Study spermatogenesis. Medical search. Frequent questions

We induced high fat diet (HFD) obesity in low-density lipoprotein receptor knock-out Leiden (Ldlr −/− .Leiden) mice, and studied the morphological structure of the testes and histologically examined the proportion of Sertoli cells, spermatocytes and spermatids in the seminiferous tubules. (nature.com)
Transplantation experiments have revealed that most cells which can perform the hallmark feature of SSCs (that is, re-establishing full spermatogenesis in testes lacking germ cells) are found within the single uSPG population, but may also be present among paired and aligned progenitors ( Kubota and Brinster, 2018 ). (elifesciences.org)
Overall, these results demonstrate that not all genes highly and specifically expressed in the testes are essential for spermatogenesis, and in particular, we conclude that bi-allelic variants of C1orf185 and CCT6B are most likely not to be involved in NOA and male fertility. (nih.gov)
In this study, we evaluated the effect of chronic radiation exposure associated with FDNPP accident on the testes of large Japanese field mice. (intechopen.com)
Morphological analysis of testes based on H&E staining showed that the spermatogenesis was observed normally in the breeding season of wild mice in the heavily contaminated area. (intechopen.com)
In conclusion, even if the testes and the process of spermatogenesis are hypersensitive to radiation, we could not detect radiation effects on the spermatogenesis and Cs in the examined large Japanese field mice testes following chronic radiation exposure associated with the FDNPP accident. (intechopen.com)
In the past, testes size in bottlenose dolphins was studied in carcasses, thus seasonality was postulated on a cross-sectional basis. (vin.com)
The aim of the overall study is to find out when the onset of spermatogenesis occurs and monitor changes in testes size and testosterone levels during sexual maturation. (vin.com)
This study was designed to ascertain the accuracy, sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of ultrasonography in the localisation of the undescended testes in children. (bvsalud.org)
Results: Forty boys with 52 undescended testes were studied. (bvsalud.org)
Most studies located provided information on thyroid hormones, with fewer studies on anterior pituitary, adrenal medulla, ovaries, and testes. (cdc.gov)

Then, a bioinformatic study of the identified genetic mutations is carried out to assess their pathogenicity and to be able to inform about the reproductive prognosis of the patient. (institutobernabeu.com)
In this study, we evaluated the effect of heat stress (HS) on the development of cells secreting major reproductive hormones of the HPG axis (i.e., hypothalamus, pituitary gland, ovary, and testis) of Wenchang chicks. (scielo.br)
Offspring sex ratio is often used in demographic, environmental, and occupational studies to assess the impact of certain exposures on reproductive and endocrine health. (health.mil)
One mouse study found that alcohol damage on the male reproductive tract was somewhat reversible after 10 weeks of abstaining from alcohol. (healthline.com)
The study, which is published online today (Tuesday) in Human Reproduction [1], one of the world's leading reproductive medicine journals, shows that men who ate the highest amount of fruit and vegetables with high levels of pesticide residue had a 49% lower sperm count and a 32% lower percentage of normally-formed sperm than men who consumed the least amount. (eurekalert.org)
Prof Chavarro, his student Dr Yu-Han Chiu and colleagues analysed 338 semen samples from 155 men attending a fertility centre between 2007-2012 as part of the ongoing, prospective "Environment and Reproductive Health" (EARTH) Study. (eurekalert.org)

For in vitro studies, immature Leydig cells were isolated from 35-day-old male rats and treated with 50 μM piperine in the presence of different steroidogenic stimulators/substrates for 24 h. (frontiersin.org)
The present study examined the influence of combined ginger and cinnamon on spermatogenesis in STZ-induced diabetes in maleWistar rats. (ajol.info)
Effects of exposure to extremely low frequency magnetic fields on spermatogenesis in adult rats med. (emf-portal.org)
We identified 74 oral exposure studies in rats that provided relevant information on 30 chemicals from 21 profiles. (cdc.gov)

In contrast to monocultures, fragment/3D cultures are able to establish in vitro conditions that can somewhat resemble the testicular microenvironment to allow a more accurate study of the testicular physiology and its associations with the in vitro development of sperm cells. (wikipedia.org)
Undifferentiated spermatogonia divide mitotically to both repopulate the testicular stem cell population and provide progenitor cells that undergo spermatogenesis. (jci.org)
Testicular biopsies are necessary to examine cellular alterations in spermatogenesis changes in men, which is a limitation in this type of research. (nature.com)
Testicular biopsy is indicated in azoospermic men with a normal-sized testis and normal findings on hormonal studies to evaluate for ductal obstruction, to further evaluate idiopathic infertility, and to retrieve sperm. (medscape.com)

