• Given the close relationship between protein structure and function, protein structure searches have long played an established role in bioinformatics. (biorxiv.org)
  • As such, understanding protein structure is a central goal within structural bioinformatics. (biorxiv.org)
  • BMC Bioinformatics, 22(Suppl 10):494, doi: 10.1186/s12859-021-04403-1. (nctu.edu.tw)
  • Computational investigation were performed to exploit their physicochemical characteristics, structural properties including three dimensional (3D) model, model quality analysis, phylogenetic assessment and functional analysis along with the cancer-cell killing mechanism of PS-5 and PS-6 proteins using standard tools of bioinformatics. (emanresearch.org)
  • BMC Bioinformatics 22(Suppl 7):345. (cnr.it)
  • BMC Bioinformatics 2016 Mar 2;17 Suppl 4:61. (cnr.it)
  • Proteins: Structure, Function, and Bioinformatics 39 (3): 204-211. (mdc-berlin.de)
  • Especially, deep learning is increasingly used in the bioinformatics field by virtue of its ability to learn generalized representations from DNA and protein sequences. (biomedcentral.com)
  • Lakshminarayanan R, Bromley KM, Lei YP, Snead ML, Moradian-Oldak J. Perturbed amelogenin secondary structure leads to uncontrolled aggregation in amelogenesis imperfecta mutant proteins. (medlineplus.gov)
  • Predicting the stability of mutant proteins by computational approaches: an overview. (cnr.it)
  • A number of normal (wild-type) and mutant proteins are susceptible to such misfolding and aggregation (amyloidogenic proteins), thus accounting for the wide variety of causes and types of amyloidosis. (msdmanuals.com)
  • The objective is to develop new computational methods that can be applied also to prediction and validation of protein-protein interactions. (unipv.it)
  • In the present study, we explored the structural aspect of HomA and HomB proteins using various computational, biophysical and small-angle X-ray scattering (SAXS) techniques. (nature.com)
  • Chia-Tzu Ho, Yu-Wei Huang, Chia-Hua Lo, Wei-Cheng Lo * (2021, Nov). Discovering the ultimate limits of protein secondary structure prediction. (nctu.edu.tw)
  • Teng-Ruei Chen, Yen-Cheng Lin, Yu-Wei Huang, Chih-Chieh Chen, Wei-Cheng Lo * (2021, Oct). CirPred, the first structure modeling and linker design system for circularly permuted proteins. (nctu.edu.tw)
  • Giordano D, De Masi L, Argenio MA, Facchiano A. (2021)Structural Dissection of Viral Spike-Protein Binding of SARS-CoV-2 and SARS-CoV-1 to the Human Angiotensin-Converting Enzyme 2 (ACE2) as Cellular Receptor. (cnr.it)
  • The main scope of this topic is to search proteins structural similarities in database (PDB). (unipv.it)
  • Comparing our results to the output of mTM, SSM, and the CATHEDRAL structural scan, it is clear that RUPEE has set a new bar for purely geometric big data approaches to protein structure searches. (biorxiv.org)
  • Our study provides essential structural information of unexplored proteins of the Hom family that can help in a better understanding of H. pylori pathogenesis. (nature.com)
  • Structural and functional insights of anti-cancer proteins from Bacillus thuringiensis . (emanresearch.org)
  • Are there temperature-dependent structural transitions in the "intrinsically unstructured" protein prothymosin α? (mdc-berlin.de)
  • Fluoroalcohol-induced structural changes of proteins: some aspects of cosolvent-protein interactions. (mdc-berlin.de)
  • As is shown in Table 1 , these methods mostly employ RNA sequence and structural information to predict protein-RNA interactions. (biomedcentral.com)
  • The secondary structural analysis further validates the stability owing to higher α-helices. (springeropen.com)
  • Further, biophysical experiments suggested that HomA and HomB are dimeric and most likely the cysteine residues present on surface-exposed loops participate in protein-protein interactions. (nature.com)
  • Lipid research encompasses the large-scale profiling of cellular lipids, the quantification of specific lipids in biological samples and the documentation of the interactions between lipids and other lipids, proteins and metabolites within the body. (sanbio.nl)
  • Oli [ 16 ] uses k-mer frequency as input feature into an SVM classifier to predict RNA-protein interactions. (biomedcentral.com)
  • A hypothesis on the capacity of plant odorant-binding proteins to bind volatile isoprenoids based on in silico evidences. (cnr.it)
  • Mrozek D, Mastej A, Malysiak B: Protein Molecular Viewer for Visualizing Structures Stored in the PDBML Format. (bioclipse.net)
  • Simple operands like dilation or erosion can be applied to protein molecular surface modeling. (unipv.it)
