Targets in cancer therapy aurora kinases. Medical search. Frequent questions

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Anatomy18

Cell Line, Tumor Spindle Apparatus Kinetochores HeLa Cells Centrosome Tumor Cells, Cultured Microtubules Cell Line Blastodisc Centromere Microtubule-Organizing Center Chromosomes HCT116 Cells Cells, Cultured Cell Nucleus Neoplastic Stem Cells Oocytes Fibroblasts

Organisms7

Mice, Nude Potoroidae Mice, SCID Chordata Mice, Inbred BALB C Saccharomycetales Mice, Inbred C57BL

Diseases25

Neoplasms Breast Neoplasms Polyploidy Ovarian Neoplasms Prostatic Neoplasms Chondroma Cell Transformation, Neoplastic Lung Neoplasms Colonic Neoplasms Neoplasm Metastasis Neoplasm Invasiveness Pancreatic Neoplasms Stomach Neoplasms Chromosomal Instability Aneuploidy Carcinoma Disease Progression Carcinoma, Non-Small-Cell Lung Neovascularization, Pathologic Carcinoma, Squamous Cell Colorectal Neoplasms Uterine Cervical Neoplasms Urinary Bladder Neoplasms Genetic Predisposition to Disease Liver Neoplasms

Chemicals and Drugs114

Aurora Kinases Aurora Kinase A Aurora Kinase B Aurora Kinase C Protein-Serine-Threonine Kinases Protein Kinase Inhibitors Phosphatidylinositol 3-Kinases Protein Kinases Antineoplastic Agents Piperazines Cell Cycle Proteins Calcium-Calmodulin-Dependent Protein Kinases src-Family Kinases Benzamides Azepines Organophosphates RNA, Small Interfering Protein Kinase C Pyrimidines Microtubule-Associated Proteins p38 Mitogen-Activated Protein Kinases Enzyme Inhibitors Mitogen-Activated Protein Kinase 1 Cyclic AMP-Dependent Protein Kinases Histones Quinazolines Aneugens Neoplasm Proteins JNK Mitogen-Activated Protein Kinases Pyrazoles Mitogen-Activated Protein Kinase Kinases Protein-Tyrosine Kinases CDC2 Protein Kinase Mitogen-Activated Protein Kinase 3 p21-Activated Kinases Tumor Suppressor Protein p53 RNA, Messenger Cyclin-Dependent Kinases Proto-Oncogene Proteins Nuclear Proteins Collagen Type XI Chromosomal Proteins, Non-Histone MAP Kinase Kinase Kinases Creatine Kinase Casein Kinase II Extracellular Signal-Regulated MAP Kinases Proto-Oncogene Proteins c-akt Receptor Protein-Tyrosine Kinases eIF-2 Kinase Tumor Markers, Biological MAP Kinase Kinase 1 Casein Kinases Pyruvate Kinase Thymidine Kinase Ribosomal Protein S6 Kinases Intracellular Signaling Peptides and Proteins Isoenzymes Mitogen-Activated Protein Kinases MAP Kinase Kinase 4 Glycogen Synthase Kinase 3 Cancer Vaccines TOR Serine-Threonine Kinases Imidazoles Receptor, Epidermal Growth Factor Paclitaxel Phosphotransferases (Alcohol Group Acceptor)Thiazoles CDC2-CDC28 Kinases DNA-Binding Proteins 1-Phosphatidylinositol 4-Kinase Recombinant Fusion Proteins I-kappa B Kinase Cyclin B1 Recombinant Proteins Pyridines rho-Associated Kinases Phosphoproteins Protein Kinase C-alpha Protein Kinase C-delta Indoles Tumor Suppressor Proteins Receptor, erbB-2 Transcription Factors AMP-Activated Protein Kinases Antibodies, Monoclonal Inhibitor of Apoptosis Proteins Antineoplastic Agents, Phytogenic Diacylglycerol Kinase Focal Adhesion Kinase 1 Serine Adaptor Proteins, Signal Transducing Focal Adhesion Protein-Tyrosine Kinases Janus Kinase 2 Carrier Proteins MAP Kinase Kinase 2 Myosin-Light-Chain Kinase Receptors, Estrogen Cyclin-Dependent Kinase 2 DNA Primers Chromones Morpholines Tyrosine Cyclin-Dependent Kinase Inhibitor p21 Ribosomal Protein S6 Kinases, 90-kDa Membrane Proteins Cisplatin DNA, Neoplasm MAP Kinase Kinase Kinase 1 NF-kappa B Androstadienes Tetradecanoylphorbol Acetate raf Kinases Proto-Oncogene Proteins p21(ras)Protein Kinase C beta

