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AllelesHaplotypesGenotypePolymorphism, GeneticGene FrequencyPolymorphism, Single NucleotideMolecular Sequence DataLinkage DisequilibriumPolymerase Chain ReactionBase SequenceMutationGenetic VariationGenetic Predisposition to DiseaseAmino Acid SequenceGenetic MarkersChromosome MappingGenetics, PopulationCase-Control StudiesMicrosatellite RepeatsPedigreePhenotypeHomozygoteSequence Analysis, DNAGenetic LinkageFounder EffectHeterozygoteModels, GeneticPolymorphism, Restriction Fragment LengthPhylogenyHLA-DRB1 ChainsHLA-DQ AntigensAsian Continental Ancestry GroupEuropean Continental Ancestry GroupGenetic Association StudiesHLA-DR AntigensDNA Mutational AnalysisEvolution, MolecularHLA AntigensExonsMajor Histocompatibility ComplexRecombination, GeneticGenetic LociSelection, GeneticHLA-DQ alpha-ChainsCarrier ProteinsCrosses, GeneticDNA PrimersHLA-DQ beta-ChainsCyclophilin ADNA, MitochondrialPromoter Regions, GeneticDNAGenome-Wide Association StudyQuantitative Trait LociChinaIntronsGeographyAfrican Continental Ancestry GroupRisk FactorsHLA-DR3 AntigenSpecies SpecificityGenes, DominantGenes, RecessiveGenome, HumanHLA-B AntigensGenetic TestingPhylogeographyHeterozygote DetectionLikelihood FunctionsHLA-A AntigensAlgorithmsJewsCohort StudiesMutation, MissenseLod ScoreHLA-B8 AntigenMinisatellite RepeatsY ChromosomeHLA-C AntigensEuropeEthnic GroupsHaploidyGenotyping TechniquesNuclear FamilyTandem Repeat SequencesPoint MutationGenes, MHC Class IIChromosomes, Human, Pair 6Computer SimulationJapanInheritance PatternsDisease SusceptibilityHistocompatibility TestingPolymorphism, Single-Stranded ConformationalMultigene FamilyEpistasis, GeneticAge of OnsetAfricaProteinsGenetic Heterogeneity
LociChromosomalMajor histocoRegionHighRiskAssociationHumanLevel
Loci1
  • The haplotype can be written in an extended form covering the major histocompatibility loci as follows: HLA Cw*0702 : B*0702 : DRB1*1501 : DQA1*0102 : DQB1*0602 The older literature may describe this haplotype in two different ways. (wikipedia.org)
Chromosomal2
  • Chromosomal recombination fragments multigene haplotypes as the distance to that ancestor increases in number of generations. (wikipedia.org)
  • Our analyses of the zebra finch MHC suggest a complex history involving chromosomal fission, gene duplication and translocation in the history of the MHC in birds, and highlight striking differences in MHC structure and organization among avian lineages. (biomedcentral.com)
Major histoco2
Region3
  • Therefore, the presence of these genes, along with Class I and Class II genes can be used to define the MHC region. (biomedcentral.com)
  • In addition to Class I and Class II genes, many of the other genes in the MHC region also play a role in immune response. (biomedcentral.com)
  • These guarantee onset of early-onset familial Alzheimer disease and all occur in the region of the APP gene that encodes the Aβ domain. (findzebra.com)
High1
  • The haplotype is nodal in Ireland but is also at high frequency in Switzerland, it has a subnode in the Pasiegos of northern Spain. (wikipedia.org)
Risk2
  • However, the haplotype is a risk factor in cervical cancer. (wikipedia.org)
  • The aim of the study is to identify additional celiac disease associated loci in the major histocompatibility complex (MHC) independent from classical HLA risk alleles (HLA-DR3-DQ2) and to characterize their potential functional impact in celiac disease pathogenesis at the intestinal level. (nih.gov)
Association2
  • In the current study, we aimed to identify genes that have strong association with AML based on a cross-species integrative approach. (bvsalud.org)
  • Enrichment analysis confirmed an association of these genes with hematopoietic and immune-related functions, phenotypes, processes, and pathways. (bvsalud.org)
Human4
  • Methods: We used Weighted Gene Co-Expression Network Analysis (WGCNA) to identify co-expressed gene modules significantly correlated with human AML, and further selected the genes exhibiting a significant difference in expression between AML and healthy mouse. (bvsalud.org)
  • Results: The cross-species approach identified a total of 412 genes associated with both human and mouse AML. (bvsalud.org)
  • Six of these genes (except ETS1) showed significant differential expression between human AML and healthy samples in an independent microarray dataset. (bvsalud.org)
  • Furthermore, subtype-specific analysis of the hub genes in human AML indicated high expression of NFE2 across all the subtypes (M0 through M7) and enriched expression of ETS1, LEF1, GATA1, and TAL1 in M6 and M7 subtypes. (bvsalud.org)
Level1
  • A significant correlation between methylation status and expression level was observed for most of these genes in AML patients. (bvsalud.org)