  • Proteins represent the functional end-product within the central dogma of molecular biology [ 1 ]. (biorxiv.org)
  • Molecular cloning, characterization and three-dimensional structure prediction of Lipoxygenase from Finger millet [Eleusine coracana (L.) Gaertn. (molquest.com)
  • Animal models of the disease, created using neurotoxins such as rotenone or 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), or transgenic mice that overexpress human SYN gene (for ï ¡-synuclein) mutations, do not faithfully replicate the structure and antigenicity of the Lewy bodies found in PD (Dickson 2001). (ukessays.com)
  • 1997), a protein whose gene (SYN, aka PARK 1) has been linked to familial PD (Athanassiadou et al. (ukessays.com)
  • Lipids are vital building blocks of living organisms, essential to cell structure and signaling, and energy metabolism. (sanbio.nl)
  • [2] [3] The cells within the biofilm produce the EPS components, which are typically a polymeric conglomeration of extracellular polysaccharides , proteins , lipids and DNA . (wikipedia.org)
  • Assembly of Protein Tertiary Structures from Fragments with Similar Local Sequences using Simulated Annealing and Bayesian Scoring Functions. (rosettacommons.org)
  • Although a poxvirus genome, for example, may be less than 200 kb, it probably encodes close to 200 proteins using multiple classes of promoters with frequent overlapping of promoters and coding sequences and even some overlapping of genes. (biomedcentral.com)
  • Key distinctive features of the original BBB were its ability to read annotations (CDS positions) from GenBank files, an explicit display of differences between sequences and a tool to compare genomes, including the ability to summarize the consequences of all nucleotide changes on encoded proteins throughout a genome. (biomedcentral.com)
  • We have developed RUPEE, a fast, scalable, and purely geometric structure search combining techniques from information retrieval and big data with a novel approach to encoding sequences of torsion angles. (biorxiv.org)
  • Fig. 1: Photochemistry of light-oxygen-voltage receptors and sequences of proteins under study. (nature.com)
  • Specifically, we used word embedding algorithm to extract features of RNA sequences and secondary structures, i.e., distributed representation of k-mers sequence rather than traditional one-hot encoding. (biomedcentral.com)
  • The distributed representations of RNA sequences and secondary structures can effectively detect the latent relationship and similarity between k-mers, and thus improve the predictive performance. (biomedcentral.com)
  • The AMELX gene provides instructions for making a protein called amelogenin, which is essential for normal tooth development. (medlineplus.gov)
  • Some AMELX gene mutations lead to the production of an abnormal version of the amelogenin protein that can interfere with the formation and organization of enamel crystals. (medlineplus.gov)
  • Other AMELX gene mutations prevent one copy of the gene from producing any amelogenin protein at all. (medlineplus.gov)
  • Cryptosporidium oocyst wall protein (COWP) gene ( 11 ). (cdc.gov)
  • Heterozygous loss-of-function variants in the suppressor of fused protein gene (SUFU) can result in Gorlin syndrome, which is characterized by an increased frequency of basal cell carcinoma, medulloblastoma, odontogenic keratocysts, as well as other tumors. (stanford.edu)
  • IONMF [ 15 ] proposes a feature representation method of orthogonal matrix eigendecomposition, which integrates the k-mer sequence, secondary structure, gene ontology (GO) information and region type as input into a machine learning model to predict binding sites. (biomedcentral.com)
  • The primary amino acid sequence of a protein is a translated version from its gene sequence which carries important messages and information concealed therein. (springeropen.com)
  • AD is characterized diagnostically by two histologic findings: (1) extracellular amorphus eosinophilic deposits of amyloid consisting of Aβ peptides (a cleavage product of amyloid precursor protein [APP]), which are referred to as amyloid plaques, and (2) intraneuronal aggregates of abnormally modified microtubule-associated protein tau (neurofibrillary tangles) (see the image below). (medscape.com)
  • Please improve this article by adding secondary or tertiary sources . (wikipedia.org)
  • Built tertiary protein models designated as ACCNK1-ACCNK40 have been deposited in the PMDB with accessions PM0083418-39 and PM0083476-93. (springeropen.com)
  • Exosomes are natural endogenous extracellular vesicles with phospholipid-based bilayer membrane structures. (bvsalud.org)
