• asenapine
  • Based on its extremely high, unequaled (among antipsychotics) affinity for the 5-HT2A, 5-HT2C, 5-HT6, and 5-HT7 receptors, and high affinity for the H1 receptor, asenapine, given normal tolerability, should theoretically demonstrate among the highest improvements in the negative symptomology of schizophrenia among all current antipsychotics (August 2017), such as high cognitive improvements and positive mood maintenance. (wikipedia.org)
  • A Lancet review found that it is in the middle range of 15 antipsychotics for effectiveness, approximately as effective as haloperidol and quetiapine and slightly more effective than ziprasidone, chlorpromazine, and asenapine, with better tolerability compared to the other antipsychotic drugs (4th best for weight gain, 5th best for extrapyramidal symptoms, best for prolactin elevation, 2nd best for QTc prolongation, and 5th best for sedation). (wikipedia.org)
  • hepatitis C vir
  • The liver safety and tolerability of boosted atazanavir (ATV/r) has been evaluated in human immunodeficiency virus and hepatitis C virus (HIV/HCV) coinfected patients with advanced liver disease (decompensated cirrhosis) (Hermida JM et al. (clinicaltrials.gov)
  • Phase I, Open Label, Unicentric Study of Multiple-dose Pharmacokinetics of Raltegravir in Patients Infected With Human Immunodeficiency Virus and Hepatitis C Virus With and Without Advanced (Child-Pugh C) Hepatic Cirrhosis. (clinicaltrials.gov)
  • assess
  • GEICAM/2012-07 is a study phase III, prospective, open, randomized, multicenter and national designed to assess patient preference for intravenous (IV) or subcutaneous (SC) of trastuzumab , and within the SC by the administration through the vial or device self-administration in patients with disseminated breast cancer HER2. (clinicaltrials.gov)
  • rates
  • Although dropout rates for toxicity were low, that is not to say the therapy was without symptomatic toxicity, and indeed a spectrum of toxicities might be encountered and need to be weighed in the analysis of the net clinical benefit patients experience on a clinical trial with Pegylated Interferon Alfa-2a. (clinicaltrials.gov)
  • Phase IIb data presented at the 20th Conference on Retroviruses and Opportunistic Infections (CROI) in March 2013 showed similar viral suppression rates of 76% for patients taking 100 mg cenicriviroc, 73% with 200 mg cenicriviroc, and 71% with efavirenz. (wikipedia.org)
  • Non-response rates were higher with cenicriviroc, however, largely due to greater drop-out of patients. (wikipedia.org)
  • A Cochrane review comparing aripiprazole with placebo concluded that high dropout rates in clinical trials, and a lack of outcome data regarding general functioning, behavior, mortality, economic outcomes, or cognitive functioning make it difficult to definitively conclude that aripiprazole is useful for the prevention of relapse. (wikipedia.org)
  • psychosis
  • Behavioural and psychological symptoms in dementia (BPSD), such as agitation, aggression and psychosis, occur at some point in over 80% of patients with dementia ( Ballard et al , 1995 ). (rcpsych.org)
  • therapy
  • It has been shown to be highly efficacious and well tolerated in phase III clinical trials in multidrug experienced human immunodeficiency virus(HIV)-infected patients, as well as initial therapy in untreated patients. (clinicaltrials.gov)
  • 1.3 Patients without any local or systemic therapy for HCC within 4 weeks. (knowcancer.com)
  • 1.6.6 Serum creatinine tumors less than one half of the whole liver and the tumors can be encompassed within RT fields 1.8 Signed informed consent 1.9 Sexually active patients, in conjunction with their partner, must practice birth control during, and for 2 months after, thalidomide therapy. (knowcancer.com)
  • Patients who have major systemic diseases that the attending physicians consider inappropriate for radiotherapy or thalidomide therapy. (knowcancer.com)
  • fewer
  • As functional and behavioral changes often have more clinical relevance than cognitive scores, this may mean that fewer patients will need to be treated to achieve a clinically important improvement than the cognitive data suggest. (acpjc.org)
  • symptoms
  • These symptoms are distressing to patients and troublesome to carers, and often precipitate admission to residential facilities. (rcpsych.org)
  • The elderly are particularly vulnerable to these side-effects, and Parkinsonian symptoms reportedly occur in over 50% of all elderly patients receiving these drugs ( Avorn et al , 1994 ). (rcpsych.org)
  • interferon
  • Studies of monotherapy with conventional or pegylated interferon in patients on maintenance haemodialysis, peritoneal dialysis, or with chronic renal failure not yet requiring dialysis, were eligible for inclusion. (york.ac.uk)
  • Interferon (rIFN -2b), is a drug that appears to be non-leukemogenic, and may have a preferential activity on the malignant clone in PV, as suggested by cytogenetic remissions obtained in patients treated with rIFN -2b. (clinicaltrials.gov)
