AnatomyDiseasesChemicals and DrugsPhenomena and ProcessesInformation Science
ThrombomodulinReceptors, ThrombinProtein CThrombinCarboxypeptidase UReceptors, Cell SurfaceBlood CoagulationEndothelium, VascularThromboplastinBlood Coagulation FactorsAntithrombin IIIHirudinsHemostasisDisseminated Intravascular CoagulationFibrinopeptide BProthrombinUmbilical VeinsFibrinogenThrombosisvon Willebrand FactorRecombinant ProteinsFibrinopeptide AFactor VFibrinolysisMolecular Sequence DataCells, CulturedFactor VaChondroitin LyasesEndotheliumKineticsHemangiomaCarboxypeptidase BEncyclopedias as Topic
THBDSolubleRecombinant human thrombomodulinLectin domainEndothelial cellsThrombin generationMoleculeGlycoproteinGeneProcoagulantCarboxypeptidaseAnticoagulantRegulatesBoundHumanSepticComplexPlasmaCellSoluble ThrombomodulinThrombin-thrombomodulin complexEndothelial cellLevel of thrombomodulinCofactorThromboembolicCoagulationAttenuated TAFI activationTAFISerumTissue factorInhibitorReceptorProtein C activationFactorRabbitActivationBoundAbsenceIdenticalSurfaceInjuryWomen
THBD3
  • In humans, thrombomodulin is encoded by the THBD gene. (wikipedia.org)
  • citation needed] Thrombomodulin is a glycoprotein on the surface of endothelial cells that, in addition to binding thrombin, regulates C3b inactivation by factor I. Mutations in the thrombomodulin gene (THBD) have also been reported to be associated with atypical hemolytic-uremic syndrome (aHUS). (wikipedia.org)
  • Here we pursue an a priori hypothesis that genetic variation in the endothelial-based receptors of the thrombomodulin-protein C system (THBD and PROCR) may similarly be associated with early-onset ischemic stroke. (lu.se)
Soluble8
  • Thrombomodulin Alfa is a novel, recombinant and soluble thrombomodulin (ART-123). (drugbank.com)
  • Thrombomodulin (TM) alfa, a recombinant human soluble TM, enhances activation of pro-carboxypeptidase B2 (pro-CPB2) by thrombin. (drugbank.com)
  • Thrombomodulin alfa is a soluble form of recombinant human thrombomodulin comprising all extracellular domains of thrombomodulin. (drugbank.com)
  • Kearon C, Comp P, Douketis J, Royds R, Yamada K, Gent M: Dose-response study of recombinant human soluble thrombomodulin (ART-123) in the prevention of venous thromboembolism after total hip replacement. (drugbank.com)
  • A rare genetic coagulation disorder characterized by marked bleeding tendency and posttraumatic bleeding with easy bruising soft tissue and muscle bleeding hemarthroses and menorrhagia due to an increase of soluble thrombomodulin in plasma with subsequent protein C activation and reduction of thrombin generation within a potential thrombus. (globalgenes.org)
  • 5) Increases in soluble thrombomodulin and EPCR likely leave less surface bound forms, inhibiting the ability of endothelial cells to activate cytoprotective pathways through PAR-1 and increasing their susceptibility to immune mediated destruction. (cdc.gov)
  • Recombinant human soluble thrombomodulin (rhs-TM) has a potent anticoagulant effect on septic disseminated intravascular coagulation (DIC) by binding to thrombin and activating protein C. The infusion dosage of rhs-TM should be reduced for patients with renal failure. (biomedcentral.com)
  • Diabetic nephropathy (DN) is a leading selectin), and soluble thrombomodulin--are cause of chronic renal failure and is a grow- providing further evidence of the relation- ing concern given the increasing incidence ship between endothelial cell activation and of type 2 diabetes. (who.int)
Recombinant human thrombomodulin2
  • We studied the efficacy of recombinant human thrombomodulin (rhTM) α for acute exacerbation of idiopathic pulmonary fibrosis. (or.jp)
