DoxorubicinLiposomalVyxeosChemotherapyAntineoplasticAnthracyclinesEtoposideTopoisomeraseInhibitsLiposomeInjectionAnthracycline antibioticHarm the fetusMedicationAcuteCardiac toxicityLiposomesDrugsIntercalationCompoundLeukemiaIntravenousMedicinesMedicationsCitationPregnantPregnancyTreatmentCombinationDoctorPatientsMedicalCancerWorks
Doxorubicin5
- citation needed] Daunorubicin is also used as the starting material for semi-synthetic manufacturing of doxorubicin, epirubicin and idarubicin. (wikipedia.org)
- Similar to doxorubicin, daunorubicin interacts with DNA by intercalation and inhibition of macromolecular biosynthesis. (wikipedia.org)
- Daunorubicin is an antineoplastic anthracycline antibiotic with actions similar to those of doxorubicin. (e-lactancia.org)
- Liposomal formulations of daunorubicin and doxorubicin have been approved that appear to be somewhat less toxic to cardiac tissue. (wikidoc.org)
- Anthracyclines, e. g. daunorubicin, doxorubicin, and idarubicin, consist of a tetracycline moiety linked via a glycosidic bond to a sugar residue, usually the aminosugar daunosamine. (lu.se)
Liposomal3
- A liposomal formulation known as liposomal daunorubicin also exists. (wikipedia.org)
- www.drugguide.com/ddo/view/Davis-Drug-Guide/110585/all/daunorubicin_cytarabine_liposomal. (drugguide.com)
- Vallerand AHA, Sanoski CAC, Quiring CC. Daunorubicin/cytarabine liposomal. (drugguide.com)
Vyxeos8
- Patients who have a history of serious hypersensitivity to daunorubicin, cytarabine or any component of the formulation should not use Vyxeos. (lls.org)
- The prescribing information for Vyxeos includes a boxed warning not to interchange Vyxeos with other daunorubicin- and/or cytarabine-containing products. (lls.org)
- VYXEOS is a combination of 2 chemotherapies, daunorubicin and cytarabine, into tiny, bubble-like carriers called liposomes. (vyxeos.com)
- WARNING: VYXEOS has different dosage recommendations from other medications that contain daunorubicin and/or cytarabine. (vyxeos.com)
- Do not substitute VYXEOS for other daunorubicin and/or cytarabine-containing products. (vyxeos.com)
- VYXEOS should not be given to patients who have a history of serious allergic reaction to daunorubicin, cytarabine, or any of its ingredients. (vyxeos.com)
- VYXEOS has different dosage recommendations than daunorubicin hydrochloride injection, cytarabine injection, daunorubicin citrate liposome injection, and cytarabine liposome injection. (vyxeospro.com)
- Presentations include clinical data from trials of Vyxeos ® (daunorubicin and cytarabine). (lls.org)
Chemotherapy5
- Daunorubicin, also known as daunomycin, is a chemotherapy medication used to treat cancer. (wikipedia.org)
- Daunorubicin has been used with other chemotherapy agents to treat the blastic phase of chronic myelogenous leukemia. (wikipedia.org)
- Daunorubicin injection must be given in a hospital or medical facility under the supervision of a doctor who is experienced in giving chemotherapy medications for cancer. (medlineplus.gov)
- Daunorubicin comes as a solution (liquid) or as a powder to be mixed with liquid to be injected intravenously (into a vein) by a doctor or nurse in a medical facility along with other chemotherapy medications. (medlineplus.gov)
- Standard chemotherapy was cytarabine 100 mg/m 2 and daunorubicin 60 mg/m 2 . (vyxeos.com)
Antineoplastic2
- Daunorubicin belongs to the group of antineoplastic (cancer-fighting medicines) known as anthracyclines. (magicinepharma.com)
- An anthracycline antineoplastic agent, daunorubicin inhibits DNA and RNA synthesis by intercalating between DNA base pairs. (medscape.com)
Anthracyclines1
- Daunorubicin is in a class of medications called anthracyclines. (medlineplus.gov)
Etoposide1
- Lenalidomide monotherapy and in combination with cytarabine, daunorubicin and etoposide for high-risk myelodysplasia and acute myeloid leukaemia with chromosome 5 abnormalities. (ox.ac.uk)
Topoisomerase1
- Daunorubicin stabilizes the topoisomerase II complex after it has broken the DNA chain for replication, preventing the DNA double helix from being resealed and thereby stopping the process of replication. (wikipedia.org)
Inhibits1
- Daunorubicin also inhibits polymerase activity, affects the regulation of gene expression, and produces free radical damage to DNA. (magicinepharma.com)
Liposome1
- GGP modified daunorubicin plus dioscin liposome has suitable particle size , narrow PDI, zeta potential of about -5 mV, long cycle effect, and enhanced cell uptake due to surface modification of GGP making the liposome could enter the inside of the tumor to fully exert its anti- tumor effect. (bvsalud.org)
Injection1
- tell your doctor and pharmacist if you are allergic to daunorubicin, any other medications, or any of the ingredients in daunorubicin injection. (medlineplus.gov)
Anthracycline antibiotic1
- A water-soluble anthracycline antibiotic medication (daunorubicin DNR) was loaded into oxidized porous silicon (pSiO2) microparticles and encapsulated using a level of polymer (poly lactide-co-glycolide PLGA) to research their synergistic results ICOS in charge of DNR discharge. (research-in-field.com)
Harm the fetus1
- Daunorubicin and cytarabine lipid complex may harm the fetus. (safemedication.com)
Medication3
- Daunorubicin is in the anthracycline family of medication. (wikipedia.org)
- Daunorubicin is an anti-cancer medication, which is used to treat a type of cancer that affects the red blood cells, platelets, and white blood cells except for lymphocytes. (magicinepharma.com)
