Therapeutic placebos. Medical search. Frequent questions

We conducted double-blind, placebo-controlled trials assessing the efficacy and tolerability of favipiravir in acute influenza. (nih.gov)
Because epoetin alfa has demonstrated efficacy in correcting cancer-related anaemia, the impact of this treatment on quality of life was evaluated in a multinational, randomised, double-blind, placebo-controlled trial in 375 anaemic cancer patients receiving non-platinum-based chemotherapy. (nature.com)
Martin Reck, MD, PhD , of the LungenClinic, discusses findings of the KEYNOTE-598 study, which showed that pembrolizumab plus ipilimumab was more toxic and offered no more benefit in terms of efficacy than pembrolizumab plus placebo in first-line therapy for patients with metastatic high PD-L1-expressing non-small cell lung cancer (Abstract PS01.09). (ascopost.com)
The reduction of harm through an ineffective treatment, the possibility of individualized dosing, the reduction of sample size, and the possible evaluation of the influence of the placebo effect on efficacy outcomes justify this design for a single-centered placebo-controlled investigator-initiated trial of nabilone. (springer.com)
The present study systematically reviewed published and unpublished evidence of the acute and long-term efficacy and acceptability of agomelatine compared with placebo in the treatment of major depression. (cambridge.org)
Secondary efficacy analyses showed a significant advantage of agomelatine over placebo in terms of response (with no effect for remission). (cambridge.org)
A Randomized, double-blind, Repositioning Clinical Trial, placebo controlled, to Evaluate the Efficacy and Safety of FDA-277 in combination with standard of care in the Treatment of Infection Caused by SARS-CoV-2, in Patients With early Stage COVID-19 Disease, in Primary Heatlh Care setting. (who.int)

We conducted a randomized, double-blind, placebo-controlled trial in TB clinics at a demographic surveillance site in Guinea-Bissau. (nih.gov)
METHODS: In this randomised, double-blind, placebo-controlled, investigator-initiated phase 4 trial of the sequestrant colesevelam in bile acid diarrhoea (SINBAD), we enrolled consecutive patients aged 18-79 years without inflammatory bowel disease attending SeHCAT testing for suspected bile acid diarrhoea at four Danish secondary care centres. (aau.dk)
The present study (RAPIDS-2, for 'RAndomized, double-blind, Placebo-controlled study with bosentan on healing and prevention of Ischemic Digital ulcers in patients with systemic Sclerosis') was conducted to more fully evaluate the effects of bosentan treatment on DUs associated with SSc. (bmj.com)
Methods Randomised double-blind, placebo-controlled clinical trial comparing a 12-week programme of using a GTN or placebo patch in combination with eccentric squats on a decline board. (bmj.com)
Methods A randomised, double-blind, placebo-controlled study was carried out. (bmj.com)
9-11 We aimed to study the effect of melatonin in a double-blind, placebo controlled trial with an active comparator. (bmj.com)
The NMS-Nab Study is as a mono-centric phase II, randomized, placebo-controlled, double-blind, parallel-group, enriched enrollment withdrawal study. (springer.com)
We present the results of a double blind, placebo controlled, crossover study of ghrelin in gastric emptying in patients with diabetic gastroparesis. (bmj.com)

This project is a randomized, placebo controlled clinical trial to determine whether ranolazine, given with amiodarone, prolongs normal rhythm after cardioversion compared to amiodarone alone and whether ranolazine also improves heart function. (akcchf.org)

