Thus glioblastoma neoplastic stem cells. Medical search. Frequent questions

Glioblastoma multiforme (GBM) remains incurable despite aggressive implementation of multimodal treatments after surgical debulking. (nih.gov)
Glioblastoma, previously known as glioblastoma multiforme (GBM), is the most aggressive and most common type of cancer that originates in the brain, and has very poor prognosis for survival. (wikipedia.org)
20% of pediatric gliomas are high grade gliomas (HGGs) and include anaplastic astrocytoma (AA), diffuse intrinsic pontine glioma (DIPG), and glioblastoma multiforme (GBM). (frontiersin.org)
In patients with glioblastoma multiforme, TERT expression showed a high correlation with EGFR expression, which is closely linked to the stemness gene signature. (korea.ac.kr)
This was a patient with leptomeningeal spread of a glioblastoma multiforme. (medscape.com)

In this study, we show that human glioblastoma cells secrete soluble factors that alter the phenotype and cytokine secretion profile of both macrophages and mesenchymal stem cells (MSCs). (edu.pl)
Using a cancer stem-cell like human glioblastoma cell line in an orthotopic model, we isolated pairs of neoplastic cells growing either in the core of the tumor (Core cells) or away for the core, in the opposite hemisphere (Inv cells). (neurologycongress.com)

Because of the similarities in immunostaining of glial cells and glioblastoma, gliomas such as glioblastoma have long been assumed to originate from glial-type stem cells found in the subventricular zone. (wikipedia.org)
Diffuse spread through brain parenchyma and the presence of hypoxic foci rimmed by neoplastic cells are two cardinal features of glioblastoma, and low oxygen is thought to drive movement of malignant gliomas in the core of the lesions. (cardiff.ac.uk)
In gliomas, TERT p mutations ( TERT p mut ) mainly occur in oligodendroglioma and glioblastoma. (biomedcentral.com)
We screened, for TERT p hotspot mutations, 301 adult patients with gliomas and identified heterozygous mutations in 239 cases: 94% of oligodendroglioma, 85% of glioblastoma, and 37.5% of diffuse/anaplastic astrocytoma. (biomedcentral.com)
Immunohistological studyof mononuclear cell infiltrate in malignant gliomas. (edu.pl)
Downregulation of CDC2 could potentialy inhibit human gliomas cells growth ex vivo and in vivo. (biomedcentral.com)
To reveal the roles of CDC2/Cyclin B1 in human malignant gliomas, CDC2 in glioma cell line, it was down-regulated by retrovirus vectors expressing short hairpin RNAs (shRNAs) ex vivo and in vivo. (biomedcentral.com)
Overexpression of TERT712, a telomerase activity-deficient form of TERT, in U87MG cells promoted cell self-renewal in vitro, and induced EGFR expression and formation of gliomas exhibiting cellular heterogeneity in vivo. (korea.ac.kr)
8. Dahlrot R.H., Hermansen S.K., Hansen S., Kristensen B. W. What is the clinical value of cancer stem cell markers in gliomas? (elpub.ru)
Functional analysis of HOXD9 in human gliomas and glioma cancer stem cells. (123dok.net)
Conclusions: Our results suggest that HOXD9 may be a novel marker of GCSCs and cell proliferation and/or survival factor in gliomas and glioma cancer stem-like cells, and a potential therapeutic target. (123dok.net)
Gliomas, especially glioblastomas (GBMs), are the most malignant primary brain tumors[1]. (123dok.net)

