• asenapine
  • A 2015 systematic review examined the effects of asenapine for people with schizophrenia: As for its efficacy in the treatment of acute mania, a recent meta-analysis showed that it produces comparatively small improvements in manic symptoms in patients with acute mania and mixed episodes than most other antipsychotic drugs (with the exception of ziprasidone) such as risperidone and olanzapine. (wikipedia.org)
  • Based on its extremely high, unequaled (among antipsychotics) affinity for the 5-HT2A, 5-HT2C, 5-HT6, and 5-HT7 receptors, and high affinity for the H1 receptor, asenapine, given normal tolerability, should theoretically demonstrate among the highest improvements in the negative symptomology of schizophrenia among all current antipsychotics (August 2017), such as high cognitive improvements and positive mood maintenance. (wikipedia.org)
  • A Lancet review found that it is in the middle range of 15 antipsychotics for effectiveness, approximately as effective as haloperidol and quetiapine and slightly more effective than ziprasidone, chlorpromazine, and asenapine, with better tolerability compared to the other antipsychotic drugs (4th best for weight gain, 5th best for extrapyramidal symptoms, best for prolactin elevation, 2nd best for QTc prolongation, and 5th best for sedation). (wikipedia.org)
  • assess
  • GEICAM/2012-07 is a study phase III, prospective, open, randomized, multicenter and national designed to assess patient preference for intravenous (IV) or subcutaneous (SC) of trastuzumab , and within the SC by the administration through the vial or device self-administration in patients with disseminated breast cancer HER2. (clinicaltrials.gov)
  • WINSTON-SALEM, N.C.--(BUSINESS WIRE)--Apr 7, 2011 - Targacept, Inc. (NASDAQ: TRGT) today announced the presentation of data from a Phase 2 clinical proof of concept trial to assess TC-5619 as an augmentation therapy to improve cognition in patients with schizophrenia at the International Congress on Schizophrenia Research (ICOSR) in Colorado Springs, Colorado. (drugs.com)
  • rates
  • Although dropout rates for toxicity were low, that is not to say the therapy was without symptomatic toxicity, and indeed a spectrum of toxicities might be encountered and need to be weighed in the analysis of the net clinical benefit patients experience on a clinical trial with Pegylated Interferon Alfa-2a. (clinicaltrials.gov)
  • Phase IIb data presented at the 20th Conference on Retroviruses and Opportunistic Infections (CROI) in March 2013 showed similar viral suppression rates of 76% for patients taking 100 mg cenicriviroc, 73% with 200 mg cenicriviroc, and 71% with efavirenz. (wikipedia.org)
  • Non-response rates were higher with cenicriviroc, however, largely due to greater drop-out of patients. (wikipedia.org)
  • better
  • First there were the anecdotal reports - FM patients were not just getting better but some, and not just a few, were getting well using something entirely new - an antiviral protocol, of all things, created not by a pain specialist or rheumatologist but by a surgeon. (simmaronresearch.com)
  • Pridgen, who's treated thousands of patients with gastrointestinal issues, came up with the protocol after he noticed that his FM patients with IBS seemed to get better and then relapse. (simmaronresearch.com)
  • moderate
  • RESEARCH DESIGN AND METHODS Diabetic patients with at least moderate neuropathic pain were randomized to placebo or lacosamide 400 (in a slow or standard titration) or 600 mg/day over 6-week titration and 12-week maintenance periods. (diabetesjournals.org)
  • therapy
  • 1.3 Patients without any local or systemic therapy for HCC within 4 weeks. (knowcancer.com)
  • 1.6.6 Serum creatinine tumors less than one half of the whole liver and the tumors can be encompassed within RT fields 1.8 Signed informed consent 1.9 Sexually active patients, in conjunction with their partner, must practice birth control during, and for 2 months after, thalidomide therapy. (knowcancer.com)
  • Patients who have major systemic diseases that the attending physicians consider inappropriate for radiotherapy or thalidomide therapy. (knowcancer.com)
  • severe
  • Higher educated MS patients with lower age at onset, shorter disease duration, less severe disability and less fatigue were most likely to be employed. (blogspot.gr)
  • fewer
  • As functional and behavioral changes often have more clinical relevance than cognitive scores, this may mean that fewer patients will need to be treated to achieve a clinically important improvement than the cognitive data suggest. (acpjc.org)
  • pregnancy
  • 1.10 Female patients in child-bearing age must have negative pregnancy test. (knowcancer.com)
  • Rheumatoid arthritis (RA) tends to remit during pregnancy, with more patients achieving remission in the third trimester, coinciding with an increase in levels of α-fetoprotein (AFP). (bmj.com)
