Transporter symporters. Medical search. Frequent questions

Sodium Potassium Chloride Symporter Inhibitors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
This graph shows the total number of publications written about "Sodium Potassium Chloride Symporter Inhibitors" by people in this website by year, and whether "Sodium Potassium Chloride Symporter Inhibitors" was a major or minor topic of these publications. (umassmed.edu)
Below are the most recent publications written about "Sodium Potassium Chloride Symporter Inhibitors" by people in Profiles. (umassmed.edu)
Mechanistic understanding of dynamic membrane proteins such as transporters, receptors, and channels requires accurate depictions of conformational ensembles, and the manner in which they interchange as a function of environmental factors including substrates, lipids, and inhibitors. (uni-regensburg.de)

The protein encoded by this gene is a transmembrane protein and sodium-dependent lysophosphatidylcholine transporter. (nih.gov)
carbohydrate transmembrane transporter/ hexose:hydrogen symporter/ high-affinity hydrogen:glucose symporter/ su. (cornell.edu)

The serotonin transporter (SERT) regulates neurotransmitter homeostasis through the sodium- and chloride-dependent recycling of serotonin into presynaptic neurons 1-3 . (rcsb.org)
The dopamine and noradrenaline transporters, together with SERT, are members of the neurotransmitter sodium symporter (NSS) family. (rcsb.org)
Sodium and aspartate symporter Glt Ph is an archaeal homolog of human glutamate transporters, which clear the neurotransmitter glutamate from the synaptic cleft following rounds of neurotransmission ( Danbolt, 2001 ). (elifesciences.org)
MetS, as described in the Gram-positive bacterium Corynebacterium glutamicum, is the small subunit of MetPS, an NSS (Neurotransmitter:Sodium Symporter) transporter involved in methionine and alanine import. (nih.gov)

Arribas-González E, de Juan-Sanz J, Aragón C, López-Corcuera B (2015) Molecular basis of the dominant negative effect of a glycine transporter 2 mutation associated with hyperekplexia. (springer.com)

To facilitate uptake and conversion of glucose at low extracellular concentrations, activity of high-affinity transporters ( K M ~ 1 mM) is required, in combination with hexokinase activity to 'trap' the sugar inside the cell in its phosphorylated form and therefore maintain a glucose concentration gradient over the cellular membrane [ 15 ]. (biomedcentral.com)

In response to parathyroid hormone and dietary inorganic phosphate, the renal cotransporter is rapidly inserted into and retrieved from the renal brush border membrane in a fashion similar to that by which the glucose transporter (Glut4) (TC# 2.A.1.1) is regulated by insulin, and aquaporins 1 and 2 (TC# 1.A.8.1) are regulated by vasopressin (Levi et al. (tcdb.org)

The gluconate:H+ symporter (GntP) family (TC# 2.A.8) is a family of transport proteins belonging to the ion transporter (IT) superfamily. (wikipedia.org)
A representative list of proteins belonging to the GntP family can be found in the Transporter Classification Database. (wikipedia.org)
In particular, human organic cation transporter 2 (hOCT2) and multidrug and toxin extrusion proteins 1 and 2-K (hMATE1/2-K) likely mediate renal secretion of mIBG, whereas hOCT1 and hOCT3 may contribute to mIBG uptake into normal tissues such as the liver, salivary glands, and heart. (aspetjournals.org)
Norepinephrine transporter, organic cation transporters, and multidrug and toxin extrusion proteins play differential roles in tumor targeting, systemic elimination, and accumulation in normal tissues. (aspetjournals.org)
The PNaS family includes several functionally characterized, sodium-dependent, inorganic phosphate (P i ) transporter (NPT2 or NptA) proteins from mammals. (tcdb.org)
Transporters are a diverse group of membrane proteins that facilitate the movement of water-soluble solutes through the lipid bilayer of biological membranes. (biologists.com)
Multidrug resistance (MDR) proteins belonging to the ATP-Binding Cassette (ABC) transporter group play a crucial role in the export of cytotoxic drugs across cell membranes. (bvsalud.org)

To apply this strategy to increase the ethanol yield on sucrose, we constructed a platform strain in which all genes encoding hexose transporters, disaccharide transporters and disaccharide hydrolases were deleted, after which a combination of a glucose-proton symporter, fructose-proton symporter and extracellular invertase ( SUC2 ) were introduced. (biomedcentral.com)
This study provides a proof-of-concept for the replacement of the endogenous hexose transporters of S. cerevisiae by hexose-proton symport, and the concomitant decrease in ATP yield, to greatly improve the anaerobic yield of ethanol on sugar. (biomedcentral.com)
In such environments, the high extracellular glucose concentration can drive the uptake of glucose by yeast cells via diffusion, which is exemplified by the occurrence of many hexose transporters with a facilitated diffusion mechanism in S. cerevisiae . (biomedcentral.com)

Transporters on the plasma membrane of tumor cells are promising molecular "Trojan horses" to deliver drugs and imaging agents into cancer cells. (aspetjournals.org)
similarly found next to an NSS transporter large subunit, may be barely half that length and consist almost entirely of a predicted hydrophobic region that would localize to within the plasma membrane. (nih.gov)
The symporter works in the plasma membrane which exists in plants. (lu.se)