At this first forum, four world-renowned experts shared summaries of their clinical and neurobiological studies of the mechanisms behind the placebo effect. (programinplacebostudies.org)
An expert in human judgment and decision-making, he is best known for his research on placebo effects of commercial actions and on the endowment effect, and his presentations and teachings about Customer Insight. (wikipedia.org)
Participants were randomly allocated 1:1 to receive 12 days of treatment with colesevelam (overencapsulated tablets of 625 mg) or placebo, with the starting dose of two capsules twice daily and titrated to effect during the first 5 days of treatment. (aau.dk)
The placebo effect, or response, is the outcome after the sham treatment. (jneurosci.org)
Therefore, it is important to emphasize that the study of the placebo effect is the study of the psychosocial context around the patient. (jneurosci.org)
The placebo effect is a psychobiological phenomenon that can be attributable to different mechanisms, including expectation of clinical improvement and pavlovian conditioning. (jneurosci.org)
Thus, we have to look for different mechanisms in different conditions, because there is not a single placebo effect but many. (jneurosci.org)
The study of the placebo effect, at its core, is the study of how the context of beliefs and values shape brain processes related to perception and emotion and, ultimately, mental and physical health. (jneurosci.org)
The study of the placebo effect reflects a current neuroscientific thought that has as its central tenet the idea that "subjective" constructs such as expectation and value have identifiable physiological bases, and that these bases are powerful modulators of basic perceptual, motor, and internal homeostatic processes. (jneurosci.org)
The study of the placebo effect also has immediate clinical and ethical implications, because the use of inactive (placebo) conditions in clinical trials when effective treatments are available has created an ethical controversy. (jneurosci.org)
This is the placebo effect: somehow, sometimes, a whole lot of nothing can be very powerful. (newscientist.com)
Doctors have known about the placebo effect for decades, and the naloxone result seems to show that the placebo effect is somehow biochemical. (newscientist.com)
It is possible that the placebo effect plays a role. (medicalnewstoday.com)
Furthermore, a 2022 study in Perspectives in Psychiatric Care found that therapeutic touch had a positive effect on the spiritual well-being and sleep quality of 73 people receiving palliative care in a hospital setting. (medicalnewstoday.com)
Both light and tryptophan have a therapeutic effect in the treatment of seasonal affective disorder. (greenmedinfo.com)
Some of the forms mentioned here are controversial in that some observers believe they have only placebo effect, while others believe that they can have direct therapeutic effects, which never excludes placebo effect. (citizendium.org)
It is the first antidepressant that targets the circadian system and mediates its therapeutic effect through the melatonergic system. (cambridge.org)
Ang ibig sabihin po ng placebo, ang matatanggap ng kalahati ay walang therapeutic effect. (gmanetwork.com)
You've most likely been subject to the placebo effect at various times in your life, without even realizing it. (thealternativedaily.com)
In a recent randomised controlled trial of nasal CPAP on the symptoms of OSA, using nasal CPAP at subtherapeutic pressures to provide a control arm, we found large treatment responses but also a significant placebo effect. (bmj.com)
20 This makes it particularly important to show that any improvements in performance seen on nasal CPAP are real and are not due to a placebo effect. (bmj.com)
Frequently, it is not known the isolated effect of a determined therapeutic modality on the signs and symptoms of the disorder and which of them was responsible for the patient's clinical improvement. (bvsalud.org)
Thereby, the aim of the present study was to evaluate the immediate effect of ultrasound, ultrasound combined with stretching of the mandibular elevator muscles and placebo on the activation pattern and symmetry of these muscles in women with myogenic and mixed TMD. (bvsalud.org)
Ted Kaptchuk talks about the placebo effect and the therapeutic encounter, including the role of placebo in scientific research and what consumers should know about the placebo effect in their health care decision-making. (bvsalud.org)

Conclusion It seems that continuous topical GTN treatment in addition to an eccentric exercise programme does not improve clinical outcome compared to placebo patches and an eccentric exercise programme in patients with chronic patellar tendinopathy. (bmj.com)
Any medical treatment is surrounded by a psychosocial context that affects the therapeutic outcome. (jneurosci.org)
The relationship between expectation and therapeutic outcome is a wonderful model to understand mind-body interaction," he says. (newscientist.com)
A total of 38 patients will have 80% power to detect a probability of 0.231 that an observation in the treatment group is less than an observation in the placebo group using a Wilcoxon rank-sum test with a 0.050 two-sided significance level assuming a true difference of 2.5 points between nabilone and placebo in the primary outcome measure and a standard deviation of the change of 2.4 points. (springer.com)

