IndomethacinCyclooxygenase InhibitorsToxicity TestsAnti-Inflammatory Agents, Non-SteroidalProstaglandinsDinoprostoneProstaglandins EDose-Response Relationship, DrugToxicity Tests, AcuteProstaglandin-Endoperoxide SynthasesProstaglandin AntagonistsDuctus Arteriosus, PatentCyclooxygenase 14,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amineStomach UlcerArachidonic AcidsIbuprofenGastric MucosaMasoprocol6-Ketoprostaglandin F1 alphaArachidonic AcidMeclofenamic AcidDrug Administration ScheduleCyclooxygenase 2Prostaglandins FLipoxygenase InhibitorsRats, WistarEpoprostenolLethal Dose 50Rats, Sprague-DawleyBradykininCyclooxygenase 2 InhibitorsDrug InteractionsAspirinAntineoplastic Combined Chemotherapy Protocols16,16-Dimethylprostaglandin E2Nitric OxideVasodilationTime FactorsNitrobenzenesBiological FactorsAntineoplastic AgentsToxicity Tests, ChronicNG-Nitroarginine Methyl Ester5,8,11,14-Eicosatetraynoic AcidRabbitsGuinea PigsNitroarginineTreatment OutcomeRats, Inbred StrainsThromboxane B2Enzyme InhibitorsAdministration, OralPyrazolesSulfonamidesAcetylcholineMuscle RelaxationThromboxane A2VasoconstrictionKidneyEndothelium, VascularDuctus ArteriosusProstaglandins E, SyntheticDinoprostMuscle ContractionCells, CulturedCell SurvivalEdemaInfusions, IntravenousPiroxicamHistamineSRS-AButanonesNitric Oxide SynthaseAnti-Inflammatory AgentsDrug SynergismQuinacrineThromboxanesKetoprofenMuscle, SmoothDogsDiclofenacSodium SalicylatePhenylbutazoneCisplatinVasoconstrictor AgentsVasodilator AgentsIsoenzymesCarrageenanNo-Observed-Adverse-Effect LevelTracheaEicosanoidsFluorouracilFlurbiprofenNeoplasmsMesenteric Arteries15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic AcidDipyroneDoxorubicinMaximum Tolerated Dose