More recent studies suggest that astrocytes, oligodendrocyte progenitor cells, and neural stem cells could all serve as the cell of origin. (wikipedia.org)
Glioblastomas are intrinsic brain tumors believed to originate from neuroglial stem or progenitor cells. (frontiersin.org)
ZEB1 protein was also present in human fetal periventricular stem and progenitor cells and ZEB1 inhibition impaired migration of in vitro propagated human neural stem cells. (cardiff.ac.uk)
For an extent, this functional program of conversation may clarify the powerful character of CSC populations, and the current presence of tumor/stem progenitor cells, tumor-inducing cells and additional neoplastic components with properties that aren't typical for common glioblastoma cells (6,13,14). (abt-888.net)
Finally, we cultured human glioma cancer stem cells (GCSCs) from patient specimens found with high expression of HOXD9 in GCSCs compared with normal astrocyte cells and neural stem/progenitor cells (NSPCs). (123dok.net)
She returned to UCSF to conduct translational research, and apply her combined expertise in stem cells and signaling on the study of brain neoplasms and human stem and progenitor cells. (stanford.edu)
Dr. Petritsch is an expert in oligodendrocyte progenitor cells, and cancer stem cells, and her team's emphasis is on intra-tumoral heterogeneity, in vitro and in vivo cancer model development, and tumor-immune interactions. (stanford.edu)
Her research identified conserved mechanisms of cell fate determination in mammalian brain progenitors and led to a paradigm shift in understanding how brain progenitor cells self-renew and differentiate. (stanford.edu)
Cell fate decisions within these hierarchical brain cell lineages are tightly controlled and irreversible: e.g. cells in the state of differentiation will not turn into progenitor cells or stem cells. (stanford.edu)
this metabolite can modify DNA methylation of normal neural and glial progenitor cells causing them to produce neoplastic glioma cells. (msdmanuals.com)

Glioblastomas represent 15% of all brain tumors. (wikipedia.org)
The new 2016 WHO Classification of Tumors of the Central Nervous System was a paradigm shift: some of the tumors were defined also by their genetic composition as well as their cell morphology. (wikipedia.org)
Recent studies have suggested that many solid tumors, including GBM, are maintained by a subset of cells termed cancer stem cells (CSCs). (johnshopkins.edu)
The present study provides new insights into TERT p mutational spectrum occurring in central nervous system tumors, with the identification of new recurrent somatic gain-of-function mutations, occurring in 0.8% of glioblastoma IDH -wildtype. (biomedcentral.com)
Report shows how late-stage tumors can promote the development of 'suppressor' cells that prevent other immune cells from effectively fighting against the tumor. (hum-molgen.org)
Abnormalities in cell cycle regulation are reported to be strongly associated with tumorigenesis and progression of tumors. (biomedcentral.com)
It is now accepted that the formation of solid tumors requires the proliferation of stromal cells to support cancer cell growth, invasion, and metastasis [ 5 ] and that the stromal cell compartment comprises a heterogeneous mix of cell types responsible for the formation of blood vessels as well as supporting a microenvironment commensurate with tumor growth and proliferation. (hindawi.com)
Heterogeneity in solid tumors is not limited to the differences between neoplastic cancer cells. (por-journal.com)
Many tumors have been described to have marked immune cell infiltration. (por-journal.com)
Tumors of doxycycline-treated mice showed fewer neoplastic cells in the H&E staining (Number 6F). (tech-strategy.org)
They have complementary mechanisms to hinder the carcinogenic process by searching free radicals, inhibiting survival and multiplication of malignant cells, as well as reducing invasiveness and angiogenesis of tumors. (researchsquare.com)
We think that defective cell fate decisions fuel the intra-humoral heterogeneity and plasticity that makes treatment of human brain tumors so challenging. (stanford.edu)
Defects in cell fate control could explain many key defects present in brain tumors Of special emphasis, we study the establishment of cell fates within normal hierarchical brain lineages for comparison to the dysregulated cell-fate hierarchies seen in brain tumors. (stanford.edu)
However, targeting solid tumors is more challenging than targeting B-cell malignancies with CAR-T cells because of the histopathological structure features, specific antigens shortage and strong immunosuppressive environment of solid tumors. (ijbs.com)
Optimization of the design of CAR vectors, exploration of new targets, addition of safe switches and combination with other treatments bring new vitality to the CAR-T cell based immunotherapy against solid tumors. (ijbs.com)
In this review, we focus on the major obstacles limiting the application of CAR-T cell therapy toward solid tumors and summarize the measures to refine this new cancer therapeutic modality. (ijbs.com)
And much work remains to be done to improve the efficacy of CAR-T cell therapy for solid tumors. (ijbs.com)
It may be achieved, at least partially, by more extensive basic studies investigating the spatiotemporal dynamics of T cell activation by CARs and unraveling the connection between T cell migration in solid tumors and the effectiveness in eradication of solid tumors and metastases [ 5 ]. (ijbs.com)
In this review, we discuss the current status and major obstacles for the treatment of solid tumors with CAR-T cells, thus provide some potential measures to refine this novel therapeutic modality. (ijbs.com)
In a first clinical trial, a natural killer cell immunotherapy derived from induced pluripotent stem cells is being tested for safety in 64 patients with a variety of solid tumors. (issca.us)
Von Hippel-Lindau (VHL) disease is an autosomal dominant genetic neoplastic disorder caused by germline mutation or deletion of the VHL gene, characterized by the tendency to develop multisystem benign or malignant tumors. (biomedcentral.com)
VHL disease encompasses various types of tumors, including retinal or central nervous system hemangioblastoma (RH or CNSH), clear cell renal cell carcinoma (RCC), pheochromocytoma (PHE), multiple pancreatic cysts or tumors (PCT), epididymal or broad ligament cystadenomas and endolymphatic sac tumor. (biomedcentral.com)
Both primary and secondary glioblastomas have distinct genetic characteristics, which can change as the tumors evolve. (msdmanuals.com)
Furthermore, transgenic mice harboring the viral-encoded large T-antigen (LT-Ag) alone develop tumors of neuroectodermal origin, including malignant peripheral nerve sheath tumors (MPNSTs) and glioblastomas. (cdc.gov)

