• Choriocarcinoma are trophoblastic tumors that form in the uterus from villous cells. (wikipedia.org)
  • others are invasive mole (chorioadenoma destruens), choriocarcinoma, placental site trophoblastic tumor (PSTT), and epithelioid trophoblastic tumor (ETT). (medscape.com)
  • Smith HO, Kohorn E, Cole LA. Choriocarcinoma and gestational trophoblastic disease. (medscape.com)
  • Unlike the HYDATIDIFORM MOLE, choriocarcinoma contains no CHORIONIC VILLI but rather sheets of undifferentiated cytotrophoblasts and syncytiotrophoblasts (TROPHOBLASTS). (umassmed.edu)
  • Choriocarcinoma of the ovary is a highly malignant ovarian tumor which is characterized pathologically by the presence of trophoblastic malignant cells, and biochemically by the production of the pregnancy hormone human chorionic gonadotrophin (hCG) in the absence of an ongoing pregnancy. (atlasgeneticsoncology.org)
  • Microscopically, hemorrheage and necrosis are found, and tumor cells resemble placental trophoblastic cells: cytotrophoblast (CT), intermediate trophoblast (IT), and syncytiotrophoblast (ST). The CT and IT tend to grow in clusters and sheets separated by ST. The typical pattern of choriocarcinoma has been called two cell pattern, biphasic-terms that reflect the relatively regular, alternating arrangement of CT and ST in the tumor interspread with intermediate trophoblast. (atlasgeneticsoncology.org)
  • others are invasive mole (chorioadenoma destruens), choriocarcinoma, and placental site trophoblastic tumor (PSTT). (medscape.com)
  • These tumors include postmolar gestational trophoblastic neoplasia (gestational trophoblastic neoplasia that develops after a molar pregnancy), placental-site trophoblastic tumor, epithelioid trophoblastic tumor, choriocarcinoma, and invasive mole. (msdmanuals.com)
  • Elevated ratio of hCG indicates trophoblastic disease (moles, choriocarcinoma) and certain testicular tumors. (wefocusoncare.com)
  • In patients following the diagnosis of hydatidiform mole, GTM, or choriocarcinoma, if there is complete resolution of measurable hCG, and then titers slowly rise and then plateau, this is indicative of quiescent gestational trophoblastic disease. (elsevierpure.com)
  • After histopathological examination, 48 cases were complete molar pregnancy, 9 were partial moles, 1 placental site trophoblastic tumour and 1 choriocarcinoma. (bmj.com)
  • Marked proliferation of the trophoblasts is observed. (medscape.com)
  • Our results indicate a reduction in vascular placental cells, especially cells responsible for structural integrity, and increase in trophoblast proliferation in animals exposed to particulate matter. (nature.com)
  • We have reported that BCL6 is required for the proliferation, survival, fusion, and syncytialization of trophoblasts. (uni-frankfurt.de)
  • The hydatidiform mole encompasses a heterogeneous group of lesions that feature an abnormal non-neoplastic proliferation of trophoblasts ( 1 ). (iiarjournals.org)
  • Gestational trophoblastic disease is proliferation of trophoblastic tissue in pregnant or recently pregnant women. (msdmanuals.com)
  • General references Gestational trophoblastic disease is proliferation of trophoblastic tissue in pregnant or recently pregnant women. (msdmanuals.com)
  • This study was conducted to evaluate the effect of curcumin on apoptosis, proliferation, and nuclear translocation of endothelial nitricoxide synthase in trophoblast cells induced by estradiol in complete hydatidiform mole (CHM). (ui.ac.id)
  • Curcumin inhibits the proliferation and modulates the apoptosis of trophoblast cells induced by estradiol in CHM involvement. (ui.ac.id)
  • Here, we demonstrated a preconditioning strategy with trophoblast stem cell-derived extracellular vesicles (TSC-EVs) to boost the proliferation and regenerative capacity of MSCs. (biomedcentral.com)
  • This is a group of disorders that have in common the proliferation of gestational trophoblast. (healthzigzag.com)
  • It is a rare disease that comprises a heterogeneous group of placental lesions arising from abnormal proliferation of the trophoblast. (bmj.com)
  • As soon as the zygote becomes embedded in the decidua its trophoblast undergoes rapid proliferation. (co.ma)
