The molecular interaction of the PTH2 receptor with the peptide TIP39 has been characterized in full 3D molecular detail, identifying among other residues Tyr-318 in transmembrane helix 5 as a key residue for high affinity binding. (wikipedia.org)
Molecular determinants of tuberoinfundibular peptide of 39 residues (TIP39) selectivity for the parathyroid hormone-2 (PTH2) receptor. (wikipedia.org)
A novel peptide, parathyroid hormone related peptide (PTHrP-2), is assumed as multifunctional factor in angiogenesis, fibrogenesis and re-epithelization. (biomedcentral.com)
Functional1
Three cell types are closely related in anatomic and functional aspects. (biomedcentral.com)
Tuberoinfundibular peptide3
Recent behavioral evidence suggests that the neuropeptide tuberoinfundibular peptide of 39 residues (TIP39), via its receptor, the parathyroid hormone 2 receptor (PTH2R), modulates fear memory. (nih.gov)
Molecular determinants of tuberoinfundibular peptide of 39 residues (TIP39) selectivity for the parathyroid hormone-2 (PTH2) receptor. (wikipedia.org)
Here, we report the cryogenic electron microscopy structure of PTH2R bound to its endogenous ligand, tuberoinfundibular peptide (TIP39), and a heterotrimeric Gs protein at a global resolution of 2.8 Å. (bvsalud.org)
PTH2R4
Contextual freezing, a behavioral sign of fear memory, was significantly greater in PTH2R knock-out than wild-type male mice 2 and 4 weeks after a 2 s 1.5 mA footshock. (nih.gov)
PTH2R knock-out mice had significantly reduced c-Fos activation in the medial amygdala (MeA) following both footshock and fear recall, but had normal activation in the hypothalamic paraventricular nucleus and the amygdalar central nucleus compared with wild-type. (nih.gov)
Parathyroid hormone 2 receptor is a protein that in humans is encoded by the PTH2R gene. (wikipedia.org)
The parathyroid hormone receptor 2 (PTH2R) is a class B1 G protein-coupled receptor (GPCR) involved in the regulation of calcium transport, nociception mediation, and wound healing. (bvsalud.org)
Protein-coupled receptor1
The protein encoded by this gene is a member of the G protein-coupled receptor family 2. (wikipedia.org)
Molecular2
The molecular interaction of the PTH2 receptor with the peptide TIP39 has been characterized in full 3D molecular detail, identifying among other residues Tyr-318 in transmembrane helix 5 as a key residue for high affinity binding. (wikipedia.org)
The AutoDock vina 1.1.2 program was used to verify the molecular docking of the core active compounds and core target genes. (bvsalud.org)
Genes1
The drug-compound-target-disease (D-C-T-D) network and protein-protein interaction (PPI) network were constructed by Cytoscape 3.7.2 and STRING database, and the core target genes and core active compounds were identified. (bvsalud.org)
Database1
IUPHAR Database of Receptors and Ion Channels. (wikipedia.org)
Unique2
The structure reveals that TIP39 adopts a unique loop conformation at the N terminus and deeply inserts into the orthosteric ligand-binding pocket in the transmembrane domain. (bvsalud.org)
Rather, TnsA looks like a type II restriction enzyme, making it a truly unique transposase. (nih.gov)