  • Recombinant human thrombomodulin α has the possibility of improving prognosis in acute exacerbation of idiopathic pulmonary fibrosis. (or.jp)
Lectin domain1
  • A missense mutation in lectin domain of thrombomodulin causing functional deficiency. (nih.gov)
Endothelial cells1
  • Thrombomodulin (TM), CD141 or BDCA-3 is an integral membrane protein expressed on the surface of endothelial cells and serves as a cofactor for thrombin. (wikipedia.org)
Thrombin generation3
  • Bound to thrombin, Thrombomodulin alfa inhibits its procoagulant activity and promotes activation of protein C. Thrombomodulin alfa inhibits thrombin generation by the activation of protein C and the subsequent inactivation of factor Va in the presence of protein S. Thrombomodulin alfa attenuates the extension of the clot by inhibiting further thrombin generation on clots, while other anticoagulants inhibit the initiation of clot formation. (drugbank.com)
  • A higher concentration of Thrombomodulin alfa is needed to affect clotting time and platelet aggregation than thrombin generation. (drugbank.com)
  • Abnormal laboratory findings include markedly elevated plasma thrombomodulin reduced prothrombin consumption and decreased thrombin generation. (globalgenes.org)
Molecule1
  • Background: Thrombomodulin (TM) is a key molecule mediating circulation homeostasis through its binding to thrombin. (tmu.edu.tw)
Glycoprotein1
  • Thrombomodulin (TM) is an endothelial glycoprotein that plays a crucial role as a natural anticoagulant, binding thrombin to activate protein C (PC). (isth.org)
Gene1
  • Association of SNP (rs1042579) in thrombomodulin gene and plasma thrombomodulin level in North Indian children with Kawasaki disease. (nih.gov)
Procoagulant1
Carboxypeptidase2
  • Tawara S, Sakai T, Matsuzaki O: Anti-inflammatory and anti-fibrinolytic effects of thrombomodulin alfa through carboxypeptidase B2 in the presence of thrombin. (drugbank.com)
  • Carboxypeptidase B2 (CPB2) is released into the circulation as a proenzyme which is activated by the THROMBIN-THROMBOMODULIN complex. (bvsalud.org)
Anticoagulant2
  • Thrombomodulin functions as a cofactor in the thrombin-induced activation of protein C in the anticoagulant pathway by forming a 1:1 stoichiometric complex with thrombin. (wikipedia.org)
  • e.g., thrombin when bound to thrombomodulin activates protein C. Another example is factor V (FV), which in addition to being a procofactor to FVa has emerged as an anticoagulant. (lu.se)
Regulates1
  • Aberrant promoter hypermethylation regulates thrombomodulin in high altitude induced deep vein thrombosis. (nih.gov)
Bound1
Human3
  • Thrombomodulin is also expressed on human mesothelial cell, monocyte and a dendritic cell subset. (wikipedia.org)
  • Matsusaki M, Omichi M, Maruyama I, Akashi M: Physical adsorption of human thrombomodulin (ART-123) onto polymeric biomaterials for developing an antithrombogenic blood-contacting material. (drugbank.com)
  • Hearts transplanted into Group A baboons (n=4) expressed additional CD55, and those into Group B (n=3) expressed human thrombomodulin (TBM). (unict.it)
Septic1
  • Role of the lectin-like domain of thrombomodulin in septic cardiomyopathy. (nih.gov)
Complex2
  • We present nuclear magnetic resonance (NMR) and hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments on the thrombin-thrombomodulin (TM) complex. (escholarship.org)
  • The isolated protein was activated by thrombin/thrombomodulin complex and further purified. (rndsystems.com)
Plasma1
  • Plasma Thrombomodulin Levels and Ischemic Stroke: A Population-Based Prognostic Cohort Study. (nih.gov)
Cell1
  • Genetics of the thrombomodulin-endothelial cell protein C receptor sys" by John W. Cole, Huichun Xu et al. (aku.edu)
Soluble Thrombomodulin6