  • Gestational trophoblastic tumors are sensitive to many antineoplastic agents, especially those that act in the S phase or the M phase of the cell cycle. (medscape.com)
  • What is the best protocol of single-agent methotrexate chemotherapy in nonmetastatic or low-risk metastatic gestational trophoblastic tumors? (medscape.com)
  • Roberts JP, Lurain JR. Treatment of low-risk metastatic gestational trophoblastic tumors with single-agent chemotherapy. (medscape.com)
  • A malignant metastatic form of trophoblastic tumors. (umassmed.edu)
  • Gestational trophoblastic neoplasias are malignant placental tumors. (msdmanuals.com)
  • After the first differentiation, the cells in the human embryo lose their totipotency because they can no longer form a trophoblast. (wikipedia.org)
  • Preeclamptic placentas are characterized by various defects like deregulated differentiation and impaired fusion of trophoblasts. (uni-frankfurt.de)
  • These data suggest that an accurately regulated expression of BCL6 is important for proper differentiation and successful syncytialization of trophoblasts. (uni-frankfurt.de)
  • While deregulated BCL6 is linked to lymphomagenesis by blocking lymphocyte terminal differentiation, increased BCL6 in the placenta contributes to the development of preeclampsia by impairing trophoblast differentiation and fusion. (uni-frankfurt.de)
  • He did his Ph.D. in Biochemistry at All India Institute of Medical Sciences, New Delhi, working on reproductive immunology, with the focus on trophoblast invasion and differentiation and their role in human blastocyst implantation. (stanford.edu)
  • The phosphatidylinositol 3-kinase/Akt signaling pathway modulates the endocrine differentiation of trophoblast cells. (virascience.com)
  • Activation of Lyn, a Src-related nonreceptor tyrosine kinase, in trophoblast cells is associated with trophoblast giant cell differentiation. (virascience.com)
  • The purpose of the present work was to use Lyn as a tool to identify signaling pathways regulating the endocrine differentiation of trophoblast cells. (virascience.com)
  • Background: Epithelial to mesenchymal transition (EMT) is critical for human placental development, trophoblastic differentiation, and pregnancy-associated diseases. (impleomedical.com)
  • Hydatidiform mole (HM) is an abnormal pregnancy, characterized by trophoblastic hyperplasia, vesicular swelling of the chorionic villi, and without a viable fetus. (au.dk)
  • In the Danish Mole Project We are collecting samples from hydatidiform moles and other trophoblastic diseases. (au.dk)
  • The complete hydatidiform mole is a diploid androgenetic conceptus with indiscriminate hyperplasia of the villous trophoblast and generalized swelling of the hydatidiform villous without detectable fetal tissues. (iiarjournals.org)
  • The partial hydatidiform mole is characterized by a diandric triploid conceptus, accompanying focal trophoblastic hyperplasia and villous hydrops, and an ascertainable fetus. (iiarjournals.org)
  • Therefore, the possibility of progressing to gestational trophoblastic neoplasia and the need for clinical processing and follow-up of the patient emphasizes the importance of differentiating between complete and partial hydatidiform moles. (iiarjournals.org)
  • After a complete hydatidiform mole, approximately 15 to 20% of patients are treated for gestational trophoblastic neoplasia. (msdmanuals.com)
  • Hydatidiform mole is the most common type of gestational trophoblastic tumor. (studybuff.com)
  • A form of gestational trophoblastic neoplasia similar to a hydatidiform mole but with deep invasion into the myometrium and histologically characterized by hyperplasia of trophoblasts generalized cystic degeneration of chorionic villi and the presence of molar villi in the myometrium and/ or uterine blood vessels. (globalgenes.org)
  • These data suggest BCL6 as a crucial player in the migration and invasion of trophoblasts in the early stages of placental development through the regulation of various genes associated with the migratory machinery. (uni-frankfurt.de)
  • With the major attention to the pivotal roles of PPARs in diverse aspects of energy metabolism, the essential functions of PPARgamma and PPARbeta/delta in placental development came as a surprise and were often considered a nuisance en route to their genetic analysis. (virascience.com)