This phenomenon occurs during spermatogenesis, resulting in three copies of the chromosome 21. (bvsalud.org)

The aim was to use this database to identify developmental toxicity studies reporting alterations in hormone levels in the developing fetus and offspring and identify windows of sensitivity. (cdc.gov)
Patient who shows alterations of the spermatogenesis and/or benign prostatic hyperplasia. (who.int)

Piperine stimulates pubertal Leydig cell development by increasing Leydig cell number and promoting its maturation while it inhibits spermatogenesis in the rat. (frontiersin.org)
Possible cause of male infertility: Gina Esther Merges and Prof. Hubert Schorle study genes involved in sperm maturation. (innovations-report.com)

A case-referent study nested in a cohort monitored biologically for exposure to six organic solvents ( styrene , toluene, xylene, tetrachloroethylene, trichloroethylene, and 1,1,1-trichloroethane) was conducted to investigate the effects of paternal exposure on pregnancy outcome. (cdc.gov)
This cohort study examined the relationship between VOC exposure and fetal growth retardation (measured as SGA and decreased MBW) and preterm delivery in three groups with different exposures to contaminated drinking water and in an unexposed comparison population. (cdc.gov)

Isolated cell culture, specifically co-culture of testis tissue, has been a useful technique for examining the influences of specific factors such as hormones or different feeder cells on the progression of spermatogenesis in vitro. (wikipedia.org)
In fragment cultures, the testis is removed and fragments of tissue are cultured in supplemental media containing different growth factors to induce spermatogenesis and form functional gametes. (wikipedia.org)
The objective of the present study was to investigate the effects of piperine on the testis development in the pubertal rat. (frontiersin.org)
In the present study, we investigated the localization of PRKRA in the mammalian testis by immunofluorescence and immunoelectron microscopic techniques. (hindawi.com)
Chimento A, Sirianni R, Casaburi I, Pezzi V. Role of Estrogen Receptors and G Protein-Coupled Estrogen Receptor in Regulation of Hypothalamus-Pituitary-Testis Axis and Spermatogenesis. (scielo.br)
ABSTRACT This study was carried out to document the prevalence of inguinal hernia, hypospadias, undescended testis and varicocele in 3057 male applicants to the military wing of Mu'ta University in the south of Jordan. (who.int)
In undescended testis there is increased incidence of infertility, torsion, In any community, statistical studies of malignancy and exposure to trauma. (who.int)

From this point forward, the steps and cell types of spermatogenesis are conserved between mice and humans. (jci.org)
During my Master's project, I studied spermatogenesis in senescence-accelerated mice. (uib.no)
Therefore, after I finished my Masters, I was sure that I did not want to work on mice and my preference was to study some exotic marine creatures instead and I really wanted to use molecular biology methods. (uib.no)
Now, researchers from the University Hospital Bonn (UKB) and the Transdisciplinary Research Unit "Life & Health" at the University of Bonn have found that a loss of the structural protein ACTL7B blocks spermatogenesis in male mice. (innovations-report.com)
Professor Laurence Hurst from the Milner Centre for Evolution which carried out the study, proposes that 'selfish' mutations which destroy embryos, may have an advantage in mice (which birth multiple offspring), as aneuploid embryos perishing earlier may enable siblings to benefit from a greater share of resources in the womb. (planer.com)

This involves spermatogonial stem cells (SSCs) dividing to form undifferentiated spermatogonia (uSPGs), which then progress through the meiotic and haploid phases of spermatogenesis to form mature sperm ( de Rooij, 1998 ). (elifesciences.org)
Contrary to expectations, a fragment containing the entire region between the TBPH gene and the bgcn translational start drove strong HEG expression only during late spermatogenesis rather than in the germline stem cells and spermatogonia as expected. (plos.org)

Spermatogenesis in adult mammals is highly organized, with the goal being continual sperm production. (jci.org)
In our study, we aim to elucidate at which cellular level of adult spermatogenesis the detrimental effects of obesity manifest. (nature.com)
The objective of the study is to investigate whether there is an association between concurrent serum levels of several PFAAs and gout, serum uric acid (SUA) or hyperuricemia in the U.S. adult population as represented by the National Health and Nutrition Examination Survey (NHANES) 2009-2014 sample (n = 4917). (cdc.gov)

