• Initiate drug discovery efforts to develop novel therapeutic agents against at least 6 novel therapeutic targets. (nih.gov)
  • Initiate first in human, Phase 1 drug trials for therapeutic agents against at least 6 novel therapeutic targets. (nih.gov)
  • Initiate Phase 2 (proof of concept) drug trials for agents against 3-6 novel therapeutic targets. (nih.gov)
  • There is a critical need to identify new therapeutic targets and develop treatment strategies that a) have lower bleeding risk, b) can be used over longer time- windows, and c) minimize neuronal damage. (nih.gov)
  • Lipid kinases have come under the most intense focus as therapeutic targets, with several companies currently developing PI3K inhibitors. (genengnews.com)
  • Development of individualized cancer therapy often starts with the identification and characterization of reliable biomarkers and therapeutic targets. (biomedcentral.com)
  • While some biomarkers can be used as tools for diagnosis and prognosis assessment, others can also be developed as therapeutic targets. (biomedcentral.com)
  • This research field facilitates the development of diagnostic and prognostic tools and validates the utilities of therapeutic targets. (biomedcentral.com)
  • discuss the potential roles of cytoskeleton protein filamin-A, and the cyclooxygenases and prostanoid receptors of the prostaglandin pathway as biomarkers and therapeutic targets. (biomedcentral.com)
  • Prior to 2020, PHIAs tracked progress toward 90-90-90 targets - which reflect a snapshot of progress at the time of the survey. (cdc.gov)
  • This document describes the steps taken to develop the Health 2020 targets and indicators through the work of two international expert groups and country consultation with Member States. (who.int)
  • Specifically, it gives an overview of the 20 core and 17 additional indicators adopted by the 53 Member States of the WHO European Region in September 2013 to measure progress with the six targets identified for Health 2020. (who.int)
  • One of the first steps in discovering a new therapeutic is identifying a specific molecular target or phenotypic readout for which there is sufficient evidence that it plays a key role in disease progression or symptomology. (nih.gov)
  • Below are 15 players to target or search for on the waiver wire. (nfl.com)
  • Millennium Development Goals (MDGs) have passed their target year of 2015 and are followed by Sustainable Development Goals (SDGs). (nature.com)
  • To address this knowledge gap, NIEHS and the National Institute on Drug Abuse funded the first phase of the multiphase Toxicant Exposures and Responses by Genomic and Epigenomic Regulators of Transcription (TaRGET) program. (nih.gov)
  • Joint United Nations Programme on HIV/AIDS (UNAIDS) global targets for HIV epidemic control call for finding and diagnosing people living with HIV and ensuring they receive sustained antiretroviral treatment. (cdc.gov)
  • It was the first target achieved in the long history of internationally agreed global targets on drinking water. (nature.com)
  • Some targeted therapies are given as pills. (medlineplus.gov)
  • Targeted therapies can treat most types of cancers. (medlineplus.gov)
  • Your provider will decide whether targeted therapies may be an option for your type of cancer. (medlineplus.gov)
  • Doctors thought that targeted therapies might have fewer side effects than other cancer treatments. (medlineplus.gov)
  • Targeted therapies are promising new treatments, but they have limitations. (medlineplus.gov)
  • Targeted therapies are newer and cost more to make. (medlineplus.gov)
  • Two articles in this collection by Sabtivasi and Xia, and by Zhang discuss these aspects of targeted therapies. (biomedcentral.com)
  • Aligning with a 1.5°C Science Based Target, a first major milestone by 2030 is to cut emissions by 50% in the supply chain and portfolio use, and to become Net Zero in our own activities. (ericsson.com)
  • Suppliers are to set a public target in line with halving greenhouse gas emissions by 2030. (ericsson.com)
  • Investigators are encouraged to use in vitro and in vivo studies with various levels of target expression and to address confounding factors that influence the overall physiological response to changes in a given molecular target. (nih.gov)
  • Possible Molecular Targets for Nutrients Advances in biology have identified several regulatory sites that may serve as potential molecular targets for prostate cancer prevention. (nih.gov)
  • Expanding these findings to several factors influencing other processes of prostate cancer cells will clarify if AR can serve as a molecular target or surrogate marker for nutrients. (nih.gov)
  • Aside from the kinase superfamily, there is tremendous diversity in the types of adenine nucleotide-utilizing enzymes that are being targeted for therapeutic intervention both in humans and for anti-infectives, including molecular chaperonins, phosphodiesterases, and topoisomerases. (genengnews.com)
  • In pemphigus vulgaris, B cells make specialized receptors that recognize and target the Dsg3 protein. (nih.gov)
  • Not surprisingly, many enzymes and receptors that utilize adenine nucleotides are being targeted for therapeutic intervention in diverse disease areas. (genengnews.com)
