Take diazepam. Medical search. Frequent questions

Diazepam, first marketed as Valium, is a medicine of the benzodiazepine family that acts as an anxiolytic. (wikipedia.org)
Diazepam (valium) is a benzodiazepine anxiolytic used in the treatment of anxiety disorders, seizures, muscle spasms, and alcohol withdrawal. (erowid.org)
Valium (diazepam) is a benzodiazepine derivative. (nih.gov)
Valium is available for oral administration as tablets containing 2 mg, 5 mg or 10 mg diazepam. (nih.gov)
Diazepam, a benzodiazpine frequently abused recreationally, is sold under the trade name Valium. (cerilliant.com)
Diazepam, also known as Valium is a sedative drug that slows down the activity of your brain and nervous system. (gameworld.gr)
With shortest-acting being Lorazepam ( ativan ), then Alprazolam ( xanax ) , then Clonazepam ( klonopin ), then diazepam ( valium ) which can have half-life of up to 100 hours. (healthtap.com)

Because of its relatively long duration of action, and evidence of safety and efficacy, diazepam is preferred over other benzodiazepines for treatment of persons experiencing moderate to severe alcohol withdrawal. (wikipedia.org)
However, benzodiazepines such as diazepam can be used for their muscle-relaxant properties to alleviate pain caused by muscle spasms and various dystonias, including blepharospasm. (wikipedia.org)
Long-acting benzodiazepines, such as diazepam tablets, should be avoided to the elderly. (janusinfo.se)
A woman who had been abusing benzodiazepines was taking diazepam 80 mg and oxazepam 30 mg daily at the time of study. (nih.gov)
Diazepam belongs to the class of medications called benzodiazepines . (pharmasave.com)
Ethanol, which has a pharmacological profile similar to those of barbiturates and benzodiazepines, enhances [ 3 H]diazepam binding to the crude Lubrol-solubilized fraction. (aspetjournals.org)
Conventionally short acting benzodiazepines (Diazepam, midazolam ) are given by parental routes (IV or IM) for acute management of seizures. (pediatriconcall.com)
Diazepam shalina 10mg 250 tablets belongs to the class of drugs called benzodiazepines. (ukpharma4u.com)
Diazepam belongs to a group of medicines called benzodiazepines. (ukpharma4u.com)

How does Diazepam shalina 10mg work? (ukpharma4u.com)
This medication may be harmful to people for whom it has not been prescribed.What form (s) does Diazepam Daz 10mg come in? (ukpharma4u.com)

Our results demonstrate that diazepam, which is practically insoluble, can be delivered intranasally with rapid and complete absorption by coadministering avizafone with aminopeptidase B. Furthermore, even faster rates of absorption might be attained simply by increasing the enzyme concentration, potentially supplanting intravenous diazepam or lorazepam or intramuscular midazolam in the treatment of seizure emergencies. (healthpartners.com)
BestBets: Buccal Midazolam vs Rectal Diazepam: Which is more effective in the treatment of acute seizures in children in Accident and emergency department.Update. (bestbets.org)
61/109) 56% for buccal midazolam and (30/110) 27% for rectal diazepam (% difference 29%, 95% CI 16-41). (bestbets.org)
Treatment failure occurred in 71/165 (43%) in diazepam group compared with 50/165 (30.3%) in midazolam group (p=0.016). (bestbets.org)
To compare the clinical efficacy of two routes of midazolam intranasal vs. intravenous, in relation to intravenous diazepam for control of seizures. (pediatriconcall.com)
Group-I was given intranasal midazolam at 0.3 mg /kg, Group-II was given intravenous midazolam at 0.3mg/kg and Group-III was given intravenous diazepam at 0.3 mg /kg. (pediatriconcall.com)
Mean time from physician contact to drug administration was significantly shorter with intranasal midazolam as compared to intravenous midazolam and intravenous diazepam (0.40±0.10min vs. 1.06±0.40 min and 1.06±40 min) (p-0.03). (pediatriconcall.com)
Mean time from drug administration to cessation of seizures was lesser in midazolam (1.6 ± 0.3mins(IN) and 1.6±0.3min(IV) as compared to diazepam (2.26±0.6 min) (p-0.06). (pediatriconcall.com)
We conducted this study to evaluate the efficacy of intranasal midazolam vs. intravenous midazolam and intravenous diazepam in convulsing neonates and children. (pediatriconcall.com)
Midazolam has twice the affinity for benzodiazepine receptors than diazepam. (medscape.com)