  • Recombinant human soluble thrombomodulin (rhTM) forms a complex with thrombin to inactivate coagulation. (nih.gov)
  • Since 2008, recombinant human soluble thrombomodulin (rTM) has been used to treat disseminated intravascular coagulation in Japan. (haematologica.org)
  • Rabbit Soluble thrombomodulin ELISA kit is suitable for detecting samples from rabbit species. (elisakit.cc)
  • 5) Increases in soluble thrombomodulin and EPCR likely leave less surface bound forms, inhibiting the ability of endothelial cells to activate cytoprotective pathways through PAR-1 and increasing their susceptibility to immune mediated destruction. (cdc.gov)
  • soluble thrombomodulin (sTM). (emedicinehealth.com)
  • The purpose of this study is to determine if objective serum tests, such as levels of soluble thrombomodulin (sTM) and soluble intercellular adhesion molecule-1 (sICAM-1), may be used in the diagnosis and staging of HAVS. (cdc.gov)
Thrombin-thrombomodulin complex2
  • 2021 ) Serine protease dynamics revealed by NMR analysis of the thrombin-thrombomodulin complex. (academictree.org)
  • The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. (nih.gov)
Endothelial cell4
  • Elevated lavels of soluble tumour necrosis factor receptor 1, thrombomodulin and soluble endothelial cell adhesion molecules in patients with dengue haemorrhagic fever. (who.int)
  • Mean s-thrombomodulin concentrations, a marker for endothelial cell injury, were highest in rabbits exposed to US at 0.85 and 3.9 MPa, suggesting that vascular injury may be physiological and not accompanied by irreversible cellular injury. (illinois.edu)
  • Thrombomodulin an endothelial cell surface glycoprotein act as a co-factor for thrombin catalyzed activation of protein C. activated protein C inhibits coagulation by inactivation the coagulation factor Va and VIIIa. (ginekologiaipoloznictwo.com)
  • 12. Transgenic Expression of Human Thrombomodulin Inhibits HMGB1-Induced Porcine Aortic Endothelial Cell Activation. (nih.gov)
Level of thrombomodulin1
  • A similar trend was observed in the level of thrombomodulin. (who.int)
Cofactor3
  • Thrombomodulin (TM), CD141 or BDCA-3 is an integral membrane protein expressed on the surface of endothelial cells and serves as a cofactor for thrombin. (wikipedia.org)
  • Thrombomodulin functions as a cofactor in the thrombin-induced activation of protein C in the anticoagulant pathway by forming a 1:1 stoichiometric complex with thrombin. (wikipedia.org)
  • In addition to its multiple procoagulant roles, thrombin also acts as an anticoagulant when combined with the cofactor thrombomodulin in the protein Case complex. (hindawi.com)
Thromboembolic1
  • The malignant mesothelioma (MM) is often complicated by thromboembolic episodes, with thrombomodulin (TM) playing a role in the anti-coagulant process. (nih.gov)
Coagulation2
Attenuated TAFI activation1
  • Inhibitory effects of clone 1 on thrombomodulin-dependent TAFI activation were confirmed in clot lysis assays: Clone 1 fully attenuated TAFI activation in a dose-dependent manner when thrombomodulin was present, but not in its absence. (isth.org)
TAFI4
  • To develop variable domain of heavy-chain-only antibody (VhH) clones that inhibit TAFI activation by targeting human thrombomodulin. (isth.org)
  • In a microfluidic fibrinolysis model in which recalcified whole blood was perfused over a collagen, tissue factor and thrombomodulin surface in the presence of tissue plasminogen activator, clone 1 fully prevented TAFI activation. (isth.org)
  • Thrombin-thrombomodulin also activates thrombin-activatable fibrinolysis inhibitor (TAFI) that slows down fibrin degradation by plasmin. (hindawi.com)