  • Because MRI contrast agents need to be shuttled through the circulatory system-in the highly oxygenated blood-Eu would be inactivated before reaching a low-oxygen target such as a tumor that grows rapidly in a low-oxygen environment. (nih.gov)
  • Candidate targets for examination should not only be influenced by a nutrient but also be closely linked to a significant proportion of prostate tumors, be relatively specific for prostate cancer across various genetic backgrounds, and be related to changes in tumor risk and/or behavior when modified. (nih.gov)
  • As a hallmark of tumor cells, metabolic alterations play a critical role in tumor development and could be targeted for tumor therapy. (biomedcentral.com)
  • You can calculate the on-target percentage reach by dividing the on-target demographic reach by the on-target demographic population. (google.com)
  • Science Based Targets initiative (SBTi) - Used to publicly announce 1.5°C aligned targets and has useful information for how to calculate targets. (ericsson.com)
  • What Eu-5 has accomplished is dramatically slowing the process, which would enable the compound to move through the blood to arrive at hypoxic tissue targets making it useful as an MRI probe to identify and monitor regions of low oxygen in tissues. (nih.gov)
  • The goal of this initiative would be to accelerate the discovery and validation of new biological targets for treating brain disorders. (nih.gov)
  • Definition of Treatment Targets in Rheumatoid Arthritis: Is It Time for Reappraisal? (nih.gov)
  • Researchers from two independent research teams have discovered how the mislocalization of a protein, known as TDP-43, alters the genetic instructions for UNC13A, providing a possible therapeutic target that could also have implications in treating amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and other forms of dementia. (nih.gov)
  • Researchers at São Paulo State University (UNESP) in Brazil have studied a protein in sperm and discovered two new targets that can be used in combination to develop male contraceptives. (eurekalert.org)
  • The supplier can also choose to sign up to an organization such as Science Based Targets initiative (SBTi) or SME Climate Hub , however this is not a requirement from Ericsson. (ericsson.com)
  • You may receive targeted therapy along with surgery, chemotherapy, hormonal therapy , or radiation therapy . (medlineplus.gov)
  • 1. Hormonal Regulation Factors involved in hormonal regulation may serve as targets since sex hormones are known to have a pivotal role in growth, differentiation, and function of prostate tissue. (nih.gov)
  • Subsequent surveys now track progress towards the more ambitious 95-95-95 targets. (cdc.gov)
  • Data highlights from participating countries' surveys showing progress toward UNAIDS targets and HIV incidence, prevalence, and viral load suppression. (cdc.gov)
  • Subsequent surveys track progress toward more ambitious 95-95-95 targets. (cdc.gov)
  • The S&P 500 has basically achieved its mid-2014 target as tapering delays and fiscal progress have contributed to lower risk premiums and higher P/E multiples," wrote Levkovich. (businessinsider.com)
  • The progress for reaching the set climate target is also expected to be reported publicly by the supplier on an annual basis. (ericsson.com)
  • Targeted therapy uses drugs to stop cancer from growing and spreading. (medlineplus.gov)
  • Targeted therapy drugs work in a few different ways. (medlineplus.gov)
  • Drugs can be difficult to develop for some targets. (medlineplus.gov)
  • The second phase of this program, TaRGET II, established a consortium consisting of five production awards and a Data Coordination Center to validate the possibility of using surrogate tissues - accessible tissues that stand in for harder-to-reach tissues - from mice for detecting epigenetic changes. (nih.gov)
  • He was probably just following my original patch which was created before Richard updated the files to define TARGET_DEFAULT symbolicly. (gnu.org)
  • While TI hit the targets, investors seemed shaken by drops in revenue from the same quarter last year. (zdnet.com)
  • And so with EW crossing above that average target price of $95.33/share, investors in EW have been given a good signal to spend fresh time assessing the company and deciding for themselves: is $95.33 just one stop on the way to an even higher target, or has the valuation gotten stretched to the point where it is time to think about taking some chips off the table? (nasdaq.com)
  • Subclinical Treatment Targets in Rheumatology: Lessons from Randomized Clinical Trials in Rheumatoid Arthritis. (nih.gov)
  • Standard chemotherapy works by killings cancer cells and some normal cells, targeted treatment zeroes in on specific targets (molecules) in or on cancer cells. (medlineplus.gov)
  • These targets play a role in how cancer cells grow and survive. (medlineplus.gov)
  • Using these targets, the drug disables the cancer cells so they cannot spread. (medlineplus.gov)
  • People with the same type of cancer may have different targets in their cancer cells. (medlineplus.gov)
  • So, if your cancer does not have a specific target, the drug will not work to stop it. (medlineplus.gov)
