Transplantation intervertebral disc degeneration. Medical search. Frequent questions

Her work focuses on degenerative disc disease, specifically to modulate inflammatory pain, extracellular matrix regulation, disc microstructure, and molecular, proteome and glycome profiling in disc degeneration using a biomaterial approach. (ukm.my)
How Can Stem Cells Treat Degenerative Disc Disease? (bioxcellerator.com)
Degenerative disc disease (DDD), a common aging-related condition, is caused when the discs in your neck and spine-located between bones-begin to shrink and deteriorate as they become dehydrated. (bioxcellerator.com)
Pain resulting from degenerative disc disease can be debilitating and severe, making it uncomfortable to sit, stand, bend over, squat, twist, and participate in your favorite recreational activities-even simply to get a good night's sleep. (bioxcellerator.com)
Degenerative disc disease is a major problem, causing billions of dollars in lost work and medication. (stemcellpatents.com)
The lifetime prevalence of degenerative disc disease is dramatically high. (biomedcentral.com)
The lifetime prevalence of degenerative disc disease (DDD) is very high. (biomedcentral.com)
Degenerative disc disease (DDD) poses a substantial socioeconomic burden in developed countries [ 1 ]. (biomedcentral.com)
Degenerative disc disease ( DDD ) is a medical condition in which there are anatomic changes and a loss of function of varying degrees of one or more intervertebral discs of the spine of sufficient magnitude as to cause symptoms. (siddhaspirituality.com)
Degenerative disc disease can result in the lower back or upper neck pain. (siddhaspirituality.com)
Nevertheless, degenerative disc disease is one of the most common sources of back pain and affects approximately 30 million people every year. (siddhaspirituality.com)
With symptomatic degenerative disc disease, the pain can vary depending on the location of the affected disc. (siddhaspirituality.com)
Degenerative disc disease can lead to a chronic debilitating condition and can have a serious negative impact on a person's quality of life. (siddhaspirituality.com)
Because degenerative disc disease is largely due to natural daily stresses, the American Academy of Orthopaedic Manual Physical Therapists has suggested it is not truly a "disease" process. (siddhaspirituality.com)
The aim of this study was to evaluate the comparative safety and effectiveness of lumbar total disc replacement (TDR) in the treatment of patients with symptomatic degenerative disc disease (DDD) who are unresponsive to nonsurgical therapy. (medscape.com)
In patients with progressively symptomatic degenerative disc disease (DDD), significant pain and quality of life limitations can be associated with a substantial economic burden. (medscape.com)

Mesenchymal stem cells reduce intervertebral disc fibrosis and facilitate repair. (bioxcellerator.com)
Treatment of Intervertebral Disc Degeneration in Wistar Rats with Mesenchymal Stem Cells. (bioxcellerator.com)
Mesenchymal stem cells: potential application in intervertebral disc regeneration. (bioxcellerator.com)
Human umbilical cord-derived mesenchymal stem cells and their chondroprogenitor derivatives reduced pain and inflammation signaling and promote regeneration in a rat intervertebral disc degeneration model. (bioxcellerator.com)
Mesenchymal Stem Cells Arrest Intervertebral Disc Degeneration Through Chondrocytic. (stemcellpatents.com)

The author's group has already found that nucleus pulposus cells activated annulus fibrous cells, and reinsertion of nucleus pulposus cells slowed further disc degeneration. (cellsurgicalnetwork.com)
Cheng CC, Uchiyama Y, Hiyama A, Gajghate S, Shapiro IM, Risbud MV. PI3K/AKT regulates aggrecan gene expression by modulating Sox9 expression and activity in nucleus pulposus cells of the intervertebral disc. (jefferson.edu)

Regenerative medicine approaches, including autologous chondrocyte implantation (ACI) and matrix-assisted autologous chondrocyte transplantation (MACT), involve harvesting healthy cartilage cells from the patient, expanding them in the lab, and then implanting them into the damaged area. (spinewala.com)