  • Amyloidosis is any of a group of disparate conditions characterized by extracellular deposition of insoluble fibrils composed of misaggregated proteins. (msdmanuals.com)
  • Activated protein C is found at levels approximately 2000 times lower than this. (medscape.com)
  • The first use of the Rosetta algorithm successfully predicted ab initio protein structures to an RMSD within 6.4, 6.0, and 3.8Å. (rosettacommons.org)
  • Chi-Chun Chen, Yu-Wei Huang, Hsuan-Cheng Huang, Wei-Cheng Lo *, Ping-Chiang Lyu* (2022, Nov). SeqCP: A sequence-based algorithm for searching circularly permuted proteins. (nctu.edu.tw)
  • These fibril proteins are deposited into various organs and tissues, preferentially the nervous system and cardiac tissue, resulting in their inherent dysfunction. (medscape.com)
  • Saraiva MJ, Birken S, Costa PP. Amyloid fibril protein in familial amyloidotic polyneuropathy, Portuguese type. (medscape.com)
  • Amyloidosis can occur de novo or be secondary to various infectious, inflammatory, or malignant conditions. (msdmanuals.com)
  • For amyloidosis to develop, in addition to production of amyloidogenic proteins, there is probably also a failure of the normal clearance mechanisms for such misfolded proteins. (msdmanuals.com)
  • In systemic amyloidosis, circulating amyloidogenic proteins form deposits in a variety of organs. (msdmanuals.com)
  • Localized forms of amyloidosis appear to be caused by local production and deposition of an amyloidogenic protein (most often immunoglobulin light chains) within the affected organ rather than by deposition of circulating proteins. (msdmanuals.com)
  • Sub-angstrom modeling of complexes between flexible peptides and globular proteins. (rosettacommons.org)
  • The generated 3D models of PS proteins upon verification by Ramachandran plot analysis confirmed that our prediction lies in the good quality model range and facilitated the understanding of the very protein folding, assembly into complexes and cell killing mechanisms. (emanresearch.org)
  • The first residue of the PWWP motif modulates HATH domain binding, stability, and protein-protein interaction. (nctu.edu.tw)
  • Comparative analysis of the relationship between translation efficiency and sequence features of endogenous proteins in multiple organisms. (go.jp)
  • Ab initio protein structure prediction of CASP III targets using ROSETTA. (rosettacommons.org)
  • The theoretical overview of this research would facilitate the researchers with valuable insights of the PS protein structures, cancer cell killing mechanism of PS-5 and PS-6 proteins eventually in tumor micro-environment and their receptor molecules with a view to develop anti-cancer drugs. (emanresearch.org)
  • Trifluoroethanol-induced conformational transitions of proteins: Insights gained from the differences between alpha-lactalbumin and ribonuclease A. Gast, K. and Zirwer, D. and Mueller-Frohne, M. and Damaschun, G. (mdc-berlin.de)
  • HomB protein contributes to the colonization and persistence of H. pylori , and the presence of homB genes affects the number of bacteria adhering to the host cells. (nature.com)
  • En ese sentido, existe un creciente enfoque en la identificación de genes, polimorfismos genéticos asociados y loci de susceptibilidad múltiples. (scielo.br)
  • La presente revisión destaca los genes y polimorfismos genéticos actualmente estudiados, identificados como influyentes en la génesis de la EI, como los genes MMP-3, IL-6, colágeno tipo 1 y receptores de vitamina D y de estrógeno. (scielo.br)
  • Due to their unique protein-decorated membrane properties, exosomes have been regarded as promising drug carriers to deliver small molecules and genes. (bvsalud.org)
  • Rational thermostabilisation of four-helix bundle dimeric de novo proteins. (go.jp)
  • EVA: Evaluation of protein structure prediction servers. (rostlab.org)
  • Yun-Tzai Lee, Tz-Hsiang Su, Wei-Cheng Lo , Ping-Chiang Lyu* and Shih-Che Sue* (2012, Aug). Circular permutation prediction reveals a viable backbone disconnection for split proteins: an approach in identifying a new functional split intein. (nctu.edu.tw)
  • The tests used for protein C testing can include enzyme-linked immunosorbent assay (ELISA), chromogenic assays, and the activated partial thromboplastin time (aPTT)-based functional protein C assay. (medscape.com)
  • An ELISA measures protein C immunological levels with very high sensitivity but cannot detect functional defects. (medscape.com)
  • Chromogenic assays can detect low levels of protein C with high sensitivity and can detect most functional defects. (medscape.com)