The pharmacological correction of folding defects was originally explored in mutants of the serotonin transporter (SERT, SLC6A4), which were created to study the COPII-dependent export from the endoplasmic reticulum. (springer.com)
Anderluh A, Hofmaier T, Klotzsch E, Kudlacek O, Stockner T, Sitte HH, Schütz GJ (2017) Direct PIP2 binding mediates stable oligomer formation of the serotonin transporter. (springer.com)
Bhat S, Hasenhuetl PS, Kasture A, El-Kasaby A, Baumann MH, Blough BE, Sucic S, Sandtner W, Freissmuth M (2017) Conformational state interactions pro-vide clues to the pharmacochaperone potential of serotonin transporter partial sub-strates. (springer.com)

The SURFE²R 96SE is a 96 well plate-based analysis device for the measurements of electrogenic transporters (symporters, exchangers and uniporters) and pumps. (selectscience.net)
The least complex transporters are the uniporters ( Kakuda and MacLeod, 1994 ). (biologists.com)
At the opposite end of the transporter spectrum from uniporters are the molecular devices that carry out primary active transport. (biologists.com)

non-synonymous changes in the coding sequence give rise to mutated transporters, which are misfolded and thus cause diseases in the affected individuals. (springer.com)

The structural bases of their function are well established, particularly within a model archaeal homolog, sodium, and aspartate symporter Glt Ph . (elifesciences.org)
Briefly, the transporters are homotrimers with each protomer consisting of a centrally located scaffold or trimerization domain and a peripheral transport domain that harbors the L-aspartate (L-asp) and three sodium (Na + ) ions binding sites. (elifesciences.org)

high confidence medium confidence low confidence transporter - transporters and PTS systems are shaded because predicting their specificity is particularly challenging. (lbl.gov)

Since carriers are much more closely related, at least mechanistically, to symporters and antiporters than to channels, they are the type of uniporter emphasized in this volume. (biologists.com)
Nelson and Lill, 1994 ) the decision as to whether they are symporters or antiporters depends upon the direction of translocation, relative to that of the primary driving ion, of the substrate of greatest physiological importance. (biologists.com)

Agents that inhibit SODIUM-POTASSIUM-CHLORIDE SYMPORTERS which are concentrated in the thick ascending limb at the junction of the LOOP OF HENLE and KIDNEY TUBULES, DISTAL. (umassmed.edu)
A subclass of symporters that specifically transport SODIUM CHLORIDE and/or POTASSIUM CHLORIDE across cellular membranes in a tightly coupled process. (nih.gov)

Glutamate transporters are essential players in glutamatergic neurotransmission in the brain, where they maintain extracellular glutamate below cytotoxic levels and allow for rounds of transmission. (elifesciences.org)

Asjad HMM, Kasture A, El-Kasaby A, Sackel M, Hummel T, Freissmuth M, Sucic S (2017) Pharmacochaperoning in a Drosophila model system rescues human dopamine transporter variants associated with infantile/juvenile parkinsonism. (springer.com)
Beerepoot P, Lam VM, Salahpour A (2016) Pharmacological chaperones of the dopamine transporter rescue dopamine transporter deficiency syndrome mutations in heterologous cells. (springer.com)

In the yeast Saccharomyces cerevisiae , which is widely applied for industrial bioethanol production, uptake of hexoses is mediated by transporters with a facilitated diffusion mechanism. (biomedcentral.com)

The tonoplast H+:Inositol symporter 1, Int1 (mediates efflux from the tonoplast to the cytoplasm (Schneider et al. (lbl.gov)

In vertebrate skeletal muscle, the vitamin C transporter SVCT2 is preferentially expressed in slow muscle fibers. (nih.gov)
The vertebrate sodium-iodide symporter (NIS or SLC5A5) transports iodide into the thyroid follicular cells that synthesize thyroid hormone. (zfin.org)

Using the same set of states shown, we can wire together a 'symporter' (co-transporter) which transports one A and one B molecule together. (physicallensonthecell.org)

Employing solid-supported membrane (SSM)-based electrophysiology, SURFE²R 96SE can resolve small currents of transporters and pumps in a high-throughput format that makes it ideal for screening assays. (selectscience.net)
The SURFE²R 96SE is designed for activity measurement of electrogenic membrane transporters and pumps, which generate currents too low to resolve by patch clamp or which are not expressed in membranes accessible for patch clamp (e.g. bacterial, organelles). (selectscience.net)

Introduction of heterologous glucose- or fructose-proton symporters in an hxt 0 yeast background strain (derived from CEN.PK2-1C) restored growth on the corresponding sugar under aerobic conditions. (biomedcentral.com)

The Organization for Economic Co-operation and Development (OECD) refers to the NIS transporter as a potential target of environmental chemicals that influence thyroid hormone synthesis. (solvobiotech.com)

They successfully detected the inward and outward confirmations of the symporter Sugar Transport Protein 10 (STP10) - a protein responsible for monosaccharide transport across cell membranes - at high resolutions (1.8 and 2.6 Å respectively) in Arabidopsis thaliana. (lu.se)