Degeneration of lumbar intervertebral discs is a major cause of low back complaints, an irreversible occurrence with no currently available treatment. (cellsurgicalnetwork.com)
it has been The researchers note that the underlying mechanism of this response is caused by a reduction or migration of a painful and abnormally displaced nucleus pulposus to a more central position in the lumbar disc, thereby reducing pain. (ptpainite.com)
Mini-open Anterior Lumbar Interbody Fusion for Recurrent Lumbar Disc Herniation Following Posterior Instrumentation. (medscape.com)
Association Between Lumbar Spine Sagittal Alignment and L4-L5 Disc Degeneration Among Asymptomatic Young Adults. (medscape.com)
On the basis of randomized controlled trials comparing TDR to fusion surgery, two lumbar artificial discs (Charité, DePuy Spine and ProDisc-L, Synthes Spine) have been approved by the FDA in the United States. (medscape.com)

PURPOSES: To evaluate the effects of low frequency whole-body vibration (WBV) on degeneration of articular cartilage and subchondral bone in mice with destabilization of the medial meniscus (DMM)induced osteoarthritis(OA) and mice with normal knee. (bvsalud.org)
CONCLUSION: WBV accelerated cartilage degeneration and caused slight changes in subchondral bone in a DMM-induced OA model. (bvsalud.org)

Current animal and laboratory investigations are looking into the viability of bringing stem cell therapy into clinical practice for regeneration in muscular dystrophy, intervertebral disc degeneration, cerebral infarctions, and transplantation medicine. (elis.sk)
She is also developing a bioengineered hydrogel to support stem cell transplantation for disc regeneration targeting inflammatory pain. (ukm.my)
Her major achievements include the patent filed of the technology to promote disc regeneration targeting pain and the recipient of prestigious awards, including the Emerging Investigator Award for Health from the Health Research Board, Ireland, Outstanding Anatomist Award (Research) by the Malaysian Anatomical Association, Julia Polak European Doctorate Award from the European Society for Biomaterials and First Prize Young Researcher Award from AO Spine. (ukm.my)
Patents such as # 6,723,335 cover the use of stem cell injection into the nucleus pulposus of the disc in order to stimulate regeneration. (stemcellpatents.com)
Regenerative approaches, such as intradiscal PRP or stem cell injections, aim to stimulate tissue regeneration within the discs, promoting disc health and reducing pain. (spinewala.com)
Detailed understanding of the ontogenetic, cellular and molecular characteristics of functional intervertebral disc (IVD) cell populations is pivotal to the successful development of cell replacement therapies and IVD regeneration. (biomedcentral.com)

2022). Intervertebral Disc Degeneration: Biomaterials And Tissue Engineering Strategies Toward Precision Medicine. (ukm.my)
Stergar J, Gradisnik L, Velnar T, Maver U. Intervertebral disc tissue engineering: A brief review. (bjbms.org)
This significantly impacted the development of tissue engineering in various medical fields, including regenerative techniques for intervertebral disc (IVD) degeneration (IDD). (bjbms.org)
In mature discs, the distance between an AF or NP cell and CEP is up to 6-8 mm and can only be overcome by free diffusion of fluids through the IVD tissue [ 3 ]. (biomedcentral.com)
A number of promising clinical trials have been conducted using tissue engineering and biological interventions for disc degeneration. (edu.au)
In the alternative, the healing of trauma to the outer anulus fibrosus may result in the innervation of the scar tissue and pain impulses from the disc, as these nerves become inflamed by nucleus pulposus material. (siddhaspirituality.com)
This is confirmed by histological studies demonstrating tissue degeneration vs. acute inflammation. (journalofprolotherapy.com)
These affected connective tissue become weak and brittle with time, leading to chronic inflammation, degeneration, and osteoarthritis. (medscape.com)

2023). Discogenic Low Back Pain: Anatomy, Pathophysiology And Treatments Of Intervertebral Disc Degeneration. (ukm.my)