  • Activation of TAFI is most effectively done in complex with thrombomodulin (TM). (uwo.ca)
Serum2
  • Our study found that there was high significant difference (p≤0.01) between pre-eclampsia patients and healthy control group regarding serum thrombomodulin protein level and serum thrombomodulin protein increases significantly with mild and severe preeclampsia and HELLP syndrome and considered a good marker for evaluation of hypertensive patients with pregnancy. (ginekologiaipoloznictwo.com)
  • Serum thrombomodulin protein level is considered a good marker for evaluation of hypertensive patients with pregnancy. (ginekologiaipoloznictwo.com)
Tissue factor2
  • To mitigate against these effects, we propose to derive triple transgenic animals over-expressing two human natural anticoagulants (called tissue factor pathway inhibitor and thrombomodulin) and the thromboregulatory factor CD39, which was found by the Applicant to profoundly inhibit the activation of platelets irrespective of the species of origin. (rotrf.org)
  • Circulating concentrations of soluble (s)L- and sE-selectins (sL-, sE-selectins), vascular and intercellular adhesion molecules (sVCAM-1, sICAM-1), pro/antiinflammatory cytokines [tumor necrosis factor (TNF)-α and interleukin (IL-10)], tissue factor (sTF), thrombomodulin (sTM) and D-dimers (D-D) were assessed by enzyme immunoassay. (biomedcentral.com)
Inhibitor1
  • Targeting senescent hepatocytes using the thrombomodulin-PAR1 inhibitor vorapaxar ameliorates NAFLD progression. (bvsalud.org)
Receptor2
  • We previously found that the fifth epidermal growth factor-like domain of thrombomodulin (TME5) exerts cytoprotective and pro-angiogenic functions via G-protein coupled receptor 15 (GPR15). (haematologica.org)
  • We have demonstrated that exposure of bovine and human endothelial cells to TNF leads to suppression of the functional cell surface thrombin receptor, thrombomodulin (TM), and TM mRNA of virtually identical magnitude. (qxmd.com)
Protein C activation1
  • [ 6 ] ART-123 (Artisan Pharma, Waltham, MA) is a soluble recombinant human thrombomodulin that acts by reducing thrombin-mediated clotting and enhancing protein C activation at the site of clotting. (medscape.com)
Factor1
  • provides novel evidence that PAR2 is cleaved by thrombin in presence of the co-factor thrombomodulin and thus induces pro-inflammatory signaling of alveolar type II epithelial cells. (usz.ch)
Rabbit1
  • Arterial injury resulting from the interaction of contrast agent (CA) with ultrasound (US) was studied in rabbit auricular arteries and assessed by histopathologic evaluation and s-thrombomodulin concentrations. (illinois.edu)
Activation1
  • Based on our novel findings, we are interested on the effects of the PAR2 activation by thrombomodulin-bound thrombin on the alveolar barrier. (usz.ch)
Bound1
  • VhH anti-TM clone 1 bound recombinant thrombomodulin with a binding affinity (KD) of 1.7±0.4nM and showed binding to native thrombomodulin. (isth.org)
Absence1
  • Thrombogram was also assessed in the presence or absence of thrombomodulin and the corresponding ration was calculated. (confex.com)
Identical1
  • The antigen described as BDCA-3 has turned out to be identical to thrombomodulin. (wikipedia.org)
Surface1
  • Affinity was determined with Surface Plasmon Resonance and binding to native thrombomodulin was confirmed with flow cytometry. (isth.org)
Injury1
  • 8. Thrombomodulin as a Physiological Modulator of Intravascular Injury. (nih.gov)
Women2
  • 2004). Thrombomodulin Ala455Val Polymorphism and the risk of cerebral infarction in a biracial population: the Stroke Prevention in Young Women Study. (cdc.gov)
  • to assess the changes in thrombomodulin level in women with preeclampsia. (ginekologiaipoloznictwo.com)