The glucose transporters expressed in the renal proximal tubule ensure that less than 0.5 g/day (range 0.03-0.3 g/d) is excreted in the urine of healthy adults. (medscape.com)
Consequently the affinity of the transporters for glucose along the tubule increases to allow for complete reabsorption of glucose from the urine. (medscape.com)
Secondary active transport occurs in the intestine and the kidney tubules (predominantly proximal tubule) and is mediated by members of the SGLT transporter family. (medscape.com)

Our "Gold Standard" as secondary assay system for electrogenic transporters. (selectscience.net)

HP2 lies on the surface of a large extracellular bowl formed by the transporter and occludes L-asp and three Na + -binding sites (NA1, 2, and 3). (elifesciences.org)

An ordered binding model of sodium/substrate transport suggests that sodium binds to the empty transporter first, thereby inducing a conformational alteration which increases the affinity of the transporter for the solute. (embl.de)

Emerging evidences suggest that the polyspecific organic cation transporters play important roles in systemic disposition and tissue-specific uptake of mIBG. (aspetjournals.org)
Emerging evidences suggest that the polyspecific organic cation transporters are the major transporters driving the systemic elimination and tissue-specific disposition of mIBG in normal organs. (aspetjournals.org)

For diverse bacteria and archaea that can utilize a carbon source, there is a complete high-confidence catabolic pathway (including a transporter) just 38% of the time, and there is a complete medium-confidence pathway 63% of the time. (lbl.gov)

The SLC5A protein family includes transporters of vitamins, minerals, and nutrients. (zfin.org)
This form of glucose transport is predominantly mediated by members of the GLUT transporter family. (medscape.com)

4] "Molecular and physiological analysis of the role of osmolyte transporters BetL, Gbu, and OpuC in growth of Listeria monocytogenes at low temperatures. (tcdb.org)

Sugar-proton symporter PLT5. (lbl.gov)

3] "Transcriptional regulation and posttranslational activity of the betaine transporter BetL in Listeria monocytogenes are controlled by environmental salinity. (tcdb.org)

Substrate and sodium are released and the empty transporter re-orientates in the membrane allowing the cycle to start again. (embl.de)

The clinical use of mIBG as a radiopharmaceutical in cancer diagnosis and treatment can be further improved by taking a holistic approach considering mIBG transporters in both cancer and normal tissues. (aspetjournals.org)

A symporter is an integral membrane protein that is involved in the transport of two different molecules across the cell membrane in the same direction. (lu.se)

Ben-Yona A, Kanner BI (2013) Functional defects in the external and internal thin gates of the γ-aminobutyric acid (GABA) transporter GAT-1 can compensate each other. (springer.com)

As a pioneer in the drug transporter field for 20 years, SOLVO is dedicated to exploring the science of transporters and their role in xenobiotic efficacy and safety. (solvobiotech.com)

In this extensive review, we provide an overview of ABC transporters, including their classifications and structural similarities. (bvsalud.org)

For instance, the use of 131 I radiotherapy to treat thyroid cancer is highly dependent on the selective expression of the sodium/iodine symporter on these cells ( Kogai and Brent, 2012 ). (aspetjournals.org)
These transporters require energy and are sodium dependent. (medscape.com)

Our original antiporter cycle is a perfect 1:1 transporter - each time one A molecule moves in one direction (e.g., out-to-in) a B molecule moves in the opposite direction (e.g., in-to-out). (physicallensonthecell.org)
The NKCC1 transporter is a symporter (moves atoms in the same directions) that moves 2 Cl- and one K+ and one Na+ outside the cell at a time. (yale.edu)

Transporter-mediated uptake has been exploited successfully in nuclear medicine to deliver several radiopharmaceuticals for cancer imaging and treatment ( Zhang and Wang, 2020 ). (aspetjournals.org)

Major myo-inositol transporter IolT. (lbl.gov)

Thus, despite the apparent maintenance of its barrier function, canonical metabolite transporters are missing in this membrane. (frontiersin.org)
AE1 and NBCe1), and (iii) may provide sites for regulation of transporter function via protein kinase A phosphorylation (e.g. (tcdb.org)

Anatomy22

Organisms12

Chemicals and Drugs162

Analytical, Diagnostic and Therapeutic Techniques and Equipment16

Phenomena and Processes41

Disciplines and Occupations1

Information Science4

Inhibitors4

Transmembrane2

Neurotransmitter4

Glycine1

High affinity1

Cotransporter1

Proteins7

Hexose3

Plasma membrane3

Serotonin transporter3

Uniporters3

Coding sequence1

Aspartate2

Specificity1

Antiporters2

Potassium2

Glutamate1

Dopamine2

MECHANISM1

Mediates1

Vertebrate2

Transports1

Pumps2

Heterologous1

Chemicals1

STP101

Tubule3

Secondary1

Extracellular1

Conformational1

Organic2

Catabolic1

Family2

Molecular1

Proton1

Activity1

Substrate1

Holistic1

Transport1

Acid1

Role1

Similarities1

Dependent2

Moves2

Successfully1

Major1

Function2