This placebo-controlled study evaluated two doses of F4/AS01 1-month apart in antiretroviral treatment (ART)-experienced and ART-naive HIV-1-infected subjects (1:1 randomisation in each cohort). (uni-koeln.de)
Healthy men and women, 18 to 45 years old (inclusive), were sequentially assigned to the tramadol 200, 400, or 600 mg/day treatment cohort and within each cohort, randomized (4:1) to either tramadol or placebo every 6 hours for 9 oral doses. (unibas.ch)
Serum high sensitivity CRP levels at week 16 were significantly reduced with secukinumab 75 mg, 150 mg and 300 mg doses versus placebo. (bmj.com)
[ 6 ] As of yet, PDE11 inhibition with therapeutic doses of tadalafil has shown no clinical significance. (medscape.com)

INTERPRETATION: Colesevelam was superior to placebo at inducing remission of bile acid diarrhoea diagnosed with C4 concentration greater than 46 ng/mL. (aau.dk)

Eleven dogs received conventional antiarrhythmic treatment (amiodarone plus placebo) and 11 received ranolazine (in addition to amiodarone). (akcchf.org)

Disease activity score in 28 joints (DAS28)-C-reactive protein (CRP) was a secondary endpoint and clinically relevant decreases with secukinumab 75-300 mg were reported versus placebo. (bmj.com)
Occurrence of PONV is influenced signed by block randomization to one differences between the 3 treatment by various factors such as duration of of4groupsof25patients:placebo(2 groups versus placebo. (who.int)

Acute treatment with agomelatine was associated with a statistically significant superiority over placebo of −1.51 HRSD points (99% Cl −2.29 to −0.73, nine studies). (cambridge.org)
The electromyographic values for the maximum intercuspation as well as the symmetry of anterior temporal muscle (p=0.47, p=0.84, p=0.84) and anteroposterior coefficient (p=0.07, p=0.84, p=0.57) showed no statistically significant difference after the intervention, placebo, ultrasound and ultrasound with stretching. (bvsalud.org)

Rather than raise unrealistic expectations (two chapters acknowledge the reality of practicing when time and resources are scarce), the goal of this book is to help pharmacotherapists mitigate the stigma, apprehension, or resignation their patients may have and instead build and maintain a trusting relationship that will be key to successful therapeutic outcomes. (appi.org)

The intervention was 100,000 IU of cholecalciferol or placebo at inclusion and again 5 and 8 months after the start of treatment. (nih.gov)
Serious games are currently used, inter alia, in therapeutic education, prevention, treatment of various medical conditions, rehabilitation, or as an educational tool for healthcare professionals ( 7 - 9 ). (frontiersin.org)
To do this, a sham treatment (the placebo) is given, but the patient believes it is effective and expects a clinical improvement. (jneurosci.org)
Any form of health treatment may have a placebo effects. (citizendium.org)
Use of some parts of a treatment that do have physical effects on a subject, which are intended to act as placebo where it is impossible to have a completely neutral equivalent to the treatment. (citizendium.org)
Randomised controlled trials comparing agomelatine with placebo in the treatment of unipolar major depression were systematically reviewed. (cambridge.org)
A comparison of the effectiveness of paroxetine, problem-solving therapy, and placebo in the treatment of minor depression and dysthymia in primary care patients: background and research plan. (thieme-connect.com)
CONCLUSIONS Therapeutic NCPAP improves steering performance and reaction time to target stimuli in patients with OSA, lending further support to the hypothesis that OSA impairs driving, increases driving accident rates, and that these improve following treatment with NCPAP. (bmj.com)
Analysis of plasma from dogs treated with ranolazine confirmed therapeutic drug concentrations in all dogs in the treatment group. (akcchf.org)
See Pain Management: Concepts, Evaluation, and Therapeutic Options , a Critical Images slideshow, to help assess pain and establish efficacious treatment plans. (medscape.com)
Ultrasound is one the physical therapeutic modalities used in the TMD treatment. (bvsalud.org)
This provides new opportunities to investigate integrin α10β1-selected MSCs as a treatment for a disease which does not yet have any definitive therapeutic options. (lu.se)

