ColobomaDown SyndromeSyndromeCostello SyndromePrurigoAbnormalities, MultipleMicrophthalmosChromosomes, Human, Pair 22AnophthalmosGenetic Diseases, InbornChoanal AtresiaDevelopmental DisabilitiesPedigreeHeart Defects, CongenitalInfant, NewbornFetal DiseasesChromosome DisordersBirth WeightPregnancyQuantitative Trait, HeritableEye AbnormalitiesHypertelorismChromosome AberrationsMutationPupil DisordersPremature BirthIrisPAX2 Transcription FactorPosterior Eye SegmentBirth RateMetabolic Syndrome XPhenotypeInfant, Low Birth WeightFundus OculiChoroidEyeCHARGE Syndrome