Cell therapy (also called cellular therapy, cell transplantation, or cytotherapy) is a therapy in which viable cells are injected, grafted or implanted into a patient in order to effectuate a medicinal effect, for example, by transplanting T-cells capable of fighting cancer cells via cell-mediated immunity in the course of immunotherapy, or grafting stem cells to regenerate diseased tissues. (wikipedia.org)
Although such attempts produced no positive benefit, further research found in the mid twentieth century that human cells could be used to help prevent the human body rejecting transplanted organs, leading in time to successful bone marrow transplantation as has become common practice in treatment for patients that have compromised bone marrow after disease, infection, radiation or chemotherapy. (wikipedia.org)
We aimed for addressing the role of FasL expression in human intervertebral disc degeneration (IDD) and immune privilege in terms of the interaction between NP cells and immunocytes via the FasL-Fas machinery. (medsci.org)
Moreover, studies with human disc cells, especially focusing on nucleus pulposus (NP) cells, are seldom found in the literature. (medsci.org)
The Application of Mesenchymal Stromal Cells and Their Homing Capabilities to Regenerate the Intervertebral Disc. (bioxcellerator.com)
On the other hand, recent experimental studies on disc cells have demonstrated an important role for the nucleus pulposus in preserving overall disc structure. (cellsurgicalnetwork.com)
Numerous investigations on disc degeneration have been performed on cells from annulus fibrosus (AF) and nucleus pulposus (NP) of the intervertebral disc (IVD) in cell culture experiments utilising a broad variety of basal culture media. (biomedcentral.com)
In this study, we evaluated the most common media used for monolayer expansion of AF and NP cells to set standards for disc cell culture. (biomedcentral.com)
Human AF and NP cells were isolated from cervical discs. (biomedcentral.com)
Both cell types showed similar cell morphology and characteristics of dedifferentiation known for cultured disc cells independently from the media. (biomedcentral.com)
Although disc cells are adapted to the limited nutrient supply, an imbalance in the ECM maintenance occurs with age. (biomedcentral.com)
In disc cell therapy, cells are isolated from the disc and are expanded ex vivo before they are implanted into the impaired disc. (biomedcentral.com)

The intervertebral disc (IVD) consists of a central gelatinous nucleus pulposus (NP) encircled by an elastic, ligamentous annulus fibrosus (AF) and is flanked superiorly and inferiorly by cartilaginous endplates. (biomedcentral.com)
Discogenic pain is pain caused by stimulation of pain-sensitive afferent nerves within the annulus fibrosus and is a distinct condition from radiculopathy associated with disc herniation. (ptpainite.com)
The endplates serve as the interface between the intervertebral disc and the vertebrae, covering the upper and lower layers of the annulus fibrosus and nucleus pulposus. (ptpainite.com)
it absorbs water and compresses the disc, it also distributes weight to the annulus fibrosus and vertebral endplates and maintains disc height. (ptpainite.com)
However natural daily stresses and minor injuries can cause these discs to gradually lose water as the annulus fibrosus, or the rigid outer shell of a disc weakens. (siddhaspirituality.com)

Bone marrow transplants are the most common and well established cell transplantation therapies. (wikipedia.org)
Current therapies for IDD include conservative and invasive approaches, but none of those treatments are able to restore the disc structure and function. (bjbms.org)
Our findings are valuable for the harmonisation of preclinical study results and thereby push the development of cell therapies for clinical treatment of disc degeneration. (biomedcentral.com)

Advanced cell therapy offers new hope to some patients with spine and disc conditions when standard treatments such as medications or surgery may provide only temporary relief or no relief at all. (bioxcellerator.com)
Degeneration of the IVD alters disk height and the mechanics of the spine, leading to chronic segmental spinal instability. (bjbms.org)
A type of juvenile osteochondrosis affecting the fibrocartilaginous disc ( INTERVERTEBRAL DISC ) in the thoracic or thoracolumbar region of the SPINE . (lookformedical.com)
The pain may be related to different types of pain that come from the muscles, bones, or joints in the spine rather than the discs or other structures in the spine. (ptpainite.com)
The intervertebral disc (IVD) is the main joint between the two vertebrae in the spine. (ptpainite.com)
Intervertebral discs mechanically resemble thick-walled fiber-reinforced pressure vessels, absorbing strain energy and transferring loads to the spine. (ptpainite.com)
There is a disc between each of the vertebrae in the spine. (siddhaspirituality.com)
A healthy, well-hydrated disc will contain a great deal of water in its center, known as the nucleus pulposus, which provides cushioning and flexibility for the spine. (siddhaspirituality.com)

