IntestinalLysateLipidMacrophagesGlucose2020Water-solubleProliferationInflammationExtractsFractionMembraneCompoundsEpithelial cellEndothelial CellsHepaticHumanMiceUptakeInfectionTumorRatsCardiacProteinsActivityHumansChronicProteinEffectsAbsorptionInflammatoryImmuneExtracellularTreatmentRangesTypeNormalCultureSignalEffect
Intestinal6
- The enzyme-treated polysaccharide fraction of natto inhibits glucose uptake by Caco-2 cells, human intestinal epithelial cells. (go.jp)
- These findings suggest that the polysaccharide components of natto selected on the basis of their suppressive effects on sucrose-induced hyperglycemia in silkworms inhibit glucose uptake by human intestinal cells. (go.jp)
- Increasing expression of Foxa2 leads to altering the composition of intestinal epithelial cell (IEC) exosomes of mice fed a HFD and prevents IEC exosome mediated insulin resistance. (thno.org)
- Herein we investigated whether lupin proteins compared to casein modulate sterol excretion and mRNA expression of intestinal sterol transporters by use of pigs as an animal model with similar lipid metabolism as humans, and cellular cholesterol-uptake by Caco-2 cells. (biomedcentral.com)
- There are growing concerns that daily oral TiO 2 -NP intake is associated with an increased risk of chronic intestinal inflammation and carcinogenesis. (nature.com)
- It enters the gastrointestinal tract and is absorbed across the brush border of the small intestine into the enterocytes of the apical membrane of the intestinal epithelium, mediated by glucose transporter 5 (GLUT5) or Solute carrier family 2 A5 (SLC2A5). (openveterinaryjournal.com)
Lysate2
- Membrane enriched extracts (40 µg lysate) of Caco-2 (Lane 1), Caco-2 treated with IFN Gamma (50 ng/mL for 24hrs) (Lane 2), A-431 (Lane 3), HEL 92.1.7 (Lane 4) and Jurkat (Lane 5). (thermofisher.com)
- Western Blot: SR-BI Antibody [NB400-104] - SR-BI antibody was tested in human adrenal cell lysate. (novusbio.com)
Lipid3
- Finally, lipid accumulation in cells induced to undergo adipogenesis and treated with BPC decreased although without significant differences at different concentrations. (unav.edu)
- The low total lipid contents of adzuki beans is similar to other foods - cereals as rice and rye, and legumes as bean, chick-pea and beans, that have less than 2% of fat, but with the advantage that the fat of the adzuki bean possesses a healthy Polyunsaturated fatty acids (PUFAs) omega-6/omega-3 which are essential fatty acids for human nutrition. (healthjade.com)
- Ubiquinone or coenzyme Q (CoQ) is a lipid-soluble molecule of the electron transport chain located in the mitochondrial inner membrane of human cells as well as the cytoplasmic membrane of bacteria. (ijbiotech.com)
Macrophages3
- Nozzles liver of M Or mouse peritoneal macrophages in three ml cold buffered sucrose, containing 100 mM sucrose, 50 mMKCl, 40mMKH2PO4 30mMEDTA and have been suspended inside a Teflon homogenizer. (mirnamimics.com)
- The itaconate produced facilitates cytokine production and subsequently activates anti-inflammatory transcription factors, shielding macrophages from infection-induced cell death. (bvsalud.org)
- Lastly, treatment with FZHY was able to inhibit the activation of HSCs induced by supernatants from macrophages. (bvsalud.org)
Glucose3
- Here we found that the water-soluble viscous fraction of natto inhibits sucrose- or glucose-induced hyperglycemia in silkworms. (go.jp)
- The adzuki bean paste showed potential hypoglycemic activity in both normal mice and streptozotocin (STZ)-induced diabetic rats after an oral administration of sucrose, but did not show any effect on the blood glucose concentration after glucose administration, suggesting that the active fraction suppressed the postprandial blood glucose level by inhibiting alpha-glucosidase and alpha-amylase, irrespective of the endogenous blood insulin level. (healthjade.com)