  • Gestational trophoblastic disease is a pregnancy-associated concept, forming from the villous and extravillous trophoblast cells in the placenta. (wikipedia.org)
  • They consist of proliferations of villous trophoblasts. (msdmanuals.com)
  • Trophoblastic cells are the early targets of L. monocytogenes and bacteria then disseminate rapidly to the other trophoblastic structures, such as the syncytiotrophoblast cells lining the villous core in the labyrinthine zone of the placenta [ 10 ]. (biomedcentral.com)
  • Most women with gestational trophoblastic neoplasia (GTN) receive their diagnosis during their reproductive years. (medscape.com)
  • Kashef MA, Dehaghani AS, Naeimi S, Fattahi MJ, Ghaderi A. Interleukin-18 gene promoter polymorphisms in women with gestational trophoblastic diseases. (umassmed.edu)
  • Suppressed follicle-stimulating hormone (FSH) in women with gestational trophoblastic neoplasms. (umassmed.edu)
  • Gestational Trophoblastic Neoplasms" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • This graph shows the total number of publications written about "Gestational Trophoblastic Neoplasms" by people in Harvard Catalyst Profiles by year, and whether "Gestational Trophoblastic Neoplasms" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Gestational Trophoblastic Neoplasms" by people in Profiles. (harvard.edu)
  • In this project we are developing methods for diagnosing the origin of malignant trophoblastic tumours. (au.dk)
  • Gestational trophoblastic disease includes a spectrum of proliferative disorders ranging from nonneoplastic hydatiform moles to malignant neoplastic disorders. (msdmanuals.com)
  • This guideline reviews the clinical evaluation and management of gestational trophoblastic diseases, including surgical and medical management of benign, premalignant, and malignant entities. (bvsalud.org)
  • Clinically, complete moles show a much higher incidence (18-29%) of developing into gestational trophoblastic neoplasia, whereas persistent trophoblastic neoplasia occurs only in 1.0-5.6% of partial mole cases ( 3 , 4 ). (iiarjournals.org)
  • These range from areolae in moles through complexly folded hemophagous regions in tenrecs to the trophoblastic annulus in shrews. (ehu.eus)
  • Gestational trophoblastic neoplasia (GTN) is a collective term for gestational trophoblastic diseases that invade locally or metastasize. (medscape.com)
  • Gestational trophoblastic disease (GTD) is a group of rare diseases in which a tumor develops inside the uterus from tissue that forms after conception. (dartmouth.edu)
  • Deficiency in the invasiveness of trophoblasts is associated with a spectrum of gestational diseases, such as preeclampsia (PE). (uni-frankfurt.de)
  • Thus, a fairly rapid, simple and economical technique is needed to serve as a useful adjunct to conventional methods in the diagnosis of gestational trophoblastic diseases. (iiarjournals.org)
  • Barut A, Harma M, Arikan I, Barut F. Endothelial nitric oxide synthase expression in gestational trophoblastic diseases. (ui.ac.id)
  • The incidence of trophoblastic diseases in Indonesia and developing countries is relatively high compared to the developed countries. (unpad.ac.id)
  • Gestational trophoblastic disease (GTD) is a group of rare diseases in which abnormal trophoblast cells grow inside the uterus after conception. (studybuff.com)
  • In addition, cytotrophoblasts in the tips of villi can differentiate into another type of trophoblast called the extravillous trophoblast. (wikipedia.org)
  • Extravillous trophoblasts grow out from the placenta and penetrate into the decidualized uterus. (wikipedia.org)
  • The invasion of a specific type of trophoblast (extravillous trophoblast) into the maternal uterus is a vital stage in the establishment of pregnancy. (wikipedia.org)
  • This study aims to analyze the effects of low and high doses of cortisol on an extravillous trophoblast cell line, and the effects of various exposures to this hormone. (fapesp.br)
  • The placenta is a heterogeneous organ whose development involves complex interactions of trophoblasts with decidual, vascular, and immune cells at the fetal-maternal interface. (nature.com)
