Prostatic inflammation was demonstrated by experimental hyperprolactinemia induced by chronic administration of sulpiride, a dopamine D2 antagonist with antipsychotic effect. (nih.gov)
Inhibition of forskolin-stimulated cAMP accumulation by agonists was not affected by exposure of the cells to the antagonist (-)-sulpiride. (aspetjournals.org)
In contrast to most other neuroleptics which block both dopamine D1 and D2 receptors, Sulpiride is more selective and acts primarily as a dopamine D2 antagonist. (pharmfair.com)
These improving effects of galantamine were blocked by the treatment with mecamylamine, SCH-23390, a dopamine-D1 receptor antagonist, and sulpiride, a dopamine-D2 receptor antagonist, but not by scopolamine, a muscarinic acetylcholine receptor antagonist. (nih.gov)
Dopamine2
The participants next completed experiments after taking an inactive placebo, methylphenidate, or sulpiride-an antipsychotic medication that, at low doses, increases dopamine levels. (nih.gov)
Sulpiride, sold under the brand name Dogmatil among others, is an atypical antipsychotic (although some texts have referred to it as a typical antipsychotic) medication of the benzamide class which is used mainly in the treatment of psychosis associated with schizophrenia and major depressive disorder, and sometimes used in low dosage to treat anxiety and mild depression. (wikipedia.org)
Sulpiride, a potent antipsychotic with weak anti-calmodulin activity, was a relatively weak inhibitor of Ca-activated K channels. (aspetjournals.org)
Sulpiride is a type of medicine called an antipsychotic. (israelpharm.com)
Lactation3
Lactation: Sulpiride is found in the milk of lactating women. (wikipedia.org)
These data indicate that poor initiation of puerperal lactation in primiparous mothers can be effectively treated with oral sulpiride. (nih.gov)
Augmentation of puerperal lactation by oral administration of sulpiride. (nih.gov)
Pharmacokinetics1
The pharmacokinetics of sulpiride was studied in 6 healthy volunteers after intravenous and oral (tablets) administration of 100 mg. (nih.gov)
Adverse effects3
Sulpiride is usually well tolerated, producing few adverse effects. (wikipedia.org)
Two studies found no adverse effects in breastfed infants whose mothers were treated with sulpiride for 2 to 4 weeks as a galactogogue, although others estimated that the dose in milk was high enough to increase serum prolactin in breastfed infants. (nih.gov)
Pierre Simon relates that reports of adverse effects of sulpiride were censored by the French drug company Delagrange. (benzo.org.uk)
Reported in mothers1
Significant increases in prolactin and milk volume (Ylikorkala 1984 and 1982, Polatti 1982, Aono 1979) and increased duration of breastfeeding have been reported in mothers treated with sulpiride, also weight gain has been observed in their infants. (e-lactancia.org)
Spiroperidol2
In separate studies either spiroperidol (1 mg/kg) or sulpiride (50 mg/kg) were given i.p., 30 min before the ergot derivatives. (erowid.org)
The PRL-lowering activity of LHM was fully antagonized by pretreatment with the DA-antagonists spiroperidol or sulpiride. (erowid.org)
Drugs3
Contraindications Hypersensitivity to sulpiride Pre-existing breast cancer or other prolactin-dependent tumors Phaeochromocytoma Intoxication with other centrally-active drugs Concomitant use of levodopa Acute porphyria Comatose state or CNS depression Bone-marrow suppression Cautions Pre-existing Parkinson's disease Patients under 18 years of age (insufficient clinical data) Pre-existing severe heart disease/bradycardia, or hypokalemia (predisposing to long QT syndrome and severe arrhythmias) Patients with pre-existing epilepsy. (wikipedia.org)
Some of these drugs like amisulpiride and sulpiride are available in Europe only and this is why they come up with zero values across the board. (rxisk.org)
Unmarketed drugs such as sulpiride and pipothiazine are especially interesting. (pni.org)
Receptors2
The effect of (-)-sulpiride on high affinity binding sites was blocked by cycloheximide, but only after incubation of cells for sufficient time to induce an increase in the total number of receptors. (aspetjournals.org)
After incubation of cells with (-)-sulpiride for a short time, the increase in the number of receptors with a high affinity for agonists was unaffected by cycloheximide. (aspetjournals.org)
Serum3
Determinations of daily serum levels of prolactin in 20 primiparous women revealed significantly higher concentrations in the sulpiride group. (nih.gov)
Sulpiride increases serum prolactin, but its clinical value in increasing milk supply is questionable. (nih.gov)
In female volunteers, sulpiride increased serum PRL to 100 ng/ml, this effect being reduced by bromocriptine-pretreat ment. (erowid.org)
Placebo2