- Fructose is a class of monosaccharides with the highest level of sweetness compared to glucose and sucrose, often used as a sweetener by the food and beverage industry ( Douard and Ferraris, 2008 ). (openveterinaryjournal.com)
20202
- TY - JOUR AU - Meslé, Margaux M. I. AU - Sinnathamby, Mary AU - Mook, Piers AU - Pebody, Richard AU - Protić, Jelena PY - 2023 UR - http://intor.torlakinstitut.com/handle/123456789/846 AB - Background The emergence of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in early 2020 and subsequent implementation of public health and social measures (PHSM) disrupted the epidemiology of respiratory viruses. (torlakinstitut.com)
- article{ author = "Meslé, Margaux M. I. and Sinnathamby, Mary and Mook, Piers and Pebody, Richard and Protić, Jelena", year = "2023", abstract = "Background The emergence of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in early 2020 and subsequent implementation of public health and social measures (PHSM) disrupted the epidemiology of respiratory viruses. (torlakinstitut.com)
Water-soluble2
- The water-soluble viscous fraction treated with DNase I, RNase A, and proteinase K, followed by phenol extraction also suppressed sucrose-induced hyperglycemia in silkworms. (go.jp)
- 17) have shown recently that a water-soluble extract of the adzuki beans could inhibit acetaminophen-induced liver damage. (healthjade.com)
Proliferation1
- erbB 2 antisense oligonucleotides inhibit proliferation of breast cancer cells with erbB oncogene amplification rkungsfaktorsteuerung second Br J Cancer. (mirnamimics.com)
Inflammation2
- Interestingly, oral administration of GDNP also extended the life span of the mice and inhibited skin inflammation. (thno.org)
- Lipases are involved in diverse biological processes ranging from routine metabolism of dietary triglycerides to cell signaling and inflammation. (isotonix.com)
Extracts1
- Ethanolic extracts were used in 3T3-L1 cell culture. (unav.edu)
Fraction1
- Food-grade titanium dioxide (TiO 2 ) containing a nanoscale particle fraction (TiO 2 -NPs) is approved as a white pigment (E171 in Europe) in common foodstuffs, including confectionary. (nature.com)
Membrane3
- L. acidophilus has one phospholipid bilayer membrane with a large cell wall consisting of peptidoglycan exterior to the membrane. (wikipedia.org)
- It is a region where the plasma membrane of adjacent cells forms a series of contacts that appears to completely occlude the extracellular space as observed by transmission EM. (rupress.org)
- Western Blot: SR-BI Antibody [NB400-104] - Detection of SR-BI in rat H4IIE total cell lysates and plasma membrane proteins. (novusbio.com)
Compounds1
- The lactic acid produced from fermentation broth usually contains numerous impurities such as bacterial cells, residual carbohydrates, proteins, vitamins, and phenolic compounds. (springeropen.com)
Epithelial cell2
- To study the role of occludin in the formation of the tight junction seal, synthetic peptides (OCC1 and OCC2) corresponding to the two putative extracellular domains of occludin were assayed for their ability to alter tight junctions in Xenopus kidney epithelial cell line A6. (rupress.org)
- Despite the increased paracellular permeability, there were no changes in gross epithelial cell morphology as determined by scanning EM. (rupress.org)
Endothelial Cells1
- The tight junction, also known as zonula occludens , is the apical-most component of the junctional complex of epithelial and endothelial cells. (rupress.org)
Hepatic1
- The effects of macrophage NLRP3 inflammasome activation on the function of hepatic stellate cells (HSCs) were explored by treating primary HSCs with preconditioned media from BMDMs culture. (bvsalud.org)
Human3
- Also, inhibited the ACAT activity t in microsomes of human Caco 2 cells Hnlichen IC50 values. (mirnamimics.com)
- In rats orally exposed for one week to E171 at human relevant levels, titanium was detected in the immune cells of Peyer's patches (PP) as observed with the TiO 2 -NP model NM-105. (nature.com)