  • IFPA Meeting 2012 Workshop Report III: trophoblast deportation, gestational trophoblastic disease, placental insufficiency and fetal growth restriction, trophoblast over-invasion and accreta-related pathologies, placental thrombosis and fibrinolysis. (virascience.com)
  • Invasion of the trophoblast too deeply may cause conditions such as placenta accreta, placenta increta, or placenta percreta. (wikipedia.org)
  • The histomorphology analysis of placentas from tolcapone treated mice exhibited abnormalities in trophoblast layer and the hampered trophoblast invasion in decidua. (biorxiv.org)
  • In mechanistic study, we revealed that tolcapone inhibited the invasion and migration of trophoblast in vitro , with the changes in protein expressions of Snail, Twist and E-cadherin. (biorxiv.org)
  • In conclusion, tolcapone causes embryo lethality and growth restriction in early gestation, while in mid-gestation tolcapone causes preeclampsia-like phenotypes in mice with defective trophoblast invasion. (biorxiv.org)
  • D: Microscopy showing mononuclear intermediate trophoblastic cells, increased mitotic activity, and destructive invasion of the left ovary, 2020. (wjgnet.com)
  • In the present work, we show that the inhibition of BCL6, either by its gene silencing or by using specific small molecule inhibitors, impairs the migration and invasion of trophoblastic cells, by reducing cell adhesion and compromising the dynamics of the actin cytoskeleton. (uni-frankfurt.de)
  • Trophoblasts are specialized cells of the placenta that play an important role in embryo implantation and interaction with the decidualized maternal uterus. (wikipedia.org)
  • Some of these trophoblasts even replace the endothelial cells in the uterine spiral arteries as they remodel these vessels into wide bore conduits that are independent of maternal vasoconstriction. (wikipedia.org)
  • Trophoblast stem cells (TSCs) are cells that can regenerate and they are similar to embryonic stem cells (ESCs) in the fact that they come from early on in the trophoblast lifetime. (wikipedia.org)
  • In the placenta, these stem cells are able to differentiate into any trophoblast cell because they are pluripotent. (wikipedia.org)
  • 2) Diagnostics using analysis of circulating DNA and circulating cells in diagnostics of the origin of trophoblastic neoplasias. (au.dk)
  • This tissue is made of trophoblast cells and normally surrounds the fertilized egg in the uterus. (dartmouth.edu)
  • Trophoblast cells help connect the fertilized egg to the wall of the uterus and form part of the placenta. (dartmouth.edu)
  • The uptake of abortion-inducing pathogens by trophoblast giant (TG) cells is a key event in infectious abortion. (biomedcentral.com)
  • We found that there was a higher degree of bacterial colonization in the placenta than in other organs, that there were many bacteria in trophoblast giant (TG) cells in the placenta and that an intracellular replication-defective mutant did not induce abortion. (biomedcentral.com)
  • In this in vitro study, trophoblast cells were divided into six groups, the control group (trophoblast cells were exposed to 100 pg/mL of 17-β estradiol) and the treatment group (trophoblast cells were exposed to 100 pg/mL of 17-β estradiol in the presence of curcumin with doses: 50, 100, 200, 400, and 800 μM). (ui.ac.id)
  • Trophoblasts are multifunctional placental cells critical in pregnancy maintenance and communication between the fetus and mother [ 12 ]. (biomedcentral.com)
  • After implantation, self-renewal and proliferative cytotrophoblasts appear in the early first trimester (6-9 weeks) and can help identify trophoblast stem cells (TSCs) [ 13 ]. (biomedcentral.com)
  • Importantly, E2 , but not T0 , actively enhanced melatonin synthetase AANAT expression and melatonin production in primary human trophoblast (PHT) cells through GPER1-PKA-CREB signaling pathway. (bvsalud.org)
  • Many insectivores have complex arrangements for histotrophic nutrition involving columnar trophoblast cells. (ehu.eus)
  • These changes may affect trophoblastic cells and modulate the development of the embryo and the placental tissue itself. (fapesp.br)
  • We show here that BCL6 is present throughout the cell fusion process in the fusogenic trophoblastic cell line BeWo. (uni-frankfurt.de)