- Keywords: Porous silicon oxide Poly (dl-lactide-co-glycolide) Daunorubicin Ocular medication delivery Intro Proliferative vitreoretinopathy (PVR) may be the most frequent reason behind failing for retinal detachment medical procedures [1]. (research-in-field.com)
Acute2
- Doctors prescribe daunorubicin for certain types of acute myeloid leukemia (AML) and acute lymphocytic leukemia (ALL) . (medicalnewstoday.com)
- Higher daunorubicin exposure benefits FLT3 mutated acute myeloid leukemia. (ox.ac.uk)
Cardiac toxicity2
- However, by 1967, it was recognized that daunorubicin could produce fatal cardiac toxicity. (wikipedia.org)
- The long infusion of daunorubicin is used to minimize the risk for cardiac toxicity. (cancercentrum.se)
Liposomes2
- GGP modified daunorubicin plus dioscin liposomes inhibit breast cancer by suppressing epithelial-mesenchymal transition. (bvsalud.org)
- In this study, GGP modified daunorubicin plus dioscin liposomes are constructed and characterized. (bvsalud.org)
Drugs1
- This study evaluated the in vitro effects of the combination of PKC412 and ara-C or daunorubicin, studying the effect of co-incubation, pre-incubation and sequential incubation of the drugs in patient samples and cell lines. (lu.se)
Intercalation1
- Daunorubicin forms complexes with DNA by intercalation between base pairs. (magicinepharma.com)
Compound1
- Since a group of French researchers discovered the same compound at about the same time, the two teams named the compound daunorubicin, combining the name Dauni, a pre-Roman tribe that occupied the area of Italy where the compound was isolated, with the French word for ruby, rubis, describing the color. (wikipedia.org)
Leukemia1
- Small volumes of daunorubicin can be wrapped up in these minuscule pods, which can then be released into a leukemia cell-filled environment. (wikipedia.org)
Intravenous1
- Daunorubicin should only be administered in a rapid intravenous infusion. (wikipedia.org)
Medicines1
- Daunorubicin is sometimes given together with certain other medicines. (mayoclinic.org)
Medications2
- Other medications may also interact with daunorubicin, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. (medlineplus.gov)
- Daunorubicin and cytarabine lipid complex is different than other products containing these medications and should not be substituted for one another. (safemedication.com)
Citation1
- citation needed] In addition to its major use in treating AML, daunorubicin is also used to treat neuroblastoma. (wikipedia.org)
Pregnant3
- You or your partner should not become pregnant while you are receiving daunorubicin and cytarabine lipid complex. (safemedication.com)
- If you become pregnant while receiving daunorubicin and cytarabine lipid complex, call your doctor. (safemedication.com)
- Do not use Daunorubicin if you are pregnant or planning to become pregnant. (magicinepharma.com)
Pregnancy1
- You should use birth control to prevent pregnancy in yourself or your partner during your treatment with daunorubicin and cytarabine lipid complex and for 6 months after your final dose. (safemedication.com)
Treatment8
- Daunorubicin may cause serious or life-threatening heart problems at any time during your treatment or months to years after your treatment has ended. (medlineplus.gov)
- Your doctor will order tests before and during your treatment to see if your heart is working well enough for you to safely receive daunorubicin. (medlineplus.gov)
- When daunorubicin is used to treat AML, it is usually injected once a day on certain days of your treatment period. (medlineplus.gov)
- You should not breastfeed during your treatment with daunorubicin and cytarabine lipid complex and for at least 2 weeks after your final dose. (safemedication.com)
- By colorimetric MTT assay, it was found that contrast media (0-3500 μM) had no effect on both K562 and K562/adr cell viabilities, but in co-treatment with daunorubicin (DNR), diatrizoate decreased cell viability in K562/adr cells by decreasing IC so of DNR from 610.7 ±74.5 nM to 360±108.9 nM. (thescipub.com)
- Before starting treatment with Daunorubicin, please inform your doctor about your previous medical history. (magicinepharma.com)
- Daunorubicin (DAN) is mostly used in the treatment of leukaemia and some solid tumour such as glioma. (farmaciajournal.com)
- The recommended initial intensive treatment for AML outside a clinical study is DA, i.e., daunorubicin, i.v. infusion 60 mg/m 2 /8h daily for 3 days in combination with cytarabine, i.v. infusion 1 g/m 2 /2h b.i.d daily for 5 days. (cancercentrum.se)
Combination1
- The combination of daunorubicin and PKC412 resulted in more synergistic and less antagonistic effects compared to combinations with ara-C, in both patient material and cell lines. (lu.se)
Doctor3
- Your doctor will order certain tests to check your body's response to daunorubicin. (medlineplus.gov)
- While you are receiving daunorubicin, your doctor may want you to drink extra fluids so that you will pass more urine. (mayoclinic.org)
- if you are having surgery, including dental surgery, tell the doctor or dentist that you are receiving daunorubicin and cytarabine lipid complex. (safemedication.com)
Patients1
- Patients in the standard arm (surgery alone) will undergo large en- bloc curative intent surgery will be performed within 4 weeks following randomization. (who.int)
Medical1
- Daunorubicin was approved for medical use in the United States in 1979. (wikipedia.org)
Cancer1
- Daunorubicin and cytarabine lipid complex slows or stops the growth of cancer cells in your body. (safemedication.com)
Works1
- Previous research show that daunorubicin (DNR) works well in inhibiting PVR development [2] looked after has been proven to work for the treating experimental PVR [3-5]. (research-in-field.com)