The combination of these two agonists enhanced the expression of cytokines for Th1 and Th17 responses and suppressed the expression of cytokines for Th2 response in these cells. (ijbs.com)
Cells2
Our laboratory has a long-standing interest in immune signaling and cell metabolism underlying the differentiation and function of T cells, a central cell type in adaptive immunity and cancer immunotherapy. (stjude.org)
Nat Cell Biol 24:1642-1654, 2022 (highlighted by News and Views "PTEN checkMAITs type-17 innate-like T cells" in the same issue). (stjude.org)
Role2
At Trudeau, Khader demonstrated that the cytokine Interleukin-17 played a critical role in vaccine-induced immunity to the infectious disease tuberculosis. (wikipedia.org)
Eichenberger R.M., Dent L.A., Robertson A.A.B., Kupz A., Brough D., Loukas A., Sutherland T.E ., Allen J.E., Giacomin P.R. Inflammasome-Independent Role for NLRP3 in Controlling Innate Antihelminth Immunity and Tissue Repair in the Lung. (manchester.ac.uk)
Cellular immunity3
Interferon-γ (IFN-γ) plays a key role in activation of cellular immunity and subsequently, stimulation of antitumor immune-response. (biomedcentral.com)
Pre-conception maternal helminth infection transfers via nursing long-lasting cellular immunity against helminths to offspring. (seattlechildrens.org)
Impact of maternal HIV exposure, feeding status, and microbiome on infant cellular immunity. (seattlechildrens.org)
Microbiome1
The gut microbiome, which impacts the innate and adaptive branches of immunity, not only influences the development of autoimmune disorders but may interact with sex-hormones to modulate disease progression and sex-bias. (nih.gov)
Immune cells2
Aryl hydrocarbon receptor (AHR) is a transcription factor that regulates the activity of multiple innate and adaptive immune cells subsequent to binding to numerous endogenous and exogenous ligands. (aacrjournals.org)
After an acute stroke, sensors of the innate immune system such as Toll-like receptors (TLRs) and innate immune cells, are activated by brain ischemia, leading to amplification of the inflammatory cascade. (en-journal.org)
Endogenous2
Inflammasomes are cytosolic multimolecular protein complexes which respond to innate immune recognition induced by microbial infections and endogenous danger signals [ 9 , 10 ]. (biomedcentral.com)
Additionally, adaptive immunosuppression merits further consideration as a potential endogenous protective mechanism. (en-journal.org)
Function2
In this review, we highlight recent studies regarding the effects and mechanism of immunosuppression on the pathophysiology of stroke, with the hope that a better understanding of the function of both of innate and adaptive immunity in this setting will facilitate the development of effective therapies for post-stroke inflammation. (en-journal.org)
Impact of hormonal contraceptives on cervical Th17 phenotype and function in adolescents: Results from a randomized cross-over study comparing long-acting injectable norethisterone oenanthate (NET-EN), combined oral contraceptive pills, and combined contraceptive vaginal rings. (seattlechildrens.org)