In addition, it allows to complement other results of genetic studies of the male such as, for example, karyotype and FISH or seminal TUNEL . (institutobernabeu.com)

The process could be useful for fertility preservation, infertility treatment and may further develop the understanding of spermatogenesis at the cellular and molecular level. (wikipedia.org)
Nuclear positioning, germinal vesicle breakdown, spindle migration, spindle rotation, chromosome segregation, and polar body extrusion are the most critical cellular processes during oocyte meiosis I and II, and a growing number of studies primarily using the mouse oocyte model revealed that actin filaments were critical for these processes, especially for spindle migration. (bioone.org)

Studies have concluded that different factors can influence the culture of germ cells e.g. media, growth factors, hormones and temperature. (wikipedia.org)

We combine structure-based protein engineering and molecular genetics to restrict the activity of the potentially toxic endonuclease to spermatogenesis. (nature.com)

We showed that homozygous KO males were fertile and displayed normal sperm parameters and a functional spermatogenesis. (nih.gov)
The effect was intermittent in males throughout the study. (fluoridealert.org)
Methods: The current study enrolled 12 consecutive head and neck cancer patients (seven males and four females) who underwent transoral robotic RPLN dissection with the da Vinci surgical robotic system at the Sun Yat-sen University Cancer Center from May 2019 to July 2020. (bvsalud.org)

During metaphase the X-shaped structure is called a metaphase chromosome, which is highly condensed and thus easiest to distinguish and study. (wikipedia.org)
A multicopy target sequence (black bars) on the X chromosome (but not present on the Y chromosome) is targeted by an endonuclease (red triangle) during spermatogenesis. (nature.com)
The expression of wild-type I-PpoI during spermatogenesis in transgenic mosquitoes causes cleavage of the paternal X chromosome but also results in complete male sterility because the protein's stability and persistence in mature sperm cells leads to subsequent cleavage of the maternal X chromosome in the zygote 9 . (nature.com)

Male sperm cells are constantly produced in large quantities in the testicles during so-called spermatogenesis. (innovations-report.com)

It is estimated that at least 4000 genes are involved in human spermatogenesis, but only few have so far been extensively studied. (nih.gov)
The importance of phosphorylation in sperm during spermatogenesis has not been pursued extensively. (cdc.gov)

In order to examine whether PIP affected spermatogenesis by interfering with Leydig cell testosterone production, in the current study we evaluated the effects of PIP on pubertal Leydig cell development. (frontiersin.org)
This will then result in increased testosterone production, ultimately augmenting spermatogenesis. (medscape.com)
Exogenous testosterone decreases intratesticular testosterone production, thus inhibiting Sertoli cell function and spermatogenesis. (medscape.com)

12 A 2004 survey-based study did not corroborate this finding, but it did report a decrease in offspring sex ratio with additional time in the submarine community and detected lower sex ratios among submariners with certain naval ratings (i.e., occupational specialties), such as sonar technicians. (health.mil)
Previous studies have shown that occupational exposure to pesticides might have an effect on semen quality, but so far there has been little investigation of the effects of pesticides in diet. (eurekalert.org)

Although the results of animal studies don't always carry over to humans, the results of this study suggest that at least a partial recovery is possible. (healthline.com)
They continue: "These findings suggest that exposure to pesticides used in agricultural production through diet may be sufficient to affect spermatogenesis in humans. (eurekalert.org)

However, few studies have investigated how paternal factors can affect children. (genengnews.com)
Although we cannot define at this point which obesity-related factor may cause an epigenetic effect, we measured in this study a significant association between paternal obesity and aberrant methylation profiles in the offspring," concludes Dr. Soubry. (genengnews.com)

Who's studying Genes Expression & Epigenetics? (umassmed.edu)
Hence, Instituto Bernabeu has developed a panel of 426 genes that evaluates the main genes involved in spermatogenesis to complete the diagnosis of male infertility from the genetic point of view by personalizing in vitro fertilization (IVF) treatment. (institutobernabeu.com)
Advances in molecular biology and the development of massive sequencing techniques - together with the constant investment of the most avant-garde technology of Instituto Bernabeu - have allowed us to design the most complete genetic study of male fertility, identifying a total of 426 related genes with male gametogenesis. (institutobernabeu.com)
Hanna says that the study relies on comparing the physical characteristics of the lab-grown sperm with natural healthy sperm, and on confirming activity in certain genes linked with various stages in sperm maturity. (newscientist.com)