Here we show that TGF-beta regulates proliferation, migration, and tumorigenicity of mesenchymal GBM cancer stem cells (CSCs) in vivo and in vitro. (uni-regensburg.de)
For childhood neoplasms, it is safe to assume that cancer is the product of degeneration in a neoplastic sense of tissues undergoing very rapid proliferation and differentiation, in which proliferative and differentiative programs are being disturbed by increasingly early (maternal-fetal) exposure to a growing number of environmental stressors and pollutants. (frontiersin.org)
Enhancement of head andneck squamous cell carcinoma proliferation, invasion, andmetastasis by tumor-associated fibroblasts in preclinicalmodels. (edu.pl)
A phenotypic assessment showed significantly decreased animal survival, increased cancer stemness and invasion but decreased proliferation of the Inv cells in comparison to Core cells. (neurologycongress.com)
With the help of intercellular interactions, Rabbit polyclonal to AKAP5 the coordinated regulation of metabolism, cell and differentiation proliferation occurs in various cells. (abt-888.net)
Silencing CD151 inhibited neurosphere forming capacity, neurosphere cell proliferation, and migration and attenuated the expression of markers and transcriptional drivers of the GSC phenotype. (elsevierpure.com)
Retroviral vectors expressing short hairpin RNAs (shRNAs) against CDC2 caused efficient deletion of CDC2, cellular G2/M arrest concluding in apoptosis and inhibition of proliferation in human glioma cells U251 and SHG-44 cell lines ex vivo. (biomedcentral.com)
Indeed, cell culture studies have demonstrated endosialin to be directly involved in regulating cellular proliferation [ 13 ] and in a subset of cells this proliferation appears to involve the PDGFR- β pathway [ 14 , 15 ]. (hindawi.com)
JCI20679 suppresses the proliferation of glioblastoma stem cells by activating AMPK and decreasing NFATc2 expression levels. (addgene.org)
Inside our research, the cell proliferation assay demonstrated that ATP1B2 shRNA-1# and shRNA-2# successfully inhibited the cell proliferation price of both U87 and T98G cell lines. (tech-strategy.org)
decreased cell proliferation, cell cycle arrest, and induction of apoptosis. (123dok.net)
It was suggested that HOXD9 contributes to both cell proliferation and/or cell survival. (123dok.net)
HOXD9 siRNA treatment of SK-MG-1 SP cells resulted in reduced cell proliferation. (123dok.net)
Homeobox proteins are master regulators of develop-ment and control many cellular processes, including proliferation, apoptosis, cell shape, and cell migration. (123dok.net)
Inactivation of tumor suppressor genes, whose products normally provide negative control of cell proliferation, contributes to malignant transformation in various cell types. (medscape.com)

Specifically, the concepts of tumour heterogeneity, oncogene addiction, non-oncogene addiction, tumour initiating cells, tumour microenvironment, non-coding sequences and DNA damage response will be reviewed. (bmj.com)
purchase Cediranib this change might start cell migration from hypoxic areas to the areas with an improved bloodstream source, where the regional microenvironment could be even more beneficial. (abt-888.net)
The coordinated growth and cross-talk between stromal cell components are critical for establishing a microenvironment that can support the growth and maintenance of tumor cells. (hindawi.com)
Taken together, these data suggest that endosialin plays a role in forming and/or stabilizing the tumor ECM and thus the tumor microenvironment, in addition to its roles in neovascularization and cross-talk between various cell types. (hindawi.com)
A novel spontaneous hepatocellular carcinoma mouse model for studying T-cell exhaustion in the tumor microenvironment. (addgene.org)
Nowadays, with single-cell approaches, tumor heterogeneity, the tumor microenvironment, and the interplay between tumor cells and their surroundings can be described in unprecedented detail. (por-journal.com)