- The present invention provides a simple and robust human liver cell-based system in which persistent hepatitis C infection, persistent hepatitis B infection or ethanol exposure induces a clinical Prognostic Liver Signature (PLS) high-risk gene signature. (sumobrain.com)
Mice2
- ApoE / Mice had been fed with 0.15% cholesterol with or while not beauveriolide III for 2 months. (mirnamimics.com)
- In this study, mice were fed high-fat high-sucrose (HFHS) diet supplemented either with C3G-rich extract (HFHS + CE) or berry powder with low C3G (HFHS + BP). (researchgate.net)
Uptake1
- Cholesterol-uptake studies were performed with Caco-2 cells that were incubated with lupin conglutin γ, phytate, ezetimibe or albumin in the presence of labelled [4- 14 C]-cholesterol. (biomedcentral.com)
Infection1
- While vaccination campaigns are ongoing worldwide, there is still a tremendous medical need for efficient antivirals against SARS-CoV-2 infection. (mdpi.com)
Tumor1
- It regulates HLA class I and induces apoptosis in HER2/neu beneficial tumor cell lines. (mirnamimics.com)
Rats2
- In all TiO 2 -treated rats, stimulation of immune cells isolated from PP showed a decrease in Thelper (Th)-1 IFN-γ secretion, while splenic Th1/Th17 inflammatory responses sharply increased. (nature.com)
- Subsequently, 30 male albino rats ( R. novergicus ) were used, divided into the normal group (NG), treatment group 1 (T1G), treatment group 2 (T2G), Quercetin group (QG), Moringa group (MG). Quercetin and moringa leaf powder (M. oleifera) was administered at 50 and 500 mg/kgbw for 28 days. (openveterinaryjournal.com)
Cardiac1
- ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue. (thermofisher.com)
Proteins2
- The cell wall of L. acidophilus is interwoven with teichoic acids and surface proteins, with anionic and neutral polysaccharides as well as an S-layer lining the exterior of the cell. (wikipedia.org)
- The S-layer proteins of L. acidophilus have been shown to adhere to epithelial cells as well as mucus and other extracellular proteins. (wikipedia.org)
Activity1
- 2002 ) that inhibit its activity. (texasorganicresearchcenter.org)
Humans1
- These data should be considered for risk assessments of the susceptibility to Th17-driven autoimmune diseases and to colorectal cancer in humans exposed to TiO 2 from dietary sources. (nature.com)
Chronic2
- Furthermore, it is estimated that 30-40% of people with type 2 diabetes will develop chronic renal disease. (heraldopenaccess.us)
- The obesity epidemic has expanded globally, due in large part to the increased consumption of high-fat diets (HFD), and has increased the risk of major chronic diseases, including type 2 diabetes. (thno.org)
Protein2
- The effect on occludin was specific because other tight junction components, ZO-1, ZO-2, cingulin, and the adherens junction protein E-cadherin, were unaltered by OCC2 treatment. (rupress.org)
- Glycoconjugate synthesis, in particular expression of oligosaccharyltransferase PglB, strongly inhibited growth of E. coli cells after induction, making it necessary to separate biomass growth and recombinant protein expression phases. (biomedcentral.com)
Effects3
- Chemotherapy is known to cause side effects because it damages not only cancerous cells but healthy cells. (jcpjournal.org)
- Seventy to eighty percent of cancer patients in chemotherapy experienced side effects such as anemia, the decreased number of white blood cells and/or platelets, oral mucositis, vomiting, diarrhea, hair loss, and disabled generative functions as chemotherapy also affects the rapidly proliferating normal cells. (jcpjournal.org)
- To decrease side effects from non-specific cytotoxicity, new drugs, such as targeted agents, are being developed to selectively destroy specific cancer cells. (jcpjournal.org)
Absorption2