Three therapeutic principles are reported in the literature, namely the inhibition of the contralesional motor cortex (e.g. the constraint-induced movement therapy (CIMT)), activation of the ipsilesional motor cortex (e.g. the mental practice, bimanual therapy, CIMT) and modulation of sensory afferents (e.g. mirror therapy). (lww.com)

Benedetti has since shown that a saline placebo can also reduce tremors and muscle stiffness in people with Parkinson's disease . (newscientist.com)
Cette étude clinique en double aveugle évaluait l'incidence des nausées et des vomissements après une chirurgie de la cataracte avec anesthésie par voie intraveineuse chez 100 patients auxquels un placebo (eau saline), du métoclopramide (10 mg), de la dexaméthasone (8 mg) ou les deux médicaments associés avaient été administrés de manière randomisée avant l'opération. (who.int)

After a 4-week baseline phase, 196 participants were randomised to placebo, amitriptyline 25 mg or melatonin 3 mg, and 178 took a study medication and were followed for 3 months (12 weeks). (bmj.com)
RÉSUMÉ Les études ayant examiné le processus du consentement éclairé chez les participants à des études de recherche dans les pays en développement sont peu nombreuses. (who.int)

Methods Patients (n=237) with inadequate response to methotrexate were randomly assigned to receive monthly subcutaneous injections of secukinumab 25 mg, 75 mg, 150 mg, 300 mg or placebo. (bmj.com)

Thus, placebo effects may represent points of either strength or vulnerability for the expression and maintenance of various pathological states and their inherent therapeutic interventions. (jneurosci.org)
3-4 The initial severity of the stroke is one of the most important predictors but variability remains high, likely influenced by therapeutic interventions. (lww.com)

For example, a placebo can reduce pain by both opioid and non-opioid mechanisms ( Colloca and Benedetti, 2005 ) ( Fig. 1 ). (jneurosci.org)
In an experimental model of pain ( Amanzio and Benedetti, 1999 ), the placebo response could be blocked by naloxone if it was induced by strong expectation cues, whereas if the expectation cues were reduced, it was insensitive to naloxone. (jneurosci.org)

Predictors of therapeutic benefit from amitriptyline in mild depression: A general practice placebo-controlled trial. (thieme-connect.com)

However, this was not a placebo-controlled study. (medscape.com)
In the same study, if the placebo response was obtained after exposure to opioid drugs, it was naloxone reversible, whereas if it was obtained after exposure to non-opioid drugs, it was naloxone insensitive. (jneurosci.org)
19 Although this study had normal control subjects, it did not have placebo treated controls. (bmj.com)
This study aimed to evaluate the informed consent process, therapeutic misconception and motivation for participation among Egyptians participating in clinical trials. (who.int)

Many cancer patients require therapeutic intervention to correct the underlying anaemia. (nature.com)

While a pill with no active ingredients can be a placebo, for surgery, sham surgery would require at least anesthesia and an incision. (citizendium.org)

Scientists are interested in placebo responses because the effects of belief on human experience and behavior provide an entry point for studying internal control of affective, sensory, and peripheral processes. (jneurosci.org)

Conclusions Melatonin 3 mg is better than placebo for migraine prevention, more tolerable than amitriptyline and as effective as amitriptyline 25 mg. (bmj.com)
Data extracted from three relapse prevention studies failed to show significant effects of agomelatine over placebo (relative risk 0.78, 99% Cl 0.41−1.48). (cambridge.org)

Anecdotal reports suggest that therapeutic touch may reduce anxiety. (medicalnewstoday.com)