Malignant cells carried in the CSF may spread (rarely) to the spinal cord or cause meningeal gliomatosis. (wikipedia.org)
We take advantage of the similarity between neural developmental processes and cancer hierarchy to mitigate, if not completely abolish, the malignant nature of tumor cells and pave the way for new intervention strategies. (lu.se)
This is especially true for malignant glioma cells, which simultaneously express markers of different lineages and states exhibiting incomplete differentiation. (stanford.edu)
These cell populations provide platforms to develop new cell-based therapies to treat both malignant and nonmalignant hematological diseases. (issca.us)

The cause of most cases of glioblastoma is not known. (wikipedia.org)

Metformin, a common oral biguanide used to treat type 2 diabetes, has been demonstrated to have anti-neoplastic effects. (weeksmd.com)
This is mainly mediated by a subpopulation of cells with stemness traits termed glioblastoma stem-like cells (GSCs), which are extremely resistant to anti-neoplastic drugs. (bvsalud.org)

This article reviews the key principles that drive the formulation of therapeutic strategies in glioblastoma. (bmj.com)
Although next generation sequencing led to genomic landscaping of glioblastoma, there is little insight into the mechanism of neoplastic cell invasion, the detection of the invasive cells or their therapeutic targeting. (neurologycongress.com)
These findings identify CD151 and its interactions with integrins α3 and α6 as potential therapeutic targets for inhibiting stemness-driving mechanisms and stem cell populations in GBM. (elsevierpure.com)
Topics include but are not limited to in vitro and in vivo cancer therapeutic responses, targeted therapies (including metabolism and immunotherapy, such involving CAR-T cells), identification of novel therapeutic targets, and evaluation of novel diagnosis and prognosis markers and the assessment of their impact on morphological, phenotypical, and molecular classifications. (mdpi.com)
Recent years, we have witnessed significant progresses in both basic and clinical studies regarding novel therapeutic strategies with genetically engineered T cells. (ijbs.com)
Advances in our understanding on the interaction between the immune system and tumor cells have contributed to the rapid development of novel therapeutic strategies based on chimeric antigen receptor (CAR) or T cell receptor (TCR) modified T cells. (ijbs.com)
The emerging therapeutic approach of CAR-T cell therapy has sparked great interests, extensive studies in preclinical and clinical trials have revealed encouraging therapeutic efficacy in treating a variety of cancers, particularly in treating B-cell hematologic malignancies with CD19 CAR-T cells [ 3 ]. (ijbs.com)
Pluripotent stem cells could provide an estimable source of T lymphocytes, but the therapeutic potential of human pluripotent stem cell-derived lymphoid cells generated to date remains uncertain. (issca.us)

Sagittal T1-weighted postcontrast image of the lumbar spine with fat saturation reveals diffuse tumor seeding of the cauda equina from metastatic squamous cell carcinoma. (medscape.com)

The concept of heterogeneity has been around for several decades and gained attention in the 1990s when cancer stem cells were identified in acute myeloid leukemia [ 2 ]. (por-journal.com)

Our results suggest that the orchestrated response of macrophages and stromal elements to neoplastic cells enhances tumor progression through the release of soluble factors. (edu.pl)
Some of these cells have antitumoral behavior (NK cells, CD8 + T cells, CD4 + Th1 cells, and APCs), while others can promote tumor progression (CD4 + Th2 cells, regulatory T cells, and tumor-associated macrophages) [ 13 ]. (por-journal.com)
However, several lines of evidence indicate that many cancer cells exhibit shorter telomere length than normal tissues, implying an additional function of TERT in tumor formation and progression. (korea.ac.kr)
The CDK4-cyclinD complex normally phosphorylates the retinoblastoma protein (Rb protein), leading to release of the E2F transcription factor and cell cycle progression. (medscape.com)

