• Chlordiazepoxide hydrochloride, is the prototype for the benzodiazepine compounds. (nih.gov)
  • Chlordiazepoxide hydrochloride is 7-chloro-2-(methylamino)-5-phenyl-3H-1,4-benzodiazepine 4-oxide hydrochloride. (nih.gov)
  • Chlordiazepoxide hydrochloride and clidinium bromide capsules, USP is a fixed-combination of chlordiazepoxide hydrochloride, a benzodiazepine, and clidinium bromide, an anticholinergic. (themeditary.com)
  • The first benzodiazepine, chlordiazepoxide (Librium) was discovered serendipitously in 1954 by the Austrian scientist Leo Sternbach (1908-2005), working for the pharmaceutical company Hoffmann-La Roche . (wikidoc.org)
  • Three years later chlordiazepoxide was marketed as a therapeutic benzodiazepine medication under the brand name Librium. (wikidoc.org)
  • Following chlordiazepoxide in 1963 diazepam hit the market under the brand name Valium, followed by many further benzodiazepine compounds which were introduced over the subsequent years and decades. (wikidoc.org)
  • FDA approved first benzodiazepine, chlordiazepoxide in 1960 followed by many subsequent medicines falling under this class. (publicsafetyandvigilance.com)
  • Transplacental distribution has resulted in neonatal CNS depression and also withdrawal phenomena following the ingestion of therapeutic doses of a benzodiazepine hypnotic during the last weeks of pregnancy. (dvago.pk)
  • Before prescribing chlordiazepoxide hydrochloride and clidinium bromide capsules and throughout treatment, assess each patient's risk for abuse, misuse, and addiction (see WARNINGS). (themeditary.com)
  • Abrupt discontinuation or rapid dosage reduction of chlordiazepoxide hydrochloride and clidinium bromide capsules after continued use may precipitate acute withdrawal reactions, which can be life-threatening. (themeditary.com)
  • Each chlordiazepoxide hydrochloride and clidinium bromide capsules USP, 5 mg/2.5 mg contains the active ingredients 5 mg chlordiazepoxide hydrochloride and 2.5 mg clidinium bromide. (themeditary.com)
  • Chlordiazepoxide Hydrochloride and Clidinium Bromide (Heritage Pharmaceuticals. (medlibrary.org)
  • Chlordiazepoxide hydrochloride and clidinium bromide capsules may produce physical dependence from continued therapy. (medlibrary.org)
  • Tolerance to chlordiazepoxide hydrochloride and clidinium bromide capsules may develop from continued therapy. (medlibrary.org)
  • Because of the varied individual responses to tranquilizers and anticholinergics, the optimum dosage of chlordiazepoxide hydrochloride and clidinium bromide capsules varies with the diagnosis and response of the individual patient. (medlibrary.org)
  • The initial dose should not exceed 2 chlordiazepoxide hydrochloride and clidinium bromide capsules per day, to be increased gradually as needed and tolerated. (medlibrary.org)
  • Chlordiazepoxide hydrochloride and clidinium bromide capsules are available in light green opaque capsules, each containing 5 mg chlordiazepoxide hydrochloride and 2.5 mg clidinium bromide in bottles of 100 capsules (NDC 23155-808-01), with "VP302" imprinted on the cap of the capsule. (medlibrary.org)
  • Combining the anxiolytic effect of (Chlordiazepoxide) with the anticholinergic action of clidinium bromide, Llbrax® provides rapid stabilization of visceromotor function. (medicinep.com)
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  • Ananth J. Abstinence Syndrome from Therapeutic Doses of Oxazepam. (benzo.org.uk)
  • In therapeutic doses Librax® is well tolerated. (medicinep.com)
  • Before prescribing chlordiazepoxide hydrochloride capsules and throughout treatment, assess each patient's risk for abuse, misuse, and addiction (see WARNINGS ). (nih.gov)
  • Abrupt discontinuation or rapid dosage reduction of chlordiazepoxide hydrochloride capsules after continued use may precipitate acute withdrawal reactions, which can be life-threatening. (nih.gov)
  • To reduce the risk of withdrawal reactions, use a gradual taper to discontinue chlordiazepoxide hydrochloride capsules or reduce the dosage (see DOSAGE AND ADMINISTRATION and WARNINGS ). (nih.gov)
  • Chlordiazepoxide hydrochloride is among the safer of the effective psychopharmacologic compounds available, as demonstrated by extensive clinical evidence. (nih.gov)
  • Chlordiazepoxide hydrochloride is available as capsules containing 5 mg, 10 mg or 25 mg chlordiazepoxide hydrochloride. (nih.gov)
  • Chlordiazepoxide hydrochloride has antianxiety, sedative, appetite-stimulating and weak analgesic actions. (nih.gov)
  • Chlordiazepoxide hydrochloride revealed a "taming" action with the elimination of fear and aggression. (nih.gov)
