A 2013 Cochrane review found that therapeutic hypothermia is useful in full term babies with encephalopathy. (wikipedia.org)
Therapeutic hypothermia (TH) aims to ameliorate further injury in infants with moderate and severe hypoxic ischemic encephalopathy (HIE). (nature.com)
Therapeutic hypothermia (TH) is now standard of care for infants with moderate and severe HIE ( 15 ). (nature.com)
To present our preliminary experience with the first cases of clinical application of therapeutic hypothermia for PA-HIE [1] in what we believe is the first report on non-experimental hypothermia for PA-HIE from Israel. (ima.org.il)
To examine the frequency and types of placental pathology observed in encephalopathic newborns presenting for therapeutic hypothermia. (jnpm.org)
Placental pathology was common in infants with neonatal encephalopathy admitted for therapeutic hypothermia, especially in those with no clinically recognized sentinel birth events. (jnpm.org)
Hypoxic ischemic7
Mild total body hypothermia, induced by cooling a baby to 33-34°C for three days after birth, is nowadays a standardized treatment after moderate to severe hypoxic ischemic encephalopathy in full-term and near to fullterm neonates. (wikipedia.org)
Hypoxic ischemic encephalopathy has many causes and is defined essentially as the reduction in the supply of blood or oxygen to a baby's brain before, during, or even after birth. (wikipedia.org)
Recognition of infants with marginal external signs of asphyctic damage at birth, who still develop moderate hypoxic ischemic encephalopathy would be enhanced by finding more reliable bio-markers or physiologic tests accurately predicting the risk for progressive damage. (wikipedia.org)
Hypoxic ischemic encephalopathy (HIE) occurs in 1-6 per 1,000 live full-term births and is caused by the interruption of blood and/or oxygen supply to the brain in the perinatal period ( 1 , 2 ). (nature.com)
Major advances in the treatment of perinatal asphyxial-hypoxic ischemic encephalopathy followed the translation of hypothermia animal studies into successful randomized controlled clinical trials that substantially influenced the current standard of care. (ima.org.il)
Perinatal asphyxia, more appropriately known as hypoxic-ischemic encephalopathy (HIE), is characterized by clinical and laboratory evidence of acute or subacute brain injury due to asphyxia. (medscape.com)
Despite the advent of hypothermia therapy for the treatment of hypoxic-ischemic encephalopathy (HIE), treatment options following asphyxia at birth remain limited, particularly in low-resource settings where the incidence of birth asphyxia is highest. (frontiersin.org)
Neonatal3
Between May 2006 and April 2010, 140 term newborns with neonatal encephalopathy were admitted for cooling. (jnpm.org)
If the part of neonatal anoxia in neonatal mortality is known in Mali [6] , however, its epidemio-clinical characteristics had never been studied before. (scirp.org)
This study will determine whether high-dose DHA enteral supplementation during the neonatal period is associated with the risk of severe BPD at 36 weeks' postmenstrual age (PMA) compared with control, in contemporary cohorts of preterm infants born at less than 29 weeks of gestation. (bvsalud.org)
Asphyxia2
The fetal sheep asphyxia model also suggests a six-hour window post asphyxia in which hypothermia will have greatest benefit. (wikipedia.org)
Furthermore, we reviewed the current treatments available for neonates who have undergone intrapartum asphyxia, and highlight the emergence of maternal dietary creatine supplementation as a preventative therapy, which has been shown to provide multi-organ protection from birth asphyxia-induced injury in our preclinical studies. (frontiersin.org)
Infants7
At present data relate only to full term infants, and all human studies of hypothermia treatment have so far been restricted to infants >36 weeks out of an expected 40 weeks gestation. (wikipedia.org)
Previous studies have not investigated the effect of TH on HRV in infants with moderate and severe HIE independently. (nature.com)
These studies are important as infants with moderate and severe HIE are known to have very different long-term neurodevelopmental outcomes. (nature.com)
This is a novel study as it investigates HRV in infants with moderate and severe HIE independently. (nature.com)
To our knowledge, this is also the first study to compare HRV data between normothermic and hypothermic infants with HIE. (nature.com)
This observational study compares HRV features in infants recruited from 2003 to 2007, prior to the introduction of TH in the NICU (pre-TH group) ( 14 ) and infants recruited from 2009 to 2014, after the implementation of TH in our NICU (TH group). (nature.com)
The aim of this study was to describe the breast milk oxylipin profile following a docosahexaenoic acid (DHA) supplementation of mothers of preterm infants. (bvsalud.org)
Placenta1
Permeability of human placenta to bicarbonate: In vitro perfusion studies. (newbornjournal.org)
Newborns2
We reviewed the medical records, imaging scans, electroencephalograms and outcome data of the six identified asphyxiated newborns who were managed with hypothermia in our services in 2008-2009. (ima.org.il)
The objective of this work is to study the epidemiological and clinical characteristics of PA, as well as the immediate outcome of newborns included. (scirp.org)
Clinical1
It is the study of epidemiological and clinical characteristics, the immediate outcome and the factors associated with newborn (NB) mortality with NA. (scirp.org)
Long-term1
None of these programmes have sufficient power to make confident assessments of the long-term effect of hypothermia, however even these underpowered studies give important information on whether the therapeutic effects of cooling are sustained beyond the first two years after birth. (wikipedia.org)