However, intravenous lorazepam has advantages over intravenous diazepam, including a higher rate of terminating seizures and a more prolonged anticonvulsant effect. (wikipedia.org)
Diazepam gel was better than placebo gel in reducing the risk of non-cessation of seizures. (wikipedia.org)
The anticonvulsant effects of diazepam can help in the treatment of seizures due to a drug overdose or chemical toxicity as a result of exposure to sarin, VX, or soman (or other organophosphate poisons), lindane, chloroquine, physostigmine, or pyrethroids. (wikipedia.org)
Diazepam is sometimes used intermittently for the prevention of febrile seizures that may occur in children under five years of age. (wikipedia.org)
However, evidence suggests that with significant poisoning, the administration of diazepam is effective, and (even in the absence of seizures) increases survival and reduces CNS damage, and cardiac dysfunction. (cdc.gov)
Currently, the administration of diazepam is recommended to treat or prevent these seizures. (cdc.gov)
Current recommendations are for the administration of diazepam for seizures due to nerve agent poisoning and even for severe toxicity (severe respiratory distress or neuromuscular signs) in the absence of seizures. (cdc.gov)
Prevention and treatment of seizures with diazepam is an important aspect of patient management. (cdc.gov)
This Phase 3, multicenter, open-label study of chronic, intermittent use of study drug (DBSF) is designed to evaluate the safety and tolerability of the buccal formulation of diazepam in children, adolescents and adults with acute repetitive seizures. (cureepilepsy.org)
Emergency treatment for prolonged tonic-clonic seizures has long involved early administration of benzodiazepine drugs, for example, diazepam via the rectal route or lorazepam via intravenous route where available. (bestbets.org)
Following treatment with diazepam, patients achieved resolution of clinical relevant seizures within 10 minutes, with no adverse events that led to discontinuation or respiratory depression. (neurologylive.com)
In addition, diazepam-treated participants remained free from seizures or convulsions for 30 minutes after starting treatment. (neurologylive.com)
1. Aculys Pharma delivers positive phase 3 clinical study interim analysis result of a diazepam nasal spray: an antiepileptic drug for the treatment of epileptic seizures. (neurologylive.com)

Intravenous diazepam or lorazepam are first-line treatments for status epilepticus. (wikipedia.org)
In a 1-day postpartum woman, a colostrum diazepam level of 100 mcg/L milk level was found 25 hours after the last of 3 intravenous 5 mg doses of diazepam given over a 4-hour period. (nih.gov)
Each had also received intravenous diazepam 20 mg immediately prior to delivery. (nih.gov)
Eight women who were at least 1 month postpartum received intravenous diazepam during a surgical sterilization procedure. (nih.gov)

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After a single dose of diazepam, as for sedation before a procedure or for a seizure, there is usually no need to wait to resume breastfeeding, although with a newborn or preterm infant, a cautious approach would be to wait a period of 6 to 8 hours before resuming nursing. (nih.gov)
We sought to determine whether tolerance occurs to the anticonvulsant activity of ganaxolone in the pentylenetetrazol seizure test and whether there is cross-tolerance with diazepam. (aspetjournals.org)

Diazepam is rarely used for the long-term treatment of epilepsy because tolerance to its anticonvulsant effects usually develops within six to twelve months of treatment, effectively rendering it useless for that purpose. (wikipedia.org)
Diazepam is a benzodiazepine that exerts anxiolytic, sedative, muscle-relaxant, anticonvulsant and amnestic effects. (nih.gov)
On the day after the chronic treatment periods, the anticonvulsant potencies of ganaxolone and diazepam were determined. (aspetjournals.org)
In contrast, in animals that were treated chronically with ganaxolone for 7 days, there was a significant reduction in the anticonvulsant potency of diazepam (ED 50 = 4.0 versus 1.9 mg/kg for naive controls). (aspetjournals.org)
We conclude that there is no tolerance to the anticonvulsant activity of ganaxolone nor is there cross-tolerance to ganaxolone when tolerance develops to diazepam. (aspetjournals.org)