  • The aPTT-based functional protein C assay may yield misleadingly low protein C levels in the presence of (1) a factor V Leiden mutation and some other causes of activated protein C resistance, (2) elevated plasma factor VIII levels, or (3) hyperlipidemia. (medscape.com)
  • Functional states of the sodium channel (closed, open, and inactivated) and their structure help to understand the cardiac regulation processes. (bvsalud.org)
  • In this paper, we implemented a novel deep neural network model, DeepRKE, which combines primary RNA sequence and secondary structure information to effectively predict RBP binding sites. (biomedcentral.com)
  • These proteins may accumulate locally, causing relatively few symptoms, or widely, involving multiple organs and causing severe multiorgan failure. (msdmanuals.com)
  • Serum-resistant B. burgdorferi strains bind complement factor H (FH) and FH-like protein 1 (FHL-1) on the spirochaete surface. (ox.ac.uk)
  • Finally, how the proteins bind to the ECM may differ, with some being sequestered while others are left free to signal. (forex-consultant.com)
  • H. pylori attaches and colonizes to the human epithelium using some of their outer membrane proteins (OMPs). (nature.com)
  • Outer membrane proteins (OMPs) of H. pylori play a crucial role in the host-pathogen interaction, virulence and pathogenesis. (nature.com)
  • Hom (Helicobacter outer membrane) family of OMPs in H. pylori consists of four members (HomA, B, C and D). In the H. pylori genome jhp 0870 open-reading frame (ORF) that codes for HomB outer membrane protein is associated with many stomach diseases and is a novel co-marker for peptic ulcer disease (PUD) 9 , 10 . (nature.com)
  • Outer membrane proteins (OMPs) are distinctive features of Gram-negative bacteria. (nature.com)
  • A total of five major Open Reading Frames (ORF) were found in COVID-19: the ORF 1a/b region coding replicase and other enzymes, the spike or S protein ORF, M or membrane glycoprotein ORF, E or small membrane protein ORF and the N or nucleocapsid ORF ( fig. 1 )[ 5 ]. (ijpsonline.com)
  • Serine protease present on cell membrane, is used by SARS-CoV-2 for associating spike protein to enable its fusion with host cells[ 12 - 14 ]. (ijpsonline.com)
  • The method is based on analyses of the relative frequencies of each amino acid in alpha helices, beta sheets, and turns based on known protein structures solved with X-ray crystallography. (wikipedia.org)
  • From these frequencies a set of probability parameters were derived for the appearance of each amino acid in each secondary structure type, and these parameters are used to predict the probability that a given sequence of amino acids would form a helix, a beta strand, or a turn in a protein. (wikipedia.org)
  • Unlike the more complex GOR method, it does not reflect the conditional probabilities of an amino acid to form a particular secondary structure given that its neighbors already possess that structure. (wikipedia.org)
  • The fACCD were found 16.18-82.47 kDa proteins having 149-750 amino acid residues. (springeropen.com)
  • Our analysis indicates that its protein topology apparently evolved to provide a high affinity interaction site for FH/FHL-1 and leads to an atomic-level hypothesis for the functioning of BbCRASP-1. (ox.ac.uk)
  • Classification of microbial transglutaminases by evaluation of evolution trees, sequence motifs, secondary structure topology and conservation of potential catalytic residues. (cnr.it)
  • Structure-function mapping of BbCRASP-1, the key complement factor H and FHL-1 binding protein of Borrelia burgdorferi. (ox.ac.uk)
  • This binding is dependent on the expression of proteins termed complement-regulator acquiring surface proteins (CRASPs). (ox.ac.uk)
  • The complement system is a tightly regulated, cascading protein network representing a key component linking the innate and humoral immune systems. (jrheum.org)
  • 7 - 9 A TMA is called "primary" when a genetic or acquired defect in a complement protein is identified (as in atypical hemolytic uremic syndrome [aHUS]) or "secondary" when occurring in the context of another disease process or factor such as infection, autoimmune disease, malignancy, or drugs. (jrheum.org)
  • 10 This distinction is not absolute because genetic defects in complement proteins have been identified in secondary TMA. (jrheum.org)
  • 10 Differentiating between a primary complement-mediated process and one triggered by secondary factors is critical since the former is nonresponsive to supportive therapy and has a high risk of recurrence. (jrheum.org)
