SupplementationMetabolismLysineEndothelial functionMeta-analysisMutationErectile dysfunctionAmino acidCitrullinePrecursorPathwayNitric oxide levelsSupplementsSubstrateGlutamineSignificantlyDerivativesUtilizationVascularStudiesEffectivenessProteinTreatmentClinicalVitaminSequenceEffectOralEvaluateCardiovascularReview of the literatureCancerRiskLiteratureEffectsStrokeProductionResults
Supplementation12
- We previously reported that dietary arginine supplementation protected the intestinal mucosa of broiler chickens with necrotic enteritis, but the related protective mechanisms remain unclear. (biomedcentral.com)
- The in vivo trial was designed as a 2 × 2 factorial arrangement to evaluated the effects of arginine supplementation on inflammatory responses, arginine transporters, arginine catabolism and JAK-STAT signalling pathway in broiler chickens challenged with C. perfringens or without C. perfringens . (biomedcentral.com)
- Supplementation of L-arginine may improve endothelial and muscle function by stimulating nitric oxide synthesis. (c19early.org)
- L-arginine plus vitamin C supplementation improved walking performance, muscle strength, endothelial function, and fatigue in adults with long COVID. (c19early.org)
- Alvares, Conte-Junior, Silva, Paschoalin, L-arginine does not improve biochemical and hormonal response in trained runners after 4 weeks of supplementation, Nutr. (c19early.org)
- L-arginine supplementation prolongs exercise capacity in congestive heart failure, Kardiol. (c19early.org)
- In April 2019 researchers from Iran published their review of the medical scientific literature to assess the effect of L-arginine supplementation on body weight, BMI and waist circumference. (lifesciencereview.com)
- Results showed that L-arginine supplementation appeared to significantly reduce waist circumference but had no significant effect on body weight and BMI. (lifesciencereview.com)
- The Effect of L-Arginine Supplementation on Obesity-Related Indices: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. (lifesciencereview.com)
- A randomized double-blind controlled study of 6 months of oral nutritional supplementation with arginine and omega-3 fatty acids in HIV-infected patients. (therapeuticresearch.com)
- The present systematic review and meta-analysis aimed to assess the effect of flaxseed supplementation on glycemic control variables and insulin resistance in prediabetes and T2DM. (unboundmedicine.com)
- Over the long term, arginine supplementation should include a maintenance dose of 1.2-2g daily for 7+ weeks to improve aerobic performance, and 10-12g daily for 8 weeks to improve anaerobic performance. (feastgood.com)
Metabolism4
- This enzyme participates in 3 metabolic pathways: lysine degradation, D-glutamine and D-glutamate metabolism, and D-arginine and D-ornithine metabolism. (wikipedia.org)
- Regulated Arginine Metabolism in Immunopathogenesis of a Wide Range of Diseases: Is There a Way to Pass between Scylla and Charybdis? (mdpi.com)
- Ratner, S. Urea synthesis and metabolism of arginine and citrulline. (enzyme-database.org)
- Notably, alterations in gene sets involved in arginine metabolism were observed in both the host and MAP, along with significant downregulation of NOS2 expression. (biomedcentral.com)
Lysine4
- L‐lysine: Its antagonism with L‐arginine in controlling viral infection. (karger.com)
- To improve outcome, a lysine-restricted diet and competitive inhibition of lysine transport through the use of pharmacologic doses of arginine have been recommended as an adjunct therapy. (nih.gov)
- Notably, residues of receptor-binding domain (RBD) showing crucial interactions with angiotensin-converting enzyme 2 (ACE2) and cross-reacting neutralizing antibody were found to be conserved among the analyzed virus strains, except for replacement of lysine with arginine at 378th position of the cryptic epitope of a Shanghai isolate, hCoV-19/Shanghai/SH0007/2020 (EPI_ISL_416320). (nature.com)
- Among the transporters identified, we characterized the cationic amino acid transporter SLC7A3 as a gene that, when up-regulated, overcame low availability of arginine and lysine by increasing their uptake, whereas SLC7A5 was able to sustain cellular fitness upon deprivation of several neutral amino acids. (life-science-alliance.org)
Endothelial function4
- In this review, the role of cerebrovascular reactivity to L-arginine (CVR-L-Arg) for assessment of cerebral endothelial function is discussed. (hindawi.com)