Tcf3 is an integral component of the core regulatory circuitry of embryonic stem cells // Genes & Development. (elpub.ru)
Background: HOX genes encode a family of homeodomain-containing transcription factors involved in the determination of cell fate and identity during embryonic development. (123dok.net)
Dr. Multani has extensive expertise in the field of Human and Mammalian Cytogenetics, and specializes in the evaluation of genetic instability and complex chromosomal rearrangements in cancer cells, telomere dysfunction, characterization of embryonic stem cells, and authentication of cell lines. (mdanderson.org)
Human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) provide an accessible, genetically tractable, and homogenous starting cell population to efficiently study human blood cell development. (issca.us)
Earlier studies have revealed that the embryonic stem (ES) cell/early PGC state is associated with tumourigenicity. (biomedcentral.com)

While a few studies have attempted reprogramming of glioblastoma (GBM) cells toward a neuronal fate, this approach has not yet been used to induce differentiation into other lineages and in vivo data on reduction in tumorigenicity are limited. (lu.se)
Most importantly, forced differentiation substantially reduces tumorigenicity of GBM cells in an in vivo xenotransplantation model. (lu.se)
Microarray profiling of Core and Inv cells for differences of expression of mRNAs and microRNAs resulted in the identification of differentially expressed gene targets controlling metabolic pathways, cell-cell and cell-matrix adhesion and cell differentiation. (neurologycongress.com)
Induction of differentiation and TERT-knockdown in glioma stem cells led to a marked reduction in EGFR expression, cancer stemness, and anticancer drug resistance. (korea.ac.kr)
Symmetric cell division prompts multiplication and asymmetric cell division is an enlightening advance for differentiation. (researchsquare.com)

On a functional level, proneural CSC lines caused a significantly stronger TGF-beta-dependent suppression of NKG2D expression on CD8(+) T and NK cells in vitro providing a mechanistic explanation for the reduced immune infiltration of proneural GBMs. (uni-regensburg.de)
Transcription factors associated with epithelial‐to‐mesenchymal transition (EMT) have been linked to this invasion, and we found that hypoxia increased in vitro invasion up to fourfold in glioblastoma neurosphere lines and induced the expression of ZEB1. (cardiff.ac.uk)

By secreting components of the extracellular matrix and interacting with them, a cancer cell may penetrate the surrounding tissues. (abt-888.net)
Cancerous cells are embedded into diverse tissues consisting of cancer-associated fibroblasts, extracellular matrix, vascular and lymphatic networks, and immune cells, among others. (por-journal.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Invasion and metastasis in colorectal cancer: epithelial- mesenchymal transition, mesenchymal- epithelial transition, stem cells and beta-catenin // Cells Tissues Organs. (elpub.ru)
Results: In this study, we found high expression of the HOXD9 gene transcript in glioma cell lines and human glioma tissues by quantitative real-time PCR. (123dok.net)
Using immunohistochemistry, we observed HOXD9 protein expression in human brain tumor tissues, including astrocytomas and glioblastomas. (123dok.net)

Emerging roles ofthe tumor-associated stroma in promoting tumor metastasis.Cell Adh Migr. (edu.pl)
Biology of Metastasis - Adhesion Molecules and Cell-Cell/Matrix Interactions 1 (Migration) ( MSc Oncology , A34C02/L/05 Tumour Physiology) (2015-present). (nottingham.ac.uk)
Biology of Metastasis - Adhesion Molecules and Cell-Cell/Matrix Interactions 2 (Invasion) ( MSc Oncology , A34C02/L/05 Tumour Physiology) (2015-present). (nottingham.ac.uk)
Curcumin reduces fascin expression through JAK/STAT3 pathway inhibition, which interferes with the cellular interactions essential for the metastasis and recurrence of ovarian cancer cells. (biomedcentral.com)

The best available evidence suggests that glioblastomas originate from cells that give rise to glial cells. (bmj.com)

Glioblastoma (GBM) stem cells (GSCs) represent tumor-propagating cells with stem-like characteristics (stemness) that contribute disproportionately to GBM drug resistance and tumor recurrence. (elsevierpure.com)
Conversely, forced CD151 expression promoted neurosphere self-renewal, cell migration, and expression of stemness-associated transcription factors. (elsevierpure.com)
Here, we report a telomerase activity-independent function of TERT that induces cancer stemness in glioma cells. (korea.ac.kr)

