• citation needed] Three hypotheses have gained widespread attention among immunologists: Clonal deletion theory, proposed by Burnet, according to which self-reactive lymphoid cells are destroyed during the development of the immune system in an individual. (wikipedia.org)
  • How immunological tolerance develops is not yet understood, but three popular theories among immunologists are described below. (news-medical.net)
  • The "Clonal Deletion theory," suggests that self-reactive lymphoid cells are eliminated during immunological development. (news-medical.net)
  • Idiotype network theory, proposed by Jerne, wherein a network of antibodies capable of neutralizing self-reactive antibodies exists naturally within the body. (wikipedia.org)
  • The "Idiotype Network theory," first described by Jerne, held that certain antibody networks could neutralize autoantibodies. (news-medical.net)
  • The exact genesis of immunological tolerance is still elusive, but several theories have been proposed since the mid-twentieth century to explain its origin. (wikipedia.org)
  • Clonal anergy theory, proposed by Nossal, in which self-reactive T- or B-cells become inactivated in the normal individual and cannot amplify the immune response. (wikipedia.org)
  • Proposed by Gustav Nossal, the "Clonal Anergy theory" suggests that reactive T- or B-cells become deactivated during development and fail to increase immune responses. (news-medical.net)
  • The "Suppressor population or Regulatory T cell theory," holds that regulatory T-lymphocytes such as CD4+FoxP3+ cells prevent, down regulate or reduce aggressive immune responses to self tissues. (news-medical.net)
  • Clonal anergy theory, proposed by Nossal, in which self-reactive T- or B-cells become inactivated in the normal individual and cannot amplify the immune response. (wikipedia.org)
  • Some of these autoantigens are tissue-specific, no antigen is available to drive negative selection in the thymus. (umn.edu)
  • It plays an important role in immunity by regulating the expression of a wide array of SELF-ANTIGENS and negative selection of autoreactive T-cells in the thymus. (nih.gov)