  • Clinical characteristics and treatment of gestational trophoblastic tumor with vaginal metastasis. (medscape.com)
  • Strohl A, Lurain J. Clinical epidemiology of gestational trophoblastic disease. (ui.ac.id)
  • This test is approved by the Food and Drug Administration and readily available at national clinical laboratories (Nichols Institute Laboratories, Invasive Trophoblast Antigen test). (elsevierpure.com)
  • Often the trophoblastic disease is diagnosed after all tissue has been formalin fixed, making karyotyping impossible. (au.dk)
  • Beta HCG is chemically produced by trophoblast tissue. (wefocusoncare.com)
  • The plasmodial portion of the trophoblast invades and destroys the surrounding maternal tissue, and at the same time spaces appear in its substance. (co.ma)
  • 5-day methotrexate for women with metastatic gestational trophoblastic disease. (medscape.com)
  • All placentas were positive for SARS-CoV-2 infection by RNA in situ hybridization and demonstrated variable degrees of histiocytic intervillositis, perivillous fibrin deposition, and trophoblast necrosis. (allenpress.com)
  • SARS-CoV-2 placentitis is defined by the triad of histiocytic intervillositis, perivillous fibrin deposition, and trophoblast necrosis. (allenpress.com)
  • were the first to assess nanoparticle-like exosomes released from trophoblasts and determine the functional activity of trophoblast exosomes in human uterine spiral artery remodeling by inducing vascular smooth muscle cell migration for successful pregnancy [ 16 ]. (biomedcentral.com)
  • After blastulation, the trophoblast is contiguous with the ectoderm of the embryo and is referred to as the trophectoderm. (wikipedia.org)
  • Kvinder med tidligere mola har 10 gange øget risiko for en opleve en ny molagraviditet sammenlignet med kvinder, der aldrig har haft en molagraviditet (1). (medpdfarticles.com)
  • A recent study supports the pivotal role of trophoblast exosomes in that extracellular vesicles (EVs) derived from TSCs promote fertility by regulating endometrial cell receptivity [ 17 ]. (biomedcentral.com)
  • As the plasmodium destroys the walls of the dilated maternal blood-vessels, channels are made through which the maternal blood flows into the spaces in the plasmodium, and thus maternal blood begins to circulate in the trophoblast of the zygote. (co.ma)
  • Portions of the placental surface are 'smooth', with trophoblastic cover but very few villi. (ucsd.edu)
  • In the meantime the extra-embryonic coelom has appeared in the primary mesoderm of the zygote, and the outer layer of the mesoderm has associated itself with the trophoblast to form the chorion. (co.ma)
  • Changes in cortisol levels are associated with impaired trophoblast implantation and function, in addition to other pregnancy complications. (fapesp.br)
  • This can also be consistent with the diagnosis of quiescent gestational trophoblastic disease, and does not respond to therapy [1-7]. (elsevierpure.com)
  • Here, we investigated the effects of hedgehog (HH) signaling on EMT in human trophoblasts, and further explored the underlying mechanism. (impleomedical.com)
  • Relapse rate of patients with low-risk gestational trophoblastic tumor initially treated with single-agent chemotherapy. (medscape.com)
  • Is lack of response to single-agent chemotherapy in gestational trophoblastic disease associated with dose scheduling or chemotherapy resistance? (medscape.com)
  • Renal metastases of gestational trophoblastic disease: a report of eight cases. (medscape.com)
  • Rapid escalation of weekly intramuscular methotrexate for nonmetastatic gestational trophoblastic disease: a Gynecologic Oncology Group study. (medscape.com)
  • Next we will attempt to further refine the methods, in order to improve the follow-up of patients after being treated for a trophoblastic disease. (au.dk)
  • Gestational trophoblastic disease can occur during or after an intrauterine or ectopic pregnancy. (msdmanuals.com)
  • 35 years old and those who have previously had gestational trophoblastic disease. (msdmanuals.com)
  • These include false-positive hCG, quiescent gestational trophoblastic disease, and pituitary hCG. (elsevierpure.com)