Brain1
There are both more potential side effects on the developing premature with lung disease, and there is more evident protection by hypothermia when a greater volume of complex brain is actively developing. (wikipedia.org)
Events1
The presence or absence of recognized asphyxial ("sentinel") birth events was noted. (jnpm.org)
Major1
The périnatal anoxia (PA) is a major health issue in Mali because of its frequency and severity. (scirp.org)
Determine1
Studies have been undertaken to determine the effects of hypothermia beyond early childhood. (wikipedia.org)
Significant1
The most significant follow-up study published so far is the assessment of the NICHD trial participants at 6-7 years. (wikipedia.org)
Hypoxic ischemic encephalopathy9
Mild total body hypothermia, induced by cooling a baby to 33-34°C for three days after birth, is nowadays a standardized treatment after moderate to severe hypoxic ischemic encephalopathy in full-term and near to fullterm neonates. (wikipedia.org)
Hypoxic ischemic encephalopathy has many causes and is defined essentially as the reduction in the supply of blood or oxygen to a baby's brain before, during, or even after birth. (wikipedia.org)
Recognition of infants with marginal external signs of asphyctic damage at birth, who still develop moderate hypoxic ischemic encephalopathy would be enhanced by finding more reliable bio-markers or physiologic tests accurately predicting the risk for progressive damage. (wikipedia.org)
Perinatal asphyxia, more appropriately known as hypoxic-ischemic encephalopathy (HIE), is characterized by clinical and laboratory evidence of acute or subacute brain injury due to asphyxia. (medscape.com)
Providing standard intensive care support, correcting metabolic acidosis, close monitoring of the fluid status, and seizure control are the main elements of treatment in patients with hypoxic-ischemic encephalopathy (HIE). (medscape.com)
Elevated temperature after hypoxic-ischemic encephalopathy: risk factor for adverse outcomes. (medscape.com)
Effect of depth and duration of cooling on death or disability at age 18 months among neonates with hypoxic-ischemic encephalopathy: a randomized clinical trial. (medscape.com)
This study aimed to identify potential biomarkers of neonatal hypoxic-ischemic encephalopathy (HIE) via a novel proteomic approach, the isobaric tags for absolute and relative quantification (iTRAQ) method. (biomedcentral.com)
Neonatal hypoxic ischemic encephalopathy (HIE) is a severe form of neonatal brain damage caused by an asphyxia-related decrease in cerebral blood flow and hypoxia. (biomedcentral.com)
Ischaemic encephalopathy3
Neonatal encephalopathy (NE), formerly known as Hypoxic - ischaemic encephalopathy (HIE) is a major challenge in newborn care worldwide. (ispub.com)
Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy: synthesis and meta-analysis of trial data. (evelinalondon.nhs.uk)
Assessment of brain tissue injury after moderate hypothermia in neonates with hypoxic-ischaemic encephalopathy: a nested substudy of a randomised controlled trial. (evelinalondon.nhs.uk)
This study will determine whether high-dose DHA enteral supplementation during the neonatal period is associated with the risk of severe BPD at 36 weeks' postmenstrual age (PMA) compared with control, in contemporary cohorts of preterm infants born at less than 29 weeks of gestation. (bvsalud.org)
Pathophysiology1
Recent advances in the pathophysiology of neonatal encephalopathy include the role of increased cytosolic influx of calcium ions, excitatory amino acid neurotransmitters and mediators of inflammation like nitric oxide and free radicals in the disruption of neuronal metabolism thus, resulting in widespread neuronal deaths. (ispub.com)
Cerebral1
Neuroimaging features of NE include cerebral oedema and haemorrhages within the first one week of asphyxial insult while cerebral necrosis and atrophy occur subsequently. (ispub.com)
Neonatology1
He trained at the Medical School at Guy's Hospital and studied neonatology at University College London before moving to the Hammersmith Hospital and Imperial College. (evelinalondon.nhs.uk)
Childhood2
Studies have been undertaken to determine the effects of hypothermia beyond early childhood. (wikipedia.org)
Perinatal cortical growth and childhood neurocognitive abilities. (evelinalondon.nhs.uk)
Newborn2
Neonatal encephalopathy is important for its association with significant morbidity and mortality in the newborn period as well as chronic handicapping conditions later in life. (ispub.com)
In the current study, the similarities and differences in serum protein expression between newborn HIE patients and healthy newborns were detected by a novel isobaric tag for absolute and relative quantitation (iTRAQ)-based quantitative clinical proteomics approach. (biomedcentral.com)
Effects2
None of these programmes have sufficient power to make confident assessments of the long-term effect of hypothermia, however even these underpowered studies give important information on whether the therapeutic effects of cooling are sustained beyond the first two years after birth. (wikipedia.org)
There are both more potential side effects on the developing premature with lung disease, and there is more evident protection by hypothermia when a greater volume of complex brain is actively developing. (wikipedia.org)
Assessment1
The most significant follow-up study published so far is the assessment of the NICHD trial participants at 6-7 years. (wikipedia.org)
Group1
PREEMPT 1 Chronic Migraine Study Group. (jicna.org)
Found1
A 2013 Cochrane review found that therapeutic hypothermia is useful in full term babies with encephalopathy. (wikipedia.org)