Modification with chimeric antigen receptors (CARs) endows T cells with tumor specific cytotoxicity and thus induce anti-tumor immunity against malignancies. (ijbs.com)
Recently, some Approved cell therapies for Cancer also rely on modifying T cells, in those cases to produce cancer cell-binding chimeric antigen receptors (CARs), and have been effective in treating certain cancers such as leukemia. (issca.us)
Therapies that contains such chimeric antigen receptor (CAR) T cells have been approved for some types of so-called liquid cancers of the blood and bone marrow, large B-cell lymphoma and B-cell acute lymphoblastic leukemia. (issca.us)

CAR-T cell therapy has achieved outstanding progresses in clinical observations, which makes it even more attractive in the development of cancer adoptive immunotherapy. (ijbs.com)

Almost all patients with GBM relapse within a narrow margin around the initial resected lesion due to postsurgery residual glioma stem cells (GSCs). (nih.gov)
ATP1B2 is certainly portrayed higher in glioblastoma stem-like cells (GSCs) than in GBM cells and its own Rabbit Polyclonal to NPM downregulation induces apoptosis of GSCs. (tech-strategy.org)
A previous study recognized GSK1292263 higher ATP1B2 manifestation in GSCs than in GBM cells [25]. (tech-strategy.org)

Therefore, our work establishes a locoregional treatment strategy for priming cancer stem cell-specific tumoricidal immunity with broad application in patients suffering from recurrent malignancies. (nih.gov)
One potential target is the cancer stem cell (CSC). (weeksmd.com)
There are two not mutually exclusive models explaining tumor heterogeneity: the cancer stem cell and the clonal evolution model. (por-journal.com)

Immune cell infiltration varies widely between different glioblastomas (GBMs). (uni-regensburg.de)
In vivo, a substantially increased infiltration of immune cells was observed in mesenchymal GBMs, while immune infiltrates were rare in proneural GBMs. (uni-regensburg.de)
Tumor cell hierarchies are poorly understood, providing no explanation for why tumor cells with stem-like, progenitor-like, and differentiated features co-exist and interact with normal brain cells and immune-infiltrating cells within a single tumor entity, and how this heterogeneity relates to the lack of active immune infiltration. (stanford.edu)

Studies carried out over the past three decades suggest that glioblastomas, like other cancers, arise secondary to the accumulation of genetic alterations. (bmj.com)
In this review article we aimed to emphasize the importance of single-cell analyses by presenting tumor heterogeneity and the limitations of conventional investigational approaches, followed by an overview of the whole single-cell analytic workflow from sample isolation to amplification, sequencing and bioinformatic analysis and a review of recent literature regarding the single-cell analysis of colorectal cancers. (por-journal.com)
A prior research indicated which the 3 subunit (ATP1B3) is normally overexpressed in gastric cancers, and its own downregulation induced significant cancers cell apoptosis [35]. (tech-strategy.org)
Another important class of tumor suppressor genes involved in cell cycle control and in the generation of human cancers is the cyclin-dependent kinase (CDK) inhibitors. (medscape.com)

Because they can propagate indefinitely, as well as give rise to every other cell type in the body (such as neurons, heart, pancreatic, and liver cells), they represent a single source of cells that could be used to replace those lost to damage or disease. (issca.us)

The multifunctional nuclear protein large T-antigen was detectable by immunohistochemical analyses in a subset of neoplastic cells. (cdc.gov)

Induced pluripotent stem cells (also known as iPS cells or iPSCs) are a type of pluripotent stem cell that can be generated directly from a somatic cell. (issca.us)
Pluripotent stem cells hold promise in the field of regenerative medicine. (issca.us)
The FT500 NK cells do not undergo any further alterations and after their derivation from the induced pluripotent stem cells (iPSCs), offering the possibility of a quicker, ready-made treatment. (issca.us)
The ability to induce pluripotent stem cells from committed, human somatic cells provides tremendous potential for regenerative medicine. (issca.us)

In glioma CSC (GCSC), the expression of some neural stem markers, such as SOX2 and Musa-shi-1, has been reported[6,7]. (123dok.net)
Her postdoctoral studies on neural stem cells and asymmetric cell division in the Lab of Dr. Yuh Nung Jan at the Howard Hughes Medical Institute and University of San Francisco, California implied for the first time a minus-end directed myosin in the process of cell fate determination. (stanford.edu)

ECE1cK6R behaved as a highly stable protein in all cell lines, and its expression promoted self-renewal and the enrichment of a stem-like population characterized by enhanced neurospheroid formation, as well as increased expression of stem-like surface markers. (bvsalud.org)