  • alcohol
  • Prospective randomized double blind controlled trial in prevention of relapse in recently detoxified alcohol dependent patients with levetiracetam and placebo. (clinicaltrials.gov)
  • Out-patients with alcohol dependence recently detoxified Primary goal size is the duration of the Abstinenz up to the heavy relapse. (clinicaltrials.gov)
  • 1.1 Patients with measurable, locally advanced HCC that are not suitable for other local therapies, including surgery, TAE, alcohol injection, or radiofrequency ablation. (knowcancer.com)
  • Primary
  • These disorders include Polycythemia Vera (PV), Essential Thrombocythemia (ET) and Primary Myelofibrosis (PM). Recently an acquired somatic mutation in the intracellular kinase, JAK2 (JAK2V617F) has been observed in 95% of patients with PV, 50% of patients with ET and 50% of patients with primary myelofibrosis. (clinicaltrials.gov)
  • lower
  • Several investigators recently reported that patients with PV treated with rIFN -2b had lower JAK2V617F allele burdens as compared to a control group that included patients treated with phlebotomy, hydroxyurea, or anagrelide, or who remained untreated. (clinicaltrials.gov)
  • Patients were allocated to receive either rivastigmine, 1 to 4 mg/d (lower-dose group) ( n = 243) or 6 to 12 mg/d (higher-dose group) ( n = 243), or placebo ( n = 239). (acpjc.org)
  • Nearly half of all MS patients were still employed after almost two decades of having MS. Lower age at onset, shorter disease duration, higher education, less fatigue and less disability were independently associated with current employment. (blogspot.gr)
  • investigators
  • The investigators hypothesized that pharmacokinetics will not be altered in HIV/HCV patients with advanced (Child-Pugh grade C) cirrhosis or in those with no histologic liver damage. (clinicaltrials.gov)
  • Approximately
  • Approximately 195 patients will be included to receive subcutaneous trastuzumab a fixed dose of 600 mg every 3 weeks for 4 cycles (2 administered from the injection of a vial with a syringe and 2 with the injection device). (clinicaltrials.gov)
  • among
  • These key clinical and demographic factors are important to understand the reasons to work ability in MS. The findings highlight the need for environmental adjustments at the workplace to accommodate individual 's needs in order to improve working ability among MS patients. (blogspot.gr)
  • chronic
  • Up to one in four patients with diabetes may be affected by chronic diabetic painful neuropathy (DPN) ( 1 , 2 ) and suffer substantial morbidity and impaired quality of life ( 3 ). (diabetesjournals.org)
  • 1.2 Patients with histological confirmed HCC or patients who do not have histological diagnosis but have met all of the following criteria: 1.2.1 Presence of chronic viral hepatitis and/or cirrhosis 1.2.2 Presence of hepatic tumor(s) with image findings (sonography, CT scan) compatible with HCC. (knowcancer.com)
  • Drug
  • Drug tolerability should not be confused with drug tolerance, which refers to subjects' reduced reaction to a drug following its repeated use. (wikipedia.org)
  • Interferon (rIFN -2b), is a drug that appears to be non-leukemogenic, and may have a preferential activity on the malignant clone in PV, as suggested by cytogenetic remissions obtained in patients treated with rIFN -2b. (clinicaltrials.gov)
  • For all the reports of Pridgen helping FM patients, they mean nothing to Pridgen's hopes of producing an FDA approved drug. (simmaronresearch.com)
  • treatments
  • In dementia, they should only be considered after other treatments have failed and if the patient is a risk to himself and/or others. (wikipedia.org)
  • weeks
  • Following administration of these four cycles, the patient will decide whether or not to continue with the subcutaneous formulation of trastuzumab every 3 weeks until progression. (clinicaltrials.gov)
  • less
  • OCB-negative patients, known to differ genetically from OCB-positives, are characterized by less global and regional brain atrophy. (blogspot.gr)
  • disease
  • The results confirm the hypothesis that rIFN -2b preferentially targets the malignant clone in PV and raises the possibility that the JAK2V617F allele burden, and a reversion of clonal hematopoiesis monitored in females by expression of X-chromosome polymorphic alleles maybe useful in monitoring minimal residual disease in PV patients. (clinicaltrials.gov)
  • 12 patients with RA, who had active disease and were on stable doses of methotrexate, received weekly subcutaneous injections of placebo or 21 mg of MM-093. (bmj.com)
  • There was one dropout in the placebo group, due to flare of disease. (bmj.com)
  • Demographic and clinical factors were compared between patients being employed versus patients being unemployed and according to disease course of MS. (blogspot.gr)