Reduction in TBscore and sputum smear conversion rates did not differ among patients treated with vitamin D or placebo. (nih.gov)
The Robert Wood Johnson Foundation has funded PiPS to curate a series of five public forums that will increase awareness and foster dialog about placebo effects among a wider range of audiences, including patients, health policy-makers, providers, and researchers from other fields. (programinplacebostudies.org)
He began an inquiry into what was really happening when therapeutic techniques, that today might be dismissed and ridiculed, were deemed efficacious by clinicians and patients alike. (programinplacebostudies.org)
Although this doesn't make much therapeutic sense, it is something that patients seek out. (medscape.com)
FINDINGS: Between Oct 25, 2018, and July 1, 2021, 168 patients were randomly assigned to receive colesevelam (n=84) or placebo (n=84). (aau.dk)
41 patients had C4 concentration greater than 46 ng/mL (22 assigned to the colesevelam group and 19 to the placebo group). (aau.dk)
For patients receiving placebo, four had abdominal pain, four had bloating, and one had nausea. (aau.dk)
We found evidence suggesting that a clinically important difference between agomelatine and placebo in patients with unipolar major depression is unlikely. (cambridge.org)
PEMF may be a novel, safe and effective therapeutic tool for use in at least certain subsets of patients with chronic, nonmalignant pain. (hindawi.com)
L'association du métoclopramide et de la dexaméthasone a considérablement réduit les nausées et vomissements, non seulement en salle de réveil mais également dans les 24 heures qui suivent, et est recommandée pour les groupes à haut risque, notamment pour les patients opérés en ambulatoire. (who.int)
Within this group, epilepsy is refractory in up to 40 % of patients, who have shown para el control de síntomas refractarios en a decrease in the frequency of seizures with the concomitant use of cannabidiol and conventional antiepileptics, with mild síndromes convulsivos side effects such as diarrhea and drowsiness. (bvsalud.org)
The patients were evaluated using surface electromyography (sEMG) of the masseter and anterior temporalis muscles, during maximum intercuspation, before and immediately after application of therapeutic resources. (bvsalud.org)
All patients were treated by ultrasound (US), ultrasound associated with stretching and placebo ultrasound, by turns, once a week with a one-week minimum interval between them. (bvsalud.org)

Results Mean headache frequency reduction was 2.7 migraine headache days in the melatonin group, 2.2 for amitriptyline and 1.1 for placebo. (bmj.com)
Melatonin significantly reduced headache frequency compared with placebo (p=0.009), but not to amitriptyline (p=0.19). (bmj.com)
Weight loss was found in the melatonin group, a slight weight gain in placebo and significantly for amitriptyline users. (bmj.com)

He will address the need for a clear definition of placebos as well as some of the ethical issues they raise. (programinplacebostudies.org)

In US317 (526 favipiravir, 169 placebo), favipiravir did not significantly reduce time to alleviation (median, 77.8 vs 83.9 hours). (nih.gov)
Inhalation challenge with CDE similarly and significantly reduced the forced expiratory volume at 1 second and the forced vital capacity and acutely increased total cell and neutrophil concentrations and levels of tumor necrosis factor alpha and interleukin-8 in bronchoalveolar lavage fluid in both PTX and placebo treated subjects. (cdc.gov)

Forum topics will include the neuroscience behind placebo effects, the role of clinical guidelines and the patient voice, and lessons about medical care from anthropology, philosophy, history, and religion. (programinplacebostudies.org)
Leading academic experts and clinicians examined how placebo effects might be incorporated into clinical guidelines and the decision-making process between provider and patient. (programinplacebostudies.org)
The third forum featured a keynote on February 11th by Tanya Luhrmann of Stanford titled, "Placebo and Prayer: Why Prayer Practice May Help Heal" followed by a discussion on February 12th among invited guests focused on "Health and Placebo Effects: Medicine, Religion and Ritual. (programinplacebostudies.org)
Placebo Effects & Behavior Social Science - March 9. (programinplacebostudies.org)
Placebo effects describe the environmental cues and the conscious and non-conscious learning processes that precipitate health improvement in ways that, in some cases, mimic pharmaceuticals. (programinplacebostudies.org)
the existence of placebo effects suggests that we must broaden our conception of the limits of endogenous human capability. (jneurosci.org)
However, it has been well documented that placebo effects can obscure those of active conditions, even for treatments that were eventually demonstrated to be effective. (jneurosci.org)
This article does not take a position on whether techniques have therapeutic effects in addition to placebo. (citizendium.org)
The analysis found that there are gaps in the evidence on the therapeutic effects of cannabis . (bvsalud.org)

Researchers now need to identify when and where placebo works. (newscientist.com)
Researchers are exploring whether therapeutic touch has any proven benefits. (medicalnewstoday.com)