- In the past few years cerebrovascular reactivity to L-arginine by means of TCD has emerged as a parameter for evaluation of cerebral endothelial function [ 3 - 7 ]. (hindawi.com)
- Increase in fasting vascular endothelial function after short-term oral L-arginine is effective when baseline flow-mediated dilation is low: A meta-analysis of randomized controlled trials, Am. J. Clin. (c19early.org)
- Long-term L-arginine improves small-vessel coronary endothelial function in humans. (therapeuticresearch.com)
Meta-analysis4
- A systematic review and meta-analysis. (bvsalud.org)
- Pre-eclampsia is associated with a twofold increase in diabetes: a systematic review and meta-analysis. (voedingsgeneeskunde.nl)
- Pre-eclampsia and risk of cardiovascular disease and cancer in later life: systematic review and meta-analysis. (voedingsgeneeskunde.nl)
- A systematic review and meta-analysis were conducted to know the potential role of arginine supplements on erectile dysfunction, it was found that it increased overall sexual and intercourse satisfaction, erectile function, and orgasmic function. (articlewood.com)
Mutation4
- AVP-D with an autosomal dominant pattern inheritance is due to a mutation in the prepro-arginine vasopressin ( prepro-AVP2 ) gene, mapped to locus 20p13. (medscape.com)
- In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). (yeastgenome.org)
- Accession M0030 Systematic name Allele 1: g.3520delA, c.325delA, r.325dela, Systematic name p.Thr109fsX4 Original code C.E. Description Allele 1: a frame shift deletion mutation in the exon Description 3 leading to a premature stop codon Date 05-May-2004 (Rel. (lu.se)
- Accession M0019 Systematic name Allele 1: g.3899A>G, c.518A>G, r.518a>g, p.Tyr173Cys Original code BS Description Allele 1: a point mutation in the exon 4 leading to Description an amino acid change Date 23-Mar-2004 (Rel. (lu.se)
Erectile dysfunction5
- Effect of oral administration of high-dose nitric oxide donor L-arginine in men with organic erectile dysfunction: results of a double-blind, randomized, placebo-controlled study. (therapeuticresearch.com)
- Effect of large doses of the nitric oxide precursor, L-arginine, on erectile dysfunction. (therapeuticresearch.com)
- Effectiveness of oral L-arginine in first-line treatment of erectile dysfunction in a controlled crossover study. (therapeuticresearch.com)
- The majority of research surrounding L-arginine is in regard to improving cardiovascular health and erectile dysfunction . (feastgood.com)
- L-Arginine used in making the Tupi Tea Male Enhancement capsules is known to help in improving sexual function in men with erectile dysfunction by increasing the blood flow. (articlewood.com)
Amino acid6
- Newswise - Philadelphia, March 9, 2018 - Children with mitochondrial disease s who suffered acute metabolic strokes benefited from rapid intravenous treatment with the amino acid arginine, experiencing no side effects from the treatment. (newswise.com)
- Evidence from the systematic gene-level mutational and protein profile analyses revealed a large number of amino acid (aa) substitutions (n = 744), demonstrating the viral proteins heterogeneous. (nature.com)
- L -arginine is an essential amino acid for chickens and turns out to be a conditionally essential amino acid for mammals under many stressful conditions [ 4 , 5 , 6 ]. (biomedcentral.com)
- Cellular arginine uptake is mainly mediated by the cationic amino acid transporter (CAT) family, also known as y + transporters, which is involved in active transport [ 8 ]. (biomedcentral.com)
- It is made from the amino acid, arginine which is involved in the regulation of vascular function and blood flow. (feastgood.com)
- Arginine is an amino acid that is used by the body to make protein . (feastgood.com)
Citrulline2
- The amino acids citrulline and arginine (or L-arginine ) help blood vessels relax, similar to how Viagra works . (ro.co)
- Studies suggest that citrulline and arginine may be beneficial in mild to moderate cases of ED ( Rhim, 2019 ). (ro.co)
Precursor1
- Because of its role as a precursor to muscle protein synthesis (which leads to muscle growth), there is a potential for L-Arginine to increase lean body mass and improve body composition. (feastgood.com)
Pathway2
