• protein
  • Using the sensors and instrumentation, we are exploring new applications for optical biosensor technology including protein microarrays, biosensor/mass spectrometry systems, and microfluidics-based assays using nanoliter quantities of reagents. (nanohub.org)
  • Services include identification of a biological target (protein production and assay development) to clinical drug candidates (ADME/DMPK, toxicity and safety studies, and efficacy models) to proof of concept drug candidates (Phase I and II) and to the market. (wikipedia.org)
  • vivo
  • Genetic inactivation ("knockout") of SOD produces deleterious phenotypes in organisms ranging from bacteria to mice and have provided important clues as to the mechanisms of toxicity of superoxide in vivo. (wikipedia.org)
  • assessment
  • Using data already collected ("data mining") has the advantage of being able to quickly and inexpensively make an assessment with a large dataset that would otherwise require much more time-consuming and costly specific toxicity assays. (wikipedia.org)
  • toxic
  • Even though Cl-PAHs aren't as toxic as TCDD, it has been determined using recombinant bacterial cells that the toxicities of exposure to Cl-PAHs based on AhR activity were approximately 30-50 times higher than that of dioxins. (wikipedia.org)
  • In common with many other diterpenoid alkaloids, it is toxic to animals, although the acute toxicity varies with species. (wikipedia.org)
  • Chemical
  • The studies used included synoptically collected sediment chemical analyses and toxicity effects data. (wikipedia.org)
  • Quantitative structure-activity relationship models (QSAR models) are regression or classification models used in the chemical and biological sciences and engineering. (wikipedia.org)
  • QSAR models first summarize a supposed relationship between chemical structures and biological activity in a data-set of chemicals. (wikipedia.org)
  • The tests include "fingerprinting" using spectroscopy or chromatography, chemical or biological assays, and process controls on raw material collection and processing. (wikipedia.org)
  • Medicinal chemistry and pharmaceutical chemistry are disciplines at the intersection of chemistry, especially synthetic organic chemistry, and pharmacology and various other biological specialties, where they are involved with design, chemical synthesis and development for market of pharmaceutical agents, or bio-active molecules (drugs). (wikipedia.org)
  • While a number of approaches toward the identification and development of hits exist, the most successful techniques are based on chemical and biological intuition developed in team environments through years of rigorous practice aimed solely at discovering new therapeutic agents. (wikipedia.org)
  • NIH Chemical Genomics Center Assay Operations for SAR Support Archived 2006-11-29 at the Wayback Machine. (wikipedia.org)
  • tests
  • Compiled data sets include a variety of endpoints including mortality, reproduction, growth rate, and juvenile survival in sediment toxicity data sets for all organisms for which tests have been conducted. (wikipedia.org)
  • The EPA began requiring treatment plants to conduct toxicity tests (biomonitoring) of their effluent discharges. (unt.edu)
  • Periodic toxicity was observed with these tests in the effluent and river samples after dechlorination was initiated. (unt.edu)
  • Those tests, along with in situ toxicity assays, proved to be good predictors of biological community responses. (unt.edu)
  • Eclox, which stands for Enhanced ChemiLuminescence and OXyradical test for water quality analysis, is a rapid toxicity technology that has been shown to correlate with other established toxicity tests. (wikipedia.org)
  • dose
  • Because of the difficulties in counting actual organisms in a dose, infective doses may be expressed in terms of biological assay, such as the number of LD50's to some test animal. (wikipedia.org)
  • For competition binding assays and functional antagonist assays IC50 is the most common summary measure of the dose-response curve. (wikipedia.org)
  • Graphpad Software EC50 definition definition of EC50 for quantal dose response curve Assay Operations for SAR Support Archived 2006-11-29 at the Wayback Machine. (wikipedia.org)
  • Thesis
  • Reliability of the Eclox Enhanced Chemiluminescence Assay for Rapid Field Testing of Drinking Water, Thesis, Texas A&M University System Health Science Center Whitehead, T.P., Thorpe, G.H.G., Maxwell, S.R.J., 1992. (wikipedia.org)
  • relation
  • It includes synthetic and computational aspects of the study of existing drugs and agents in development in relation to their bioactivities (biological activities and properties), i.e., understanding their structure-activity relationships (SAR). (wikipedia.org)
  • measure
  • An assay that uses a living system, such as an intact cell, to measure an effect or a molecule of interest. (thefreedictionary.com)
  • A wide variety of biological field assessments and toxicological assays were used to measure various responses. (unt.edu)
  • As a measure of toxicity, LD50 is somewhat unreliable and results may vary greatly between testing facilities due to factors such as the genetic characteristics of the sample population, animal species tested, environmental factors and mode of administration. (wikipedia.org)
  • For agonist/stimulator assays the most common summary measure is the EC50. (wikipedia.org)
  • commonly
  • NOAA originally calculated ERL/ERMs using existing toxicity data compiled from completed toxicity assays with varying endpoints, including effects on commonly tested organisms, particularly at sensitive life stages. (wikipedia.org)
  • methods
  • Studies are screened, and only those assays using standardized methods and resulting in significant effects are used for the determination of ERL/ERM guidelines. (wikipedia.org)
  • novel
  • We describe a novel approach to assess toxicity to the free-living nematode Caenorhabditis elegans that relies on the ability of firefly luciferase to report on endogenous ATP. (naver.com)
  • activity
  • Early estimates of CCK-like activity in blood were based on biological assays such as pancreatic secretion or gallbladder contraction. (thefreedictionary.com)
  • Toxicological studies have shown that some Cl-PAHs possess greater mutagenicity, aryl-hydorcarbon receptor activity, and dioxin-like toxicity than the corresponding parent PAHs. (wikipedia.org)
  • Zebra fish larval locomotor activity assay of transgenic fish embryos and individual larvae placed in a 96-well plate, monitored in a box and continuously illuminated by infrared lights, illuminated by white lights showed major similarities between fish circadian system and mammalian sleep/wake regulator for example. (wikipedia.org)
  • Drug
  • To the extent that a disease state can be mimicked by a toxin, the invention further provides an assay for drug discovery. (google.com)
  • Studies
  • In summary, the key links between the compiled studies are the testing of a specific analyte - toxicity assays used are for sediment, and a significant effect must be determined. (wikipedia.org)
  • Both the ERL and ERM have proven to be useful guideline values for predicting toxicity during studies conducted by the USGS. (wikipedia.org)
  • Development
  • Published 15 January 2010, Science 327, 348 (2010) - DOI: 10.1126/science.1183090 "Validation of a larval zebrafish locomotor assay for assessing the seizureliability of early-stage development drugs. (wikipedia.org)
  • high
  • Cl-PAHs demonstrate a high enough toxicity to be a potential health risk to human populations that come into contact with them. (wikipedia.org)
  • treatment
  • To control toxicity caused by chlorination of wastewater discharges, the EPA also began requiring some treatment facilities to dechlorinate their wastewater before discharging. (unt.edu)