Pericytes and stromal fibroblasts derive from mesenchymal stem cells [ 3 ] and, as such, endosialin has been described as a mesenchymal marker. (hindawi.com)

Glioblastoma (GBM) prognosis remains dismal, with most patients succumbing to disease within 1 or 2 years of diagnosis. (johnshopkins.edu)

It has been shown that these cells are inherently radio- and chemotherapy resistant, and may be maintained in vivo in a niche characterized by reduced oxygen tension (hypoxia). (johnshopkins.edu)
These ECE1cK6R-derived GSC-like cells also displayed enhanced resistance to the GBM-related chemotherapy drugs temozolomide and gemcitabine and increased expression of the ABCG2 efflux pump. (bvsalud.org)
Glioblastoma is a deadly brain tumor with a median survival of 1.3 years after surgery, radiotherapy and chemotherapy. (neurologycongress.com)
A restricted cell population propagates glioblastoma growth after chemotherapy // Nature. (elpub.ru)

In an orthotopic patient-derived glioblastoma humanized mouse model, the combined treatment with nanoporter-hydrogel superstructure and CD47 antibody increased the frequency of positive immune responding cells and suppressed the negative immune regulating cells, conferring a robust tumoricidal immunity surrounding the postsurgical cavity and inhibiting postoperative glioblastoma relapse. (nih.gov)

The catalytic activity of human Telomerase Reverse Transcriptase (TERT) compensates for the loss of telomere length, eroded during each cell cycle, to ensure a correct division of stem and germinal cells. (biomedcentral.com)
Telomerase reverse transcriptase (TERT), the catalytic subunit of the enzyme telomerase, is robustly expressed in cancer cells. (korea.ac.kr)

Secondary glioblastomas typically have mutations in the IDH1 or IDH2 genes. (msdmanuals.com)

Furthermore, inducible ATP1B2 knockdown considerably inhibit tumor development tumor development in mice xenografted using the extremely tumorigenic U87 GBM cell series stably expressing doxycycline-inducible shATP1B2-1#. (tech-strategy.org)

Anaplastic astrocytomas, in particular, can later evolve into glioblastomas (called secondary glioblastomas). (msdmanuals.com)

Western Blotting was used to determine the level of expression of CDC2 protein as measure to quantify down regulation of CDC2 expression along with use of flow cytometry to investigate effect of shRNAs on cell cycles and detection of apoptosis. (biomedcentral.com)
Typically, immune cells detect the major histocompatibility complex (MHC) presented on infected cell surfaces, triggering cytokine release, causing apoptosis. (issca.us)
The TP53 gene is also capable of stimulating apoptosis of cells containing damaged DNA. (medscape.com)
TP53 activates the expression of genes involved in apoptosis, cell cycle regulation (p21), and MDM2. (medscape.com)

The induction of ZEB1 protein in hypoxic glioblastoma neurospheres could be partially blocked by the HIF1alpha inhibitor digoxin. (cardiff.ac.uk)

called either cancer stem cells (CSCs) or tumor-initiat-ing cells[3]. (123dok.net)

CD151 was found to complex with integrins α3, α6, and β1 in neurosphere cells, and blocking CD151 interactions with integrins α3 and α6 inhibited AKT phosphorylation, a downstream effector of integrin signaling, and impaired sphere formation and neurosphere cell migration. (elsevierpure.com)

Endosialin, also known as Tumor Endothelial Marker-1 (TEM-1) or CD248, was first described as a vascular endothelial cell surface antigen in human fetal fibroblasts [ 1 ]. (hindawi.com)
Progress in adoptive T-cell therapy for cancer and infectious diseases is hampered by the lack of readily available antigen-specific, human T lymphocytes. (issca.us)

12 Department of Neurosurgery and Center for Stem Cell & Regenerative Medicine, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Texas. (aacrjournals.org)

TERT enables cells to avoid chromosome shortening during repeated replication by maintaining telomere length. (korea.ac.kr)

Glioblastoma (GBM) is the most common and aggressive type of brain tumor due to its elevated recurrence following treatments. (bvsalud.org)

Targeting ZEB1 blocked hypoxia‐augmented invasion of glioblastoma cells in addition to slowing them in normoxia. (cardiff.ac.uk)