  • METHODS
  • RESEARCH DESIGN AND METHODS Diabetic patients with at least moderate neuropathic pain were randomized to placebo or lacosamide 400 (in a slow or standard titration) or 600 mg/day over 6-week titration and 12-week maintenance periods. (diabetesjournals.org)
  • pregnancy
  • 1.10 Female patients in child-bearing age must have negative pregnancy test. (knowcancer.com)
  • Rheumatoid arthritis (RA) tends to remit during pregnancy, with more patients achieving remission in the third trimester, coinciding with an increase in levels of α-fetoprotein (AFP). (bmj.com)
  • lower
  • Several investigators recently reported that patients with PV treated with rIFN -2b had lower JAK2V617F allele burdens as compared to a control group that included patients treated with phlebotomy, hydroxyurea, or anagrelide, or who remained untreated. (clinicaltrials.gov)
  • Patients were allocated to receive either rivastigmine, 1 to 4 mg/d (lower-dose group) ( n = 243) or 6 to 12 mg/d (higher-dose group) ( n = 243), or placebo ( n = 239). (acpjc.org)
  • Higher educated MS patients with lower age at onset, shorter disease duration, less severe disability and less fatigue were most likely to be employed. (blogspot.gr)
  • Nearly half of all MS patients were still employed after almost two decades of having MS. Lower age at onset, shorter disease duration, higher education, less fatigue and less disability were independently associated with current employment. (blogspot.gr)
  • Primary
  • Out-patients with alcohol dependence recently detoxified Primary goal size is the duration of the Abstinenz up to the heavy relapse. (clinicaltrials.gov)
  • These disorders include Polycythemia Vera (PV), Essential Thrombocythemia (ET) and Primary Myelofibrosis (PM). Recently an acquired somatic mutation in the intracellular kinase, JAK2 (JAK2V617F) has been observed in 95% of patients with PV, 50% of patients with ET and 50% of patients with primary myelofibrosis. (clinicaltrials.gov)
  • chronic
  • Up to one in four patients with diabetes may be affected by chronic diabetic painful neuropathy (DPN) ( 1 , 2 ) and suffer substantial morbidity and impaired quality of life ( 3 ). (diabetesjournals.org)
  • 1.2 Patients with histological confirmed HCC or patients who do not have histological diagnosis but have met all of the following criteria: 1.2.1 Presence of chronic viral hepatitis and/or cirrhosis 1.2.2 Presence of hepatic tumor(s) with image findings (sonography, CT scan) compatible with HCC. (knowcancer.com)
  • antipsychotics
  • We then address special considerations in the use of antipsychotics in the elderly, including pharmacokinetic and pharmacodynamic changes in ageing, medical comorbidity, drug-drug interactions and tolerability. (rcpsych.org)
  • investigators
  • The investigators hypothesized that pharmacokinetics will not be altered in HIV/HCV patients with advanced (Child-Pugh grade C) cirrhosis or in those with no histologic liver damage. (clinicaltrials.gov)
  • Approximately
  • Approximately 195 patients will be included to receive subcutaneous trastuzumab a fixed dose of 600 mg every 3 weeks for 4 cycles (2 administered from the injection of a vial with a syringe and 2 with the injection device). (clinicaltrials.gov)
  • among
  • These key clinical and demographic factors are important to understand the reasons to work ability in MS. The findings highlight the need for environmental adjustments at the workplace to accommodate individual 's needs in order to improve working ability among MS patients. (blogspot.gr)
  • alcohol
  • Prospective randomized double blind controlled trial in prevention of relapse in recently detoxified alcohol dependent patients with levetiracetam and placebo. (clinicaltrials.gov)
  • 1.1 Patients with measurable, locally advanced HCC that are not suitable for other local therapies, including surgery, TAE, alcohol injection, or radiofrequency ablation. (knowcancer.com)
  • treatments
  • In dementia, they should only be considered after other treatments have failed and if the patient is a risk to himself and/or others. (wikipedia.org)
  • weeks
  • Following administration of these four cycles, the patient will decide whether or not to continue with the subcutaneous formulation of trastuzumab every 3 weeks until progression. (clinicaltrials.gov)
  • Drug
  • Drug tolerability should not be confused with drug tolerance, which refers to subjects' reduced reaction to a drug following its repeated use. (wikipedia.org)
  • less
  • OCB-negative patients, known to differ genetically from OCB-positives, are characterized by less global and regional brain atrophy. (blogspot.gr)
  • Atypicals are less likely than haloperidol - the most widely used typical antipsychotic - to cause extrapyramidal motor control disabilities in patients such as unsteady Parkinson's disease-type movements, body rigidity, and involuntary tremors. (wikipedia.org)