  • The complement system is a tightly regulated, cascading protein network that performs multiple roles in homeostasis and disease prevention and is a key component of both the innate and the humoral immune systems. (jrheum.org)
  • DNA-binding hot spots are dominant and fundamental residues that contribute most of the binding free energy yet accounting for a small portion of protein-DNA interfaces. (biomedcentral.com)
  • This could be applied to different levels of protein representation (atomic, secondary structure or geometric 3D surfaces). (unipv.it)
  • Elevated levels of protein C and/or protein S are not clinically significant and usually are not associated with medical problems. (medscape.com)
  • investigated pathogenesis and immunological response caused by HomB protein in clinical patients and 190 H. pylori strain isolated from patients with peptic ulcer disease (PUD) or gastritis were evaluated for the clinical importance of homB . (nature.com)
  • Design of a novel globular protein fold with atomic-level accuracy. (rosettacommons.org)
  • The atomic structure of BbCRASP-1, the key FHL-1/FH-binding protein of B. burgdorferi, has recently been determined. (ox.ac.uk)
  • Improved Recognition of Native-Like Protein Structures Using a Combination of Sequence-Dependent and Sequence-Independent Features of Proteins. (rosettacommons.org)
  • The severity of the risk is dependent on the magnitude of the deficiency and/or the degree of dysfunction of the protein. (medscape.com)
  • Similarly, the chromogenic assay is not dependent on the presence of protein S. (medscape.com)
  • These measurements are frequently used to assess nutritional status, due to plasma levels of albumin being dependent on protein intake. (cdc.gov)
  • describe the development of an improved score function containing secondary structure packing terms. (rosettacommons.org)
  • The download a bibliography on writing and of the phase, in Brooks's area pure networking, heard structures of the Fulfillment function apps of the available prison. (blueskycomputer.com)
  • The role of HomA and HomB in pathogenesis concerning their structure and function has not been evaluated yet. (nature.com)
  • If the protein is not functioning properly (ie, normal protein levels but improper function), insufficient regulation of the coagulation process ensues, which can result in an increased risk of clot development and vein blockage. (medscape.com)
  • The present study unveils the structure-function and evolutionary aspects of 1-aminocyclopropane-1-carboxylic acid deaminase (ACCD) proteins of fungal origin. (springeropen.com)
  • Still, the distribution of ACCD in fungal species is limited which consequently limits our understanding of the structure-function aspects of the fungal ACCD (fACCD). (springeropen.com)
  • The amyloid deposits themselves are metabolically inert but interfere physically with organ structure and function. (msdmanuals.com)
  • Parasporins (PS), parasporal inclusion proteins from Bacillus thuringiensis , possess specific cytotoxicity against different cancer cells which has suggested them to be potential for cancer treatment due to their specific binding to cancer cells. (emanresearch.org)
  • disorders: proteins that are congestive of providing a mental or vascular heart of list, together congestive sensation and Source. (siriuspixels.com)
  • A theoretical study on predicted protein targets of apple polyphenols and possible mechanisms of chemoprevention in colorectal cancer. (cnr.it)
  • PS proteins were found to be slightly acidic based on their isoelectric points i.e., pI ranging from 5.12- 6.19, and the instability indices (29.03- 42.31) indicate their highly stable nature in test tubes and higher aliphatic indices (62.54-94.75) indicate their thermostability, a feature suitable for high-level industrial production. (emanresearch.org)
  • Self-assembly of yeast PGK into amploid structure. (mdc-berlin.de)
  • However, some prefibrillar oligomers of amyloidogenic proteins have direct cellular toxicity, an important component of disease pathogenesis. (msdmanuals.com)
  • If test results show decreased activity or a decreased quantity of protein C, the test should be repeated before a diagnosis is made. (medscape.com)
  • Creatinine measurement is useful in the diagnosis and treatment of renal diseases, in monitoring renal dialysis, and as a calculation basis for other urinary analytes (e.g., total protein and microalbumin). (cdc.gov)
  • VeloPro: A pipeline integrating Ribo-seq and AlphaFold deciphers association patterns between translation velocity and protein structure features. (go.jp)
