• fibrosis
  • 5 Therefore, as part of the CBM signalosome, Bcl10 functions to amplify antigen receptor-driven responses in lymphocytes and NF-κB-dependent pathologies in target tissues including fibrosis in the liver and atherosclerosis in the vasculature. (ahajournals.org)
  • Moreover, through bone marrow transfer studies, the authors show that Bcl10 in both immune and nonimmune cells potentiates cardiac fibrosis, suggesting the possible involvement of both the CARMA1- and CARMA3-containing CBM signalosomes in the pathogenic process. (ahajournals.org)
  • The protection from cardiac fibrosis in the Bcl10-deficient recipients of wild-type bone marrow indicates that a population of cells resident in the heart directs CARMA3-dependent scar formation. (ahajournals.org)
  • In this regard, the hypertensive bone marrow chimeras lacking Bcl10 on somatic cells have reduced cardiac accumulation of macrophages and T lymphocytes, both of which can promote tissue fibrosis. (ahajournals.org)
  • 8 Thus, aldosterone excess may play an important role in fibrosis of both the heart and systemic organs in experimental studies. (ahajournals.org)
  • severity
  • Remote ischemic conditioning (RIC) is an experimental medical procedure that aims to reduce the severity of ischaemic injury to an organ such as the heart or the brain, most commonly in the situation of a heart attack or a stroke, or during procedures such as heart surgery when the heart may temporary suffer ischaemia during the operation. (wikipedia.org)
  • Abstract
  • Abstract- We have shown that exposure of pregnant ewes to dexamethasone (11.5 mg/d for 2 days) at 27 days of gestation (term, 150 days) led to increased blood pressure and cardiac output in adult offspring. (ahajournals.org)
  • determinant
  • Although BNP secretion appears to be regulated in a similar fashion to that of ANP, with the major determinant of secretion being the degree of ventricular stretch and work, proportionately greater increases in BNP concentrations are reported to occur in certain situations, for example in congestive HF (heart failure), reflecting the markedly augmented gene expression of BNP compared with that of ANP in the overloaded ventricles [ 1 ]. (clinsci.org)
  • clinical
  • 1 Small artery structural alterations may precede many clinical manifestations of end-organ damage in hypertensive patients 2 and predict the occurrence of future cardiovascular events. (ahajournals.org)
  • 2 3 4 It is still controversial whether cardiac structural changes in the clinical setting are due to long-term elevations in blood pressure or are a manifestation of nonhemodynamic factors acting on the myocardium. (ahajournals.org)
  • Infarct size is a predictor of future cardiovascular events as well as mortality, and researchers doing long-term follow-up on STEMI patients treated with RIC found that the reduction in heart damage at the time of the heart attack resulted in clinical improvement four years later: MACCE (major adverse cardiovascular and cerebrovascular event) rates were reduced by 47% (13.5% vs. 25.6%, p=0.018). (wikipedia.org)
  • systemic
  • Correction of nutrition, ionic and vitamin deficiencies and control of alcohol-related systemic organ damage are compulsory. (mdpi.com)
  • hormone
  • BNP, on the other hand, is primarily a ventricular hormone which is secreted constitutively from myocytes as the mature peptide, although small amounts are co-stored with ANP in atrial granules [ 1 ]. (clinsci.org)
  • heart
  • Although there are diverse different strategies to directly target alcohol-induced heart damage, they are partially effective, and can only be used as support medication in a multidisciplinary approach. (mdpi.com)
  • Planavila Porta, A. New Treatment Strategies for Alcohol-Induced Heart Damage. (mdpi.com)
  • Although a key effector of the RAS, angiotensin II (Ang II), instigates hemodynamic injury to the heart by promoting blood pressure elevation, Ang II can also exacerbate end-organ damage independently of blood pressure by stimulating immune and inflammatory signaling cascades. (ahajournals.org)
  • They find that Bcl10-deficient mice have a preserved hypertensive response leading to robust cardiac hypertrophy but are protected from the scarring in the heart that disrupts cardiac conduction and raises the susceptibility to ventricular arrhythmia. (ahajournals.org)