- Arginine prevented C. perfringens challenge-induced circulated arginine deficiency, normalized intestinal arginine transport and catabolism, down-regulated JAK-STAT signalling pathway and attenuated the inflammatory response, which exerted protective effects on the intestine of broiler chickens. (biomedcentral.com)
- Effect of long-term oral L-arginine on the nitric oxide synthase pathway in the urine from patients with interstitial cystitis. (therapeuticresearch.com)
Nitric oxide levels1
- Effects of L-arginine treatment on symptoms and bladder nitric oxide levels in patients with interstitial cystitis. (therapeuticresearch.com)
Supplements1
- Like many patients with mitochondrial disease, nearly all patients in this cohort were already taking oral "mitochondrial cocktails" of vitamins and cofactor supplements, commonly including oral arginine, at the time of their stroke-like episode. (newswise.com)
Substrate1
- In enzymology, an arginine racemase (EC 5.1.1.9) is an enzyme that catalyzes the chemical reaction L-arginine ⇌ {\displaystyle \rightleftharpoons } D-arginine Hence, this enzyme has one substrate, L-arginine, and one product, D-arginine. (wikipedia.org)
Glutamine1
- Nutritional treatment for acquired immunodeficiency virus-associated wasting using beta-hydroxy beta-methylbutyrate, glutamine, and arginine: a randomized, double-blind, placebo-controlled study. (therapeuticresearch.com)
Significantly1
- Complex treatment of patients with acute myocardial infarction and comorbid metabolic syndrome, including L-arginine and L-carnitine, can significantly increase the myocardial contractile function and ensure its electrical stability, which is accompanied by the significant frequency of decreasing life-threatening complications. (lkv.biz)
Derivatives1
- Whereas the evidence and effect with regard to alleviation of hypersensitivity is quite slim for products (toothpaste or mouth-rinse) containing PVA/MA polymers, potassium, casein derivatives or oxalates, products containing the other four ingredients ( arginine, strontium, calcium sodium phosphosilicate and tin fluoride ) showed substantially better results and should be recommended to affected patients. (wh.com)
Utilization1
- These observations suggest that the utilization of metabolites such as arginine by intracellular MAP might affect host NO production. (biomedcentral.com)
Vascular1
- Arginine is not used to treat classic, non-metabolic vascular strokes. (newswise.com)
Studies4
- Primary studies not reported in systematic reviews will therefore have not been included in our analysis. (bmj.com)
- However, no previous systematic studies were performed to objectively evaluate benefits and risks of IV arginine in other mitochondrial diseases beyond MELAS. (newswise.com)
- In a recent systematic review of 20 studies, the global prevalence by country for root caries was found to range from 8% to 74% in non-institutionalized older adults (community dwellers). (colgateoralhealthnetwork.com)
- To date, the studies looking at l-arginine and athletic performance have had mixed results, at best. (feastgood.com)
Effectiveness1
- We included published systematic reviews that examined the effectiveness of interventions and their effect on reducing the risk of PTB. (bmj.com)
Protein1
- We hypothesize that early systematic provision of ONS with a high-protein-high calorie mixture containing immunonutrients (Impact®) in addition to nutritional counseling, compared to nutritional counseling alone, is beneficial to patients with NSCLC receiving immunotherapy with or without chemotherapy. (biomedcentral.com)
Treatment2
- In a systematic overview, possible treatment approaches that could be self-administered by patients were divided and grouped according to their ingredients (West et al. (wh.com)
- A randomized double-blind trial of oral L-arginine for treatment of interstitial cystitis. (therapeuticresearch.com)
Clinical5
- Two mitochondrial medicine experts from Children's Hospital of Philadelphia (CHOP) reported on eight years of clinical experience in providing intravenous (IV) arginine when new-onset neurologic problems concerning for acute stroke-like episode developed in nine pediatric mitochondrial disease patients. (newswise.com)
- Recent clinical practice guidelines from the Mitochondrial Medicine Society recommended using IV arginine in patients having stroke-like episodes from MELAS, and considering its use at the time of stroke-like episodes in other mitochondrial diseases. (newswise.com)