The levels of diazepam measured in Swedish waters are low and are not expected to pose any environmental risk, but diazepam is metabolized partly to oxazepam, which has been measured in concentrations posing a risk. (janusinfo.se)
Diazepam is metabolized to the active metabolites nordiazepam (desmethyldiazepam) and temazepam, which are in turn metabolized to the active metabolite oxazepam. (nih.gov)

Healthy male volunteers (n = 48) aged 18-44 years received a single 10-mg oral dose of diazepam. (nih.gov)
1 ] One study found that a high dose of diazepam given during tubal ligation surgery increased the risk of infant weight loss and hyperbilirubinemia postoperatively. (nih.gov)
Milk samples were taken before and after the morning feeding following the morning dose of diazepam during a 30-day tapering dosage regimen. (nih.gov)
The recommended dose of diazepam for adults ranges from 2 mg to 10 mg, taken 2 to 4 times daily. (pharmasave.com)

Diazepam is N-demethylated by CYP3A4 and 2C19 to the active metabolite N-desmethyldiazepam, and is hydroxylated by CYP3A4 to the active metabolite temazepam. (nih.gov)
Plasma diazepam and desmethyldiazepam concentrations were measured at multiple points during the next 11 days. (nih.gov)

The present studies examined the prescription µ-opioid analgesic oxycodone (0.003-0.1 mg/kg) and the prototypical benzodiazepine anxiolytic diazepam (0.03-1.0 mg/kg), alone and in combination, using an animal model of pain that examines the restoration of conflict-related operant behavior as evidence of analgesia. (physiciansweekly.com)

People over the age of 65 years often require lower doses of diazepam. (pharmasave.com)

The medication stolen includes Diazepam 2g, 5g and 10g, and these stolen drugs could have potentially serious or fatal consequences if they are taken by anyone for whom they are not prescribed. (stv.tv)
Diazepam may have a stronger than expected effect if used in conjunction with cimetidine (an antacid more commonly known as Tagamet® ), omeprazole (an antacid more commonly known as Prilosec® ), erythromycin (an antibiotic), ketoconazole or other "azole" antifungal drugs, fluoxetine (an anti-anxiety medication), or propranolol (a heart medication). (marvistavet.com)

The use of diazepam may increase the effect of digoxin (a heart medication) and of amitriptyline (an anti-anxiety medication). (marvistavet.com)
Recently announced interim findings from a Japanese-based phase 3 study assessing Aculys Pharma's diazepam nasal spray showed that the antiseizure medication was effective across multiple clinical end points, demonstrating efficacy and safety. (neurologylive.com)
The study, the first such phase 3 study of diazepam nasal spray in Japan, assessed Aculy's formulation of the antiseizure medication for which has been FDA-approved since 2020. (neurologylive.com)

Diazepam overdose occurs when someone takes more than the normal or recommended amount of this medicine. (medlineplus.gov)
The most common symptom of a diazepam overdose is falling into a deep sleep or "coma" while still being able to breathe well enough. (medlineplus.gov)
Recovery from a diazepam overdose is very likely. (medlineplus.gov)

Diazepam and its metabolites cross the blood-brain and placental barriers and are also found in breast milk in concentrations approximately one tenth of those in maternal plasma (days 3 to 9 post-partum). (nih.gov)
In order to overcome this limitation, we used an organotypical model of human primary hepatocytes for the biotransformation of the drug diazepam with special reference to metabolites in both the cell matrix phase and supernatant and its interaction of three inducers (phenobarbital, dexamethasone, aroclor 1254) in different time responses (1, 2, 4, 8, 24 h). (cellml.org)

Diazepam is a psychoactive drug of the benzodiazepine class. (marvistavet.com)

Diazepam was patented in 1959 by Hoffmann-La Roche. (wikipedia.org)