  • The taming effect of chlordiazepoxide hydrochloride was further demonstrated in rats made vicious by lesions in the septal area of the brain. (nih.gov)
  • Reproduction studies in rats fed chlordiazepoxide hydrochloride, 10, 20 and 80 mg/kg daily (2.4, 4.8 and 19.4 times, respectively, the maximum recommended clinical dose of 40 mg/day, based on body surface area), and bred through one or two matings showed no congenital anomalies, nor were there adverse effects on growth of the newborn. (themeditary.com)
  • The BZD chlordiazepoxide (Librium) was introduced to the medical field in 1960, offering a safer alternative to barbiturates, as they cause less respiratory depression and are rarely lethal in overdose. (fcfrmd.com)
  • A total of 481 drugs are known to interact with chlordiazepoxide / clidinium . (breathinglabs.com)
  • Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum. (breathinglabs.com)
  • Antidepressants of SSRIs class can interact with other drugs, resulting in deterioration of their therapeutic effect. (ahefv.com)
  • An increased risk of congenital malformations associated with the use of diazepam and chlordiazepoxide during the first trimester of pregnancy has been suggested in several studies. (dvago.pk)
  • A free operant avoidance procedure clearly distinguished representative psychotropic compounds, including diazepam and pentobarbital, in normal subjects, and a multiple crossover procedure clearly detected antianxiety effects of diazepam in 11 psychoneurotic patients and antipsychotic effects of chlordiazepoxide in individual schizophrenic patients. (unm.edu)
  • however, if taken regularly over long periods of time, they can cause the patient to develop a tolerance, needing more of the medicine to achieve therapeutic effects, and eventually the patient will become physically and psychologically dependent upon the medicine. (fcfrmd.com)
  • Do not use more than the recommended dose of chlordiazePOXIDE, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. (breathinglabs.com)
  • The pharmacologic/therapeutic effect ( drowsiness or calming effects ) is produced by binding to gamma-aminobutyric acid (GABA) receptors in the brain and thereby reducing brain activity. (publicsafetyandvigilance.com)
  • Chlordiazepoxide is similar to phenobarbital in its anticonvulsant properties. (wikidoc.org)
  • Core Concepts in Pharmacology - Stages of Therapeutic and Biologic Drug Approval. (powershow.com)
  • Common medical laboratory uses include in vivo and animal testing to determine therapeutic value , toxicology testing by contract research organizations to determine drug safety, and analysis by drug test and forensic toxicology labs for the purposes of evaluating human exposure. (buyprescriptionmedicationonlineusa.com)
  • Once an adequate response has been achieved, dosage may be gradually reduced, with subsequent adjustment depending on therapeutic response. (rxlist.com)
  • The findings presented here suggested that GL-HP-ßCD NF could serve as a useful strategy for improving the therapeutic effects of GL. (bvsalud.org)
  • It is a versatile therapeutic agent of proven value for the relief of anxiety. (nih.gov)
  • The therapeutic value of these agents as anxiolytics and hypnotics has been well established, and they continue to serve an important role in managing many debilitating anxiety symptoms in the context of both psychiatric disorders and medical illness. (medscape.com)
  • Such procedures may serve to evaluate the effectiveness of therapeutic interventions in clinical practice as well as in research. (unm.edu)
  • Misuse is the intentional use, for therapeutic purposes, of drug by an individual in way other than prescribed by health care provider or for whom it was not prescribed. (drugcentral.org)
  • During studies, chlordiazepoxide induced muscle relaxation and a quieting effect on laboratory animals like mice, rats, cats, and dogs. (wikidoc.org)
  • Electronic Orange Book: Approved Drug Products with Therapeutic Equivalence Evaluations Food and Drug Administration. (the-medical-dictionary.com)
  • In this study, we combined the benefits of hydroxypropyl ß-cyclodextrin (HP-ßCD) supramolecular inclusion complexes and electrospun nanofibers to improve the solubility and therapeutic potential of GL. (bvsalud.org)
  • Chlordiazepoxide enabled the treatment of emotional disturbances without a loss of mental acuity or alertness. (wikidoc.org)
  • Forty-two hospital patients admitted for acute and chronic alcoholism, and various psychoses and neuroses were treated with chlordiazepoxide. (wikidoc.org)