Activation of the PI3 kinase-Akt pathways characterized the Inv cells, whereas activation of the ERK/MAP kinase pathway was specific to Core cells. (neurologycongress.com)
Two categories of targets potentially relevant for diagnostic and therapy were further addressed: enzymes involved in metabolic pathways and receptor molecules expressed at the plasma membrane of neoplastic cells. (neurologycongress.com)
Pericytes are essential to the process of angiogenesis, especially neoangiogenesis, and serve as scaffolding for endothelial cells but also communicate with endothelial cells by direct physical contact and paracrine signaling pathways [ 4 ]. (hindawi.com)
Sensitization of cancer cells to conventional drugs using multi-target agents that block survival and oncogenic pathways, alone or in combination, is an emerging strategy to overcome drug resistance. (researchsquare.com)

The molecular biology and genetics of brain tumour cells grown as 3D cultures better resembles the biology of the patients' tumour, when compared to traditional 2D cultures. (nottingham.ac.uk)
Because age-related cellular senescence and type 2 diabetes (T2D) have been recognised as risk factors for CRC development, the recent finding that type 2 diabetic patients present an elevated circulating volume of senescent cells raises the question whether type 2 diabetes facilitates the process of CRC tumorigenesis by inducing premature cell senescence. (frontiersin.org)
Researchers are hopeful that the clinical trial can help determine which cancer patients could benefit the most from NK cell treatment. (issca.us)

Retroviral vectors expressing short hairpin RNAs (shRNAs) targeted against CDC2 were designed and transducted into human glioma cell line ex vivo in order to downregulate the expression of CDC2. (biomedcentral.com)
Ex vivo drug screening refers to the out-of-body assessment of drug efficacy in patient derived vital tumor cells. (biomedcentral.com)

The intricate molecular mechanisms involved in the regenerative process of the normal intestine and the identity of putative somatic intestinal stem cells have become clear. (mdpi.com)

It is known that brain tumor cells, on the other hand, defy many general principles of neurobiology. (stanford.edu)

In fact, several studies have shown that T2D induces senescence in multiple types of cells, including fibroblasts and endothelial cells ( 11 , 12 ). (frontiersin.org)

Endosialin (CD248, TEM-1) is expressed in pericytes, tumor vasculature, tumor fibroblasts, and some tumor cells, including sarcomas, with limited normal tissue expression, and appears to play a key role in tumor-stromal interactions, including angiogenesis. (hindawi.com)

These translational findings and the implications for the diagnosis and therapy of glioblastoma will be discussed. (neurologycongress.com)

Although there have been many reports regarding the anticancer properties of curcumin, its inhibitory effects on migration and invasion of ovarian cancer cells, particularly in the context of fascin expression, have not been reported. (biomedcentral.com)
The attachment assay, migration assay and invasion assay of the ovarian cancer cells exhibited a statistically significant decrease. (biomedcentral.com)

In recent years, the evolution of the molecular biological technical background led to the widespread application of single-cell sequencing, a versatile tool particularly useful in the investigation of tumor heterogeneity. (por-journal.com)
Tumor heterogeneity means that neoplastic cells from the same tumor can genotypically, phenotypically, morphologically, or metabolically differ from each other. (por-journal.com)

Anatomy10

Diseases2

Chemicals and Drugs1

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Phenomena and Processes2

Multiforme5

Human glioblastoma2

Gliomas12

Progenitor cells10

Tumors24

Proliferation15

Microenvironment6

Malignant4

Cases of glioblastoma1

Anti-neoplastic2

Therapeutic8

Squamous Cell Carc1

Acute Myeloid1

Progression4

Embryonic5

Differentiation5

Vitro2

Tissues6

Metastasis4

Glial cells1

Stemness3

Chimeric Antigen3

Immunotherapy1

GSCs3

Cancer stem3

Infiltration3

Cancers4

Pancreatic1

Subset1

Pluripotent Stem4

Neural2

Self-renewal1

Mesenchymal stem1

Prognosis1

Chemotherapy4

Orthotopic1

Telomerase2

Mutations1

Mice1

Anaplastic1

Apoptosis4

Hypoxic1

CSCs1

Neurosphere1

Antigen2

Regenerative Medicine1

TERT1

Recurrence1

Hypoxia1

Pathways4

Patients3

Vivo2

Somatic1

Brain tumor1

Induces1

Stromal1

Translational1

Invasion2

Heterogeneity2