- Pancreatic lipases are found in the spaces outside of cells and have roles in the metabolism, absorption and transport of lipids throughout the body. (tlsslim.com)
- In Europe, the current EU Directive 94/36/EC authorizes the use of E171 in foodstuffs without establishing an acceptable daily intake level by the Joint FAO/WHO Expert Committee on Food Additives, based on TiO 2 absorption considered to be very low 5 . (nature.com)
Inflammatory2
- Dendritic cell frequency increased in PP regardless of the TiO 2 treatment, while regulatory T cells involved in dampening inflammatory responses decreased with E171 only, an effect still observed after 100 days of treatment. (nature.com)
- Furthermore, FZHY was observed to block the activation of the NLRP3 inflammasome pathway, which can lead to excessive inflammatory cytokine release in supernatants and cell lysates in response to LPS and ATP. (bvsalud.org)
Immune1
- Poorly controlled diabetes can lead to the damage of multiple organs, including the eyes, kidneys, nerves, and cardiovascular system [1] Among the two most common types of diabetes, Type 1 occurs when the insulin producing cells in the pancreas are destroyed by the immune system and there is usually no cure, while in Type 2 diabetes there is insulin resistance and relative insulin deficiency [2]. (heraldopenaccess.us)
Extracellular1
- NH 2-terminally truncated HER-2/neu SA: Vergie no partnership with extracellular Ren Ren Cathedral and prognostic components for breast cancer. (mirnamimics.com)
Treatment2
- Clinically, when GMP-level plasminogen was administered to 6 AD patients for 1-2 weeks, their average scores on the Minimum Mental State Examination (MMSE), which is a standard scoring system used to measure the memory loss and cognitive deficits, were extremely significantly improved by 4.2 +/- 2.23 points, e.g., an average increase from 15.5 +/- 8.22 before treatment to 19.7 +/- 7.09 after treatment. (inra.fr)
- Machine learning was used to develop a prediction model for treatment response, which was evaluated for accuracy and clinical benefit using the area under curve (AUC) for classification, R(2) for regression, and decision curve analysis. (inra.fr)
Ranges1
- Lactobacillus acidophilus is an immobile rod-shaped (bacillus), gram-positive organism that ranges in size from 2-10 μm in size. (wikipedia.org)
Type6
- The high prevalence of type 2 diabetes in Mauritius during the last decade has been an alarming situation that needs scrutiny for a healthier future Mauritian population. (heraldopenaccess.us)
- Diet, on the other hand, is considered a universal factor linked to type 2 diabetes [3]. (heraldopenaccess.us)
- The multi-ethnic island Mauritius which is around 1.2 million according to World Bank, 2017, has an estimated 257,442 people between the ages of 25 and 79 years living with type 2 diabetes. (heraldopenaccess.us)
- Type 2 diabetes is the second leading cause of death on the island, with a death percentage of 24.1% in 2016. (heraldopenaccess.us)
- There is also a high occurrence of pre-type 2 diabetes in the country, a condition associated with an increased risk of subsequent diabetes. (heraldopenaccess.us)
- These figures are alarming and constitute a significant threat in terms of the future social and economic burden of type 2 diabetes complications for Mauritius. (heraldopenaccess.us)
Normal1
- Normal killer T-cell cytotoxicity ENMD-2076 t Of breast cancer targets is by two unique mechanisms surveilance old K Entire body surveilance-Dependent cytotoxicity t Re Improves cellular communication LFA towards t 3 and HER2/neu. (mirnamimics.com)
Culture1
- R.I. FRESHNEY: "Culture of Animal Cells: A Manual of Basic Technique", 1987, ALAN R. LISS, INC. (sumobrain.com)
Signal1
- ZO-1 may be involved in signal transduction at cell-cell junctions. (thermofisher.com)
Effect1
- Gradual Changes of the Protective Effect of Phenols in Virgin Olive Oils Subjected to Storage and Controlled Stress by Mesh Cell Incubation. (us.es)