Forty-two primiparous and 54 multiparous women with total yields of milk not exceeding 50 ml for the first 3 postpartum days were treated with 100 mg of oral sulpiride or placebo for 4 days from the third postpartum day. (nih.gov)
In a study that enrolled only mothers with documented low milk production a few weeks postpartum, sulpiride was effective in increasing milk volume, but it was only more effective than placebo in avoiding supplementation in those with no initial milk production. (nih.gov)
Mothers8
In the primiparous mothers, the mean daily yield of milk in the sulpiride group increased significantly (p less than 0.01) over that in the control group after the fourth postpartum day. (nih.gov)
However, in the multiparous mothers, no significant difference between the control and the sulpiride group was noted in total yield of milk, since a good increase in the secretion of milk was obtained without medication in these mothers. (nih.gov)
The ratio of primiparous mothers with complete breast-feeding 1 month after delivery was higher in the sulpiride group (55%) than in the control group (30%), whereas there was no difference between the control group and the sulpiride group of multiparous women. (nih.gov)
1 , 2 ] If mothers are provided instruction in good breastfeeding technique and breastfeed frequently, sulpiride is unlikely to provide additional benefit. (nih.gov)
Postpartum mothers are at a relatively high risk for postpartum depression and sulpiride can cause depression as a side effect. (nih.gov)
Therefore, sulpiride should be avoided in women with a history of major depression and not used for prolonged periods in any mothers during this time of high susceptibility. (nih.gov)
Tiredness occurred occasionally and cases of headache and leg edema have also been reported in nursing mothers taking sulpiride as a galactogogue. (nih.gov)
Single doses of sulpiride of either 3 mg (n = 5) or 10 mg (n = 4) were given to nursing mothers. (nih.gov)
Dosage2
Sulpiride is excreted into breastmilk in rather large amounts, far above the accepted value of 10% of the maternal weight-adjusted dosage in some cases, but blood concentrations in breastfed infants have not been evaluated. (nih.gov)
The average milk sulpiride concentration was 970 mcg/L (range 260 to 1970 mcg/L).[ 7 ] This translates to an average daily maximum infant dosage of 146 mcg/kg (range 39 to 297 mcg/kg) in the infant or 8.7% (range 2 to 18%) of the weight-adjusted maternal dosage. (nih.gov)
Doses1
Published side effects occurred in patients taking sulpiride for more than 4 weeks (Shiraiwa 2018) or in high doses. (e-lactancia.org)
Concentrations1
Sulpiride was absorbed slowly, with peak concentrations appearing between 3 and 6 h after oral administration. (nih.gov)
Vertigo1
Sulpiride is indicated for the treatment of vertigo in some countries. (wikipedia.org)
Milk3
Whether sulpiride has any benefit as a galactogogue in women who continue to have insufficient milk production after nursing technique and frequency have been optimized has not been studied adequately. (nih.gov)
In a study reported only in abstract form, sulpiride was not detected in milk (study details and assay limit not stated) with maternal dosages of up to 200 mg daily. (nih.gov)
Twenty women were taking sulpiride 50 mg twice daily by mouth to enhance milk production. (nih.gov)
Infants1
In a study of 14 women given sulpiride 50 mg 3 times daily for 4 weeks, no side effects were reported in their breastfed infants. (nih.gov)
Drug2
Sulpiride is not approved for marketing in the United States by the U.S. Food and Drug Administration, but is used as a psychotherapeutic agent and galactogogue in other countries. (nih.gov)
1. Multiple drug transporters mediate the placental transport of sulpiride. (nih.gov)
Women1
Due to insufficient human data, pregnant women should be treated with sulpiride only if strictly indicated. (wikipedia.org)
Form1
This product contains Sulpiride 50mg in the form of TABLET . (pharmfair.com)
Total1
This graph shows the total number of publications written about "Sulpiride" by people in this website by year, and whether "Sulpiride" was a major or minor topic of these publications. (childrensmercy.org)
Daily1
Zolpidem was discontinued at week 28 and sulpiride 100 mg daily was begun at week 33. (nih.gov)
Major2
There is evidence, although low quality, that Sulpiride could accelerate antidepressant response in patients with major depressive disorder. (wikipedia.org)
In Japan, Sulpiride is both approved as a treatment for schizophrenia and for major depressive disorder (low dose). (wikipedia.org)
Europe1
Sulpiride is commonly used in Asia, Central America, Europe, South Africa and South America. (wikipedia.org)
Studies1
Few studies compared mid-potency first-generation medications, such as perphenazine and sulpiride, to atypicals with regard to movement disorders. (nih.gov)