  • Besides our approach to protein structure search, we introduce a polar plot for torsion angles that may have wider applicability in the study of protein structure. (biorxiv.org)
  • Ethical values supporting the disclosure of incidental and secondary findings in clinical genomic testing: a qualitative study. (philpapers.org)
  • Polymerization of proteins into amyloid protofibrils shares common critical oligomeric states but differs in the mechanisms of their formation. (mdc-berlin.de)
  • describe the method of combining simulated annealing with fragment libraries to generate native-like structures. (rosettacommons.org)
  • Lack of coupling between secondary structure formation and collapse in a model polypeptide the mimics early folding intermediates, the F2 fragment of the Escherichia coli tryptophan-synthase beta chain. (mdc-berlin.de)
  • Let's consider, for example, the secondary representation of a protein (made of Helix and Strand). (unipv.it)
  • Protein-protein docking with simultaneous optimization of rigid-body displacement and side-chain conformations. (rosettacommons.org)
  • EvoOpt: an MSA-guided, fully unsupervised sequence optimization pipeline for protein design. (go.jp)
  • The original Chou-Fasman parameters found some strong tendencies among individual amino acids to prefer one type of secondary structure over others. (wikipedia.org)
  • All proteins were found as homo-dimer except ACCNK13, a homo-tetramer. (springeropen.com)
  • The two dimensional and three dimensional structure of multi-epitope vaccine were predicted and authenticated using PROCheck and Raptor-X servers. (ijpsonline.com)
  • The influence of dataset homology and a rigorous evaluation strategy on protein secondary structure prediction. (nctu.edu.tw)
  • NCHS and contract consultants use a structured competency assessment evaluation during visits to evaluate both the quality of the laboratory work and the quality-control procedures. (cdc.gov)
  • The S1 subunit (PDB I.D-6VSB) of the spike protein being reported to acts as receptor binding domain (RBD), binding to ACE-2 receptor with higher affinity. (ijpsonline.com)
  • In 1963, Carlsson first postulated that the effects of neuroleptics were secondary to dopamine receptor blockade. (psychiatrictimes.com)
  • Slower G-protein-linked receptor systems, as seen in the dopaminergic system, work through second-messenger systems, such as cyclic adenosine monophosphate (cAMP), and have a longer duration of action. (psychiatrictimes.com)
  • It is a 160,000-d protein composed of a disulfide-linked dimer with identical polypeptide chains. (medscape.com)
  • GraphProt [ 14 ] adopts the form of graph coding to integrate RNA sequence and structure into the graph kernel to generate a feature vector of more than 3,000 dimensions, which is subsequently used as the input of an SVM model to predict RBP binding preference. (biomedcentral.com)
  • Despite their maturity, existing protein structure searches either use simplifying assumptions or compromise between fast response times and quality of results. (biorxiv.org)
  • RUPEE in top-aligned mode produces equal or better results than the best available protein structure searches, and RUPEE in fast mode demonstrates the fastest response times coupled with high quality results. (biorxiv.org)
  • RUPEE is the first, to our knowledge, purely geometric protein structure search to achieve results as good as the best available protein structure searches. (biorxiv.org)
  • Additionally, it can be argued that the kinds of matches that RUPEE does return have more added value than the current state of the art in that with equal scores it is able to return results not biased toward a structure classification hierarchy such as SCOPe or sequence clusters such as the PDB-90. (biorxiv.org)
  • Incidental findings and secondary findings, being results that are unrelated to the diagnostic question, are the subject of an important debate in the practice of clinical genomic medicine. (philpapers.org)
  • The method is at most about 50-60% accurate in identifying correct secondary structures, which is significantly less accurate than the modern machine learning-based techniques. (wikipedia.org)
  • Fast mode is significantly faster than all other protein structure searches discussed below but at the expensive of accuracy. (biorxiv.org)
  • Every detected "evidence" (say Helix or Strand) votes (with a weighted contribution) for a set of "edition" of the model each one corresponding to a given Helix or Strand of the searched protein. (unipv.it)
  • In this regard, RUPEE makes a fundamental contribution to protein structure research that lends itself to being leveraged in existing systems. (biorxiv.org)