment1
- Triple negative breast cancer (TNBC) is the most aggressive variant of breast malignancies, being a heterogeneous group with various molecular abnormalities that require differentiated approach to diagnosis and treatment. (cttjournal.com)
Widely3
- Many natural products have been widely reported to ameliorate at varying degrees the side effects of oxazophosphorines e.g. cyclophosphamide and ifosphamide (Łukasz and Piotr, 2012). (researchwap.com)
- Cyclophosphamide, [2-[bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxzaphosphorine-2- oxide] is one of the most effective and widely used cytotoxic antitumor agents. (researchwap.com)
- Immunohistochemistry (IHC) markers, together with clinicopathological variables such as tumor size, tumor grade, nodal involvement, histologic type, and surgical margins, have been widely used for prognosis, prediction and treatment selection [ 9 , 10 ]. (jcancer.org)
Cancers2
- Burkitt lymphoma (BL), in spite of its low incidence throughout most of the world, has had a major impact upon the understanding and treatment of lymphomas and doubtless upon many other cancers. (hindawi.com)
- 1995). in Five Continents, Vol. I to VIII IARC CancerBase No. 7, Lyon, [Current treatment of cancers of the anal canal]. (who.int)
Survival3
- In contrast, little progress has been made in the treatment of extensive-stage SCLC (ES-SCLC), apart from the recently documented survival gain by the addition of prophylactic cranial irradiation. (ersjournals.com)
- New treatments are needed in order to improve the prognosis of ES-SCLC, as median survival with current standard treatment is still only 9-10 months from diagnosis. (ersjournals.com)
- Combined chemo- and hormone therapy is, generally, efficient in breast cancer treatment, in terms of overall and disease-free survival. (cttjournal.com)
Immunosuppressive1
- Most uveitis seen in Western countries is noninfectious and appears to be autoimmune or autoinflammatory in nature, requiring treatment with immunosuppressive and/or anti-inflammatory drugs. (dovepress.com)
Outcomes2
- Outcomes and treatments were analyzed retrospectively. (bmj.com)
- In this article, the authors present a comprehensive review of the basic principles and practices underlying the causes, diagnosis, treatment, and outcomes of pediatric-type diffuse high-grade glioma. (medlink.com)
Prognosis4
- Although SCLC is very chemoradiosensitive and high response rates are obtained with treatment, relapse rates are high and the prognosis remains very poor. (ersjournals.com)
- Treatment recommendations are based loosely on those for ovarian carcinoma, although the two entitites differ considerably in tumor biology and prognosis. (thieme-connect.de)
- Pathologic classification and its relation to prognosis and treatment. (thieme-connect.de)
- Recently, improvement has been noted in the prognosis and clinical outcome of the disease mainly as a result of the application of macrolide treatment. (pneumon.org)
Immunotherapy1
- Important treatments include corticosteroids and immunotherapy. (medlink.com)
Clinical trials1
- Currently many clinical trials are in progress aimed at the identification of the most appropriate treatment for each specific type of bronchiolitis. (pneumon.org)
Drugs1
- However, the availability within the past decade of 3 drugs, azacitidine, lenalidomide, and decitabine, 3 - 5 which were approved by the FDA specifically for the treatment of MDS, has partly spurred the maturation rate of epidemiologic knowledge. (jnccn.org)
Tumors4
- Most of these tumors are locally confined, and complete but conservative surgical excision is the treatment of choice. (merckvetmanual.com)
- Treatment for these tumors targets local control using localized techniques described above. (merckvetmanual.com)
- When tumors are multiple or when surgical excision is not feasible, radiation therapy appears to be the best secondary treatment. (merckvetmanual.com)
- Malignant ovarian germ cell tumors: identification of novel prognostic markers and long-term outcome after multimodality treatment. (kaiserpermanente.org)
Pathophysiology1
- whilst both may present with similar clinical features, they are best considered as distinct disease entities since the underlying pathophysiology and treatment strategies are very different. (dovepress.com)
Combination1
- The results not only help the practitioner and patient choose an effective combination of therapies, but also helps them understand which cancer genes (oncogenes) are blocked by which treatments. (dunphynunley.com)
Progression1
- Yet, far less attention is paid to the effects of these treatments on tumor progression as reflected by the metastatic process. (biomedcentral.com)
Results1
- The fact that it was discovered in equatorial Africa and much of the groundwork for the evolution of its treatment was conducted in equatorial Africa in the 1960s and 70s, but little since, is an indication of the great loss to research that results from the enormous differences in resources that exist among the world's countries. (hindawi.com)
Surveillance1