This is also due to the fact that extrapolation of results obtained from experimental animal or in vitro studies remains difficult. (springer.com)

The exposures of the men during the spermatogenesis preceding the pregnancies and of the women during the first trimester of the pregnancies were obtained with questionnaires, and the available biological monitoring measurements were used in the exposure assessment. (cdc.gov)
To gather data on newborn health outcomes, the researchers followed families enrolled in the Newborn Epigenetics Study (NEST), a research program that tests the influence of environmental exposures on genetic profiles in newborns. (genengnews.com)

Antioxidants have distinctive effects on spermatogenesis, sperm biology and oxidative stress, and changes in anti-oxidant capacity are considered to be involved in the pathogenesis of chronic diabetes mellitus. (ajol.info)
This study investigated the protective effects of lyophilized aqueous seed extract of Buchholzia coriacea (B. coriacea) in enhancing memory and neuroprotection in scopolamine-induced learning and memory impairment using Morris water maze and Y maze. (researchgate.net)

A 2017 study looking at 16,395 healthy men found that heavy drinking may negatively affect semen volume and sperm morphology. (healthline.com)
Another study looking at 8,344 healthy men from Europe and the United States also found that moderate alcohol intake didn't affect semen quality. (healthline.com)
The first study to investigate the relationship between eating fruit and vegetables containing pesticide residues and the quality of men's semen has shown a link with lower sperm counts and percentages of normally-formed sperm. (eurekalert.org)
However, the study of 155 men showed that, overall, the total amount of fruit and vegetables consumed was unrelated to changes in any measurements of semen quality in the group as a whole. (eurekalert.org)
Studies of men presenting to fertility clinics like this one do over-represent men with semen quality problems. (eurekalert.org)
In our study almost half of the men had one or more semen parameters below the World Health Organization reference limits. (eurekalert.org)

Obesity can disturb spermatogenesis and subsequently affect male fertility and reproduction. (nature.com)
Obesity can affect spermatogenesis via several mechanisms and processes, among others via hormonal changes. (nature.com)
However, research examining male fertility in obesity is rather limited compared to studies in women and results are rather ambiguous. (nature.com)
The aim of this study was to determine potential associations between obesity in parents prior to conception and epigenetic profiles in offspring, particularly at certain gene regulatory regions. (genengnews.com)
The researchers noted that the changes in DNA methylation could have been a result of something related to obesity, such as eating a certain diet or having diabetes, that was not measured in this study. (genengnews.com)

Our study suggests that exposure to PFAAs may be a risk factor for hyperuricemia and gout. (cdc.gov)

Male fertility relies on the continuous production of sperm via a process known as spermatogenesis. (elifesciences.org)
The men were eligible for the study if they were aged 18-55, had not had a vasectomy, and were part of a couple planning to use their own eggs and sperm for fertility treatment. (eurekalert.org)

In this Review, we briefly outline the roles that follicle-stimulating hormone (FSH) and testosterone play in regulating spermatogenesis and describe our current understanding of how vitamin A regulates germ cell differentiation and how it may lead to the generation of both the cycle of the seminiferous epithelium and the spermatogenic wave. (jci.org)
We study whether PRKRA localizes to nuage of spermatogenic cells of rat and mouse. (hindawi.com)
Studies have found that 50 percent of heavy drinkers had spermatogenic arrest compared to only 20 percent of men without alcoholism. (healthline.com)

In addition, it is not known when PRKRA appears in and disappears from the nuage structures and the nonnuage structures during spermatogenesis. (hindawi.com)

Dose selection rationale: The doses for the study were chosen with respect to the results of the dose-range finding experiment. (europa.eu)
The results presented here are part of a longitudinal study that has been on going for more than 3 years. (vin.com)
Time to pregnancy: results of the German prospective study and impact on the management of infertility. (msdmanuals.com)

In vitro spermatogenesis is the process of creating male gametes (spermatozoa) outside of the body in a culture system. (wikipedia.org)
Spermatogenesis is a highly complex process and artificially rebuilding it in vitro is challenging. (wikipedia.org)

