AllelesGenetic traitsCandidate genesPopulationsMarkersMendelianPhenotypeCytoplasmChromosomeChromosomesInheritanceGenomeNuclearProteinDominantFoundAutismAnalysisFindingsLargeSubjectsQuantitative traiNucleotide repeatHeterozygousGenetic linkageGenomicHomozygousLocusMolecularIdentifySimilarSingleExpression
Alleles13
- In Mendelian inheritance, each parent contributes one of two possible alleles for a trait. (wikipedia.org)
- In cases of co-dominance, the genetic traits of both different alleles of the same gene-locus are clearly expressed in the phenotype. (wikipedia.org)
- citation needed] In Mendelian inheritance, genes have only two alleles, such as a and A. Mendel consciously chose pairs of genetic traits, represented by two alleles for his inheritance experiments. (wikipedia.org)
- In nature, such genes often exist in several different forms and are therefore said to have multiple alleles. (wikipedia.org)
- An individual usually has only two copies of each gene, but many different alleles are often found within a population. (wikipedia.org)
- A rabbit's coat color is determined by a single gene that has at least four different alleles. (wikipedia.org)
- In the genes for the dog coat colours there are four alleles on the Agouti-locus. (wikipedia.org)
- citation needed] Many other genes have multiple alleles, including the human genes for ABO blood type. (wikipedia.org)
- citation needed] If one or more genes cannot be expressed because of another genetic factor hindering their expression, this epistasis can make it impossible even for dominant alleles on certain other gene-loci to have an effect on the phenotype. (wikipedia.org)
- One individual was found to carry a 12 kb deletion in one copy of the ASPA gene on 17p13, which when mutated in both alleles leads to Canavan disease. (biomedcentral.com)
- REVIEW-ARTICLE Intermediate alleles of Huntington's disease HTT gene in different populations worldwide: a systematic review. (geneticsmr.com)
- The considered normal alleles have less than 27 CAG repeats. (geneticsmr.com)
- Intermediate alleles (IAs) show 27 to 35 CAG repeats and expanded alleles have more than 35 repeats. (geneticsmr.com)
Genetic traits3
- citation needed] When genes are located on the same chromosome and no crossing over took place before the segregation of the chromosomes into the gametes, the genetic traits will be inherited in connection, because of the genetic linkage. (wikipedia.org)
- citation needed] Genetic traits located on gonosomes sometimes show specific non-Mendelian inheritance patterns. (wikipedia.org)
- They offer compelling advantages for mapping complex genetic traits, particularly those that have low heritabilities. (nervenet.org)
Candidate genes3
- Next-generation sequencing of the whole exome is useful for testing for multiple candidate genes simultaneously or for discovering new, rare disorders. (medlink.com)
- METHOD: Mutation screening of positional candidate genes was performed in two stages. (neurotransmitter.net)
- The first stage involved identifying, in unrelated subjects showing linkage to 2q24-q33, genetic variants in exons and flanking sequence within candidate genes and comparing the frequency of the variants between autistic and unrelated nonautistic subjects. (neurotransmitter.net)
Populations4
- In contrast, interactions between genes and the environment cannot usually be studied using conventional mapping populations in which each animal is unique. (nervenet.org)
- These populations originated from a common ancestor, and a rapid demographic expansion began approximately 90,000 years ago. (biomedcentral.com)
- The natural populations from China with specific genetic characteristics enriched the gene pools of global A. thaliana collections. (biomedcentral.com)
- We hypothesize that there might be at least three types of autism susceptibility genes/mutations that can be (i) specific to an individual patient or family, (ii) in a genetically isolated sub-population and (iii) a common factor shared amongst different populations. (neurotransmitter.net)
Markers2
- Diversity and genetic stability in banana genotypes in a breeding program using inter simple sequence repeats (ISSR) markers. (geneticsmr.com)
- In this study we have increased the density of microsatellite markers 2- to 5-fold in each of several major RI sets that share C57BL/6 as a parental strain (AXB, BXA, BXD, BXH, and CXB). (nervenet.org)
Mendelian2
- Non-Mendelian inheritance is any pattern in which traits do not segregate in accordance with Mendel's laws. (wikipedia.org)
- Recombinant inbred (RI) strains have been used to map a wide range of Mendelian loci and quantitative traits (Taylor, 1989). (nervenet.org)
Phenotype1
- Individuals can develop a recessive trait in the phenotype dependent on their sex-for example, colour blindness and haemophilia (see gonosomal inheritances). (wikipedia.org)
Cytoplasm1
- Based on these data, he determined that the trait was transmitted through a character present in the cytoplasm of the ovule. (wikipedia.org)
Chromosome1
- Domestic cats have a gene with a similar effect on the X-chromosome. (wikipedia.org)
Chromosomes2
- These laws describe the inheritance of traits linked to single genes on chromosomes in the nucleus. (wikipedia.org)
- A partial duplication in the ASMT gene, located in the pseudoautosomal region 1 (PAR1) of the sex chromosomes and previously suggested to be involved in ASD susceptibility, was observed in 6-7% of the cases but in only 2% of controls (P = 0.003). (biomedcentral.com)
Inheritance1
- Although many genetic studies have been performed over the past century, the inheritance of the multiflorous spikelet trait is not fully understood in oat. (geneticsmr.com)
Genome1