  • The cancer may find a different way to grow and survive that does not depend on the target. (medlineplus.gov)
  • Do KT, Kummar S. Therapeutic targeting of cancer cells: era of molecularly targeted agents. (medlineplus.gov)
  • It is possible to specifically target a particular repair pathway for cancer therapy with a comprehensive understanding of how each of the DNA repair pathways interfaces with others. (biomedcentral.com)
  • The first phase, TaRGET I, focuses on how environmental exposures affect proteins and other biological factors involved in establishing and maintaining gene expression patterns and epigenetic modifications, such as DNA methylation. (nih.gov)
  • The target sometimes changes, so the treatment no longer works. (medlineplus.gov)
  • Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease. (nih.gov)
  • The second phase will focus on applications for Target managers, such as compensation planner and work force events. (kmworld.com)
  • About 180 employees in Target Corp.'s offices in India have lost their jobs as part of the retailer's series of rolling layoffs aimed at streamlining its corporate structure. (startribune.com)
  • In recent trading, shares of Edwards Lifesciences Corp (Symbol: EW) have crossed above the average analyst 12-month target price of $95.33, changing hands for $96.15/share. (nasdaq.com)
  • There are 15 different analyst targets contributing to that average for Edwards Lifesciences Corp, but the average is just that - a mathematical average. (nasdaq.com)
  • The most recent cuts in India were aimed at an area that Target is trying to strengthen - its technological capabilities - but the company said it will "continue to heavily invest in areas such as digital, personalization, data and analytics, and engineering. (startribune.com)
  • In fiscal 2009, Accenture achieved its initial target of a 25 percent reduction in carbon dioxide emitted per employee by implementing energy efficiency programs throughout its offices, reducing travel and boosting employee awareness. (environmentalleader.com)
  • Bogdanovich got the chance to make Targets because Boris Karloff owed studio head Roger Corman two days' work. (wikipedia.org)
  • Tim Clifford, president and co-CEO of Workscape, says that by integrating his company's product, "Target will reduce its HR administrative costs and provide expanded services and value to the organization by focusing on aligning human resources activities with its business strategies. (kmworld.com)
  • Harvard University has added yet another sustainable building to its campus - the Harvard Artlab, a contemporary art space projected to meet net-zero energy targets. (inhabitat.com)
  • One of the MDG targets was halving the population without sustainable access to safe drinking water. (nature.com)
  • The national targets (or equivalent) presented in this database are taken from the NBSAPs received since COP-10 , fifth national reports or from documents submitted separately. (cbd.int)
  • The target-name property specifies where to open hyperlinks (target destination). (w3schools.com)
  • In addition to the 180 positions that were eliminated, Target is also closing 125 open positions at those offices. (startribune.com)
  • At the same time, different cancers may have the same target. (medlineplus.gov)
  • However, the rookie did receive 10-plus opportunities (targets/carries) for the third time in four weeks, and found the end zone for the second time in that span as well. (nfl.com)
  • And despite just recently publishing their 2014 targets, Wall Street is already being forced to revisit their analyses as the market continues to surge to new all-time highs. (businessinsider.com)
  • Analyst reaction may also depend on the fundamental business developments that may be responsible for driving the stock price higher - if things are looking up for the company, perhaps it is time for that target price to be raised. (nasdaq.com)
  • In the study conducted at UNESP, mice received three types of antibodies to see if they would bind to EPPIN, in which case they would show which domains of the protease inhibitor could be targeted to reduce or block sperm motility. (eurekalert.org)
  • We show that the major contributors to the achievement of the MDG target were China and India and that the increase in the percentage of population with access to improved sources was closely associated with economic development in most nations during 1990-2015. (nature.com)
  • The national crisis PR firm Sitrick and Co. targets bloggers who have written about Papa John's founder and CEO John Schnatter saying that because of Obamacare, pizzas would have to go up in price about 11-14 cents and individual franchises would have to close stores and cut jobs. (politico.com)
  • China has set out its latest targets for its national industrial Internet program, much of it revolving around 5G. (lightreading.com)
  • The Israel Air Force struck four targets in the Gaza Strip early Wednesday morning in response to rocket fire at southern Israel the previous night, IDF spokesman said. (ynetnews.com)
  • Levkovich now sees the S&P 500 hitting 1,975 in 2014, up from his previous target of 1,900 . (businessinsider.com)