- Methods Between February 2013 and February 2020, all women with hydatidiform mole in Dalian Women's and Children's Medical Center (Group) were registered for surveillance and treatment when indicated. (bmj.com)
Surgical1
- Treatment measures include pharmacologic, surgical, and physical therapy. (medscape.com)
Leukemia3
- As the therapy is used, each leukemia subtype had its peculiarities regarding the treatment, especially the introduction of imatinib for chronic myeloid leukemia (CML) and prophylactic cranial irradiation for cases of ALL. (sld.cu)
- Chronic leukemia showed higher treatment duration. (sld.cu)
- Role of signal transduction inhibition in treatment of acute myelogenous leukemia/myelodysplasia. (rochester.edu)
Pregnancy1
- Risk of obstetric and perinatal complications in women presenting with breast cancer during pregnancy and the first year postpartum in Sweden 1973-2017: A population-based matched study. (cancercentrum.se)
Cases1
- Since its recognition in 1973, over 400 cases have been reported in the literature. (medlink.com)
Disorders1
- In the past, medicinal plants were used intensively in folkloric medicine for treatment of various disorders. (pharmatutor.org)
Common2
- Low risks were associated with the levels of cyclophosphamide in common use today. (elsevierpure.com)
- This drug is indicated in the treatment of moderately severe infections due to penicillin-G-susceptible microorganisms that are susceptible to serum levels common to this particular dosage form. (pfizermedicalinformation.com)
Progress3
- Progress in the Treatment of Hodgkin's Lymphoma Longo DL, DeVita VT . (yale.edu)
- Progress in the Treatment of Hodgkin's Lymphoma. (yale.edu)
- This symposium presents a remarkable opportunity to convene with other researchers, clinicians, and industry leaders to discuss the extraordinary progress and immense potential of new drug therapies and technologies in paving the way for a brighter future in cancer treatment. (nyas.org)
Data1
- Since 1973, data on ambulatory patient visits to physicians' offices have been collected through the National Ambulatory Medical Care Survey (NAMCS). (cdc.gov)
Total1
- There was little increase in the risk associated with total cyclophosphamide doses of less than 20,000 mg. (elsevierpure.com)
Medication2
- Gestonorone caproate, also known as gestronol hexanoate or norhydroxyprogesterone caproate and sold under the brand names Depostat and Primostat, is a progestin medication which is used in the treatment of enlarged prostate and cancer of the endometrium. (wikipedia.org)
- See Treatment and Medication for more detail. (medscape.com)
Characteristics1
- We also performed a brief review of the literature concerning this association, its clinical characteristics, and treatment. (ecancer.org)
Shown1
- Objectives A few studies on antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) treatments have shown the therapeutic efficacy of mycophenolate mofetil (MMF). (bmj.com)
Patient2
- Issues in Haematological Malignancy 2010 Prof. A H Goldstone CBE AML ALL CML CLL Myeloma Lymphoma There is more that can be achieved almost everywhere and the PCTs and Insurance Companies are running scared The patient over 70 years starts to get proper treatment! (slidesfinder.com)
- As with any chronic disease, patient education is vital to familiarize the patient with the symptoms, course, and treatment of the disease. (medscape.com)
Long-term1
- The 6-month remission rate (RR 1.09, 95% CI 0.86 to 1.38, p=0.48), the 6-month ANCA negativity (RR 1.31, 95% CI 0.91 to 1.90, p=0.15) and the long-term relapse rate (RR 1.36, 95% CI 0.80 to 2.31, p=0.26) were all similar between the two treatments. (bmj.com)
Molecular1
- Basal-like triple-negative breast cancer (TNBC) makes up 12-20% among other histological types, displaying a number of clinicopathological and molecular features that affect treatment strategy. (cttjournal.com)
Disease1
- No definite disease-modifying treatment exists for individuals with ankylosing spondylitis (AS) although biologic agents show evidence of such activity. (medscape.com)
Note1
- NOTE: Treatment with the recommended dosage is usually given at a single session using multiple IM sites when indicated. (pfizermedicalinformation.com)
Year2
Women1
- Instead of referring pregnant women to natural cancer treatments that are entirely safe for their unborn children, oncologists are pushing them toward the "cure-all" of the corrupt cancer industry chemo. (real-agenda.com)
Drug1
- In 2019, the US Food and Drug Administration (FDA) approved certolizumab for treatment of nonradiographic axial spondyloarthritis (nr-axSpA) with objective inflammation. (medscape.com)
Type1
- Such treatment was associated with upregulation of invasion- and inflammation-promoting soluble factors, such as matrix metalloproteinase 2 (MMP2), its activator MMP14, tissue inhibitors of matrix metalloproteinase 2 (TIMP2), chemokine ligand 2 (CCL2), and urokinase-type plasminogen activator (uPA), the latter two being linked to the recruitment of the monocytic cells. (biomedcentral.com)