The Flores Kim lab studies how bacteria build their cell envelopes and how antimicrobials disrupt these processes. (umassmed.edu)
All-trans retinoic acid (RA) is the most active metabolite of vitamin A. Several studies have described a pivotal role for RA signalling in different biological processes such as cell growth and differentiation, embryonic development and organogenesis. (mdpi.com)
Drosophila has long been an attractive, genetically tractable model system in which to study fundamental processes such as apoptosis which are common to higher eukaryotes. (caltech.edu)
This provokes speculation that core components of the cell death machinery can function to regulate processes other than apoptosis, such as spermatogenesis. (caltech.edu)

Matériel et Méthode : Il s'agissait d'une étude rétrospective portant sur 13 dossiers de patients qui ont été pris en charge au service d'Urologie-Andrologie l'hôpital Gabriel Touré du Mali pour traumatisme des bourses durant la période allant de Février 2006 à Janvier 2013. (bvsalud.org)
Patients who have not agreed to take part in the study. (who.int)

This study is encouraging, but the cells isolated are not even closely similar to mature or immature sperm, either in the rat or human," says Jacob Hanna of the Weizmann Institute of Science in Rehovot, Israel, who is part of another team attempting to grow human sperm in the lab. (newscientist.com)
While I think the study is important, the claim for complete human spermatogenesis outside the body is completely not proven in this study," he says. (newscientist.com)
A recent study has described why human embryos may exhibit such high levels of aneuploidy resulting in early pregnancy loss. (planer.com)

Therewith, excessive amounts of adipose tissue can decrease testosterone concentrations and thereby spermatogenesis through increase of leptin and oestrogen. (nature.com)

Furthermore, this study found no meaningful variation in offspring sex ratio by length of submarine or military service or by rating. (health.mil)

endpoints comprise deterioration of spermatogenesis and sperm function as well as endocrine disorders and sexual dysfunction. (springer.com)

Dr. Pryciak studies how protein kinases regulate cell signaling and the cell cycle. (umassmed.edu)

Commentary on this study, also published today in BMC Medicine, suggests that this data does not paint the entire picture. (genengnews.com)

Aneuploidies have been detected in all mammal species studied, though not in amphibians and fish (which do not carry their young). (planer.com)

Our study shows that mutations in the Actl7b gene could be the cause of male infertility," says Prof. Schorle. (innovations-report.com)

Studies of how bacteria make the walls that protect them from our immune system may lead to the development of new or improved antibiotics to address the growing threat of antibiotic resistance. (umassmed.edu)
Oral keratosis with atypia is an ideal model for the study of head and neck cancer development and chemoprevention because the lesions are readily accessible to visual examination, diagnostic sampling, and evaluation of response to treatment. (medscape.com)
The development of sperm is called spermatogenesis. (healthline.com)

The Rando Lab studies the role of epigenetic inheritance in programming health and disease. (umassmed.edu)
The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. (plos.org)
Both testosterone and FSH play a role in spermatogenesis. (healthline.com)

In this recently published study , we dynamically imaged changes in intracellular calcium concentration in the early embryos of Oikopleura dioica using the genetically encoded calcium indicator GCaMP6. (uib.no)

The aim of this study was to study the developmental change of Zn mobilization and gene expression related to key Zn transport proteins between the yolk sac membrane and embryonic liver from the incubation d 17 (E17) to d 32 (E32) during duck embryonic developing. (bvsalud.org)

Contrary to previous studies, this large, record-based analysis found no evidence to suggest the offspring sex ratio of male active duty U.S. Navy submariners is different from that of other active duty populations or the U.S. population as a whole. (health.mil)

Anatomy22

Organisms9

Diseases12

Chemicals and Drugs22

Analytical, Diagnostic and Therapeutic Techniques and Equipment9

Psychiatry and Psychology1

Phenomena and Processes25

Disciplines and Occupations1

Information Science3

Testes11

Reproductive6

Rats4

Testicular4

Occurs1

Alterations2

Maturation2

Cohort2

Testis7

Mice5

Spermatogonia2

Adult3

Karyotype1

Cellular2

Hormones1

Genetics1

Males3

Chromosome3

Testicles1

Extensively2

Testosterone production3

Occupational2

Humans2

Paternal2

Genes4

Vitro studies1

Exposures2

Effects2

Semen6

Obesity5

Exposure1

Fertility2

Spermatogenic3

Structures1

Results3

Process2

Processes4

Patients2

Human3

Decrease1

Variation1

Function1

Regulate1

Suggests1

Species1

Mutations1

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Embryos1

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