- Ganetzky pointed out that intravenous arginine is much more potent than oral arginine, adding "This study was an opportunity to more systematically analyze a therapy that is clinically used on an empiric basis in the course of acute clinical care. (newswise.com)
- Systematic Reviews of Animal Experiments DemonstratePoor Human Clinical and Toxicological Utility Animal Consultants International, London, UK Summary - The assumption that animal models are reasonably predictive of human outcomes provides the basis for their widespread use in toxicity testing and in biomedical research aimed at developing cures for human diseases. (drugstorepdfsearch.com)
- To investigate the validity of this assumption, the comprehensive Scopus biomedical bibliographic databases were searched for published systematic reviews of the human clinical or toxico- logical utility of animal experiments. (drugstorepdfsearch.com)
Vitamin3
- Participants were randomized 1:1 to receive twice-daily orally either a combination of 1.66 g L-arginine plus 500 mg liposomal vitamin C or a placebo for 28 days. (c19early.org)
- Fifty participants were randomized to receive either L-arginine plus vitamin C or a placebo. (c19early.org)
- The L-arginine plus vitamin C supplement and placebo were donated by Farmaceutici Damor, Naples, Italy. (c19early.org)
Sequence1
- Listed in square brackets [] (under Systematic Range ) are tentative assignments of a particular code based on sequence homology and/or phylogenetic relationships. (nih.gov)
Effect3
- L-arginine reverses the antinatriuretic effect of cyclosporin in renal transplant patients. (therapeuticresearch.com)
- Effect of L-arginine infusion on infants with persistent pulmonary hypertension of the newborn. (therapeuticresearch.com)
- Effect of inhaled L-arginine on exhaled nitric oxide in normal and asthmatic subjects. (therapeuticresearch.com)
Oral5
- Can oral ADS activity or arginine levels be a caries risk indicator? (bvsalud.org)
- Oral L-arginine improves endothelium-dependent dilatation and reduces monocyte adhesion to endothelial cells in young men with coronary artery disease. (therapeuticresearch.com)
- Oral administration of L-arginine potentiates allergen-induced airway inflammation and expression of interleukin-5 in mice. (therapeuticresearch.com)
- Effects of oral L-arginine on endothelium-dependent vasodilation and markers of inflammation in healthy postmenopausal women. (therapeuticresearch.com)
- Oral L-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults. (therapeuticresearch.com)
Evaluate1
- We designed the present study to evaluate the efficacy of early systematic provision of ONS enriched with immunonutrients compared to nutritional counseling alone, in patients with NSCLC undergoing immunotherapy. (biomedcentral.com)
Cardiovascular1
- Supports cardiovascular health and exercise performance by increasing production of l-arginine (5). (gmawarriorsupplements.com)
Review of the literature1
- This paper is a systematic review of the literature on the mechanisms of cell adhesion to bone grafts associated to nanotechnology, describing the importance and the role of those molecules in the adhesion and thus in tissue regeneration. (bvsalud.org)
Cancer1
- L-Arginine stimulates host defenses in patients with breast cancer. (therapeuticresearch.com)
Risk2
- We searched five electronic databases (2009-2020) and contacted experts to identify relevant systematic reviews of interventions to reduce the risk of PTB. (bmj.com)
- Arginine intake and risk of coronary heart disease mortality in elderly men. (therapeuticresearch.com)
Literature1
- Systematic literature searches were performed in electronic databases, covering the period January 1980 to September 2010. (researchgate.net)
Effects1
- This systematic review is aimed at analysing the effects of herb remedies in the above conditions. (researchgate.net)
Stroke2
- Arginine is already used to acutely treat these complex strokes in adult patients who have a well-known mitochondrial disease syndrome called MELAS (mitochondrial encephalopathy with lactic acidosis and stroke-like episodes). (newswise.com)
- Magnetic resonance imaging (MRI) performed in some patients showed that brain changes caused by the stroke returned to normal after patients received IV arginine. (newswise.com)
Production1
- L-Arginine induces vasodilatation through enhanced production of nitric oxide (NO) in the cerebral endothelium. (hindawi.com)
Results1
- Results 139 published systematic reviews were included in the review. (bmj.com)