The practice sees therapeutic touch as the way to restore the unity of body, mind, and spirit. (medicalnewstoday.com)

According to the principles of therapeutic touch, people with a good health status have a balanced energy field. (medicalnewstoday.com)

In the first case, placebo analgesia is typically blocked by the opioid antagonist naloxone, whereas in the second case it is not, depending on the procedure that is applied to induce the placebo analgesic response. (jneurosci.org)

Therapeutic touch massage (TTM) is a form of energy healing. (medicalnewstoday.com)
Healing touch therapy is similar to therapeutic touch. (medicalnewstoday.com)

In 2008 Carmon, along with his co-authors, Rebecca Waber, Dan Ariely and Baba Shiv, was awarded an Ig Nobel Prize in medicine for their research demonstrating that high-priced placebos are more effective than low-priced ones. (wikipedia.org)
In 2000 the House of Lords Select Committee (HLSC)advised the Department of Health to fund research on acupuncture, chiropractic, herbal medicine, homeopathy and osteopathy to see if these therapies were safe, more effective than placebo and good value for money, At the time I supported this decision. (dcscience.net)
Because many of these studies were uncontrolled, there has been ongoing debate about the degree to which TENS is more effective than placebo in reducing pain. (medscape.com)

For NRT, bupropion and varenicline we conducted network meta-analyses, comparing each with the others and with placebo for benefit, and varenicline and bupropion for risks of serious adverse events. (who.int)

The incidence of nausea in the recovery room was 44% with placebo, 20% with metoclopramide, 16% with dexamethasone and 8% with the combination. (who.int)

Grimes PE: Melasma: Etiologic and therapeutic considerations. (karger.com)

In order to provide a comprehensive overview of video games' use in child and adolescent psychiatry, we also focused on commercially available video games used in a therapeutic or preventive context. (frontiersin.org)

12 pigs were randomized to the treated or placebo-controlled group prior to the induction of mild to moderate ARDS via lipopolysaccharide administration. (lu.se)

While there is a clear connection between the worlds of behavioral social science and placebo studies, there has been little discussion of this link in the academy. (programinplacebostudies.org)

Lung function tests and bronchoscopy were performed following a challenge with corn dust extract (CDE) in ten healthy human subjects treated with 400 milligrams PTX or placebo three times daily for 4 days and a single dose of PTX or placebo on the day of testing. (cdc.gov)

How do the remaining treatments compare with placebo in achieving long-term abstinence? (who.int)

Investigators need to emphasize the distinction between research and clinical care to address the high rate of therapeutic misconception. (who.int)

Patient satisfaction showed no difference between GTN and placebo groups (p=0.25) after 24 weeks, but did show a significant difference over time (p=0.01). (bmj.com)

Finally, serious games are designed to include evidence-based therapeutic techniques and are often based on cognitive behavioral therapy (CBT), cognitive remediation or neuropsychological theories. (frontiersin.org)

Subjects in both the PTX and placebo groups experienced similar frequencies of acute respiratory and systemic symptoms following CDE exposure. (cdc.gov)

Anatomy1

Diseases29

Chemicals and Drugs142

Analytical, Diagnostic and Therapeutic Techniques and Equipment57

Psychiatry and Psychology12

Phenomena and Processes17

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena2

Technology, Industry, Agriculture4

Humanities1

Named Groups1

Health Care24

Efficacy7

Double-blind8

Clinical trial1

Effect24

Outcome4

Doses4

Superior to placebo1

Plus placebo1

Versus placebo2

Statistically significant2

Outcomes1

Treatment12

Inhibition1

Saline2

Participants2

Methods1

Interventions2

Benedetti2

Predictors1

Study4

Intervention1

Sham1

Peripheral1

Prevention2

Anecdotal1

Patients13

Amitriptyline3

Ethical1

Significantly2

Effects9

Researchers2

Practice1

Principles1

Naloxone1

Healing2

Effective3

Benefit1

Nausea1

Considerations1

Context1

Mild1

Studies1

Dose1

Treatments1

High1

Patient1

Techniques1

Groups1