Por su fácil administración, mínimos efectos colaterales, y claro efecto relajante muscular creemos que el diazepam puede reemplazar a tratamientos combinados de Clorpromazina, Fenobarbital y Metocarbamol. (univalle.edu.co)

For brands that may still be available, search under diazepam. (pharmasave.com)

The cocktail is reported to contain ketamine, methamphetamine, heroin and pure diazepam. (chiangraitimes.com)

Moderate reductions in synaptic γ-aminobutyric acid A receptors (GABA A Rs) have been associated with an enhanced defensive behavioral reactivity to mild threat, sensitive to diazepam. (illinois.edu)
In the absence of these receptors, diazepam through activation of α1-GABA A Rs remains effective in reducing risk assessment, but not behavioral aversion. (illinois.edu)

Diazepam is mainly used to treat anxiety, insomnia, panic attacks and symptoms of acute alcohol withdrawal. (wikipedia.org)
Diazepam is a prescription medicine used to treat anxiety disorders. (medlineplus.gov)
Diazepam is a benzodiazepine used to treat a number of symptoms from anxiety and panic attacks to insomnia. (cerilliant.com)
Buy Diazepam In The Uk Sleep problems can be caused by depression or anxiety, pain, restless leg syndrome, and many other conditions. (awlshelter.org)
In general, diazepam is useful in the symptomatic management of mild to moderate degrees of anxiety in conditions dominated by tension, excitation, agitation, fear, or aggressiveness such as may occur in psychoneurosis, anxiety reactions due to stress conditions, and anxiety states with somatic expression. (itopmeds.com)

In parallel we represented these data in the form of a mathematical model with two compartments explaining the dynamics of diazepam metabolism with the effect of these other inducers in human primary hepatocytes. (cellml.org)
In vitro metabolism of fipronil by human and rat cytochrome P450 and its interactions with testosterone and diazepam. (cdc.gov)

This stable-labeled internal standard is suited for quantitation of diazepam levels in urine, serum, or plasma by LC/MS or GC/MS for urine drug testing, clinical toxicology, forensic analysis, or isotope dilution methods. (cerilliant.com)

Moreover, in acute alcoholic withdrawal, diazepam may be useful in the symptomatic relief of acute agitation, tremor, and impending acute delirium tremens. (itopmeds.com)

Diazepam, rectally and intravenously, is recommended for epilepsy and status migrainosus in the Wise list. (janusinfo.se)

Buy Diazepam In The Uk Symptoms that patients should report immediately to their doctor include: Most patients who take clonazepam have no side effects or mild, transient side effects. (awlshelter.org)
Buy Diazepam In The Uk A blood test can detect clonazepam for two half-lives or more, so 80 hours-more than 3 days. (awlshelter.org)
Whats are the differences between diazepam, lorazepam, alprazolam and clonazepam? (healthtap.com)

Enzyme kinetics incorporated into a physiologically based pharmacokinetic model enabled estimation of the first-order absorption rate constants: 0.0689 +/- 0.0080 minutes(-1) for diazepam and 0.122 +/- 0.022 minutes(-1) for the intermediate. (healthpartners.com)

Discontinuing diazepam therapy abruptly may lead to unpleasant withdrawal symptoms similar to those that occur in humans. (marvistavet.com)

Diazepam is the most commonly used benzodiazepine for "tapering" benzodiazepine dependence due to the drug's comparatively long half-life, allowing for more efficient dose reduction. (wikipedia.org)

Diazepam is used for the emergency treatment of eclampsia, when IV magnesium sulfate and blood-pressure control measures have failed. (wikipedia.org)
Diazepam treatment alone did not produce significant antinociception. (physiciansweekly.com)
Chronic treatment with diazepam was not associated with a reduction in the potency of ganaxolone, but there was a reduction in the potency of diazepam (ED 50 = 3.7 mg/kg). (aspetjournals.org)
However, there is cross-tolerance to diazepam with chronic ganaxolone treatment. (aspetjournals.org)

Average milk levels of diazepam plus nordiazepam were 79 mcg/L after 4 days (total diazepam dosage130 mg) and 130 mcg/L after 6 days (total diazepam dosage 190 mg). (nih.gov)