Intervertebral disc degeneration (IDD) is a major cause of many spinal disorders [ 1 , 2 ]. (medsci.org)
The disk height decreases due to degeneration, altering the mechanics of the affected spinal segment. (bjbms.org)
Intervertebral disc degeneration is a common cause of back pain and spinal disorders. (spinewala.com)
His current main research interests include intervertebral disc allograft transplantation, genetics of adolescent idiopathic scoliosis and congenital scoliosis, scoliosis population screening for children, and functional magnetic resonance imaging of the spinal cord. (apssonline.org)
DDD can cause mild to severe pain, either acute or chronic, near the involved disc, as well as neuropathic pain if an adjacent spinal nerve root is involved. (siddhaspirituality.com)
Whether a patient experiences pain or not largely depends on the location of the affected disc and the amount of pressure that is being put on the spinal column and surrounding nerve roots. (siddhaspirituality.com)
This water loss makes the discs less flexible and results in the gradual collapse and narrowing of the gap in the spinal column. (siddhaspirituality.com)

2021). An Injectable Hyaluronic Acid Hydrogel Promotes Intervertebral Disc Repair In A Rabbit Model. (ukm.my)

Dr Isma has been involved in disease modelling to establish a pre-clinical model of pain induced by disc injury. (ukm.my)

Disc herniations in astronauts: What causes them, and what does it tell us about herniation on earth? (google.se)
Second, the nucleus is more susceptible to punching through the annulus, which is a common condition called a disc herniation . (siddhaspirituality.com)

After an injury, some discs become painful because of inflammation and the pain comes and goes. (siddhaspirituality.com)

in 1968, in Minnesota, the first successful human bone marrow transplantation took place. (wikipedia.org)
Our study demonstrated that FasL expression tends to decrease in degenerated discs and FasL plays an important role in human disc immune privilege, which might provide a novel target for the treatment strategies for IDD. (medsci.org)
As the largest avascular organ in the human body, the intervertebral disc is isolated from the host immune system [ 8 ]. (medsci.org)
3) the possibility of a human nucleus pulposus cell line as a cell source for cell transplantation therapy. (cellsurgicalnetwork.com)
Aberrantly expressed long noncoding RNAs in human intervertebral disc degeneration: a microarray related study. (aksomics.com)
This has been turned into the first successful allograft transplantation in a human in 2000 and the preliminary result was published in the Lancet in 2007. (apssonline.org)

Lung conditions such as acute respiratory distress syndrome have no cure with exception of transplantation, which is limited to a small number of patients. (stemcellpatents.com)
The amount of degeneration does not correlate well with the amount of pain patients experience. (siddhaspirituality.com)

[ 3 ] However, reoperation rates of 12-19% over 5 years follow-up have been reported due to complications such as pseudarthrosis, adjacent segment degeneration, and incomplete pain relief. (medscape.com)

In 1990, he and his team in China pioneered the idea of transplanting the intervertebral disc for the treatment of discogenic pathologies. (apssonline.org)

In recent decades, however, stem cell and cell transplantation has gained significant interest by researchers as a potential new therapeutic strategy for a wide range of diseases, in particular for degenerative and immunogenic pathologies. (wikipedia.org)

The use of biologics to treat disc abnormalities is a non-surgical option which can potentially bridge the gap between traditional non-surgical treatments for degenerative disc abnormalities and fusion surgery. (medicalpressopenaccess.com)

For a long time, bone marrow transplantation was the only clinically applicable method of cell transplantation, however, since the 1990s, cell therapy has been investigated for a wide scale of pathologies and disorders. (wikipedia.org)