  • The cardiac natriuretic peptides, ANP (atrial natriuretic peptide) and BNP (brain natriuretic peptide), are secreted by the heart in proportion to cardiac transmural pressures. (clinsci.org)
  • The cardiac natriuretic peptides, ANP and BNP (atrial and brain natriuretic peptides respectively), are hormones secreted predominantly by the heart. (clinsci.org)
  • Human aldosterone-producing adenoma, or PA, is relatively uncommon, and there is a paucity of information about the simultaneous effects of prolonged aldosterone excess on three major target organs-the heart, brain, and kidneys. (ahajournals.org)
  • Cardiac arrest is a sudden loss of blood flow resulting from the failure of the heart to effectively pump. (wikipedia.org)
  • The initial heart rhythm is most often ventricular fibrillation. (wikipedia.org)
  • While a cardiac arrest may be caused by heart attack or heart failure, these are not the same. (wikipedia.org)
  • Sudden cardiac arrest (SCA) and sudden cardiac death (SCD) occur when the heart abruptly begins to beat in an abnormal or irregular rhythm (arrhythmia). (wikipedia.org)
  • Without organized electrical activity in the heart muscle, there is no consistent contraction of the ventricles, which results in the heart's inability to generate an adequate cardiac output (forward pumping of blood from heart to rest of the body). (wikipedia.org)
  • Cases have shown that the most common finding at postmortem examination of sudden cardiac death (SCD) is chronic high-grade stenosis of at least one segment of a major coronary artery, the arteries that supply the heart muscle with its blood supply. (wikipedia.org)
  • The patients treated with RIC prior to surgery exhibited less heart damage, as measured by the biomarker troponin, as well as less need for supportive drugs. (wikipedia.org)
  • In seven trials comprising 2,372 STEMI patients, infarct size-a measure of damage to the heart-was reduced by 17-30% on average, and the reduction was greatest (~60%) in the largest infarcts. (wikipedia.org)
  • kidney
  • It does this by regulating the peripheral vasculature, and kidney function, which in turn affect cardiac output, vascular resistance, and fluid retention. (wikipedia.org)
  • tissue
  • Visceral obesity and the ectopic deposition of adipose tissue may be important in the activation of these systems and in the target organ damage that ensues. (physiology.org)
  • This decreases the amount of time available for perfusion of cardiac tissue, which largely occurs in diastole. (wikipedia.org)
  • This "conditioning" activates the body's natural protective physiology against reperfusion injury and the tissue damage caused by low oxygen levels-a protection present in many mammals. (wikipedia.org)
  • increases
  • Ethanol alters membrane permeability and composition, interferes with receptors and intracellular transients, induces oxidative, metabolic and energy damage, decreases protein synthesis, excitation-contraction coupling and increases cell apoptosis. (mdpi.com)
  • Exposure to stress increases sympathetic outflow, and repeated stress-induced vasoconstriction may result in vascular hypertrophy, leading to progressive increases in peripheral resistance and blood pressure. (wikipedia.org)
  • Training commonly uses the technique of progressively increasing the force output of the muscle through incremental weight increases and uses a variety of exercises and types of equipment to target specific muscle groups. (wikipedia.org)
  • blood pressure
  • Is the SPRINT Blood Pressure Treatment Target of 120/80 mm Hg Relevant for Children? (ahajournals.org)
  • The wedge pressure was held constant during an infusion of dobutamine at incremental doses (0.4 to 12 μg/kg/min) while blood pressure and cardiac output were measured. (ahajournals.org)
  • effects
  • No evidence has been found of serious adverse effects on organs or organ systems, and the drug has not been shown to have deleterious effects on perinatal or postnatal growth and development. (wikipedia.org)
  • stimulus
  • in fact, exercise can be considered a form of RIC in which the stimulus is distant from the organ being protected. (wikipedia.org)
  • treatment
  • Treatment for cardiac arrest is immediate cardiopulmonary resuscitation (CPR) and, if a shockable rhythm is present, defibrillation. (wikipedia.org)