Antacids may slow the onset of effect of diazepam. (marvistavet.com)

Two compartment model of diazepam biotransformation in an organotypical culture of primary human hepatocytes, Ali Acikgoz et al, 2009, Toxicology and applied pharmacology , 234, 179-191. (cellml.org)

Rats were treated with two daily injections of a 2 × ED 50 dose of ganaxolone (7 mg/kg s.c.), diazepam (4 mg/kg i.p.), or vehicle for 3 or 7 days. (aspetjournals.org)

Effects of oxycodone and diazepam alone and in combination on operant nociception. (physiciansweekly.com)
In combination, diazepam pretreatment shifted oxycodone functions upward in a dose-dependent manner, but the additive effects were limited to a narrow dose range. (physiciansweekly.com)
In addition, combinations of diazepam and oxycodone at higher doses abolished responding. (physiciansweekly.com)

As a result, the diazepam in it speeds up the activity of the central nervous system (CNS). (triontech.com)

Pains to an early Order Diazepam Uk cases, " having been removed to Buy Alprazolam Online Legally their normal, 589. (allclimbing.com)
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Milk levels of diazepam and nordiazepam did not differ markedly between the collection times and ranged from 17 to 39 mcg/L for diazepam and 19 to 52 mcg/L for nordiazepam. (nih.gov)

Diazepam have found the formula to ease this season's lament: ignore the warnings. (heavyplanet.net)

Buy generic and brand medications without a prescription Viagra, Cialis, Propecia, kwikmed diazepam . (apsia.org)

In view, which Buy Yellow Diazepam interfere with psychoses, excited at. (allclimbing.com)

90% of diazepam is absorbed and the average time to achieve peak plasma concentrations is 1 - 1.5 hours with a range of 0.25 to 2.5 hours. (nih.gov)

Urine dipsticks that measure glucose may be falsely negative in patients taking diazepam. (marvistavet.com)

Because it is water soluble, it takes approximately 3 times longer than diazepam to peak EEG effects. (medscape.com)

Three infants were breastfed from birth while their mothers were receiving diazepam 10 mg 3 times daily. (nih.gov)
Diazepam also crosses readily into the milk of nursing mothers and may tranquilize nursing young. (marvistavet.com)

Diazepam (DZ) 0.3 mg/kg given at 60 min antagonized some effects of CAF but failed to antagonize YOH. (nih.gov)
Previously, we have used the adult hippocampal slice preparation to study the effects of diazepam on biochemical consequences of OGD. (jneurosci.org)
α2 -/- mice, double mutant α1H101Rα2 -/- and α3H126Rα2 -/- mice, which combine a lack of α2-GABA A Rs with point-mutated diazepam-insensitive either α1H101R or α3H126R-GABA A Rs, and double point-mutated α1H101Rα 2H101R and α1H101Rα3H126R mice were used to uncover the GABA A R subtype(s) mediating the drug effects. (illinois.edu)

Anatomy10

Organisms7

Diseases15

Chemicals and Drugs145

Analytical, Diagnostic and Therapeutic Techniques and Equipment37

Psychiatry and Psychology30

Phenomena and Processes25

Technology, Industry, Agriculture1

Health Care7

Valium7

Benzodiazepines9

10mg2

Midazolam10

Seizures13

Intravenous4

Tablets5

Seizure2

Anticonvulsant5

Oxazepam2

Dose of diazepam4

Desmethyldiazepam2

Anxiolytic1

Doses of diazepam1

Drugs2

Medication3

Overdose3

Metabolites2

Psychoactive1

Roche1

Puede1

Search1

Methamphetamine1

Receptors2

Anxiety5

Metabolism2

Clinical1

Acute1

Epilepsy1

Clonazepam3

Rate constants1

Symptoms1

Benzodiazepine dependence1

Treatment4

Dosage1

Effect of diazepam1

Pharmacology1

Rats1

Oxycodone3

Nervous system1

Order diazepam5

Differ1

WARNINGS1

Prescription1

Psychoses1

Concentrations1

Patients1

Peak1

Mothers2

Effects3