Discogenic pain is attributed to degenerative changes in the intervertebral discs due to aging or trauma. (ptpainite.com)
Discogenic pain is a type of low back pain caused by chemically or mechanically damaged intervertebral discs. (ptpainite.com)
Production of these pro-inflammatory mediators occurs in the nucleus The medulla of the intervertebral disc is often regarded as the main cause of discogenic low back pain. (ptpainite.com)

London, Canada -Antibody-mediated acute vascular rejection (AVR) is a major problem in organ transplantation. (stemcellpatents.com)

[ 1 ] The etiology of low back pain is multifactorial with several potential pain generators including the intervertebral discs and the facet joints. (medscape.com)

These abnormalities include anterior and posterior osteophyte formation, disc space narrowing on plain radiographs, and nucleus pulposus desiccation on MRI scanning [23,36]. (medicalpressopenaccess.com)

New strategies for disc repair: novel preclinical trials. (cellsurgicalnetwork.com)
These strategies aim to slow down the degeneration process and are predominantly tested in preclinical studies using cell culture experiments [ 5 ]. (biomedcentral.com)

Therefore, we recommend using these media as standard medium for disc cell culture. (biomedcentral.com)
Reviewing the literature of the two last decades, we found no common protocol available for disc cell expansion. (biomedcentral.com)
Although cell growth and maintenance of disc cell viability is affected by nutrition [ 6 ], the cell culture medium differs with respect to serum and glucose concentration, as well as in supplementation of ascorbic acid, growth factors and non-essential amino acids. (biomedcentral.com)

Additionally, the body can react to the closing gap between vertebrae by creating bone spurs around the disc space in an attempt to stop excess motion. (siddhaspirituality.com)

Intervertebral disc (IVD) degeneration (IDD) is associated with low back pain and significantly affects the patient's quality of life. (bjbms.org)
A degenerated disc in the lower back can result in lower back pain , sometimes radiating to the hips, as well as pain in the buttocks, thighs, or legs . (siddhaspirituality.com)

Degenerating discs can release damaging molecules and growth factors that cause nerves to grow into the disc. (ptpainite.com)

A healthy intervertebral disc in an adult has scattered nerves, mostly confined to the outer layer. (ptpainite.com)
Each disc has a soft inner layer, called the nucleus pulposa, and a hard outer layer, the annulus. (siddhaspirituality.com)
Some people have nerve endings that penetrate more deeply into the anulus fibrosus (outer layer of the disc) than others, making discs more likely to generate pain. (siddhaspirituality.com)

Dr Isma has expertise in intervertebral disc and biomaterial research. (ukm.my)
Considerable research has focused on the development of total disc replacements (TDR) as a motion-preserving alternative to fusion. (medscape.com)

Nondegenerate healthy disc material (age range, 8 to 15 years) was obtained as surplus surgical material. (biomedcentral.com)

A degenerated disc has nerves that pass through deeper intradiscal structures to the inside One-third of the ring and nucleus. (ptpainite.com)
These nerves contain nociceptive neurotransmitters and initiate the production of cytokines that fire noxious messages from within the disc. (ptpainite.com)

Written by renowned innovators, this is the first book that covers implementation of these groundbreaking approaches for disc disease. (edu.au)

Anatomy10

Diseases16

Chemicals and Drugs7

Analytical, Diagnostic and Therapeutic Techniques and Equipment16

Phenomena and Processes3

Degenerative disc di16

Mesenchymal Stem5

Nucleus pulposus cells2

Chondrocyte transplantation1

Lumbar5

Cartilage2

Regeneration6

Tissue8

Anatomy1

Cells12

Annulus fibrosus5

Therapies3

Spine8

Spinal7

20211

Clinical1

Herniation2

Inflammation1

Human6

Patients2

Adjacent1

Treatment1

Stem cell1

Surgery1

Therapy1

Discogenic3

Acute1

Joints1

Abnormalities1

Preclinical2

Cell3

Bone spurs1

Back2

Growth1

Outer layer3

Research2

Healthy1

Nerves2

Disease1