- New technologies such as next-generation sequencing (including whole exome or whole genome sequencing) are expanding testing options, discovering new mutations, and creating challenges in counseling, interpreting, and reporting results to the patient. (medlink.com)
Nuclear1
- YBM12-A and YBM12-B). This mutation in leaf color is controlled by a single dominant nuclear gene. (geneticsmr.com)
Protein2
- Many human genes, including one for a protein that controls cholesterol levels in the blood, show co-dominance too. (wikipedia.org)
- People with the heterozygous form of this gene produce two different forms of the protein, each with a different effect on cholesterol levels. (wikipedia.org)
Dominant1
- Huntington's disease (HD) is an autosomal dominant progressive neurodegenerative disorder caused by a dynamic mutation due to the expansion of CAG repeats in the HTT gene (4p16.3). (geneticsmr.com)
Found2
- Two subjects showed partial duplication of the TM4SF2 gene on Xp11.4, previously implicated in X-linked non-specific mental retardation, but in our subsequent analyses such variants were also found in controls. (biomedcentral.com)
- Negative association findings and research involving the serotonin transporter gene, FMR1, RELN, WNT2, HOXA1, and HOXB1 genes may be found elsewhere on this site . (neurotransmitter.net)
Autism4
- The genes/mutations could act alone or interact with other genetic and/or epigenetic or environmental factors, causing autism or related disorders. (neurotransmitter.net)
- Linkage and association of the mitochondrial aspartate/glutamate carrier SLC25A12 gene with autism. (neurotransmitter.net)
- In the present study, genes across the 2q24-q33 interval were analyzed to identify an autism susceptibility gene in this region. (neurotransmitter.net)
- CONCLUSIONS: A strong association of autism with SNPs within the SLC25A12 gene was demonstrated. (neurotransmitter.net)
Analysis2
- Phylogeography and population structure analysis reveals diversity by mutations in Lasiodiplodia theobromae with distinct sources of selection. (geneticsmr.com)
- Note to the Reader Please cite this work as: Williams RW, Gu J, Qi S, Lu L (2001) The genetic structure of recombinant inbred mice: High-resolution consensus maps for complex trait analysis. (nervenet.org)
Findings1
- The results in PAR1/PAR2 are the first large-scale studies of gene dosage in these regions, and the findings at the ASMT locus indicate that further studies of the duplication of the ASMT gene are needed in order to gain insight into its potential involvement in ASD. (biomedcentral.com)
Large1
- Whole exome sequencing is not suitable for detecting polynucleotide repeat disorders or large insertion/deletions. (medlink.com)
Subjects1
- Two single nucleotide polymorphisms (SNPs) that showed evidence for divergent distribution between autistic and nonautistic subjects were identified, both within SLC25A12, a gene encoding the mitochondrial aspartate/glutamate carrier (AGC1). (neurotransmitter.net)
Quantitative trai2
- We identified 241 novel EST-SSR and G-SSR markers in J. curcas , which should be useful for genetic mapping and quantitative trait loci analysis of important agronomic traits. (biomedcentral.com)
- Eucalyptus genetic linkage maps generated with microsatellite loci were used successfully to identify quantitative trait loci (QTLs) for various economically important traits. (springeropen.com)
Nucleotide repeat1
- The relevant gene has been identified in 12 cases (SCA1-3, SCA6-8, SCA10, SCA12, FGF14, and DRPLA), and in all but the recently identified SCA14, SCA17, PRKCG and FGF14 genes, the defect consists of the expansion of a short nucleotide repeat. (nih.gov)
Heterozygous1
- People with the heterozygous form of this gene produce two different forms of the protein, each with a different effect on cholesterol levels. (wikipedia.org)
Genetic linkage1
- citation needed] When genes are located on the same chromosome and no crossing over took place before the segregation of the chromosomes into the gametes, the genetic traits will be inherited in connection, because of the genetic linkage. (wikipedia.org)
Genomic1
- This review on eucalypts microsatellites, highlights the availability and characteristics of genomic and eSSRs and their potential in genetic analysis of natural and breeding populations and also discusses the future prospects in population genetics and marker assisted selection. (springeropen.com)
Homozygous1
- Mendel's principle of segregation of genes applies too, as in the F2-generation homozygous individuals with the phenotypes of the P-generation appear. (wikipedia.org)
Locus1
- Although the allele "e" is a recessive allele on the extension-locus itself, the presence of two copies leverages the dominance of other coat colour genes. (wikipedia.org)
Molecular1
- Different molecular characterization approaches have been used simultaneously in eucalypts, however, microsatellites or simple sequence repeats (SSRs) with their prolific characteristics could occupy a special niche in Eucalyptus genetic improvement. (springeropen.com)
Identify1
- and to analyze samples from probands with negative test results at the initial screening by means of the repeat expansion detection technique to identify CAG/CTG expansions in novel loci.Patients Two hundred twenty-five unrelated Italian index cases with hereditary ataxia, most (n = 183) of whom presented with a clear dominantly transmitted trait. (nih.gov)
Similar2
- Domestic cats have a gene with a similar effect on the X-chromosome. (wikipedia.org)
- Similar studies in eucalypts may provide new insights into the genetic architecture of transcript-level variations and post transcriptional gene regulation. (springeropen.com)
Single1
Expression1
- Recent evidences suggest that the presence of SSRs in micro RNAs of plant species play a role in the quantitative trait expression. (springeropen.com)