Analytical, Diagnostic and Therapeutic Techniques and Equipment35

Xenograft Model Antitumor Assays Molecular Targeted Therapy Blotting, Western Early Detection of Cancer Drug Screening Assays, Antitumor Models, Biological Reverse Transcriptase Polymerase Chain Reaction Transfection Drug Delivery Systems Gene Expression Profiling Antineoplastic Combined Chemotherapy Protocols Clinical Trials as Topic Transplantation, Heterologous Prognosis Neoplasm Transplantation Flow Cytometry Immunohistochemistry Inhibitory Concentration 50 Tissue Array Analysis Microscopy, Fluorescence Immunoblotting Drug Evaluation, Preclinical Oligonucleotide Array Sequence Analysis Models, Molecular Gene Knockdown Techniques Tumor Burden Survival Analysis Survival Rate Combined Modality Therapy Kaplan-Meier Estimate Genetic Therapy Sequence Alignment Neoplasm Staging Follow-Up Studies Retrospective Studies

Phenomena and Processes57

Mitosis MAP Kinase Signaling System Phosphorylation Apoptosis Chromosome Segregation Cell Proliferation Cell Cycle Kinetochores Gene Expression Regulation, Neoplastic Mutation Drug Resistance, Neoplasm M Phase Cell Cycle Checkpoints Signal Transduction Cell Survival Polyploidy Cytokinesis RNA Interference Cell Cycle Checkpoints Protein Binding Cell Division Transfection Dose-Response Relationship, Drug Drug Synergism Down-Regulation Anaphase Amino Acid Sequence Enzyme Activation Gene Expression Regulation, Enzymologic Cell Physiological Processes Up-Regulation Ploidies Base Sequence Centromere G2 Phase Gene Expression Time Factors Binding Sites Inhibitory Concentration 50 Protein Structure, Tertiary Kinetics Cell Movement Meiosis Chromosomes Chromosomal Instability Aneuploidy Substrate Specificity Promoter Regions, Genetic Phenotype Transcription, Genetic Cell Growth Processes DNA Damage Protein Transport Gene Silencing Catalytic Domain Sequence Homology, Amino Acid Genetic Predisposition to Disease Gene Expression Regulation

Disciplines and Occupations2

Immunohistochemistry Medical Oncology

Anthropology, Education, Sociology and Social Phenomena1

National Cancer Institute (U.S.)

Information Science4

Molecular Sequence Data Amino Acid Sequence Base Sequence Survival Rate

Named Groups1

Health Care7

Clinical Trials as Topic Survival Analysis Survival Rate National Cancer Institute (U.S.)Kaplan-Meier Estimate Follow-Up Studies Retrospective Studies

Anatomy Organisms Diseases Chemicals and Drugs Analytical, Diagnostic and Therapeutic Techniques and Equipment Phenomena and Processes Disciplines and Occupations Information Science Health Care

Aurora Kinases Aurora Kinase A Aurora Kinase B Aurora Kinase C Protein-Serine-Threonine Kinases Protein Kinase Inhibitors Neoplasms Cell Line, Tumor Phosphatidylinositol 3-Kinases Mitosis Protein Kinases Antineoplastic Agents MAP Kinase Signaling System Phosphorylation Spindle Apparatus Apoptosis Chromosome Segregation Piperazines Cell Proliferation Mice, Nude Cell Cycle Proteins Calcium-Calmodulin-Dependent Protein Kinases Cell Cycle src-Family Kinases Benzamides Xenograft Model Antitumor Assays Kinetochores Gene Expression Regulation, Neoplastic Azepines Mutation Organophosphates RNA, Small Interfering Drug Resistance, Neoplasm M Phase Cell Cycle Checkpoints Molecular Targeted Therapy Signal Transduction Blotting, Western HeLa Cells Protein Kinase C Pyrimidines Microtubule-Associated Proteins Centrosome p38 Mitogen-Activated Protein Kinases Enzyme Inhibitors Breast Neoplasms Cell Survival Polyploidy Cytokinesis Mitogen-Activated Protein Kinase 1 Cyclic AMP-Dependent Protein Kinases Histones Early Detection of Cancer Quinazolines Ovarian Neoplasms RNA Interference Prostatic Neoplasms Aneugens Chondroma Drug Screening Assays, Antitumor Neoplasm Proteins JNK Mitogen-Activated Protein Kinases Molecular Sequence Data Pyrazoles Cell Cycle Checkpoints Mitogen-Activated Protein Kinase Kinases Protein Binding Protein-Tyrosine Kinases Models, Biological Cell Transformation, Neoplastic CDC2 Protein Kinase Lung Neoplasms Tumor Cells, Cultured Mitogen-Activated Protein Kinase 3 p21-Activated Kinases Tumor Suppressor Protein p53 Cell Division RNA, Messenger Reverse Transcriptase Polymerase Chain Reaction Transfection Cyclin-Dependent Kinases Microtubules Colonic Neoplasms Proto-Oncogene Proteins Drug Delivery Systems Dose-Response Relationship, Drug Drug Synergism Nuclear Proteins Collagen Type XI Down-Regulation Chromosomal Proteins, Non-Histone Anaphase Amino Acid Sequence Enzyme Activation Gene Expression Profiling MAP Kinase Kinase Kinases Neoplasm Metastasis Cell Line Creatine Kinase Blastodisc Casein Kinase II

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